EA200501212A2 - Полимерные конъюгаты мутантного неубластина - Google Patents

Полимерные конъюгаты мутантного неубластина

Info

Publication number
EA200501212A2
EA200501212A2 EA200501212A EA200501212A EA200501212A2 EA 200501212 A2 EA200501212 A2 EA 200501212A2 EA 200501212 A EA200501212 A EA 200501212A EA 200501212 A EA200501212 A EA 200501212A EA 200501212 A2 EA200501212 A2 EA 200501212A2
Authority
EA
Eurasian Patent Office
Prior art keywords
polymer conjugates
mutated neublastin
neublastin
polymer
mutated
Prior art date
Application number
EA200501212A
Other languages
English (en)
Other versions
EA008743B1 (ru
EA200501212A3 (ru
Inventor
Динах Вен-Йи Сах
Р. Блэйк Пепински
Паула Энн Бориак-Сйодин
Стефан С. Миллер
Энтони Россомандо
Лаура Сильвиан
Original Assignee
Байоджен Айдек Ма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Байоджен Айдек Ма Инк. filed Critical Байоджен Айдек Ма Инк.
Publication of EA200501212A2 publication Critical patent/EA200501212A2/ru
Publication of EA200501212A3 publication Critical patent/EA200501212A3/ru
Publication of EA008743B1 publication Critical patent/EA008743B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Virology (AREA)
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  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Раскрыт димер, включающий мутантный полипептид неубластина, связанный с полимером. Такие димеры проявляют продленную биодоступность и, в предпочтительных вариантах осуществления, увеличенную биологическую активность по сравнению с формами неубластина дикого типа.
EA200501212A 2003-01-31 2004-02-02 Полимерные конъюгаты мутантного неубластина EA008743B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (3)

Publication Number Publication Date
EA200501212A2 true EA200501212A2 (ru) 2006-08-25
EA200501212A3 EA200501212A3 (ru) 2006-10-27
EA008743B1 EA008743B1 (ru) 2007-08-31

Family

ID=35006489

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501212A EA008743B1 (ru) 2003-01-31 2004-02-02 Полимерные конъюгаты мутантного неубластина

Country Status (27)

Country Link
EP (3) EP1594436B1 (ru)
JP (3) JP4742025B2 (ru)
KR (2) KR101216331B1 (ru)
CN (2) CN101166753A (ru)
AT (1) ATE478891T1 (ru)
AU (1) AU2004209966B9 (ru)
BR (1) BRPI0407170A (ru)
CA (1) CA2514510C (ru)
CY (2) CY1111196T1 (ru)
DE (1) DE602004028801D1 (ru)
DK (2) DK2246362T3 (ru)
EA (1) EA008743B1 (ru)
ES (2) ES2450115T3 (ru)
GE (3) GEP20084464B (ru)
HK (1) HK1085663A1 (ru)
IL (2) IL169945A (ru)
IS (1) IS7938A (ru)
ME (1) MEP43808A (ru)
MX (1) MXPA05008168A (ru)
NO (1) NO20054025L (ru)
NZ (2) NZ581460A (ru)
PL (1) PL383683A1 (ru)
PT (2) PT1594436E (ru)
RS (1) RS52910B (ru)
SI (2) SI2246362T1 (ru)
UA (2) UA91178C2 (ru)
ZA (1) ZA200505707B (ru)

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EP1594436B1 (en) * 2003-01-31 2010-08-25 Biogen Idec MA Inc. Mutated neublastin
CN101123978B (zh) * 2004-08-19 2012-12-12 比奥根艾迪克Ma公司 神经胚素变体
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AU2018212403A1 (en) * 2017-01-25 2019-08-22 Tessa Therapeutics Ltd. TGF-ß decoy receptor
WO2021154599A1 (en) * 2020-01-27 2021-08-05 Silcotek Corp. Biopharmaceutical manufacturing process and product

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IL169945A (en) 2015-03-31
NO20054025L (no) 2005-10-31
RS52910B (en) 2014-02-28
DK2246362T3 (en) 2014-03-10
EA008743B1 (ru) 2007-08-31
EP1594436B1 (en) 2010-08-25
EP2301960A2 (en) 2011-03-30
CA2514510C (en) 2013-10-01
AU2004209966B9 (en) 2008-06-26
JP2010184924A (ja) 2010-08-26
GEP20135982B (en) 2013-12-10
KR101293805B1 (ko) 2013-08-06
NO20054025D0 (no) 2005-08-30
SI1594436T1 (sl) 2011-01-31
ES2351215T3 (es) 2011-02-01
MEP43808A (en) 2011-02-10
ZA200505707B (en) 2007-01-31
AU2004209966A2 (en) 2004-08-19
EP1594436A4 (en) 2008-05-28
DK1594436T3 (da) 2010-12-13
RS20050585A (en) 2007-11-15
EP1594436A2 (en) 2005-11-16
BRPI0407170A (pt) 2006-02-21
KR20050099514A (ko) 2005-10-13
ES2450115T3 (es) 2014-03-24
HK1085663A1 (en) 2006-09-01
NZ541921A (en) 2010-01-29
DE602004028801D1 (de) 2010-10-07
CY1111196T1 (el) 2015-06-11
EP2246362A3 (en) 2011-02-23
GEP20115137B (en) 2011-01-10
PT1594436E (pt) 2010-11-29
KR20120099161A (ko) 2012-09-06
JP2011078434A (ja) 2011-04-21
JP2007525152A (ja) 2007-09-06
PL383683A1 (pl) 2008-04-14
AU2004209966A1 (en) 2004-08-19
ATE478891T1 (de) 2010-09-15
CN102367277A (zh) 2012-03-07
PT2246362E (pt) 2014-03-10
UA91178C2 (ru) 2010-07-12
EP2246362B1 (en) 2013-12-18
EP2246362A2 (en) 2010-11-03
MXPA05008168A (es) 2005-10-05
NZ581460A (en) 2010-02-26
IS7938A (is) 2005-07-12
CN102367277B (zh) 2014-04-09
IL227752A0 (en) 2013-09-30
CN101166753A (zh) 2008-04-23
AU2004209966B2 (en) 2008-04-17
GEP20084464B (en) 2008-08-25
CY1115085T1 (el) 2016-12-14
SI2246362T1 (sl) 2014-04-30
KR101216331B1 (ko) 2012-12-28
JP4742025B2 (ja) 2011-08-10
UA105892C2 (ru) 2014-07-10
EA200501212A3 (ru) 2006-10-27
CA2514510A1 (en) 2004-08-19
EP2301960A3 (en) 2011-08-03

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