DK1585749T3 - Diazepinoindol-derivater som kinaseinhibitorer - Google Patents

Diazepinoindol-derivater som kinaseinhibitorer

Info

Publication number
DK1585749T3
DK1585749T3 DK04700145T DK04700145T DK1585749T3 DK 1585749 T3 DK1585749 T3 DK 1585749T3 DK 04700145 T DK04700145 T DK 04700145T DK 04700145 T DK04700145 T DK 04700145T DK 1585749 T3 DK1585749 T3 DK 1585749T3
Authority
DK
Denmark
Prior art keywords
kinase inhibitors
diazepinoindole
derivatives
diazepinoindole derivatives
kinase
Prior art date
Application number
DK04700145T
Other languages
Danish (da)
English (en)
Inventor
Sacha Ninkovic
Michael J Bennett
Fen Agouron Wang
Suzanne P Benedict
Min Agouron Teng
Yuanjin Eugene Rui
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK1585749T3 publication Critical patent/DK1585749T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04700145T 2003-01-09 2004-01-05 Diazepinoindol-derivater som kinaseinhibitorer DK1585749T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
DK1585749T3 true DK1585749T3 (da) 2008-09-22

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04700145T DK1585749T3 (da) 2003-01-09 2004-01-05 Diazepinoindol-derivater som kinaseinhibitorer

Country Status (35)

Country Link
US (3) US6967198B2 (xx)
EP (2) EP1585749B1 (xx)
JP (1) JP3990718B2 (xx)
KR (1) KR100697746B1 (xx)
CN (1) CN1759118B (xx)
AP (1) AP2048A (xx)
AT (1) ATE404564T1 (xx)
AU (1) AU2004203977B2 (xx)
BR (1) BRPI0406701A (xx)
CA (1) CA2512683C (xx)
CR (1) CR7899A (xx)
CY (1) CY1108408T1 (xx)
DE (1) DE602004015724D1 (xx)
DK (1) DK1585749T3 (xx)
EA (1) EA009337B1 (xx)
EC (1) ECSP055911A (xx)
ES (1) ES2309484T3 (xx)
GE (1) GEP20084367B (xx)
HK (1) HK1086257A1 (xx)
HR (1) HRP20050624A2 (xx)
IL (1) IL169082A (xx)
IS (1) IS7884A (xx)
MA (1) MA27703A1 (xx)
MX (1) MXPA05007352A (xx)
NO (1) NO20053775L (xx)
NZ (1) NZ540638A (xx)
OA (1) OA13017A (xx)
PL (1) PL378372A1 (xx)
PT (1) PT1585749E (xx)
RS (1) RS20050522A (xx)
SI (1) SI1585749T1 (xx)
TN (1) TNSN05176A1 (xx)
UA (1) UA80733C2 (xx)
WO (1) WO2004063198A1 (xx)
ZA (1) ZA200504674B (xx)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1467730A4 (en) * 2002-01-22 2010-03-10 Univ California Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof
RS20050522A (xx) * 2003-01-09 2007-12-31 Pfizer Inc., Triciklična jedinjenja inhibitori protein kinaze za pojačavanje efikasnosti anti-neoplastičnih agenasa i terapije zračenjem
AU2006215413B2 (en) * 2005-02-18 2010-10-07 Astrazeneca Ab Method for determining responsiveness to CHK1 inhibitors
EP1869020B1 (en) 2005-03-29 2010-12-01 ICOS Corporation Heteroaryl urea derivatives useful for inhibiting chk1
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
WO2007002931A2 (en) 2005-06-29 2007-01-04 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
EP1928907A4 (en) 2005-08-15 2009-03-11 Univ California ACTIVE LIGANDS BY VEGF
EP1942193A4 (en) 2005-08-25 2010-10-27 Ube Industries PROCESS FOR PRODUCING OPTICALLY ACTIVE ACID (S OR R) -a-AMINO OR OPTICALLY ACTIVE ACID (S OR R) -a-AMINO ESTER
EP1916896A4 (en) * 2005-08-26 2010-08-11 Univ California NOT STEROID-antiandrogens
WO2007113647A1 (en) * 2006-04-04 2007-10-11 Pfizer Products Inc. Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4υl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide
US20090312280A1 (en) * 2006-04-04 2009-12-17 Pfizer Inc. Combination therapy of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4-yl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide
MX2009005300A (es) * 2006-11-17 2009-06-08 Schering Corp Combinacion de un inhibidor de acido desoxirribonucleico polimerasa-alfa y un inhibidor de una cinasa de punto de verificacion para trastornos proliferativos.
US8158656B2 (en) * 2008-05-16 2012-04-17 Shenzhen Chipscreen Biosciences Ltd. 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
ES2378513T3 (es) * 2008-08-06 2012-04-13 Pfizer Inc. Compuestos 2-heterociclilamino piracinas sustituidas en posición 6 como inhibidores de CHK-1
EP2346881A1 (en) * 2008-10-10 2011-07-27 Priaxon AG Novel compounds which modulate kinase activity
US8314108B2 (en) 2008-12-17 2012-11-20 Eli Lilly And Company 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CN101906076B (zh) 2009-06-04 2013-03-13 深圳微芯生物科技有限责任公司 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用
CA2835195A1 (en) 2011-05-06 2012-11-15 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
JP2015500885A (ja) * 2011-12-22 2015-01-08 スレッショルド ファーマシューティカルズ，インコーポレイテッド 癌を治療するためのｃｈｋ１阻害剤と組み合わせた低酸素活性化プロドラッグの投与
CN106083849A (zh) 2011-12-31 2016-11-09 百济神州有限公司 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物
SG11201401726VA (en) 2011-12-31 2014-10-30 Beigene Ltd Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
WO2015013579A1 (en) 2013-07-26 2015-01-29 Update Pharma Inc. Compositions to improve the therapeutic benefit of bisantrene
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
PL3157566T3 (pl) 2014-06-17 2019-10-31 Vertex Pharma Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr
WO2017032289A1 (en) 2015-08-25 2017-03-02 Beigene, Ltd. Process for preparing parp inhibitor, crystalline forms, and uses thereof
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
US11202782B2 (en) 2016-09-27 2021-12-21 Beigene, Ltd. Treatment cancers using a combination comprising PARP inhibitors
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
WO2018157794A1 (en) 2017-02-28 2018-09-07 Beigene, Ltd. Crystalline forms of salts of fused tera or penta-cyclic dihydrodiazepinocarazolones, and uses thereof
US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
BR112020005489A2 (pt) * 2017-09-22 2020-09-24 Jubilant Epipad Llc, composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
JP2022523028A (ja) * 2019-01-25 2022-04-21 ヌメディー， インコーポレイテッド 特発性肺線維症を処置するための方法
WO2021018298A1 (zh) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 作为parp抑制剂吲哚并七元酰肟化合物
WO2021104461A1 (zh) 2019-11-29 2021-06-03 南京明德新药研发有限公司 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用
WO2022011458A1 (en) * 2020-07-13 2022-01-20 Ontario Institute For Cancer Research (Oicr) Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
JP2023537220A (ja) * 2020-07-31 2023-08-31 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｐａｒｐ阻害剤としてのインドロヘプタアシルオキシム類似体の結晶及びその製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722320D0 (en) 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
US6383744B1 (en) 1998-07-10 2002-05-07 Incyte Genomics, Inc. Human checkpoint kinase
JP2002526450A (ja) 1998-09-18 2002-08-20 スミスクライン・ビーチャム・コーポレイション Ｃｈｋ１キナーゼ阻害物質
AP1538A (en) 1999-01-11 2006-01-10 Agouron Pharma Tricyclic inhibitors of poly (adp-ribose) polymerases.
AU7070800A (en) 1999-08-27 2001-03-26 Chiron Corporation Chimeric antisense oligonucleotides and cell transfecting formulations thereof
ECSP003637A (es) 1999-08-31 2002-03-25 Agouron Pharma Inhibidores triciclicos de poli (adp-ribosa) polimerasas
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
CA2385257A1 (en) 1999-09-22 2001-03-29 Canbas Co., Ltd. Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents
US6211164B1 (en) 2000-03-10 2001-04-03 Abbott Laboratories Antisense oligonucleotides of the human chk1 gene and uses thereof
DE60142921D1 (de) * 2000-12-01 2010-10-07 Eisai Inc Azaphenanthridone-derivate und deren verwendung als parp-inhibitoren
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
RS20050522A (xx) * 2003-01-09 2007-12-31 Pfizer Inc., Triciklična jedinjenja inhibitori protein kinaze za pojačavanje efikasnosti anti-neoplastičnih agenasa i terapije zračenjem

Also Published As

Publication number Publication date
NO20053775L (no) 2005-09-16
NZ540638A (en) 2007-12-21
EA200500893A1 (ru) 2006-02-24
HRP20050624A2 (en) 2006-02-28
KR20050092397A (ko) 2005-09-21
CA2512683A1 (en) 2004-07-29
EP1947102A1 (en) 2008-07-23
AU2004203977B2 (en) 2010-06-17
ZA200504674B (en) 2006-07-26
MA27703A1 (fr) 2006-01-02
US7462713B2 (en) 2008-12-09
CY1108408T1 (el) 2014-02-12
WO2004063198A1 (en) 2004-07-29
NO20053775D0 (no) 2005-08-08
US20070135415A1 (en) 2007-06-14
BRPI0406701A (pt) 2005-12-20
CR7899A (es) 2005-08-05
ATE404564T1 (de) 2008-08-15
CN1759118A (zh) 2006-04-12
ECSP055911A (es) 2005-11-22
AP2048A (en) 2009-09-24
IS7884A (is) 2005-06-09
EA009337B1 (ru) 2007-12-28
PL378372A1 (pl) 2006-04-03
UA80733C2 (en) 2007-10-25
US7132533B2 (en) 2006-11-07
US20050075499A1 (en) 2005-04-07
OA13017A (en) 2006-11-10
PT1585749E (pt) 2008-10-23
CA2512683C (en) 2010-03-16
TNSN05176A1 (fr) 2007-06-11
AP2005003353A0 (en) 2005-09-30
JP2006516274A (ja) 2006-06-29
HK1086257A1 (en) 2006-09-15
US6967198B2 (en) 2005-11-22
MXPA05007352A (es) 2006-02-17
KR100697746B1 (ko) 2007-03-22
ES2309484T3 (es) 2008-12-16
IL169082A (en) 2011-02-28
DE602004015724D1 (de) 2008-09-25
US20060004052A1 (en) 2006-01-05
JP3990718B2 (ja) 2007-10-17
SI1585749T1 (sl) 2008-10-31
CN1759118B (zh) 2010-12-08
GEP20084367B (en) 2008-05-13
EP1585749A1 (en) 2005-10-19
RS20050522A (xx) 2007-12-31
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (en) 2008-08-13

Similar Documents

Publication Publication Date Title
DK1585749T3 (da) Diazepinoindol-derivater som kinaseinhibitorer
DK1789041T3 (da) Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK1797042T3 (da) Indozolonderivater som 11B-HSD1-inhibitorer
DK1658292T3 (da) Triazologyrimidinderivater som glycogensynthasekinase 3 - inhibitorer
DK1944305T3 (da) Quinolinderivater som phosphodiesteraseinhibitorer
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1699797T3 (da) Pyrrolotriazinforbindelser som kinasehæmmere
DK1720882T3 (da) Pyrazolopyrimidin-derivater som cyclin-afhængige kinaseinhibitorer
DK1763517T3 (da) Pyrimidinderivater som 11beta-HSD1-inhibitorer
DK1534290T3 (da) Hidtil ukendte kinasehæmmere
NO20055680D0 (no) Heksahydropyridoisokinoliner som DPP-IV-inhibitorer
DK1881976T3 (da) Substituerede amidderivater som proteinkinaseinhibitorer
DK1778686T3 (da) Triazolopyridinylsulfanylderivater som P38 MAP kinase-inhibitorer
ATE520671T1 (de) Pyrimidin-harnstoff-derivate als kinase-hemmer
DK2039685T3 (da) Heterobicycliske forbindelser som P38-inhibitorer
DK1667991T3 (da) Quinazolinderivater som tyrosinkinaseinhibitorer
DK1711481T4 (da) Krystallinsk monohydrat som kinaseinhibitorer
DK1959951T3 (da) Heteroaryl-substituerede piperidinderivater som L-CPT1-inhibitorer
ATE452891T1 (de) Pyrimidopyrimidone als kinaseinhibitoren
DK1846394T3 (da) Pyrazolylaminopyridinderivater, der er egnede som kinaseinhibitorer
NO20050665L (no) Pyrrolidonderivater som MAOE inhibitoere
IL172132A0 (en) Thienopyridone derivatives as kinase inhibitors
DK1910333T3 (da) Piperidinylsubstituerede isoquinolonderivater som RHO-kinaseinhibitorer
DK2270008T3 (da) 8-Heteroaryl-3-alkyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-oner som PI-3-kinaseinhibitorer
DK1663232T3 (da) Benzimidazolderivater som human chymase-inhibitorer