NO20040996L - Nye forbindelser og sammensetninger som catepsin-inhibitorer - Google Patents
Nye forbindelser og sammensetninger som catepsin-inhibitorerInfo
- Publication number
- NO20040996L NO20040996L NO20040996A NO20040996A NO20040996L NO 20040996 L NO20040996 L NO 20040996L NO 20040996 A NO20040996 A NO 20040996A NO 20040996 A NO20040996 A NO 20040996A NO 20040996 L NO20040996 L NO 20040996L
- Authority
- NO
- Norway
- Prior art keywords
- catepsin
- inhibitors
- compositions
- new compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32231801P | 2001-09-14 | 2001-09-14 | |
PCT/US2002/029323 WO2003024924A1 (en) | 2001-09-14 | 2002-09-16 | Novel compounds and compositions as cathepsin inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20040996L true NO20040996L (no) | 2004-05-12 |
Family
ID=23254351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040996A NO20040996L (no) | 2001-09-14 | 2004-03-09 | Nye forbindelser og sammensetninger som catepsin-inhibitorer |
Country Status (19)
Country | Link |
---|---|
US (2) | US7196099B2 (ja) |
EP (1) | EP1436255A1 (ja) |
JP (1) | JP2005504078A (ja) |
KR (1) | KR20040044920A (ja) |
CN (1) | CN1324008C (ja) |
BR (1) | BR0212535A (ja) |
CA (1) | CA2460125A1 (ja) |
CO (1) | CO5560538A2 (ja) |
HK (1) | HK1071886A1 (ja) |
HR (1) | HRP20040249A2 (ja) |
IL (1) | IL160819A0 (ja) |
MX (1) | MXPA04002282A (ja) |
NO (1) | NO20040996L (ja) |
NZ (1) | NZ531352A (ja) |
PL (1) | PL369312A1 (ja) |
RS (1) | RS19504A (ja) |
RU (1) | RU2316546C2 (ja) |
WO (1) | WO2003024924A1 (ja) |
ZA (1) | ZA200401882B (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL156577A0 (en) * | 2000-12-22 | 2004-01-04 | Axys Pharm Inc | Selective cathepsin s inhibitors and pharmaceutical compositions containing the same |
US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
CN1324018C (zh) * | 2001-11-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物 |
CN1708293A (zh) | 2002-09-24 | 2005-12-14 | 诺瓦提斯公司 | 治疗脱髓鞘疾病的鞘氨醇-1-磷酸受体激动剂 |
EP1664003A1 (en) * | 2003-09-18 | 2006-06-07 | Axys Pharmaceuticals, Inc. | Haloalkyl containing compounds as cysteine protease inhibitors |
PE20060213A1 (es) | 2004-04-30 | 2006-04-24 | Irm Llc | Compuestos y composiciones como inhibidores de catepsinas |
EP1819667B1 (en) | 2004-12-02 | 2012-10-17 | ViroBay, Inc. | Sulfonamide compounds as cysteine protease inhibitors |
WO2006064286A1 (en) * | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
PT1865940E (pt) * | 2005-03-21 | 2013-04-08 | Virobay Inc | Compostos alfa-cetoamida como inibidores de proteases de cisteína |
UA90138C2 (uk) * | 2005-03-21 | 2010-04-12 | Вайробей, Инк. | Альфа-кетоамідні сполуки як інгібітори цистеїнових протеаз |
US7893093B2 (en) | 2005-03-22 | 2011-02-22 | Virobay, Inc. | Sulfonyl containing compounds as cysteine protease inhibitors |
MX2009003563A (es) | 2006-10-04 | 2009-04-15 | Virobay Inc | Compuestos que contienen di-fluoro como inhibidores de proteasa de cisteina. |
US7893112B2 (en) | 2006-10-04 | 2011-02-22 | Virobay, Inc. | Di-fluoro containing compounds as cysteine protease inhibitors |
WO2009087379A2 (en) | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
CA2728514C (en) | 2008-06-20 | 2020-08-11 | Novartis Ag | Paediatric compositions for treating multiple sclerosis |
WO2010070615A1 (en) * | 2008-12-19 | 2010-06-24 | Medivir Uk Ltd | Cysteine protease inhibitors |
US8324417B2 (en) | 2009-08-19 | 2012-12-04 | Virobay, Inc. | Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof |
IN2012DN04914A (ja) | 2009-12-10 | 2015-09-25 | Medivir Uk Ltd |
Family Cites Families (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS429133Y1 (ja) | 1966-05-25 | 1967-05-17 | ||
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
DE3606480A1 (de) * | 1986-02-28 | 1987-09-03 | Behringwerke Ag | Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung |
US5055451A (en) | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
GB8809316D0 (en) | 1987-05-11 | 1988-05-25 | Ici America Inc | Heterocyclic ketones |
JPS63303868A (ja) | 1987-06-03 | 1988-12-12 | Oki Electric Ind Co Ltd | 誘電体セラミックスの製造方法 |
DE3827415A1 (de) | 1988-08-12 | 1990-02-15 | Behringwerke Ag | Peptidderivate, verfahren zu ihrer herstellung und ihre verwendung |
EP0376012A3 (en) | 1988-12-27 | 1992-05-06 | American Cyanamid Company | Renin inhibitors |
WO1990012005A1 (en) | 1989-04-13 | 1990-10-18 | Japan Tobacco Inc. | New amino acid derivatives having prolylendopeptidase inhibitor activity |
DK0536399T3 (da) | 1990-06-07 | 1996-06-03 | Zeria Pharm Co Ltd | Hidtil ukendt arylalkanonylaminderivat og lægemiddel indeholdende samme |
JPH08503475A (ja) * | 1992-11-25 | 1996-04-16 | メルク エンド カンパニー インコーポレーテッド | 抗変性活性剤としてのカルボキシ−ペプチジル誘導体 |
JPH06192199A (ja) | 1992-12-25 | 1994-07-12 | Mitsubishi Kasei Corp | ケトン誘導体 |
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
ZA945719B (en) | 1993-08-09 | 1996-02-01 | Lilly Co Eli | Identification and use of protease inhibitors |
CZ134296A3 (en) | 1993-11-09 | 1996-12-11 | Merck & Co Inc | Piperidine, pyrrolidine and hexahydro-1h-azepine derivatives, process of their preparation and pharmaceutical compositions containing thereof |
IL111785A0 (en) | 1993-12-03 | 1995-01-24 | Ferring Bv | Dp-iv inhibitors and pharmaceutical compositions containing them |
US5486623A (en) * | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5714484A (en) | 1993-12-08 | 1998-02-03 | Prototek, Inc. | α-(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors |
JPH07228529A (ja) | 1994-02-17 | 1995-08-29 | Zeria Pharmaceut Co Ltd | コリンエステラーゼ賦活剤 |
WO1995024382A1 (en) | 1994-03-10 | 1995-09-14 | G.D. Searle & Co. | L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5683345A (en) * | 1994-10-27 | 1997-11-04 | Novoste Corporation | Method and apparatus for treating a desired area in the vascular system of a patient |
US5498616A (en) * | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
US6015791A (en) | 1994-11-21 | 2000-01-18 | Cortech Inc. | Serine protease inhibitors-cycloheptane derivatives |
US5496616A (en) * | 1994-12-27 | 1996-03-05 | Xerox Corporation | Optical element for correcting non-uniform diffraction efficiency in a binary diffractive optical element |
US5691368A (en) | 1995-01-11 | 1997-11-25 | Hoechst Marion Roussel, Inc. | Substituted oxazolidine calpain and/or cathepsin B inhibitors |
NZ305626A (en) * | 1995-03-24 | 2000-01-28 | Axys Pharm Inc | Reversible protease inhibitors |
US6022861A (en) * | 1995-06-07 | 2000-02-08 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US6069130A (en) | 1995-06-07 | 2000-05-30 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
EP0840614A1 (en) | 1995-06-13 | 1998-05-13 | Sanofi Winthrop, Inc. | Calpain inhibitors for the treatment of neurodegenerative diseases |
US6124333A (en) * | 1995-06-22 | 2000-09-26 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
DK0871454T3 (da) | 1995-07-17 | 2004-03-22 | Cephalon Inc | Phosphorholdige inhibitorer af cystein- og serinprotease |
ES2293651T3 (es) * | 1995-11-28 | 2008-03-16 | Cephalon, Inc. | Inhibidores de cisteina y serina proteasas derivados de aminoacidos d. |
AU3359697A (en) | 1996-07-08 | 1998-02-02 | Yamanouchi Pharmaceutical Co., Ltd. | Bone resorption inhibitors |
JP2002514162A (ja) | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Xa因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
KR100318804B1 (ko) | 1996-08-28 | 2002-01-04 | 시오노 요시히코 | 티아졸릴-알라닌 잔기를 갖는 신규한 펩티드 유도체 |
EP0923535A4 (en) | 1996-08-28 | 2001-01-10 | Smithkline Beecham Corp | CYSTEINE PROTEASE INHIBITORS |
WO1998021168A1 (en) | 1996-11-13 | 1998-05-22 | Thelma Manning | High energy thermoplastic elastomer propellant |
GB9624817D0 (en) | 1996-11-28 | 1997-01-15 | British Biotech Pharm | Metalloproteinase inhibitors |
US6004933A (en) | 1997-04-25 | 1999-12-21 | Cortech Inc. | Cysteine protease inhibitors |
DE69841871D1 (en) | 1997-11-05 | 2010-10-14 | Novartis Ag | Dipeptide nitrile |
GB9723407D0 (en) * | 1997-11-05 | 1998-01-07 | Ciba Geigy Ag | Organic compounds |
US6114310A (en) * | 1998-01-23 | 2000-09-05 | Microcide Pharmaceuticals, Inc. | Efflux pump inhibitors |
WO2000032216A1 (en) * | 1998-06-03 | 2000-06-08 | Cortech Inc. | Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors |
US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
JP2002537293A (ja) | 1999-02-20 | 2002-11-05 | アストラゼネカ アクチボラグ | カテプシンlおよび/またはカテプシンsの阻害剤としてのアセタミドアセトニトリル誘導体 |
JP2002537294A (ja) | 1999-02-20 | 2002-11-05 | アストラゼネカ アクチボラグ | カテプシンl及びカテプシンsの阻害剤としてのジ−及びトリペプチドニトリル誘導体 |
GB9903861D0 (en) | 1999-02-20 | 1999-04-14 | Zeneca Ltd | Chemical compounds |
WO2000051998A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
EE200100487A (et) * | 1999-03-15 | 2003-02-17 | Axys Pharmaceuticals, Inc. | Uudsed ühendid ja kompositsioonid proteaasiinhibiitoritena |
EP1159260A1 (en) * | 1999-03-15 | 2001-12-05 | Axys Pharmaceuticals, Inc. | Novel compounds and compositions as protease inhibitors |
GB9907683D0 (en) * | 1999-04-06 | 1999-05-26 | Synphar Lab Inc | Substituted azetidin-2-ones as cysteine protease inhibitors |
AU3770600A (en) | 1999-04-06 | 2000-10-23 | Bristol-Myers Squibb Company | Selective retinoic acid analogs |
GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
JP2001011037A (ja) | 1999-07-01 | 2001-01-16 | Kissei Pharmaceut Co Ltd | シクロアルカンカルボン酸アミド誘導体 |
EP1204652B1 (en) | 1999-07-30 | 2006-05-17 | Boehringer Ingelheim Pharmaceuticals Inc. | Novel succinate derivative compounds useful as cysteine protease inhibitors |
GB9917909D0 (en) | 1999-07-31 | 1999-09-29 | Synphar Lab Inc | Cysteine protease inhibitors |
US6356115B1 (en) | 1999-08-04 | 2002-03-12 | Intel Corporation | Charge sharing and charge recycling for an on-chip bus |
JP2001055366A (ja) | 1999-08-12 | 2001-02-27 | Kissei Pharmaceut Co Ltd | ビアリール酢酸アミド誘導体 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
HUP0302380A2 (hu) | 1999-09-13 | 2004-03-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cisztein-proteázok reverzibilis inhibitoraiként alkalmazható új spiroheterociklusos vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
AU7490900A (en) | 1999-09-16 | 2001-04-17 | Axys Pharmaceuticals, Inc. | Chemical compounds and compositions and their use as cathepsin s inhibitors |
GB9925264D0 (en) | 1999-10-26 | 1999-12-29 | Zeneca Ltd | Chemical compounds |
HU227039B1 (en) | 2000-01-25 | 2010-05-28 | Egis Gyogyszergyar Nyilvanosan | New process for the production of quetiapine and intermediates therefor |
GB0003111D0 (en) | 2000-02-10 | 2000-03-29 | Novartis Ag | Organic compounds |
IL156577A0 (en) * | 2000-12-22 | 2004-01-04 | Axys Pharm Inc | Selective cathepsin s inhibitors and pharmaceutical compositions containing the same |
CA2435117A1 (en) | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
PT1362052E (pt) | 2001-01-17 | 2007-04-30 | Amura Therapeutics Ltd | Inibidores de cruzipaína e de outras proteases de cisteína |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
DE10125793C2 (de) | 2001-05-26 | 2003-08-07 | Gkn Automotive Gmbh | Differentialgetriebe mit integrierten Gleichlaufgelenken |
US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
CN1324018C (zh) * | 2001-11-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物 |
JP2005526830A (ja) * | 2002-04-16 | 2005-09-08 | アクシス・ファーマシューティカルズ・インコーポレイテッド | ヘテロアリール及び不飽和ヘテロシクロアルキルマグネシウム試薬の製造方法及び使用 |
-
2002
- 2002-09-16 BR BR0212535-8A patent/BR0212535A/pt not_active IP Right Cessation
- 2002-09-16 WO PCT/US2002/029323 patent/WO2003024924A1/en active IP Right Grant
- 2002-09-16 CN CNB028178904A patent/CN1324008C/zh not_active Expired - Fee Related
- 2002-09-16 JP JP2003528772A patent/JP2005504078A/ja active Pending
- 2002-09-16 PL PL02369312A patent/PL369312A1/xx not_active Application Discontinuation
- 2002-09-16 CA CA002460125A patent/CA2460125A1/en not_active Abandoned
- 2002-09-16 RU RU2004111291/04A patent/RU2316546C2/ru not_active IP Right Cessation
- 2002-09-16 EP EP02798975A patent/EP1436255A1/en not_active Withdrawn
- 2002-09-16 KR KR10-2004-7003765A patent/KR20040044920A/ko not_active Application Discontinuation
- 2002-09-16 RS YUP-195/04A patent/RS19504A/sr unknown
- 2002-09-16 MX MXPA04002282A patent/MXPA04002282A/es unknown
- 2002-09-16 NZ NZ531352A patent/NZ531352A/en unknown
- 2002-09-16 IL IL16081902A patent/IL160819A0/xx unknown
-
2004
- 2004-02-26 US US10/787,367 patent/US7196099B2/en not_active Expired - Lifetime
- 2004-03-08 ZA ZA200401882A patent/ZA200401882B/en unknown
- 2004-03-09 NO NO20040996A patent/NO20040996L/no not_active Application Discontinuation
- 2004-03-12 CO CO04022770A patent/CO5560538A2/es unknown
- 2004-03-12 HR HR20040249A patent/HRP20040249A2/hr not_active Application Discontinuation
-
2005
- 2005-06-08 HK HK05104782A patent/HK1071886A1/xx not_active IP Right Cessation
-
2007
- 2007-01-22 US US11/625,369 patent/US20070135386A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7196099B2 (en) | 2007-03-27 |
EP1436255A1 (en) | 2004-07-14 |
KR20040044920A (ko) | 2004-05-31 |
JP2005504078A (ja) | 2005-02-10 |
CA2460125A1 (en) | 2003-03-27 |
PL369312A1 (en) | 2005-04-18 |
BR0212535A (pt) | 2004-10-19 |
CN1553892A (zh) | 2004-12-08 |
RU2004111291A (ru) | 2005-09-10 |
ZA200401882B (en) | 2005-04-18 |
HRP20040249A2 (en) | 2005-04-30 |
NZ531352A (en) | 2006-01-27 |
RU2316546C2 (ru) | 2008-02-10 |
WO2003024924A1 (en) | 2003-03-27 |
RS19504A (en) | 2007-02-05 |
IL160819A0 (en) | 2004-08-31 |
CO5560538A2 (es) | 2005-09-30 |
MXPA04002282A (es) | 2005-03-07 |
CN1324008C (zh) | 2007-07-04 |
US20040192742A1 (en) | 2004-09-30 |
HK1071886A1 (en) | 2005-08-05 |
US20070135386A1 (en) | 2007-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20034308D0 (no) | Nye tyrokinase-inhibitorer | |
NO20034187L (no) | Nye spirotricykliske derivater og anvendelse derav som fosfodiesterase-7 inhibitorer | |
DE60234125D1 (de) | E inhibitoren | |
NO20034042D0 (no) | Metallproteinase-inhibitorer | |
NO20043004L (no) | 4-oksokinolin forbindelse og anvendelse derav som HIV-integraseinhibitor | |
NO20030867D0 (no) | Hydroksamderivater anvendelig som deacetylaseinhibitorer | |
DK1499311T3 (da) | Substituerede benzaboler og anvendelse deraf som RAF-kinaseinhibitorer | |
NO20031450D0 (no) | Fumarsyrederivater som NF-kappa B inhibitorer | |
NO20033618L (no) | Ftalayinon-piperidino-derivater som PDE-4-inhibitorer | |
DK1542977T3 (da) | 2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12 | |
DK1484970T3 (da) | Benzamider og sammensætninger omfattende benzamider til anvendelse som fungicider | |
NO20050665L (no) | Pyrrolidonderivater som MAOE inhibitoere | |
NO20040996L (no) | Nye forbindelser og sammensetninger som catepsin-inhibitorer | |
NO20041887L (no) | Benzomidazoler anvendelige som proteinkinase-inhibitorer | |
ITMI20011062A0 (it) | Composizioni fluoroelastomeriche | |
NO20034032L (no) | Metallproteinase-inhibitorer | |
NO20042719L (no) | Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer | |
NO20050620L (no) | Nye 2-aryltiazol-forbindelser som PPARALPHA og PPARGAMA agonister | |
ITMI20011061A0 (it) | Composizioni fluoroelastomeriche | |
NO20034695D0 (no) | Nye sammensetninger | |
NO20035328D0 (no) | Nye forbindelser og preparater som katepsinhibitorer | |
ITMI20011060A0 (it) | Composizioni fluoroelastomeriche | |
NO20035440D0 (no) | Pyrrolidinderivater som faktor-XA-inhibitorer | |
NO20043124L (no) | Aminoindanderivater som serotonin -og norepinefrin-opptaksinhibitorer | |
ITMI20011059A0 (it) | Composizioni fluoroelastomeriche |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |