EA201992485A1 - Р-этокси нуклеиновые кислоты для ингибирования stat3 - Google Patents

Р-этокси нуклеиновые кислоты для ингибирования stat3

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Publication number
EA201992485A1
EA201992485A1 EA201992485A EA201992485A EA201992485A1 EA 201992485 A1 EA201992485 A1 EA 201992485A1 EA 201992485 A EA201992485 A EA 201992485A EA 201992485 A EA201992485 A EA 201992485A EA 201992485 A1 EA201992485 A1 EA 201992485A1
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EA
Eurasian Patent Office
Prior art keywords
etoxy
nucleic acids
stat3 inhibition
stat3
delivery systems
Prior art date
Application number
EA201992485A
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English (en)
Inventor
Ана Тари Асидзава
Original Assignee
Байо-Пат Холдингз, Инк.
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Publication date
Application filed by Байо-Пат Холдингз, Инк. filed Critical Байо-Пат Холдингз, Инк.
Publication of EA201992485A1 publication Critical patent/EA201992485A1/ru

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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6915—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the form being a liposome with polymerisable or polymerized bilayer-forming substances, e.g. polymersomes
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    • A—HUMAN NECESSITIES
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

В данном документе предложены улучшенные системы доставки олигонуклеотидов, причем указанная система доставки содержит липосому, которая содержит нейтральные фосфолипиды и P-этокси олигонуклеотид, который нацелен на полинуклеотид, кодирующий STAT3. Также предложены способы лечения пациентов с помощью указанных систем доставки.
EA201992485A 2017-04-19 2018-04-19 Р-этокси нуклеиновые кислоты для ингибирования stat3 EA201992485A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762487292P 2017-04-19 2017-04-19
PCT/US2018/028259 WO2018195249A1 (en) 2017-04-19 2018-04-19 P-ethoxy nucleic acids for stat3 inhibition

Publications (1)

Publication Number Publication Date
EA201992485A1 true EA201992485A1 (ru) 2020-02-17

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EA201992485A EA201992485A1 (ru) 2017-04-19 2018-04-19 Р-этокси нуклеиновые кислоты для ингибирования stat3

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US (2) US11041153B2 (ru)
EP (1) EP3612159A4 (ru)
JP (1) JP7237009B2 (ru)
KR (1) KR20190141197A (ru)
CN (1) CN110636836B (ru)
AU (1) AU2018255352B2 (ru)
BR (1) BR112019021771A2 (ru)
CA (1) CA3058018A1 (ru)
EA (1) EA201992485A1 (ru)
IL (1) IL269608B2 (ru)
SA (1) SA519410315B1 (ru)
SG (1) SG11201909336VA (ru)
WO (1) WO2018195249A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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EP3512525B1 (en) 2016-09-16 2022-07-27 Bio-Path Holdings, Inc. Combination therapy with liposomal antisense oligonucleotides
CN113238053B (zh) * 2021-04-30 2022-05-13 四川大学华西医院 一种用于检测stat3二聚化的质粒

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EP3612159A4 (en) 2021-01-20
CN110636836B (zh) 2022-12-16
SG11201909336VA (en) 2019-11-28
JP2020517632A (ja) 2020-06-18
JP7237009B2 (ja) 2023-03-10
WO2018195249A1 (en) 2018-10-25
AU2018255352A1 (en) 2019-11-14
IL269608A (en) 2019-11-28
AU2018255352B2 (en) 2023-11-16
US20200040339A1 (en) 2020-02-06
US11041153B2 (en) 2021-06-22
CA3058018A1 (en) 2018-10-25
IL269608B2 (en) 2024-06-01
BR112019021771A2 (pt) 2020-05-05
EP3612159A1 (en) 2020-02-26
KR20190141197A (ko) 2019-12-23
IL269608B1 (en) 2024-02-01
SA519410315B1 (ar) 2023-12-27
CN110636836A (zh) 2019-12-31
US20220127608A1 (en) 2022-04-28

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