NO20053775L - Diazepinoindol derivater som kinaseinhibitorer. - Google Patents
Diazepinoindol derivater som kinaseinhibitorer.Info
- Publication number
- NO20053775L NO20053775L NO20053775A NO20053775A NO20053775L NO 20053775 L NO20053775 L NO 20053775L NO 20053775 A NO20053775 A NO 20053775A NO 20053775 A NO20053775 A NO 20053775A NO 20053775 L NO20053775 L NO 20053775L
- Authority
- NO
- Norway
- Prior art keywords
- kinase inhibitors
- diazepinoindole
- derivatives
- compounds
- diazepinoindole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43939603P | 2003-01-09 | 2003-01-09 | |
| PCT/IB2004/000026 WO2004063198A1 (en) | 2003-01-09 | 2004-01-05 | Diazepinoindole derivatives as kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053775D0 NO20053775D0 (no) | 2005-08-08 |
| NO20053775L true NO20053775L (no) | 2005-09-16 |
Family
ID=32713475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053775A NO20053775L (no) | 2003-01-09 | 2005-08-08 | Diazepinoindol derivater som kinaseinhibitorer. |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6967198B2 (xx) |
| EP (2) | EP1585749B1 (xx) |
| JP (1) | JP3990718B2 (xx) |
| KR (1) | KR100697746B1 (xx) |
| CN (1) | CN1759118B (xx) |
| AP (1) | AP2048A (xx) |
| AT (1) | ATE404564T1 (xx) |
| AU (1) | AU2004203977B2 (xx) |
| BR (1) | BRPI0406701A (xx) |
| CA (1) | CA2512683C (xx) |
| CR (1) | CR7899A (xx) |
| CY (1) | CY1108408T1 (xx) |
| DE (1) | DE602004015724D1 (xx) |
| DK (1) | DK1585749T3 (xx) |
| EA (1) | EA009337B1 (xx) |
| EC (1) | ECSP055911A (xx) |
| ES (1) | ES2309484T3 (xx) |
| GE (1) | GEP20084367B (xx) |
| HK (1) | HK1086257A1 (xx) |
| HR (1) | HRP20050624A2 (xx) |
| IL (1) | IL169082A (xx) |
| IS (1) | IS7884A (xx) |
| MA (1) | MA27703A1 (xx) |
| MX (1) | MXPA05007352A (xx) |
| NO (1) | NO20053775L (xx) |
| NZ (1) | NZ540638A (xx) |
| OA (1) | OA13017A (xx) |
| PL (1) | PL378372A1 (xx) |
| PT (1) | PT1585749E (xx) |
| RS (1) | RS20050522A (xx) |
| SI (1) | SI1585749T1 (xx) |
| TN (1) | TNSN05176A1 (xx) |
| UA (1) | UA80733C2 (xx) |
| WO (1) | WO2004063198A1 (xx) |
| ZA (1) | ZA200504674B (xx) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1467730A4 (en) * | 2002-01-22 | 2010-03-10 | Univ California | Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof |
| RS20050522A (xx) * | 2003-01-09 | 2007-12-31 | Pfizer Inc., | Triciklična jedinjenja inhibitori protein kinaze za pojačavanje efikasnosti anti-neoplastičnih agenasa i terapije zračenjem |
| AU2006215413B2 (en) * | 2005-02-18 | 2010-10-07 | Astrazeneca Ab | Method for determining responsiveness to CHK1 inhibitors |
| EP1869020B1 (en) | 2005-03-29 | 2010-12-01 | ICOS Corporation | Heteroaryl urea derivatives useful for inhibiting chk1 |
| GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| WO2007002931A2 (en) | 2005-06-29 | 2007-01-04 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
| EP1928907A4 (en) | 2005-08-15 | 2009-03-11 | Univ California | ACTIVE LIGANDS BY VEGF |
| EP1942193A4 (en) | 2005-08-25 | 2010-10-27 | Ube Industries | PROCESS FOR PRODUCING OPTICALLY ACTIVE ACID (S OR R) -a-AMINO OR OPTICALLY ACTIVE ACID (S OR R) -a-AMINO ESTER |
| EP1916896A4 (en) * | 2005-08-26 | 2010-08-11 | Univ California | NOT STEROID-antiandrogens |
| WO2007113647A1 (en) * | 2006-04-04 | 2007-10-11 | Pfizer Products Inc. | Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4υl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
| US20090312280A1 (en) * | 2006-04-04 | 2009-12-17 | Pfizer Inc. | Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
| MX2009005300A (es) * | 2006-11-17 | 2009-06-08 | Schering Corp | Combinacion de un inhibidor de acido desoxirribonucleico polimerasa-alfa y un inhibidor de una cinasa de punto de verificacion para trastornos proliferativos. |
| US8158656B2 (en) * | 2008-05-16 | 2012-04-17 | Shenzhen Chipscreen Biosciences Ltd. | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
| ES2378513T3 (es) * | 2008-08-06 | 2012-04-13 | Pfizer Inc. | Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1 |
| EP2346881A1 (en) * | 2008-10-10 | 2011-07-27 | Priaxon AG | Novel compounds which modulate kinase activity |
| US8314108B2 (en) | 2008-12-17 | 2012-11-20 | Eli Lilly And Company | 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts |
| US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
| US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
| CN101906076B (zh) | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
| CA2835195A1 (en) | 2011-05-06 | 2012-11-15 | Zafgen, Inc. | Tricyclic sulfonamide compounds and methods of making and using same |
| JP2015500885A (ja) * | 2011-12-22 | 2015-01-08 | スレッショルド ファーマシューティカルズ，インコーポレイテッド | 癌を治療するためのｃｈｋ１阻害剤と組み合わせた低酸素活性化プロドラッグの投与 |
| CN106083849A (zh) | 2011-12-31 | 2016-11-09 | 百济神州有限公司 | 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物 |
| SG11201401726VA (en) | 2011-12-31 | 2014-10-30 | Beigene Ltd | Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors |
| CN102746211B (zh) * | 2012-06-27 | 2015-05-27 | 上海泰坦化学有限公司 | 一种取代吲哚-3-甲醛类化合物的制备方法 |
| TWI633107B (zh) * | 2013-05-22 | 2018-08-21 | 開曼群島商百濟神州生物科技有限公司 | 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮 |
| WO2015013579A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
| US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
| PL3157566T3 (pl) | 2014-06-17 | 2019-10-31 | Vertex Pharma | Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr |
| WO2017032289A1 (en) | 2015-08-25 | 2017-03-02 | Beigene, Ltd. | Process for preparing parp inhibitor, crystalline forms, and uses thereof |
| WO2017059357A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
| US11202782B2 (en) | 2016-09-27 | 2021-12-21 | Beigene, Ltd. | Treatment cancers using a combination comprising PARP inhibitors |
| JP6541635B2 (ja) * | 2016-10-28 | 2019-07-10 | ベイジーン リミテッド | Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン |
| WO2018157794A1 (en) | 2017-02-28 | 2018-09-07 | Beigene, Ltd. | Crystalline forms of salts of fused tera or penta-cyclic dihydrodiazepinocarazolones, and uses thereof |
| US11661581B2 (en) * | 2017-05-25 | 2023-05-30 | University Of Massachusetts | Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells |
| BR112020005489A2 (pt) * | 2017-09-22 | 2020-09-24 | Jubilant Epipad Llc, | composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| JP2022523028A (ja) * | 2019-01-25 | 2022-04-21 | ヌメディー， インコーポレイテッド | 特発性肺線維症を処置するための方法 |
| WO2021018298A1 (zh) * | 2019-08-01 | 2021-02-04 | 南京明德新药研发有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
| WO2021104461A1 (zh) | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 |
| WO2022011458A1 (en) * | 2020-07-13 | 2022-01-20 | Ontario Institute For Cancer Research (Oicr) | Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof |
| JP2023537220A (ja) * | 2020-07-31 | 2023-08-31 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Ｐａｒｐ阻害剤としてのインドロヘプタアシルオキシム類似体の結晶及びその製造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9722320D0 (en) | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
| US6383744B1 (en) | 1998-07-10 | 2002-05-07 | Incyte Genomics, Inc. | Human checkpoint kinase |
| JP2002526450A (ja) | 1998-09-18 | 2002-08-20 | スミスクライン・ビーチャム・コーポレイション | Ｃｈｋ１キナーゼ阻害物質 |
| AP1538A (en) | 1999-01-11 | 2006-01-10 | Agouron Pharma | Tricyclic inhibitors of poly (adp-ribose) polymerases. |
| AU7070800A (en) | 1999-08-27 | 2001-03-26 | Chiron Corporation | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
| CA2385257A1 (en) | 1999-09-22 | 2001-03-29 | Canbas Co., Ltd. | Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents |
| US6211164B1 (en) | 2000-03-10 | 2001-04-03 | Abbott Laboratories | Antisense oligonucleotides of the human chk1 gene and uses thereof |
| DE60142921D1 (de) * | 2000-12-01 | 2010-10-07 | Eisai Inc | Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren |
| UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| RS20050522A (xx) * | 2003-01-09 | 2007-12-31 | Pfizer Inc., | Triciklična jedinjenja inhibitori protein kinaze za pojačavanje efikasnosti anti-neoplastičnih agenasa i terapije zračenjem |
-
2004
- 2004-01-05 RS YUP-2005/0522A patent/RS20050522A/sr unknown
- 2004-01-05 EP EP04700145A patent/EP1585749B1/en not_active Expired - Lifetime
- 2004-01-05 SI SI200430830T patent/SI1585749T1/sl unknown
- 2004-01-05 GE GEAP20048886A patent/GEP20084367B/en unknown
- 2004-01-05 NZ NZ540638A patent/NZ540638A/en unknown
- 2004-01-05 AT AT04700145T patent/ATE404564T1/de not_active IP Right Cessation
- 2004-01-05 CN CN2004800063838A patent/CN1759118B/zh not_active Expired - Fee Related
- 2004-01-05 PT PT04700145T patent/PT1585749E/pt unknown
- 2004-01-05 AU AU2004203977A patent/AU2004203977B2/en not_active Ceased
- 2004-01-05 EP EP08155745A patent/EP1947102A1/en not_active Withdrawn
- 2004-01-05 OA OA1200500197A patent/OA13017A/en unknown
- 2004-01-05 KR KR1020057012806A patent/KR100697746B1/ko not_active IP Right Cessation
- 2004-01-05 DK DK04700145T patent/DK1585749T3/da active
- 2004-01-05 AP AP2005003353A patent/AP2048A/xx active
- 2004-01-05 EA EA200500893A patent/EA009337B1/ru not_active IP Right Cessation
- 2004-01-05 ES ES04700145T patent/ES2309484T3/es not_active Expired - Lifetime
- 2004-01-05 WO PCT/IB2004/000026 patent/WO2004063198A1/en active IP Right Grant
- 2004-01-05 BR BR0406701-0A patent/BRPI0406701A/pt not_active IP Right Cessation
- 2004-01-05 DE DE602004015724T patent/DE602004015724D1/de not_active Expired - Lifetime
- 2004-01-05 MX MXPA05007352A patent/MXPA05007352A/es active IP Right Grant
- 2004-01-05 CA CA2512683A patent/CA2512683C/en not_active Expired - Fee Related
- 2004-01-05 JP JP2006500278A patent/JP3990718B2/ja not_active Expired - Fee Related
- 2004-01-05 PL PL378372A patent/PL378372A1/pl not_active Application Discontinuation
- 2004-01-09 US US10/754,171 patent/US6967198B2/en not_active Expired - Fee Related
- 2004-05-01 UA UAA200506730A patent/UA80733C2/uk unknown
-
2005
- 2005-06-08 ZA ZA200504674A patent/ZA200504674B/en unknown
- 2005-06-08 IL IL169082A patent/IL169082A/en not_active IP Right Cessation
- 2005-06-09 IS IS7884A patent/IS7884A/is unknown
- 2005-07-07 HR HR20050624A patent/HRP20050624A2/hr not_active Application Discontinuation
- 2005-07-08 MA MA28375A patent/MA27703A1/fr unknown
- 2005-07-08 TN TNP2005000176A patent/TNSN05176A1/fr unknown
- 2005-07-08 EC EC2005005911A patent/ECSP055911A/es unknown
- 2005-07-08 CR CR7899A patent/CR7899A/es unknown
- 2005-07-22 US US11/187,089 patent/US7132533B2/en not_active Expired - Fee Related
- 2005-08-08 NO NO20053775A patent/NO20053775L/no unknown
-
2006
- 2006-05-26 HK HK06106153.4A patent/HK1086257A1/xx not_active IP Right Cessation
- 2006-06-23 US US11/426,132 patent/US7462713B2/en not_active Expired - Fee Related
-
2008
- 2008-10-13 CY CY20081101127T patent/CY1108408T1/el unknown
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