NO20021615L - Nöytralt kationisk lipid for levering av nukleinsyre og medikament - Google Patents
Nöytralt kationisk lipid for levering av nukleinsyre og medikamentInfo
- Publication number
- NO20021615L NO20021615L NO20021615A NO20021615A NO20021615L NO 20021615 L NO20021615 L NO 20021615L NO 20021615 A NO20021615 A NO 20021615A NO 20021615 A NO20021615 A NO 20021615A NO 20021615 L NO20021615 L NO 20021615L
- Authority
- NO
- Norway
- Prior art keywords
- drug
- delivery
- nucleic acid
- cationic lipid
- sup
- Prior art date
Links
- -1 cationic lipid Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15869399P | 1999-10-08 | 1999-10-08 | |
| PCT/US2000/027974 WO2001026629A2 (en) | 1999-10-08 | 2000-10-10 | Neutral-cationic lipid for nucleic acid and drug delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20021615D0 NO20021615D0 (no) | 2002-04-05 |
| NO20021615L true NO20021615L (no) | 2002-04-05 |
Family
ID=22569279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20021615A NO20021615L (no) | 1999-10-08 | 2002-04-05 | Nöytralt kationisk lipid for levering av nukleinsyre og medikament |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6974589B1 (de) |
| EP (1) | EP1223916B1 (de) |
| JP (1) | JP2003511405A (de) |
| KR (1) | KR100723852B1 (de) |
| CN (2) | CN1915968A (de) |
| AT (1) | ATE276744T1 (de) |
| AU (2) | AU7868400A (de) |
| CA (1) | CA2386164A1 (de) |
| DE (1) | DE60014133T2 (de) |
| DK (1) | DK1223916T3 (de) |
| ES (1) | ES2226932T3 (de) |
| HU (1) | HUP0203117A3 (de) |
| IL (1) | IL148968A0 (de) |
| MX (1) | MXPA02002899A (de) |
| NO (1) | NO20021615L (de) |
| WO (2) | WO2001026625A2 (de) |
| ZA (1) | ZA200202726B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100669053B1 (ko) | 1999-04-23 | 2007-01-15 | 알자 코포레이션 | 리포좀에 사용하기 위한 절단가능 결합을 갖는 콘쥬게이트 |
| US7238368B2 (en) | 1999-04-23 | 2007-07-03 | Alza Corporation | Releasable linkage and compositions containing same |
| US7303760B2 (en) | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
| US20040197390A1 (en) * | 2001-05-29 | 2004-10-07 | Shi-Kun Huang | Neutral-cationic lipid for systemic delivery of factor VIII gene |
| WO2001026625A2 (en) * | 1999-10-08 | 2001-04-19 | Alza Corp | Neutral-cationic lipid for nucleic acid and drug delivery |
| DE10207177A1 (de) | 2002-02-19 | 2003-09-04 | Novosom Ag | Fakultativ kationische Lipide |
| SI1771206T1 (en) * | 2004-05-05 | 2018-06-29 | Silence Therapeutics Gmbh | Lipids, lipid complexes and use thereof |
| EP1935434A1 (de) * | 2006-12-19 | 2008-06-25 | Novosom AG | Konstruktion und Verwendung von transfektionsverstärkenden Elementen |
| EP2147122B1 (de) | 2007-04-20 | 2014-07-16 | Sigma-Tau Rare Diseases S.A. | Enzymatische tumortherapie |
| CN101475503B (zh) * | 2008-12-15 | 2012-02-15 | 山东大学 | 一种新型阳离子类脂及其制备方法和应用 |
| EP2532649B1 (de) * | 2011-06-07 | 2015-04-08 | Incella GmbH | Aminolipide, deren Synthese und Verwendungen davon |
| PL3586861T3 (pl) | 2011-06-08 | 2022-05-23 | Translate Bio, Inc. | Kompozycje nanocząstek lipidowych i sposoby dostarczania mrna |
| KR101480055B1 (ko) * | 2012-04-04 | 2015-01-09 | 주식회사 삼양바이오팜 | 음이온성 약물 전달체의 제조 방법 |
| CN105585598B (zh) * | 2014-10-20 | 2019-02-19 | 湖南师范大学 | 甘露糖衍生物阳离子脂质体纳米颗粒的制备方法 |
| CN108291227A (zh) | 2015-10-14 | 2018-07-17 | 拜奥-帕斯控股股份有限公司 | 用于脂质体制剂的对乙氧基核酸 |
| CN107200841B (zh) * | 2016-03-17 | 2019-02-01 | 华东师范大学 | 一种培化二酰甘油的合成方法 |
| AU2017325971A1 (en) | 2016-09-16 | 2019-04-11 | Bio-Path Holdings, Inc. | Combination therapy with liposomal antisense oligonucleotides |
| JP2020517750A (ja) * | 2017-04-19 | 2020-06-18 | エイピーエイ− アドバンスト・テクノロジーズ・リミテッドＡｐａ− Ａｄｖａｎｃｅｄ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｔｄ． | 癌処置のための融合性リポソーム、組成物、キットおよびその使用 |
| EA201992490A1 (ru) | 2017-04-19 | 2020-03-03 | Байо-Пат Холдингз, Инк. | Р-этокси нуклеиновые кислоты для ингибирования bcl2 |
| EA201992485A1 (ru) | 2017-04-19 | 2020-02-17 | Байо-Пат Холдингз, Инк. | Р-этокси нуклеиновые кислоты для ингибирования stat3 |
| KR20250150267A (ko) | 2024-04-11 | 2025-10-20 | 한국과학기술연구원 | 아연 및 디피콜릴아민을 포함하는 핵산 결합용 양쪽성 지질 화합물 및 이를 포함하는 지질 나노입자 조성물 |
| CN119792316B (zh) * | 2025-03-14 | 2025-12-09 | 中国医学科学院医学生物学研究所 | 磷脂酸在制备预防和/或治疗广谱病毒感染药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US5965434A (en) * | 1994-12-29 | 1999-10-12 | Wolff; Jon A. | Amphipathic PH sensitive compounds and delivery systems for delivering biologically active compounds |
| DE19521412A1 (de) | 1995-06-14 | 1996-12-19 | Boehringer Mannheim Gmbh | Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung |
| US5855911A (en) | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| TW520297B (en) * | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US6656498B1 (en) * | 1998-11-25 | 2003-12-02 | Vanderbilt University | Cationic liposomes for gene transfer |
| WO2001026625A2 (en) * | 1999-10-08 | 2001-04-19 | Alza Corp | Neutral-cationic lipid for nucleic acid and drug delivery |
-
2000
- 2000-10-06 WO PCT/US2000/027683 patent/WO2001026625A2/en not_active Ceased
- 2000-10-06 AU AU78684/00A patent/AU7868400A/en not_active Withdrawn
- 2000-10-10 MX MXPA02002899A patent/MXPA02002899A/es not_active Application Discontinuation
- 2000-10-10 CN CNA2006101062621A patent/CN1915968A/zh active Pending
- 2000-10-10 AT AT00970729T patent/ATE276744T1/de not_active IP Right Cessation
- 2000-10-10 JP JP2001529419A patent/JP2003511405A/ja not_active Abandoned
- 2000-10-10 IL IL14896800A patent/IL148968A0/xx unknown
- 2000-10-10 KR KR1020027004490A patent/KR100723852B1/ko not_active Expired - Fee Related
- 2000-10-10 AU AU80064/00A patent/AU778817B2/en not_active Ceased
- 2000-10-10 WO PCT/US2000/027974 patent/WO2001026629A2/en not_active Ceased
- 2000-10-10 US US09/685,940 patent/US6974589B1/en not_active Expired - Lifetime
- 2000-10-10 EP EP00970729A patent/EP1223916B1/de not_active Expired - Lifetime
- 2000-10-10 CN CN00813919A patent/CN1378536A/zh active Pending
- 2000-10-10 CA CA002386164A patent/CA2386164A1/en not_active Abandoned
- 2000-10-10 HU HU0203117A patent/HUP0203117A3/hu unknown
- 2000-10-10 ES ES00970729T patent/ES2226932T3/es not_active Expired - Lifetime
- 2000-10-10 DE DE60014133T patent/DE60014133T2/de not_active Expired - Fee Related
- 2000-10-10 DK DK00970729T patent/DK1223916T3/da active
-
2002
- 2002-04-05 NO NO20021615A patent/NO20021615L/no not_active Application Discontinuation
- 2002-04-08 ZA ZA200202726A patent/ZA200202726B/en unknown
-
2005
- 2005-05-19 US US11/133,879 patent/US20050260261A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU7868400A (en) | 2001-04-23 |
| NO20021615D0 (no) | 2002-04-05 |
| JP2003511405A (ja) | 2003-03-25 |
| DE60014133D1 (de) | 2004-10-28 |
| US20050260261A1 (en) | 2005-11-24 |
| DK1223916T3 (da) | 2005-01-31 |
| WO2001026625A2 (en) | 2001-04-19 |
| ATE276744T1 (de) | 2004-10-15 |
| HUP0203117A3 (en) | 2005-06-28 |
| HUP0203117A2 (hu) | 2003-01-28 |
| ZA200202726B (en) | 2003-06-25 |
| US6974589B1 (en) | 2005-12-13 |
| CN1378536A (zh) | 2002-11-06 |
| IL148968A0 (en) | 2002-11-10 |
| WO2001026629A2 (en) | 2001-04-19 |
| DE60014133T2 (de) | 2005-02-03 |
| KR100723852B1 (ko) | 2007-05-31 |
| AU778817B2 (en) | 2004-12-23 |
| CA2386164A1 (en) | 2001-04-19 |
| AU8006400A (en) | 2001-04-23 |
| EP1223916B1 (de) | 2004-09-22 |
| WO2001026629A3 (en) | 2002-05-10 |
| CN1915968A (zh) | 2007-02-21 |
| ES2226932T3 (es) | 2005-04-01 |
| KR20020063875A (ko) | 2002-08-05 |
| EP1223916A2 (de) | 2002-07-24 |
| MXPA02002899A (es) | 2002-10-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |