NO20075911L - Genetisk modifisert mikroorganisme og fremgangsmate for fremstilling av makrolidforbindelser ved anvendelse av mikroorganismen - Google Patents

Genetisk modifisert mikroorganisme og fremgangsmate for fremstilling av makrolidforbindelser ved anvendelse av mikroorganismen

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Publication number
NO20075911L
NO20075911L NO20075911A NO20075911A NO20075911L NO 20075911 L NO20075911 L NO 20075911L NO 20075911 A NO20075911 A NO 20075911A NO 20075911 A NO20075911 A NO 20075911A NO 20075911 L NO20075911 L NO 20075911L
Authority
NO
Norway
Prior art keywords
microorganism
genetically modified
macrolide compound
modified microorganism
macrolide compounds
Prior art date
Application number
NO20075911A
Other languages
English (en)
Inventor
Kazuhiro Machida
Yasuhide Aritoku
Original Assignee
Esai R & D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esai R & D Man Co Ltd filed Critical Esai R & D Man Co Ltd
Publication of NO20075911L publication Critical patent/NO20075911L/no

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

En genetisk modifisert mikroorganisme i stand til direkte produksjon av en 16-hydroksylert makrolidforbindelse, og en fremgangsmåte for fremstilling av en 16-hydroksylert makrolidforbindelse ved anvendelse av mikroorganismen. Spesifikt vedrører oppfinnelsen en genetisk modifisert mikroorganisme med DNA som koder for et polypeptid involvert i biosyntesen av en makrolidforbindelse pladienolid og DNA som koder for et polypeptid med en pladienolid 16-hydroksylase aktivitet, og en fremgangsmåte for å fremstille en 16-hydroksylert makrolidforbindelse som omfatter trinnene ved å dyrke den genetisk modifiserte mikroorganismen i et dyrkingsmedium og samle en 16-hydroksylert makrolidforbindelse fra dyrkingsmediet.
NO20075911A 2005-05-26 2007-11-15 Genetisk modifisert mikroorganisme og fremgangsmate for fremstilling av makrolidforbindelser ved anvendelse av mikroorganismen NO20075911L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005154114 2005-05-26
PCT/JP2006/310835 WO2006126723A1 (ja) 2005-05-26 2006-05-24 遺伝子組換え微生物およびそれらの微生物を用いるマクロライド系化合物の製造方法

Publications (1)

Publication Number Publication Date
NO20075911L true NO20075911L (no) 2008-02-26

Family

ID=37452135

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075911A NO20075911L (no) 2005-05-26 2007-11-15 Genetisk modifisert mikroorganisme og fremgangsmate for fremstilling av makrolidforbindelser ved anvendelse av mikroorganismen

Country Status (15)

Country Link
US (1) US20090215134A1 (no)
EP (1) EP1911843B1 (no)
JP (1) JPWO2006126723A1 (no)
KR (1) KR20080012845A (no)
CN (1) CN101184838B (no)
AU (1) AU2006250304B2 (no)
BR (1) BRPI0610145A2 (no)
CA (1) CA2608841A1 (no)
IL (1) IL187081A0 (no)
NO (1) NO20075911L (no)
NZ (1) NZ562921A (no)
RU (1) RU2394906C2 (no)
SG (1) SG148168A1 (no)
TW (1) TW200716744A (no)
WO (1) WO2006126723A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8008049B2 (en) * 2004-07-20 2011-08-30 Eisai R&D Management Co., Ltd. DNA coding for polypeptide participating in biosynthesis of pladienolide
JPWO2007043621A1 (ja) 2005-10-13 2009-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラジエノライドｂ及びプラジエノライドｄの全合成方法
WO2009008492A1 (ja) 2007-07-06 2009-01-15 Eisai R & D Management Co., Ltd. マクロライド系化合物の製造方法およびその製造中間体
US8512995B2 (en) 2008-06-04 2013-08-20 Eisai R&D Management Co., Ltd. DNA encoding polypeptide involved in biosynthesis of herboxidiene
UA119458C2 (uk) * 2014-05-15 2019-06-25 Ейсей Р Енд Д Менеджмент Ко., Лтд. Сполуки піридину пладієноліду та способи застосування
MD3377485T2 (ro) * 2015-11-18 2020-02-29 Eisai R&D Man Co Ltd Formă în stare solidă a unor compuși de piridină pladienolidă și metode de utilizare
CN110408643B (zh) * 2018-11-30 2023-08-22 云南大学 一种提高自溶链霉菌洋橄榄叶素及其衍生物产量的方法
CN115247179B (zh) * 2021-04-25 2024-03-12 上海健康医学院 一种聚酮化合物骨架及其后修饰物的生物合成基因簇及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
CN1329668A (zh) * 1998-10-02 2002-01-02 高山生物科学股份有限公司 多聚乙酰合成酶及其重组dna构建物
TWI312681B (en) * 2001-02-01 2009-08-01 Novel physiologically active substance
BRPI0213411B1 (pt) * 2001-10-19 2015-11-03 Sumitomo Chemical Co dna codificando uma proteína de metabolização de herbicida, seu uso, vetor e micro-organismo transgênico compreendendo o mesmo, métodos de produção de um transformante, da referida proteína, de obtenção e detecção do referido dna e de identificação de uma célula compreendendo o referido dna
ATE426671T1 (de) * 2002-04-12 2009-04-15 Mercian Corp Expressionssystem des aus actinomyceten stammenden cytochrom p-450 in escherichia coli
AU2003252445B2 (en) * 2002-07-31 2009-09-17 Eisai R & D Management Co., Ltd. Novel physiologically active substances
US7576204B2 (en) * 2002-07-31 2009-08-18 Mercian Corporation Heterocyclic macrolide pharmaceutical agent, a method of producing the same and use of the same
CA2507641A1 (en) * 2002-11-29 2004-06-17 Mercian Corporation Method of producing macrolide compound
CA2453080C (en) * 2003-01-21 2006-02-21 Ecopia Biosciences Inc. Polyene polyketides, processes for their production and their use as a pharmaceutical
KR20060110865A (ko) * 2003-11-27 2006-10-25 에자이 가부시키가이샤 매크로라이드계 화합물의 수산화에 관여하는 ｄｎａ
US8008049B2 (en) * 2004-07-20 2011-08-30 Eisai R&D Management Co., Ltd. DNA coding for polypeptide participating in biosynthesis of pladienolide

Also Published As

Publication number Publication date
NZ562921A (en) 2009-06-26
TW200716744A (en) 2007-05-01
EP1911843A4 (en) 2009-01-07
JPWO2006126723A1 (ja) 2008-12-25
KR20080012845A (ko) 2008-02-12
RU2007148928A (ru) 2009-07-10
EP1911843A1 (en) 2008-04-16
EP1911843B1 (en) 2012-03-14
AU2006250304A1 (en) 2006-11-30
US20090215134A1 (en) 2009-08-27
CN101184838B (zh) 2011-06-15
CA2608841A1 (en) 2006-11-30
RU2394906C2 (ru) 2010-07-20
IL187081A0 (no) 2008-02-09
WO2006126723A1 (ja) 2006-11-30
AU2006250304B2 (en) 2010-12-09
SG148168A1 (en) 2008-12-31
BRPI0610145A2 (pt) 2010-06-01
CN101184838A (zh) 2008-05-21

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