EA200501212A3 - Полимерные конъюгаты мутантного неубластина - Google Patents
Полимерные конъюгаты мутантного неубластинаInfo
- Publication number
- EA200501212A3 EA200501212A3 EA200501212A EA200501212A EA200501212A3 EA 200501212 A3 EA200501212 A3 EA 200501212A3 EA 200501212 A EA200501212 A EA 200501212A EA 200501212 A EA200501212 A EA 200501212A EA 200501212 A3 EA200501212 A3 EA 200501212A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- polymer conjugates
- mutated neublastin
- neublastin
- polymer
- mutated
- Prior art date
Links
- 102100026376 Artemin Human genes 0.000 title abstract 3
- 101000785776 Homo sapiens Artemin Proteins 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 239000000539 dimer Substances 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
Abstract
Раскрыт димер, включающий мутантный полипептид неубластина, связанный с полимером. Такие димеры проявляют продленную биодоступность и, в предпочтительных вариантах осуществления, увеличенную биологическую активность по сравнению с формами неубластина дикого типа.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/356,264 US7442370B2 (en) | 2001-02-01 | 2003-01-31 | Polymer conjugates of mutated neublastin |
PCT/US2004/002763 WO2004069176A2 (en) | 2001-02-01 | 2004-02-02 | Polymer conjugates of mutated neublastin |
Publications (3)
Publication Number | Publication Date |
---|---|
EA200501212A2 EA200501212A2 (ru) | 2006-08-25 |
EA200501212A3 true EA200501212A3 (ru) | 2006-10-27 |
EA008743B1 EA008743B1 (ru) | 2007-08-31 |
Family
ID=35006489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200501212A EA008743B1 (ru) | 2003-01-31 | 2004-02-02 | Полимерные конъюгаты мутантного неубластина |
Country Status (27)
Country | Link |
---|---|
EP (3) | EP2301960A3 (ru) |
JP (3) | JP4742025B2 (ru) |
KR (2) | KR101293805B1 (ru) |
CN (2) | CN101166753A (ru) |
AT (1) | ATE478891T1 (ru) |
AU (1) | AU2004209966B9 (ru) |
BR (1) | BRPI0407170A (ru) |
CA (1) | CA2514510C (ru) |
CY (2) | CY1111196T1 (ru) |
DE (1) | DE602004028801D1 (ru) |
DK (2) | DK2246362T3 (ru) |
EA (1) | EA008743B1 (ru) |
ES (2) | ES2450115T3 (ru) |
GE (3) | GEP20135982B (ru) |
HK (1) | HK1085663A1 (ru) |
IL (2) | IL169945A (ru) |
IS (1) | IS7938A (ru) |
ME (1) | MEP43808A (ru) |
MX (1) | MXPA05008168A (ru) |
NO (1) | NO20054025L (ru) |
NZ (2) | NZ581460A (ru) |
PL (1) | PL383683A1 (ru) |
PT (2) | PT1594436E (ru) |
RS (1) | RS52910B (ru) |
SI (2) | SI1594436T1 (ru) |
UA (2) | UA91178C2 (ru) |
ZA (1) | ZA200505707B (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA91178C2 (ru) * | 2003-01-31 | 2010-07-12 | Байоджен Айдек Ма Інк. | Мутантный неубластин |
WO2006023782A2 (en) * | 2004-08-19 | 2006-03-02 | Biogen Ideca Ma Inc. | Refolding transforming growth factor beta family proteins |
US20140092376A1 (en) * | 2012-10-01 | 2014-04-03 | Momentive Performance Materials, Inc. | Container and method for in-line analysis of protein compositions |
AU2018212403A1 (en) * | 2017-01-25 | 2019-08-22 | Tessa Therapeutics Ltd. | TGF-ß decoy receptor |
EP4096920A1 (en) * | 2020-01-27 | 2022-12-07 | Silcotek Corp. | Biopharmaceutical manufacturing process and product |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU187037B (en) | 1983-04-19 | 1985-10-28 | Tibor Sinko | Rope-stretching device |
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
CA2006596C (en) | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
KR100238712B1 (ko) | 1991-06-27 | 2000-01-15 | 스티븐 비. 데이비스 | 씨티엘에이4 수용체,그를 함유한 연합단백질 및 그의 용도 |
CA2092271C (en) | 1993-03-09 | 2009-10-13 | Eddie Reed | Use of g-csf for treating taxol side-effects |
US5834029A (en) | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
CA2253871C (en) | 1996-05-08 | 2005-04-26 | Biogen, Inc. | Ret ligand (retl) for stimulating neural and renal growth |
KR100195886B1 (ko) | 1996-11-01 | 1999-06-15 | 김상조 | 당뇨병 치료용 의약조성물 |
ATE375363T1 (de) * | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
US20020055467A1 (en) * | 1998-07-06 | 2002-05-09 | Johansen Teit E. | Novel neurotrophic factors |
US20020002269A1 (en) * | 1998-09-29 | 2002-01-03 | Jeffrey D. Milbrandt | Artemin, a neurotrophic factor |
AU2354600A (en) * | 1998-12-09 | 2000-06-26 | Amgen, Inc. | Grnf4 a neurotrophic factor |
IL156559A0 (en) * | 2000-12-22 | 2004-01-04 | Genentech Inc | New use of artemin, a member of the gdnf ligand family |
GEP20063916B (en) * | 2001-02-01 | 2006-09-11 | Biogen Idec Inc | Polymer conjugates of neublastin and methods of using same |
NZ529126A (en) * | 2001-03-28 | 2010-07-30 | Biogen Idec Inc | Use of neublastin polypeptides for treating allodynia, hyperalgesic pain and phantom pain |
UA91178C2 (ru) * | 2003-01-31 | 2010-07-12 | Байоджен Айдек Ма Інк. | Мутантный неубластин |
EP1897552B1 (en) * | 2003-04-18 | 2009-06-17 | Biogen Idec MA Inc. | Polymer-conjugated glycosylated neublastin |
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2004
- 2004-02-02 UA UAA200508412A patent/UA91178C2/ru unknown
- 2004-02-02 EP EP10181704A patent/EP2301960A3/en not_active Withdrawn
- 2004-02-02 CN CNA200480009133XA patent/CN101166753A/zh active Pending
- 2004-02-02 ES ES10173737.7T patent/ES2450115T3/es not_active Expired - Lifetime
- 2004-02-02 GE GEAP200411544A patent/GEP20135982B/en unknown
- 2004-02-02 CA CA2514510A patent/CA2514510C/en not_active Expired - Fee Related
- 2004-02-02 BR BRPI0407170-0A patent/BRPI0407170A/pt not_active IP Right Cessation
- 2004-02-02 UA UAA200912089A patent/UA105892C2/ru unknown
- 2004-02-02 NZ NZ581460A patent/NZ581460A/en not_active IP Right Cessation
- 2004-02-02 SI SI200431548T patent/SI1594436T1/sl unknown
- 2004-02-02 KR KR1020127021783A patent/KR101293805B1/ko not_active IP Right Cessation
- 2004-02-02 MX MXPA05008168A patent/MXPA05008168A/es active IP Right Grant
- 2004-02-02 SI SI200432136T patent/SI2246362T1/sl unknown
- 2004-02-02 DE DE602004028801T patent/DE602004028801D1/de not_active Expired - Lifetime
- 2004-02-02 PT PT04707363T patent/PT1594436E/pt unknown
- 2004-02-02 ME MEP-438/08A patent/MEP43808A/xx unknown
- 2004-02-02 GE GEAP200410236A patent/GEP20115137B/en unknown
- 2004-02-02 GE GEAP20048957A patent/GEP20084464B/en unknown
- 2004-02-02 EP EP10173737.7A patent/EP2246362B1/en not_active Expired - Lifetime
- 2004-02-02 JP JP2006503213A patent/JP4742025B2/ja not_active Expired - Fee Related
- 2004-02-02 CN CN201110239061.XA patent/CN102367277B/zh not_active Expired - Fee Related
- 2004-02-02 AU AU2004209966A patent/AU2004209966B9/en not_active Ceased
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