NO20045236L - Fusjoner av cytokiner og tumor-targeting proteiner - Google Patents
Fusjoner av cytokiner og tumor-targeting proteinerInfo
- Publication number
- NO20045236L NO20045236L NO20045236A NO20045236A NO20045236L NO 20045236 L NO20045236 L NO 20045236L NO 20045236 A NO20045236 A NO 20045236A NO 20045236 A NO20045236 A NO 20045236A NO 20045236 L NO20045236 L NO 20045236L
- Authority
- NO
- Norway
- Prior art keywords
- cytokine
- tumor
- fusions
- cytokines
- ttm
- Prior art date
Links
- 108090000695 Cytokines Proteins 0.000 title abstract 6
- 102000004127 Cytokines Human genes 0.000 title abstract 6
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102100040247 Tumor necrosis factor Human genes 0.000 abstract 3
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 2
- 102100037850 Interferon gamma Human genes 0.000 abstract 2
- 108010074328 Interferon-gamma Proteins 0.000 abstract 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical group OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 102000016359 Fibronectins Human genes 0.000 abstract 1
- 108010067306 Fibronectins Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108090000542 Lymphotoxin-alpha Proteins 0.000 abstract 1
- 102000004083 Lymphotoxin-alpha Human genes 0.000 abstract 1
- 102000007238 Transferrin Receptors Human genes 0.000 abstract 1
- 108010033576 Transferrin Receptors Proteins 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 101150047061 tag-72 gene Proteins 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0209893.7A GB0209893D0 (en) | 2002-04-30 | 2002-04-30 | Conjugate |
| PCT/IB2003/002515 WO2003092737A1 (en) | 2002-04-30 | 2003-04-30 | Fusions of cytokines and tumor targeting proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20045236L true NO20045236L (no) | 2005-01-31 |
Family
ID=9935814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045236A NO20045236L (no) | 2002-04-30 | 2004-11-29 | Fusjoner av cytokiner og tumor-targeting proteiner |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050074426A1 (zh) |
| EP (1) | EP1499362A1 (zh) |
| JP (1) | JP2005525115A (zh) |
| KR (1) | KR20050003400A (zh) |
| CN (2) | CN100457189C (zh) |
| AU (1) | AU2003236969A1 (zh) |
| CA (1) | CA2484425A1 (zh) |
| EA (2) | EA200800386A1 (zh) |
| GB (1) | GB0209893D0 (zh) |
| IL (1) | IL164897A0 (zh) |
| NO (1) | NO20045236L (zh) |
| WO (1) | WO2003092737A1 (zh) |
| ZA (1) | ZA200408768B (zh) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263739B2 (en) | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| EP1289565B1 (en) | 2000-06-02 | 2015-04-22 | Bracco Suisse SA | Compounds for targeting endothelial cells |
| CA2594927A1 (en) * | 2004-03-31 | 2005-10-13 | Buck Institute | Hunter-killer peptides and methods of use |
| EP2364995A1 (en) | 2004-12-23 | 2011-09-14 | Molmed SpA | Conjugation product |
| CN101189339A (zh) * | 2005-03-22 | 2008-05-28 | 美得思达健康有限公司 | 诊断和治疗心血管疾病的递送系统和方法 |
| CN102539734B (zh) * | 2005-05-12 | 2016-02-03 | 清华大学 | 核仁素辅助的癌症诊断与治疗方法 |
| CA2608474C (en) | 2005-05-17 | 2019-11-12 | University Of Connecticut | Compositions and methods for immunomodulation in an organism |
| GB0708864D0 (en) * | 2007-05-08 | 2007-06-13 | Molmed Spa | Cytokine Conjugate |
| EP2170956B1 (en) | 2007-06-15 | 2014-10-22 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Treatment of tumors using specific anti-l1 antibody |
| CA2691785C (en) | 2007-06-27 | 2017-01-10 | Marine Polymer Technologies Inc. | Complexes of il-15 and il-15ralpha and uses thereof |
| GB0803076D0 (en) * | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
| AU2008201871A1 (en) * | 2008-04-16 | 2009-11-26 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Inhibition of angiogenesis and tumor metastasis |
| JP5559772B2 (ja) * | 2008-05-13 | 2014-07-23 | モルメド エスピーエー | 中皮腫の治療のためのコンジュゲート |
| US20120107270A1 (en) * | 2009-06-30 | 2012-05-03 | Manuela Kaspar | Immunocytokines In Combination With Anti-ErbB Antibodies For The Treatment Of Cancer |
| US9526251B2 (en) | 2010-02-25 | 2016-12-27 | Marrone Bio Innovations, Inc. | Use of Burkholderia formulations, compositions and compounds to modulate crop yield and/or corn rootworm infestation |
| US8822193B2 (en) | 2010-02-25 | 2014-09-02 | Marrone Bio Innovations, Inc. | Isolated bacterial strain of the genus Burkholderia and pesticidal metabolites therefrom |
| CN102260352B (zh) * | 2010-05-28 | 2013-11-20 | 山东先声麦得津生物制药有限公司 | 靶向性白细胞介素融合蛋白及其制备方法与应用 |
| US9498499B2 (en) | 2012-04-19 | 2016-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Imaging-aided gene therapy using mesenchymal stem cells as target-delivery vehicle |
| US9119401B2 (en) | 2012-10-19 | 2015-09-01 | Marrone Bio Innovations, Inc. | Plant glutamine synthetase inhibitors and methods for their identification |
| CN104177500B (zh) * | 2013-05-24 | 2018-05-25 | 江苏靶标生物医药研究所有限公司 | 一种肿瘤坏死因子相关凋亡配体融合蛋白及其制法和用途 |
| SG11201600168UA (en) * | 2013-07-19 | 2016-02-26 | Vib Vzw | Targeted modified tnf family members |
| MX2017004117A (es) | 2014-09-30 | 2017-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Moleculas de enlace, especialmente anticuerpos, enlazadas a l1cam(cd171). |
| GB201419184D0 (en) | 2014-10-28 | 2014-12-10 | Adc Biotechnology Ltd | Method of synthesising biomolecule-effector/reporter-conjugates using affinity resins |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| CN106380521B (zh) * | 2015-07-02 | 2020-12-29 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
| CN112263683A (zh) | 2015-08-11 | 2021-01-26 | 同宜医药（苏州）有限公司 | 多配体药物偶联体及其用途 |
| CN105218682B (zh) * | 2015-10-26 | 2019-05-07 | 杨晶 | 经il-12/cd62l融合蛋白改造的肿瘤治疗剂及其制法和用途 |
| CN108472365A (zh) * | 2015-10-30 | 2018-08-31 | 艾丽塔生物治疗剂公司 | 用于肿瘤转导的组合物和方法 |
| CN105585637B (zh) * | 2015-12-23 | 2020-04-03 | 杨晶 | 基于il-12稳定膜表达的肿瘤治疗剂及其制法和用途 |
| CN105622759A (zh) * | 2016-01-04 | 2016-06-01 | 深圳精准医疗科技有限公司 | IL-12/CD107a融合蛋白增强CTL抗肿瘤效果的治疗剂及其制法和用途 |
| GB201602359D0 (en) * | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| EA201991204A1 (ru) | 2016-12-22 | 2019-12-30 | Университа Дельи Студи Манья Греча Катандзаро | Моноклональное антитело против уникального сиалогликозилированного опухолеассоциированного эпитопа cd43 |
| AU2018214979A1 (en) * | 2017-02-01 | 2019-08-15 | Acceleron Pharma Inc. | TGFβ and actrii antagonists for use in increasing immune activity |
| CN109467607B (zh) * | 2017-12-28 | 2020-10-30 | 北京泽勤生物医药有限公司 | 一种靶向肿瘤的酸性敏感融合肽及其应用 |
| CA3087344A1 (en) | 2018-01-05 | 2019-07-11 | Platelet Biogenesis, Inc. | Compositions and methods for producing megakaryocytes |
| CN108314741B (zh) * | 2018-03-22 | 2021-08-03 | 中国人民解放军第四军医大学 | 一种肿瘤血管靶向抗癌肽nkl-dota及其制备方法 |
| SG11202011349PA (en) * | 2018-05-14 | 2020-12-30 | Werewolf Therapeutics Inc | Activatable interleukin-2 polypeptides and methods of use thereof |
| JP2021529770A (ja) * | 2018-06-29 | 2021-11-04 | プレートレット バイオジェネシス， インコーポレイテッド | 薬物送達のための組成物およびその使用方法 |
| CN108864251B (zh) * | 2018-06-30 | 2022-06-14 | 大连理工大学 | 一类氨肽酶n激活的药物前体化合物及其制备方法和应用 |
| CN117683140A (zh) * | 2022-09-09 | 2024-03-12 | 北京昌平实验室 | 肿瘤靶向的以白介素2为活性成分的融合蛋白型药物前体 |
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| US5120829A (en) * | 1989-03-20 | 1992-06-09 | La Jolla Cancer Research Foundation | Hydrophobic attachment site for adhesion peptides |
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| US5811512A (en) * | 1991-08-22 | 1998-09-22 | The Trustees Of The University Of Pennsylvania | Non-peptide peptidomimetics and related cyclic hexapeptides |
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| US5888814A (en) * | 1994-06-06 | 1999-03-30 | Chiron Corporation | Recombinant host cells encoding TNF proteins |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
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| US6180084B1 (en) * | 1998-08-25 | 2001-01-30 | The Burnham Institute | NGR receptor and methods of identifying tumor homing molecules that home to angiogenic vasculature using same |
| CN1239675A (zh) * | 1998-06-23 | 1999-12-29 | 金斗植 | 抗肿瘤试剂 |
| US7109303B2 (en) * | 2000-02-15 | 2006-09-19 | Fondazione Centro San Raffaele Del Monte Tabor | Modified cytokines for use in cancer therapy |
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| AU2001274894A1 (en) * | 2000-05-22 | 2001-12-03 | Pharmacia And Upjohn Company | Novel matrix metalloproteinases |
| CA2414650A1 (en) * | 2000-06-30 | 2002-01-10 | Board Of Regents, The University Of Texas System | Isolation of a cell-specific internalizing peptide that infiltrates tumor tissue for targeted drug delivery |
| US20030077818A1 (en) * | 2001-03-08 | 2003-04-24 | Dickerson Erin B. | Compositions and methods for targeting interleukin-12 to malignant endothelium |
| US20040110933A1 (en) * | 2002-09-13 | 2004-06-10 | Dyax Corporation | CD44-binding ligands |
-
2002
- 2002-04-30 GB GBGB0209893.7A patent/GB0209893D0/en not_active Ceased
-
2003
- 2003-04-30 AU AU2003236969A patent/AU2003236969A1/en not_active Abandoned
- 2003-04-30 CA CA002484425A patent/CA2484425A1/en not_active Abandoned
- 2003-04-30 WO PCT/IB2003/002515 patent/WO2003092737A1/en active Application Filing
- 2003-04-30 EA EA200800386A patent/EA200800386A1/ru unknown
- 2003-04-30 JP JP2004500920A patent/JP2005525115A/ja active Pending
- 2003-04-30 US US10/492,144 patent/US20050074426A1/en not_active Abandoned
- 2003-04-30 CN CNB038152037A patent/CN100457189C/zh not_active Expired - Fee Related
- 2003-04-30 CN CNA2008101868374A patent/CN101433722A/zh active Pending
- 2003-04-30 EA EA200401447A patent/EA009955B1/ru not_active IP Right Cessation
- 2003-04-30 EP EP03735883A patent/EP1499362A1/en not_active Withdrawn
- 2003-04-30 KR KR10-2004-7017535A patent/KR20050003400A/ko not_active Application Discontinuation
-
2004
- 2004-10-28 IL IL16489704A patent/IL164897A0/xx unknown
- 2004-10-29 ZA ZA200408768A patent/ZA200408768B/en unknown
- 2004-11-29 NO NO20045236A patent/NO20045236L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050003400A (ko) | 2005-01-10 |
| US20050074426A1 (en) | 2005-04-07 |
| CN100457189C (zh) | 2009-02-04 |
| ZA200408768B (en) | 2007-03-28 |
| CA2484425A1 (en) | 2003-11-13 |
| EA009955B1 (ru) | 2008-04-28 |
| GB0209893D0 (en) | 2002-06-05 |
| CN1665543A (zh) | 2005-09-07 |
| EA200401447A1 (ru) | 2005-08-25 |
| EA200800386A1 (ru) | 2008-10-30 |
| JP2005525115A (ja) | 2005-08-25 |
| CN101433722A (zh) | 2009-05-20 |
| IL164897A0 (en) | 2005-12-18 |
| AU2003236969A1 (en) | 2003-11-17 |
| EP1499362A1 (en) | 2005-01-26 |
| WO2003092737A1 (en) | 2003-11-13 |
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