NO20052568L - Fremgangsmate for fremstilling av makrolidforbindelse - Google Patents

Fremgangsmate for fremstilling av makrolidforbindelse

Info

Publication number
NO20052568L
NO20052568L NO20052568A NO20052568A NO20052568L NO 20052568 L NO20052568 L NO 20052568L NO 20052568 A NO20052568 A NO 20052568A NO 20052568 A NO20052568 A NO 20052568A NO 20052568 L NO20052568 L NO 20052568L
Authority
NO
Norway
Prior art keywords
compound
macrolide compound
streptomyces
represented
formula
Prior art date
Application number
NO20052568A
Other languages
English (en)
Norwegian (no)
Other versions
NO20052568D0 (no
Inventor
Satoshi Yamamoto
Susumu Takeda
Takashi Sakai
Takasi Nakashima
Akifumi Okuda
Katsura Kaneko
Taira Kato
Naota Kawamura
Original Assignee
Mercian Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mercian Corp filed Critical Mercian Corp
Publication of NO20052568D0 publication Critical patent/NO20052568D0/no
Publication of NO20052568L publication Critical patent/NO20052568L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20052568A 2002-11-29 2005-05-27 Fremgangsmate for fremstilling av makrolidforbindelse NO20052568L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002346796 2002-11-29
PCT/JP2003/015170 WO2004050890A1 (fr) 2002-11-29 2003-11-27 Procede de production d'un compose macrolide

Publications (2)

Publication Number Publication Date
NO20052568D0 NO20052568D0 (no) 2005-05-27
NO20052568L true NO20052568L (no) 2005-06-29

Family

ID=32462862

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052568A NO20052568L (no) 2002-11-29 2005-05-27 Fremgangsmate for fremstilling av makrolidforbindelse

Country Status (13)

Country Link
US (1) US7745198B2 (fr)
EP (1) EP1580278A4 (fr)
JP (1) JP4439401B2 (fr)
KR (1) KR20050086873A (fr)
CN (1) CN1717493A (fr)
AU (1) AU2003284469B2 (fr)
BR (1) BR0316746A (fr)
CA (1) CA2507641A1 (fr)
MX (1) MXPA05005672A (fr)
NO (1) NO20052568L (fr)
NZ (1) NZ540103A (fr)
RU (1) RU2330069C2 (fr)
WO (1) WO2004050890A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
EP1705247A4 (fr) * 2003-11-27 2008-08-20 Mercian Corp Adn intervenant dans l'hydroxylation d'un compose macrolide
WO2006009276A1 (fr) * 2004-07-20 2006-01-26 Eisai R & D Management Co., Ltd. Adn codant pour un polypeptide participant à la biosynthèse d'un pladienolide
TW200716744A (en) * 2005-05-26 2007-05-01 Eisai R&D Man Co Ltd Genetically modified microorganism and process for production of macrolide compound using the microorganism
JPWO2007043621A1 (ja) * 2005-10-13 2009-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラジエノライドｂ及びプラジエノライドｄの全合成方法
WO2008020584A1 (fr) * 2006-08-14 2008-02-21 Eisai R & D Management Co., Ltd. Préparation lyophilisée stable
JPWO2008093853A1 (ja) * 2007-01-29 2010-05-20 エーザイ・アール・アンド・ディー・マネジメント株式会社 マクロライド系化合物の固体およびその製造法並びにその医薬組成物
AU2014248014B2 (en) * 2013-04-04 2018-11-08 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
TWI634115B (zh) 2014-05-15 2018-09-01 Eisai R&D Management Co., Ltd. 普拉二烯內酯吡啶化合物及其使用方法
CA2963815A1 (fr) 2014-10-08 2016-04-14 President And Fellows Of Harvard College Ketolides a 14 chainons et leurs procedes de preparation et d'utilisation
US10640528B2 (en) 2015-03-25 2020-05-05 President And Fellows Of Havard College Macrolides with modified desosamine sugars and uses thereof
EP3910073B1 (fr) 2015-09-01 2024-03-06 Eisai R&D Management Co., Ltd. Variants d'épissage associés à des mutants de sf3b1 néomorphes
KR20180083376A (ko) 2015-11-18 2018-07-20 에자이 알앤드디 매니지먼트 가부시키가이샤 플라디에놀리드 피리딘 화합물의 고체 상태 형태 및 사용 방법
CA3056389A1 (fr) 2017-03-15 2018-09-20 Eisai R&D Management Co., Ltd. Mutations de complexes d'epissage et leurs utilisations
MX2020004179A (es) 2017-10-31 2020-08-03 Eisai R&D Man Co Ltd Combinacion que comprende al menos un modulador de espliceosomas y al menos un inhibidor elegido de inhibidores de bcl2, bcl2/bclxl y bclxl, y metodos de uso.
SG11202009906TA (en) 2018-04-09 2020-11-27 Eisai R&D Man Co Ltd Pladienolide compounds and their use
SG11202009907XA (en) 2018-04-12 2020-11-27 Eisai R&D Man Co Ltd Pladienolide derivatives as spliceosome targeting agents for treating cancer
US11998544B2 (en) 2018-06-01 2024-06-04 Eisai R&D Management Co., Ltd. Methods of using splicing modulators
WO2022098712A1 (fr) 2020-11-04 2022-05-12 Eisai R&D Management Co., Ltd. Biomarqueurs pour le syndrome myélodysplasique (mds) et leurs méthodes d'utilisation
CN114478257A (zh) * 2021-12-29 2022-05-13 福建省山河药业有限公司 一种抗肿瘤霉菌酸类化合物及其制备方法、应用
WO2023131866A1 (fr) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarqueurs pour le syndrome myélodysplasique (mds) et leurs méthodes d'utilisation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04352783A (ja) 1991-05-27 1992-12-07 Taisho Pharmaceut Co Ltd １２員環マクロライド系化合物
CA2376010A1 (fr) 1999-06-03 2000-12-14 The United States Of America, Represented By The Secretary, Department O F Health And Human Services Mycolactone et composes et compositions qui y sont lies ainsi que procedes d'utilisation correspondants
WO2002012533A2 (fr) 2000-08-03 2002-02-14 Kosan Biosciences, Inc. Fermentation et purification des mycolactones
TWI312681B (en) * 2001-02-01 2009-08-01 Novel physiologically active substance
TWI233361B (en) * 2001-04-13 2005-06-01 Gen Hospital Corp Methods of preventing UVB-induced skin damage
TWI334866B (en) 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
BR0313039A (pt) * 2002-07-31 2005-08-09 Mercian Corp Composto, medicamento, composição farmacêutica, método para prevenir ou tratar uma doença contra a qual um controle da expressão do gene é eficaz, método para prevenir ou tratar uma doença contra a qual a supressão da produção de vegf é eficaz, método para prevenir ou tratar uma doença contra a qual uma inibição da angiogênese é eficaz, uso do composto, método para produzir um composto 9-desoxi 1107, linhagem streptomyces sp. a-1543 (ferm bp-8442), método de produzir um composto 6- desoxi, e linhagem a-1544 (ferm bp-8446) ou linhagem a-1545 (ferm bp-8447)
JPWO2007043621A1 (ja) * 2005-10-13 2009-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラジエノライドｂ及びプラジエノライドｄの全合成方法

Also Published As

Publication number Publication date
KR20050086873A (ko) 2005-08-30
RU2330069C2 (ru) 2008-07-27
JP4439401B2 (ja) 2010-03-24
NO20052568D0 (no) 2005-05-27
AU2003284469A1 (en) 2004-06-23
CN1717493A (zh) 2006-01-04
NZ540103A (en) 2007-05-31
AU2003284469B2 (en) 2008-02-21
CA2507641A1 (fr) 2004-06-17
BR0316746A (pt) 2005-10-18
US20060141589A1 (en) 2006-06-29
US7745198B2 (en) 2010-06-29
EP1580278A1 (fr) 2005-09-28
RU2005120390A (ru) 2006-01-27
MXPA05005672A (es) 2005-08-16
EP1580278A4 (fr) 2010-08-25
WO2004050890A1 (fr) 2004-06-17
JPWO2004050890A1 (ja) 2006-03-30

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