NO20034345D0 - Pyridazinon aldose reduktase inhibitorer - Google Patents

Pyridazinon aldose reduktase inhibitorer

Info

Publication number
NO20034345D0
NO20034345D0 NO20034345A NO20034345A NO20034345D0 NO 20034345 D0 NO20034345 D0 NO 20034345D0 NO 20034345 A NO20034345 A NO 20034345A NO 20034345 A NO20034345 A NO 20034345A NO 20034345 D0 NO20034345 D0 NO 20034345D0
Authority
NO
Norway
Prior art keywords
reductase inhibitors
aldose reductase
pyridazinone aldose
pyridazinone
inhibitors
Prior art date
Application number
NO20034345A
Other languages
English (en)
Norwegian (no)
Other versions
NO20034345L (no
Inventor
Banavara Lakshman Mylari
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20034345L publication Critical patent/NO20034345L/no
Publication of NO20034345D0 publication Critical patent/NO20034345D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20034345A 2001-03-30 2003-09-29 Pyridazinon aldose reduktase inhibitorer NO20034345D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28005101P 2001-03-30 2001-03-30
PCT/IB2002/000320 WO2002079198A1 (en) 2001-03-30 2002-01-31 Pyridazinone aldose reductase inhibitors

Publications (2)

Publication Number Publication Date
NO20034345L NO20034345L (no) 2003-09-29
NO20034345D0 true NO20034345D0 (no) 2003-09-29

Family

ID=23071435

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20034345A NO20034345D0 (no) 2001-03-30 2003-09-29 Pyridazinon aldose reduktase inhibitorer

Country Status (44)

Country Link
US (2) US6579879B2 (is)
EP (3) EP1491540B1 (is)
JP (1) JP2004528319A (is)
KR (1) KR100586138B1 (is)
CN (1) CN1215067C (is)
AP (1) AP2002002461A0 (is)
AR (1) AR035798A1 (is)
AT (3) ATE286049T1 (is)
AU (1) AU2002226634B2 (is)
BG (1) BG108179A (is)
BR (1) BR0208571A (is)
CA (1) CA2442476A1 (is)
CZ (1) CZ20032563A3 (is)
DE (3) DE60216823T2 (is)
DK (2) DK1373259T3 (is)
EA (1) EA006023B1 (is)
EC (1) ECSP034671A (is)
EE (1) EE200300470A (is)
ES (2) ES2231681T3 (is)
GE (1) GEP20053675B (is)
HK (1) HK1061678A1 (is)
HR (1) HRP20030752A2 (is)
HU (1) HUP0303644A3 (is)
IL (1) IL156462A0 (is)
IS (3) IS2205B (is)
MA (1) MA27003A1 (is)
MX (1) MXPA03008850A (is)
MY (1) MY134304A (is)
NO (1) NO20034345D0 (is)
NZ (1) NZ528406A (is)
OA (1) OA12453A (is)
PA (1) PA8541801A1 (is)
PE (1) PE20030007A1 (is)
PL (1) PL365294A1 (is)
PT (2) PT1491540E (is)
SI (1) SI1373259T1 (is)
SK (1) SK11852003A3 (is)
TN (1) TNSN02037A1 (is)
TW (1) TWI245762B (is)
UA (1) UA73236C2 (is)
UY (1) UY27237A1 (is)
WO (1) WO2002079198A1 (is)
YU (1) YU71403A (is)
ZA (1) ZA200304671B (is)

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CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ-氨基丁酸及其衍生物
ES2240657T3 (es) * 2001-02-28 2005-10-16 Pfizer Products Inc. Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
EE200300470A (et) * 2001-03-30 2004-02-16 Pfizer Products Inc. Aldoosreduktaasi püridasinooninhibiitorid
AU761191B2 (en) * 2001-05-24 2003-05-29 Pfizer Products Inc. Therapies for tissue damage resulting from ischemia
IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents
US7419981B2 (en) * 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US20040092522A1 (en) * 2002-08-15 2004-05-13 Field Mark John Synergistic combinations
US6872833B2 (en) * 2003-04-14 2005-03-29 Hoffmann-La Roche Inc. Adenosine receptor ligands
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AR049384A1 (es) 2004-05-24 2006-07-26 Glaxo Group Ltd Derivados de purina
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
WO2006028565A2 (en) * 2004-06-30 2006-03-16 Whitehead Institute For Biomedical Research Novel methods for high-throughput genome-wide location analysis
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
KR20080114688A (ko) * 2006-01-13 2008-12-31 와이어쓰 5-히드록시트립타민 수용체에 대한 리간드로서의 술포닐 치환된 1h-인돌
PT2248812E (pt) 2006-06-27 2014-03-12 Takeda Pharmaceutical Compostos cíclicos fundidos como moduladores do receptor gpr40
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US8173645B2 (en) * 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
JP5815552B2 (ja) 2009-12-08 2015-11-17 ケース ウェスタン リザーブ ユニバーシティCase Westernreserve University 眼疾患を治療する化合物および方法
US8916563B2 (en) 2010-07-16 2014-12-23 The Trustees Of Columbia University In The City Of New York Aldose reductase inhibitors and uses thereof
CA2848877A1 (en) * 2011-09-15 2013-03-21 Taipei Medical University Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103739547B (zh) * 2014-01-03 2015-09-02 沈阳药科大学 2-[6-甲氧基-3-(2,3-二氯苯基)甲基-4-氧代-1,4-二氢-1(4h)-喹啉基]乙酸的合成方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3283074A4 (en) * 2015-04-14 2018-12-05 Case Western Reserve University Compositions and methods of modulating short-chain dehydrogenase activity
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
EP4316603A3 (en) 2016-06-21 2024-04-17 The Trustees of Columbia University in the City of New York 4-oxo-3,4-dihydrothieno[3,4-d]pyridazine compounds as aldose reductase inhibitors and methods of use thereof
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
WO2018058109A1 (en) * 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
JP2020502070A (ja) 2016-11-30 2020-01-23 ケース ウエスタン リザーブ ユニバーシティ 15−pgdh阻害剤とコルチコステロイドおよび/またはtnf阻害剤との組み合わせならびにその使用
JP2020514323A (ja) 2017-02-06 2020-05-21 ケース ウエスタン リザーブ ユニバーシティ 短鎖デヒドロゲナーゼ活性を調節する組成物と方法
EP4417260A2 (en) 2017-07-28 2024-08-21 Applied Therapeutics, Inc. Compositions and methods for treating galactosemia
SG11202107614PA (en) 2019-01-18 2021-08-30 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof
AU2020268368A1 (en) 2019-05-07 2022-01-06 Ucl Business Ltd Treatment and detection of inherited neuropathies and associated disorders
MX2021014441A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
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IE47592B1 (en) 1977-12-29 1984-05-02 Ici Ltd Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4939140A (en) 1985-11-07 1990-07-03 Pfizer Inc. Heterocyclic oxophthalazinyl acetic acids
US4996204A (en) 1989-05-11 1991-02-26 Pfizer Inc. Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors
FR2647676A1 (fr) 1989-06-05 1990-12-07 Union Pharma Scient Appl Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
EP0516860A4 (en) * 1990-11-30 1993-12-01 Tsumura & Co. Chromone derivative and aldose reductase inhibitor containing the same as active ingredient
AU658887B2 (en) 1991-03-28 1995-05-04 Pfizer Inc. Pyridazinone acetic acids as aldose reductase inhibitors
US5834466A (en) 1994-12-22 1998-11-10 The Regents Of The University Of California Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
TWI238064B (en) 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
SK3902000A3 (en) * 1997-09-24 2000-12-11 Orion Corp Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors
FR2822827B1 (fr) * 2001-03-28 2003-05-16 Sanofi Synthelabo Nouveaux derives de n-(arylsulfonyl) beta-aminoacides comportant un groupe aminomethyle substitue, leur procede de preparation et les compositions pharmaceutiques en contenant
EE200300470A (et) * 2001-03-30 2004-02-16 Pfizer Products Inc. Aldoosreduktaasi püridasinooninhibiitorid
HUP0303920A3 (en) * 2001-04-30 2004-07-28 Pfizer Prod Inc Pharmaceutical compositions containing combinations of aldose reductase inhibitor pyridazinons and cyclooxygenase 2 inhibitors
IL162594A0 (en) * 2002-01-09 2005-11-20 Pfizer Prod Inc Process and intermediates for pyridazinone antidiabetic agents

Also Published As

Publication number Publication date
DE60217930D1 (de) 2007-03-15
AP2002002461A0 (en) 2002-06-30
YU71403A (sh) 2006-05-25
EP1373259B1 (en) 2004-12-29
IS2205B (is) 2007-02-15
EA006023B1 (ru) 2005-08-25
HUP0303644A2 (hu) 2004-03-01
EE200300470A (et) 2004-02-16
DK1491540T3 (da) 2007-03-26
ZA200304671B (en) 2004-06-25
BR0208571A (pt) 2004-03-23
PE20030007A1 (es) 2003-01-28
DK1373259T3 (da) 2005-03-29
US20020143017A1 (en) 2002-10-03
AR035798A1 (es) 2004-07-14
NZ528406A (en) 2004-03-26
CA2442476A1 (en) 2002-10-10
NO20034345L (no) 2003-09-29
PT1491540E (pt) 2007-01-31
MA27003A1 (fr) 2004-12-20
AU2002226634B2 (en) 2007-01-25
DE60216823T2 (de) 2007-10-04
PA8541801A1 (es) 2002-10-28
TWI245762B (en) 2005-12-21
OA12453A (en) 2006-05-24
EA200300673A1 (ru) 2003-12-25
WO2002079198A1 (en) 2002-10-10
EP1491540A1 (en) 2004-12-29
ATE348100T1 (de) 2007-01-15
UY27237A1 (es) 2002-12-31
DE60202452T2 (de) 2006-02-09
CN1215067C (zh) 2005-08-17
SI1373259T1 (en) 2005-04-30
ATE286049T1 (de) 2005-01-15
HUP0303644A3 (en) 2008-06-30
US6849629B2 (en) 2005-02-01
DE60202452D1 (de) 2005-02-03
HRP20030752A2 (en) 2005-06-30
EP1491540B1 (en) 2006-12-13
CZ20032563A3 (cs) 2004-05-12
DE60202452C5 (de) 2006-11-23
IS8250A (is) 2006-01-23
IS6845A (is) 2003-06-16
SK11852003A3 (sk) 2004-07-07
CN1500087A (zh) 2004-05-26
DE60216823D1 (de) 2007-01-25
MXPA03008850A (es) 2003-12-04
UA73236C2 (en) 2005-06-15
ECSP034671A (es) 2003-08-29
MY134304A (en) 2007-12-31
EP1491541B1 (en) 2007-01-24
IS8251A (is) 2006-01-23
EP1491541A1 (en) 2004-12-29
DE60217930T2 (de) 2007-10-18
BG108179A (en) 2004-09-30
IL156462A0 (en) 2004-01-04
HK1061678A1 (en) 2004-09-30
EP1373259A1 (en) 2004-01-02
ES2274369T3 (es) 2007-05-16
US20030162784A1 (en) 2003-08-28
KR20030088484A (ko) 2003-11-19
PL365294A1 (en) 2004-12-27
US6579879B2 (en) 2003-06-17
PT1373259E (pt) 2005-03-31
TNSN02037A1 (fr) 2005-12-23
KR100586138B1 (ko) 2006-06-07
GEP20053675B (en) 2005-11-25
ATE352551T1 (de) 2007-02-15
JP2004528319A (ja) 2004-09-16
ES2231681T3 (es) 2005-05-16

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