NO20042634L - 3-Cyanokinoliner som inhibitorer for EGF-R og HER2-kinaser - Google Patents

3-Cyanokinoliner som inhibitorer for EGF-R og HER2-kinaser

Info

Publication number
NO20042634L
NO20042634L NO20042634A NO20042634A NO20042634L NO 20042634 L NO20042634 L NO 20042634L NO 20042634 A NO20042634 A NO 20042634A NO 20042634 A NO20042634 A NO 20042634A NO 20042634 L NO20042634 L NO 20042634L
Authority
NO
Norway
Prior art keywords
cyanoquinolines
egf
inhibitors
her2 kinases
her2
Prior art date
Application number
NO20042634A
Other languages
English (en)
Norwegian (no)
Inventor
Allan Wissner
Hwei-Ru Tsou
Bernard Dean Johnson
Jr Middleton Brawner Floyd
Elsebe Geral Overbeek-Klumpers
Original Assignee
Wyeth Holdings Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings Co filed Critical Wyeth Holdings Co
Publication of NO20042634L publication Critical patent/NO20042634L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
NO20042634A 2001-11-27 2004-06-23 3-Cyanokinoliner som inhibitorer for EGF-R og HER2-kinaser NO20042634L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33356801P 2001-11-27 2001-11-27
PCT/US2002/037918 WO2003050090A1 (en) 2001-11-27 2002-11-26 3-cyanoquinolines as inhibitors of egf-r and her2 kinases

Publications (1)

Publication Number Publication Date
NO20042634L true NO20042634L (no) 2004-06-23

Family

ID=23303345

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042634A NO20042634L (no) 2001-11-27 2004-06-23 3-Cyanokinoliner som inhibitorer for EGF-R og HER2-kinaser

Country Status (24)

Country Link
US (1) US6821988B2 (zh)
EP (1) EP1448531B1 (zh)
JP (1) JP2005514384A (zh)
KR (1) KR20050044599A (zh)
CN (1) CN1659145A (zh)
AR (1) AR037438A1 (zh)
AT (1) ATE370123T1 (zh)
AU (1) AU2002359489B2 (zh)
BR (1) BR0214485A (zh)
CA (1) CA2467573A1 (zh)
CO (1) CO5580828A2 (zh)
DE (1) DE60221886D1 (zh)
EC (1) ECSP045122A (zh)
HU (1) HUP0402228A2 (zh)
IL (1) IL161921A0 (zh)
MX (1) MXPA04004969A (zh)
NO (1) NO20042634L (zh)
NZ (1) NZ533118A (zh)
PL (1) PL370137A1 (zh)
RU (1) RU2309150C2 (zh)
TW (1) TW200300348A (zh)
UA (1) UA77469C2 (zh)
WO (1) WO2003050090A1 (zh)
ZA (1) ZA200405025B (zh)

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US7781591B2 (en) 2006-06-13 2010-08-24 Wyeth Llc Substituted 3-cyanopyridines as protein kinase inhibitors
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TW200616612A (en) * 2004-10-08 2006-06-01 Wyeth Corp Method for the teatment of polycystic kidney disease field of invention
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KR101472600B1 (ko) 2006-08-28 2014-12-15 에자이 알앤드디 매니지먼트 가부시키가이샤 미분화형 위암에 대한 항종양제
JP5319306B2 (ja) 2007-01-29 2013-10-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 未分化型胃癌治療用組成物
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
US8952035B2 (en) 2007-11-09 2015-02-10 Eisai R&D Management Co., Ltd. Combination of anti-angiogenic substance and anti-tumor platinum complex
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
EP3135285B1 (en) 2008-06-17 2018-08-15 Wyeth LLC Antineoplastic combinations containing hki-272 and vinorelbine
EP2326329B1 (en) 2008-08-04 2017-01-11 Wyeth LLC Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
ITMI20082336A1 (it) * 2008-12-29 2010-06-30 Univ Parma Composti inibitori irreversibili di egfr con attivita' antiproliferativa
SG173014A1 (en) 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
DK3000467T3 (da) 2009-04-06 2023-03-27 Wyeth Llc Behandling med neratinib mod brystkræft
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
ES2729677T3 (es) 2009-11-09 2019-11-05 Wyeth Llc Esferoides de fármacos recubiertos y sus usos para eliminar o reducir condiciones, como la emesis y la diarrea
WO2011153942A1 (zh) * 2010-06-09 2011-12-15 天津和美生物技术有限公司 氰基喹啉衍生物
CN102958523B (zh) 2010-06-25 2014-11-19 卫材R&D管理有限公司 使用具有激酶抑制作用的组合的抗肿瘤剂
EA025451B1 (ru) * 2010-08-26 2016-12-30 Симфони Эволюшн, Инк. Модулятор киназы рецепторного типа и способы лечения поликистозной болезни почек
AU2010363329A1 (en) 2010-11-07 2013-05-09 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN102675287A (zh) * 2011-03-11 2012-09-19 江苏恒瑞医药股份有限公司 (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用
WO2012144463A1 (ja) 2011-04-18 2012-10-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療剤
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BR112015009004A8 (pt) 2012-12-21 2021-07-20 Eisai R&D Man Co Ltd forma amorfa de derivado de quinolina e método de produção da mesma
CN103214489B (zh) * 2013-02-25 2016-10-26 中国人民解放军第二军医大学 一类具有抗肿瘤活性的多靶点激酶抑制剂及其制备方法
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Also Published As

Publication number Publication date
US20030149056A1 (en) 2003-08-07
MXPA04004969A (es) 2004-08-11
RU2004119414A (ru) 2006-02-27
EP1448531B1 (en) 2007-08-15
ATE370123T1 (de) 2007-09-15
UA77469C2 (en) 2006-12-15
US6821988B2 (en) 2004-11-23
AU2002359489A1 (en) 2003-06-23
BR0214485A (pt) 2004-09-14
WO2003050090A1 (en) 2003-06-19
ECSP045122A (es) 2004-07-23
CO5580828A2 (es) 2005-11-30
KR20050044599A (ko) 2005-05-12
AR037438A1 (es) 2004-11-10
TW200300348A (en) 2003-06-01
AU2002359489B2 (en) 2008-10-30
CN1659145A (zh) 2005-08-24
PL370137A1 (en) 2005-05-16
EP1448531A1 (en) 2004-08-25
RU2309150C2 (ru) 2007-10-27
IL161921A0 (en) 2005-11-20
DE60221886D1 (de) 2007-09-27
HUP0402228A2 (hu) 2005-02-28
ZA200405025B (en) 2006-12-27
JP2005514384A (ja) 2005-05-19
CA2467573A1 (en) 2003-06-19
NZ533118A (en) 2006-07-28

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