NO20052546L - Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. - Google Patents

Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon.

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Publication number
NO20052546L
NO20052546L NO20052546A NO20052546A NO20052546L NO 20052546 L NO20052546 L NO 20052546L NO 20052546 A NO20052546 A NO 20052546A NO 20052546 A NO20052546 A NO 20052546A NO 20052546 L NO20052546 L NO 20052546L
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Norway
Prior art keywords
formula
compounds
compound
administering
treating
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NO20052546A
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English (en)
Norwegian (no)
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NO20052546D0 (no
Inventor
Milind Deshpande
Dawei Chen
Andrew Thurkauf
Avinash Phadke
Xiangzhu Wang
Yiping Shen
Cuixian Liu
Jesse Quinn
Junko Ohkanda
Shouming Li
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Achillon Pharmaceuticals Inc
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Publication of NO20052546D0 publication Critical patent/NO20052546D0/no
Publication of NO20052546L publication Critical patent/NO20052546L/no

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    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
NO20052546A 2002-11-19 2005-05-26 Substituert arylthiourea og relaterte forbindelser; inhibitorer av viral reproduksjon. NO20052546L (no)

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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2506415A1 (fr) * 2002-11-19 2004-06-03 Achillion Pharmaceuticals, Inc. Aryl thio-urees substituees et composes analogues, inhibiteurs de la replication virale
AU2005326813B2 (en) * 2002-11-19 2011-08-04 Achillion Pharmaceuticals, Inc. Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
GB0500020D0 (en) 2005-01-04 2005-02-09 Novartis Ag Organic compounds
TW200528459A (en) 2004-01-06 2005-09-01 Achillion Pharmaceuticals Inc Azabenzofuran substituted thioureas; inhibitors of viral replication
US7501510B2 (en) * 2004-03-26 2009-03-10 The University Of Hong Kong Thiourea compositions and uses thereof
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
JP2008536932A (ja) * 2005-04-18 2008-09-11 サイード・アール・カーン チューブリン重合阻害剤:ボンゾイルフェニル尿素(bpu)硫黄類似体の設計及び合成
WO2007035895A2 (fr) * 2005-09-21 2007-03-29 Cook Incorporated Ensemble de transport endoluminal
TWI329102B (en) * 2006-08-15 2010-08-21 Nat Health Research Institutes Thiourea compounds and method for inhibiting hepatitis c virus infection
JP2010513508A (ja) * 2006-12-18 2010-04-30 アキリオン ファーマシューティカルズ,インコーポレーテッド C型肝炎感染を処置するための併用療法
US7985763B2 (en) * 2007-04-10 2011-07-26 National Health Research Institutes Hepatitis C virus inhibitors
WO2008154091A1 (fr) * 2007-06-08 2008-12-18 National Health Research Institutes Dérivés de thiourée
TWI361808B (en) 2008-01-08 2012-04-11 Nat Health Research Institutes Imidazolidinone and imidazolidinethione derivatives
US8198284B2 (en) 2008-04-30 2012-06-12 National Health Research Institutes Treatment of neurodegenerative disorders with thiourea compounds
NZ593808A (en) * 2008-12-03 2014-04-30 Presidio Pharmaceuticals Inc Inhibitors of hcv ns5a
FR2943056A1 (fr) * 2009-03-16 2010-09-17 Sanofi Aventis Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
AU2010253791A1 (en) 2009-05-29 2011-11-24 Merck Sharp & Dohme Corp. Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C
WO2010151797A2 (fr) * 2009-06-26 2010-12-29 University Of Massachusetts Composés de modulation des protéines de liaison à l'arn et applications associées
EP2503881B1 (fr) 2009-11-25 2015-05-13 Merck Sharp & Dohme Corp. Composés tricycliques fusionnés et leurs dérivés utiles pour le traitement de maladies virales
US20130156731A1 (en) 2009-12-22 2013-06-20 Kevin X. Chen Fused tricyclic compounds and methods of use thereof for the treatment of viral diseas
ES2558554T3 (es) 2010-03-09 2016-02-05 Merck Sharp & Dohme Corp. Compuestos de sililo tricíclicos condensados y métodos de uso de los mismos para el tratamiento de enfermedades víricas
US20130157924A1 (en) * 2010-04-23 2013-06-20 The Regents Of The University Of California Reducing transmission of sexually transmitted infections
AU2011286276A1 (en) 2010-07-26 2013-01-24 Merck Sharp & Dohme Corp. Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
EP2621279B1 (fr) 2010-09-29 2018-04-04 Merck Sharp & Dohme Corp. Dérivés tétracycliques condensés et procédés d'utilisation de ceux-ci dans le traitement de maladies virales
CA2832459A1 (fr) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. Derives de nucleoside 2'-substitues et procedes d'utilisation de ceux-ci pour le traitement de maladies virales
WO2012142075A1 (fr) 2011-04-13 2012-10-18 Merck Sharp & Dohme Corp. Dérivés de nucléosides à substitution 2'-azido et leurs procédés d'utilisation pour le traitement de maladies virales
WO2012162025A1 (fr) * 2011-05-20 2012-11-29 President And Fellows Of Harvard College Procédés de sélection de patients cancéreux pour traitement par des composés de n,n'-diarylurée et de n,n'-diarlythiourée
KR20140045542A (ko) 2011-07-12 2014-04-16 다우 아그로사이언시즈 엘엘씨 살충 조성물 및 그에 관한 방법
WO2013033899A1 (fr) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Composés benzofuranes substitués et leur procédés d'utilisation pour le traitement de maladies virales
WO2013033900A1 (fr) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de maladies virales
WO2013033901A1 (fr) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Dérivés benzofuranes substitués par un hétérocycle et leurs procédés d'utilisation pour le traitement de maladies virales
US20140378416A1 (en) 2011-09-14 2014-12-25 Michael P. Dwyer Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases
JP2015525758A (ja) * 2012-07-09 2015-09-07 ダウ アグロサイエンシィズ エルエルシー 農薬組成物およびそれらに関する方法
US10188538B2 (en) 2015-12-30 2019-01-29 Cook Medical Technologies Llc Hybrid trigger wire for endografts
WO2017197055A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères hétérocycliques pour la dégradation de protéines cibles
WO2017197046A1 (fr) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles
EP3454862B1 (fr) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Dégronimères spirocycliques pour la dégradation de protéines cibles
CN110087469A (zh) * 2016-12-21 2019-08-02 美国陶氏益农公司 具有某些杀虫效用的分子、以及与其相关的中间体、组合物、和方法
US20190167670A1 (en) * 2017-10-31 2019-06-06 Nutech Ventures Methods of treating or preventing zika virus infection

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL160809C (nl) 1970-05-15 1979-12-17 Duphar Int Res Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen.
US3699110A (en) 1970-11-05 1972-10-17 Monsanto Co Certain 1-aryl or aralkyl-3-(pyridyl) formimidoyl-ureas or thioureas
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
DE2303761A1 (de) 1973-01-26 1974-08-01 Henkel & Cie Gmbh Neue n,n'-disubstituierte thioharnstoffe, deren herstellung sowie verwendung als antimikrobielle substanzen
GB1433934A (en) 1973-05-31 1976-04-28 Wyeth John & Brother Ltd Thioureas
JPS5143742A (ja) * 1974-09-30 1976-04-14 Haruo Ogura Tansonukureoshidojudotai no seizoho
JPS51125323A (en) * 1975-04-11 1976-11-01 Haruo Ogura Prosecc for preparing new c-nucleoside derivatives
BR7701058A (pt) 1976-02-23 1977-11-01 Gulf Research Development Co Processo e composto para combater insetos
US4160037A (en) 1977-09-30 1979-07-03 The Upjohn Company Compounds, compositions and methods of combatting pest employing thioureas
ZA793186B (en) * 1978-07-06 1981-02-25 Duphar Int Res New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds
JPS55167282A (en) * 1979-06-12 1980-12-26 Fujisawa Pharmaceut Co Ltd Piperazine derivative or its salt and its preparation
JPS5625148A (en) 1979-08-08 1981-03-10 Ishihara Sangyo Kaisha Ltd N-benzoyl-n'-phenoxyphenylurea-based compound, and insecticide comprising it
US4338257A (en) 1980-03-04 1982-07-06 Gulf Oil Corporation Benzoyl arylthioureas and use as plant growth regulators
GB2115419B (en) 1981-08-24 1985-10-02 Rorer International Heterocyclic amidino substituted ureas and their pharmaceutical uses
DE3217620A1 (de) 1982-05-11 1983-11-17 Bayer Ag, 5090 Leverkusen 2,5-dihalogenbenzoyl-(thio)harnstoffe, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
US4880838A (en) 1982-06-30 1989-11-14 Rhone-Poulenc Pesticidal 1-(4-Phenoxyphenyl)-5-Benzoyl urea compounds and process for preparation
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5001266A (en) 1982-07-26 1991-03-19 The Dow Chemical Company Substituted aniline compounds
US4868215A (en) 1982-07-26 1989-09-19 The Dow Chemical Company Substituted N-aroyl N'-phenyl urea compounds
US4602109A (en) 1982-12-30 1986-07-22 Union Carbide Corporation Novel pesticidal phenoxyphenyl and phenoxypyridyl benzoyl ureas and process for preparation
DK147084A (da) 1983-03-19 1984-09-20 Bayer Ag 1-phenyl-3-benzoyl-(thio)-urinstoffer, deres fremstilling og anvendelse som skadedyrsbekaempelsesmidler
US4665097A (en) 1983-03-31 1987-05-12 Union Carbide Corporation Novel bicyclooxyaryl thioureas and process for preparation
US4873264A (en) 1983-05-20 1989-10-10 Rhone-Poulenc Nederlands B.V. Novel pesticidal 1-(alkyl-phenoxy-aryl)-3-benzoyl ureas and process for preparation
US4659736A (en) 1984-01-21 1987-04-21 Bayer Aktiengesellschaft Benzoyl urea compounds as agents for repelling snails and slugs
JPS61106551A (ja) 1984-10-30 1986-05-24 Sumitomo Chem Co Ltd ジフエニルエ−テル誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4638088A (en) * 1984-11-15 1987-01-20 Union Carbide Corporation Pesticidal biphenylyloxy and biphenylylalkoxy aryl acyl urea compounds
US5135953A (en) 1984-12-28 1992-08-04 Ciba-Geigy Use of acyl urea compounds for controlling endoparasites and ectoparasites of warm-blooded animals
US5166180A (en) 1988-01-11 1992-11-24 Duphar International Research B.V. Method of treating hematologic diseases and pharmaceutical composition to be used therefor
US5268389A (en) 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
CA2032559C (fr) 1989-12-28 2001-11-06 Kiyofumi Ishikawa Pentapeptides cycliques antagonistes de l'endotheline
JPH04366852A (ja) 1991-06-13 1992-12-18 Canon Inc 電子写真感光体、該電子写真感光体を備えた電子写真装置並びにファクシミリ
EP0539709A1 (fr) 1991-09-18 1993-05-05 FUJIREBIO Inc. Dérivés de l'acide 3,5-dihydroxyheptanoique et leurs lactones comme inhibiteurs d'HMG-CoA réductase
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
AU665073B2 (en) 1992-06-03 1995-12-14 Ciba-Geigy Ag Novel thiosemicarbazone derivatives
JPH063787A (ja) 1992-06-18 1994-01-14 Konica Corp ハロゲン化銀写真感光材料用固形発色現像処理剤及び該固形発色現像処理剤を用いた処理方法
DE4236902A1 (de) 1992-10-31 1994-05-05 Hoechst Ag Neue Phenylsulfonylharnstoffe, Darstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US5723409A (en) 1992-10-31 1998-03-03 Hoechst Schering Agrevo Gmbh Intermediates for the preparation of phenylsulfonylurea herbicides and plant growth regulators
JPH06287171A (ja) 1993-02-05 1994-10-11 Takeda Chem Ind Ltd セミカルバジド誘導体、その製造法およびその殺虫組成物
US5656642A (en) 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
JP3203108B2 (ja) 1993-08-26 2001-08-27 協和メデックス株式会社 グルコース−6−リン酸デヒドロゲナーゼの安定化方法
JPH07206811A (ja) * 1994-01-18 1995-08-08 Wakunaga Pharmaceut Co Ltd チオウレア誘導体、その製造法及びその利用
DE4442236A1 (de) 1994-11-28 1996-05-30 Hoechst Schering Agrevo Gmbh N-substituierte Hydrazinophenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
DE19506742A1 (de) 1995-02-27 1996-08-29 Bayer Ag Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen
GB9504460D0 (en) 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
IN186549B (fr) 1995-04-19 2001-09-29 Kumiai Chemical Co Ltd
WO1997003976A1 (fr) 1995-07-21 1997-02-06 Nissan Chemical Industries, Ltd. Derives de semicarbazone et pesticides
CN1055083C (zh) 1995-09-08 2000-08-02 化学工业部沈阳化工研究院 用于杀虫杀螨的吡唑类化合物及其制剂
WO1997011050A1 (fr) 1995-09-19 1997-03-27 Ube Industries, Ltd. Composes de benzylidenhydrazine, leur procede de production et pesticides agricoles et horticoles
EP0852498A1 (fr) 1995-09-26 1998-07-15 Takeda Chemical Industries, Ltd. Phosphorylamides, leur preparation et leur utilisation
US5908621A (en) 1995-11-02 1999-06-01 Schering Corporation Polyethylene glycol modified interferon therapy
DE69629838T2 (de) 1995-11-15 2004-07-08 Yamanouchi Pharmaceutical Co., Ltd. Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate
GB9525262D0 (en) 1995-12-11 1996-02-07 Bayer Ag Heterocyclylcarbonyl substituted benzofuranyl-ureas
AU1730497A (en) 1996-02-17 1997-09-02 Agrevo Uk Limited Fungicidal 1,2,4-oxadiazoles and analogues
WO1997041846A1 (fr) 1996-05-06 1997-11-13 Eli Lilly And Company Composes antiviraux
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
WO1998042323A1 (fr) 1997-03-25 1998-10-01 Takeda Chemical Industries, Ltd. Inhibiteur de l'urease stabilise
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
EP1023042A1 (fr) 1997-10-14 2000-08-02 The Procter & Gamble Company Compositions de nettoyage pour l'hygiene personnelle comprenant des tensioactifs ramifies en milieu de chaine
ES2234169T3 (es) 1997-12-23 2005-06-16 Warner-Lambert Company Llc Compuestos de tiourea, composiciones y procedimientos de tratamiento o prevencion de enfermedades inflamatorias y ateroesclerosis.
US6138826A (en) 1998-02-02 2000-10-31 Fuji Photo Film Co., Ltd. Waterproof case for camera
US5874615A (en) 1998-03-17 1999-02-23 American Cyanamid Co Method for the preparation of insecticidal benzoylurea compounds
AU4005299A (en) 1998-05-19 1999-12-06 Regents Of The University Of California, The Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
JPH11335375A (ja) 1998-05-20 1999-12-07 Mitsui Chem Inc ヒストン脱アセチル化酵素阻害作用を有するベンズアミド誘導体
US6440985B1 (en) 1998-09-04 2002-08-27 Viropharma Incorporated Methods for treating viral infections
WO2000018231A1 (fr) 1998-09-25 2000-04-06 Viropharma Incorporated Procedes de traitement ou de prevention d'infections virales et de maladies associees
US6207715B1 (en) 1998-12-09 2001-03-27 American Home Products Corporation Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group
US6255349B1 (en) 1998-12-09 2001-07-03 American Home Products Corporation Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group
US6335350B1 (en) 1998-12-09 2002-01-01 American Home Products Corporation Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses
US6677360B2 (en) 1998-12-16 2004-01-13 Bayer Aktiengesellschaft Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6420396B1 (en) 1998-12-16 2002-07-16 Beiersdorf Ag Biphenyl and biphenyl-analogous compounds as integrin antagonists
EE200100317A (et) 1998-12-16 2002-08-15 Bayer Aktiengesellschaft Uued bifenüül- ja bifenüülanaloogsed ühendid kui integriini antagonistid
AU758207B2 (en) 1999-05-28 2003-03-20 Cj Cheiljedang Corporation Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same
US6331539B1 (en) 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6541485B1 (en) 1999-06-10 2003-04-01 3M Innovative Properties Company Urea substituted imidazoquinolines
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
US6143780A (en) 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
CZ20021074A3 (cs) 1999-09-24 2002-08-14 Nihon Nohyaku Co., Ltd. Deriváty aromatických diamidů a jejich soli, zemědělské a zahradnické přípravky a způsoby pouľití
GB9929988D0 (en) 1999-12-17 2000-02-09 Celltech Therapeutics Ltd Chemical compounds
IL150269A0 (en) 1999-12-22 2002-12-01 Nihon Nohyaku Co Ltd Aromatic diamide derivatives, chemicals for agricultural or horticultural use and usage thereof
ATE289311T1 (de) 1999-12-24 2005-03-15 Kyowa Hakko Kogyo Kk Kondensierte purinderivate
AU2223201A (en) 1999-12-24 2001-07-09 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives and drugs containing the same
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
TWI284639B (en) 2000-01-24 2007-08-01 Shionogi & Co A compound having thrombopoietin receptor agonistic effect
US6727267B2 (en) 2000-04-05 2004-04-27 Tularik Inc. NS5B HVC polymerase inhibitors
JP2003532726A (ja) 2000-05-05 2003-11-05 スミスクライン・ビーチャム・コーポレイション 新規抗感染症薬
WO2001085172A1 (fr) 2000-05-10 2001-11-15 Smithkline Beecham Corporation Nouveaux anti-infectieux
AU2001281817B2 (en) 2000-06-21 2005-11-24 F. Hoffmann-La Roche Ag Benzothiazole derivatives
US6736336B2 (en) 2000-10-13 2004-05-18 International Concepts, Inc. Shower head
DE10123163A1 (de) 2001-05-09 2003-01-16 Gruenenthal Gmbh Substituierte Cyclohexan-1,4-diaminderivate
AR035543A1 (es) 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
EP1442019B8 (fr) 2001-11-01 2013-10-30 Janssen Pharmaceutica NV Derives amides utilises en tant qu'inhibiteurs de la glycogene synthase kinase 3-beta
BR0309972A (pt) * 2002-05-16 2005-03-01 Bayer Cropscience Gmbh Derivados de piridina carboxamida e seu uso como pesticidas
WO2003097605A1 (fr) 2002-05-16 2003-11-27 Bayer Cropscience Gmbh Derives pyridinecarboxamide pesticides
US7517894B2 (en) 2002-07-31 2009-04-14 Bayer Schering Pharma Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
US7148357B2 (en) 2002-07-31 2006-12-12 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
CA2506415A1 (fr) * 2002-11-19 2004-06-03 Achillion Pharmaceuticals, Inc. Aryl thio-urees substituees et composes analogues, inhibiteurs de la replication virale

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CN1738797A (zh) 2006-02-22
US7476686B2 (en) 2009-01-13
KR20050111306A (ko) 2005-11-24
EP1562895A1 (fr) 2005-08-17
US7094807B2 (en) 2006-08-22
US20040138205A1 (en) 2004-07-15
JP4206382B2 (ja) 2009-01-07
AU2003295605A1 (en) 2004-06-15
BR0316397A (pt) 2005-09-27
JP2007084548A (ja) 2007-04-05
US20060014836A1 (en) 2006-01-19
OA12961A (en) 2006-10-13
JP2006506439A (ja) 2006-02-23
NO20052546D0 (no) 2005-05-26
CA2506415A1 (fr) 2004-06-03
MXPA05005379A (es) 2006-02-17
WO2004046095A1 (fr) 2004-06-03
NZ540033A (en) 2007-05-31
AP2005003319A0 (en) 2005-06-30

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