DK1594436T3 - Polymerkonjugater af muteret neublastin - Google Patents

Polymerkonjugater af muteret neublastin

Info

Publication number
DK1594436T3
DK1594436T3 DK04707363.0T DK04707363T DK1594436T3 DK 1594436 T3 DK1594436 T3 DK 1594436T3 DK 04707363 T DK04707363 T DK 04707363T DK 1594436 T3 DK1594436 T3 DK 1594436T3
Authority
DK
Denmark
Prior art keywords
polymer conjugates
mutated neublastin
neublastin
mutated
polymer
Prior art date
Application number
DK04707363.0T
Other languages
English (en)
Inventor
R Blake Pepinsky
Paula Ann Boriack-Sjodin
Stephan S Miller
Laura Silvian
Anthony Rossomando
Dinah Wen-Yee Sah
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Application granted granted Critical
Publication of DK1594436T3 publication Critical patent/DK1594436T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
DK04707363.0T 2003-01-31 2004-02-02 Polymerkonjugater af muteret neublastin DK1594436T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (1)

Publication Number Publication Date
DK1594436T3 true DK1594436T3 (da) 2010-12-13

Family

ID=35006489

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04707363.0T DK1594436T3 (da) 2003-01-31 2004-02-02 Polymerkonjugater af muteret neublastin
DK10173737.7T DK2246362T3 (da) 2003-01-31 2004-02-02 Polymerkonjugater af muteret neublastin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10173737.7T DK2246362T3 (da) 2003-01-31 2004-02-02 Polymerkonjugater af muteret neublastin

Country Status (27)

Country Link
EP (3) EP1594436B1 (da)
JP (3) JP4742025B2 (da)
KR (2) KR101293805B1 (da)
CN (2) CN101166753A (da)
AT (1) ATE478891T1 (da)
AU (1) AU2004209966B9 (da)
BR (1) BRPI0407170A (da)
CA (1) CA2514510C (da)
CY (2) CY1111196T1 (da)
DE (1) DE602004028801D1 (da)
DK (2) DK1594436T3 (da)
EA (1) EA008743B1 (da)
ES (2) ES2351215T3 (da)
GE (3) GEP20135982B (da)
HK (1) HK1085663A1 (da)
IL (2) IL169945A (da)
IS (1) IS7938A (da)
ME (1) MEP43808A (da)
MX (1) MXPA05008168A (da)
NO (1) NO20054025L (da)
NZ (2) NZ541921A (da)
PL (1) PL383683A1 (da)
PT (2) PT1594436E (da)
RS (1) RS52910B (da)
SI (2) SI2246362T1 (da)
UA (2) UA105892C2 (da)
ZA (1) ZA200505707B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS52910B (en) * 2003-01-31 2014-02-28 Biogen Idec Ma Inc. POLYMER CONJUGATES OF MUTATED NEUBLASTINE
CN101043899B (zh) * 2004-08-19 2011-03-30 比奥根艾迪克Ma公司 重折叠转化型生长因子beta家族蛋白
US20140092376A1 (en) * 2012-10-01 2014-04-03 Momentive Performance Materials, Inc. Container and method for in-line analysis of protein compositions
WO2018138003A1 (en) * 2017-01-25 2018-08-02 Tessa Therapeutics Pte. Ltd. TGF-ß DECOY RECEPTOR
EP4096920A1 (en) * 2020-01-27 2022-12-07 Silcotek Corp. Biopharmaceutical manufacturing process and product

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EP0401384B1 (en) 1988-12-22 1996-03-13 Kirin-Amgen, Inc. Chemically modified granulocyte colony stimulating factor
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
ATE170562T1 (de) 1991-06-27 1998-09-15 Bristol Myers Squibb Co Ctl4a rezeptor, ihn enthaltenden fusionsproteine und deren verwendungen
CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
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US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
TR200103297T2 (tr) 1996-05-08 2002-06-21 Biogen, Inc. Nöral ve renal gelişmenin uyarılması için Ret ligandı (RetL)
KR100195886B1 (ko) 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
AU751898B2 (en) * 1997-07-14 2002-08-29 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
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US20020002269A1 (en) * 1998-09-29 2002-01-03 Jeffrey D. Milbrandt Artemin, a neurotrophic factor
JP2002531128A (ja) * 1998-12-09 2002-09-24 アムジエン・インコーポレーテツド 神経栄養因子ｇｒｎｆ４
JP2005502582A (ja) * 2000-12-22 2005-01-27 ジェネンテック， インコーポレイテッド Ｇｄｎｆリガンドファミリーのメンバーである、アルテミンの新たな使用
KR100872807B1 (ko) 2001-02-01 2008-12-09 바이오겐 아이덱 엠에이 인코포레이티드 누블라스틴의 중합체 컨쥬게이트 및 이의 사용 방법
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RS52910B (en) * 2003-01-31 2014-02-28 Biogen Idec Ma Inc. POLYMER CONJUGATES OF MUTATED NEUBLASTINE
CA2864810A1 (en) * 2003-04-18 2004-11-04 Biogen Idec Ma, Inc. Polymer-conjugated glycosylated neublastin

Also Published As

Publication number Publication date
JP2011078434A (ja) 2011-04-21
EP2246362A3 (en) 2011-02-23
CA2514510A1 (en) 2004-08-19
HK1085663A1 (en) 2006-09-01
EP2246362A2 (en) 2010-11-03
PT1594436E (pt) 2010-11-29
UA105892C2 (uk) 2014-07-10
AU2004209966B2 (en) 2008-04-17
NZ541921A (en) 2010-01-29
ZA200505707B (en) 2007-01-31
KR101216331B1 (ko) 2012-12-28
SI2246362T1 (sl) 2014-04-30
EA008743B1 (ru) 2007-08-31
CY1111196T1 (el) 2015-06-11
EP1594436B1 (en) 2010-08-25
BRPI0407170A (pt) 2006-02-21
EP2301960A3 (en) 2011-08-03
NO20054025D0 (no) 2005-08-30
ATE478891T1 (de) 2010-09-15
SI1594436T1 (sl) 2011-01-31
AU2004209966A1 (en) 2004-08-19
MEP43808A (en) 2011-02-10
MXPA05008168A (es) 2005-10-05
NZ581460A (en) 2010-02-26
KR20050099514A (ko) 2005-10-13
AU2004209966B9 (en) 2008-06-26
CA2514510C (en) 2013-10-01
NO20054025L (no) 2005-10-31
GEP20135982B (en) 2013-12-10
PT2246362E (pt) 2014-03-10
UA91178C2 (ru) 2010-07-12
KR101293805B1 (ko) 2013-08-06
CN102367277A (zh) 2012-03-07
EP1594436A4 (en) 2008-05-28
PL383683A1 (pl) 2008-04-14
RS52910B (en) 2014-02-28
GEP20084464B (en) 2008-08-25
CN102367277B (zh) 2014-04-09
JP4742025B2 (ja) 2011-08-10
EP1594436A2 (en) 2005-11-16
GEP20115137B (en) 2011-01-10
JP2010184924A (ja) 2010-08-26
IL227752A0 (en) 2013-09-30
CY1115085T1 (el) 2016-12-14
EP2246362B1 (en) 2013-12-18
ES2450115T3 (es) 2014-03-24
EA200501212A2 (ru) 2006-08-25
JP2007525152A (ja) 2007-09-06
IL169945A (en) 2015-03-31
DK2246362T3 (da) 2014-03-10
CN101166753A (zh) 2008-04-23
EA200501212A3 (ru) 2006-10-27
AU2004209966A2 (en) 2004-08-19
ES2351215T3 (es) 2011-02-01
KR20120099161A (ko) 2012-09-06
EP2301960A2 (en) 2011-03-30
DE602004028801D1 (de) 2010-10-07
IS7938A (is) 2005-07-12
RS20050585A (en) 2007-11-15

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