NO20012931L - Nye tyroidreseptorligander og fremgangsmate II - Google Patents
Nye tyroidreseptorligander og fremgangsmate IIInfo
- Publication number
- NO20012931L NO20012931L NO20012931A NO20012931A NO20012931L NO 20012931 L NO20012931 L NO 20012931L NO 20012931 A NO20012931 A NO 20012931A NO 20012931 A NO20012931 A NO 20012931A NO 20012931 L NO20012931 L NO 20012931L
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- hydrogen
- failing
- metabolism
- cycloalkyl
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
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- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C07C311/51—Y being a hydrogen or a carbon atom
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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Abstract
Det er tilveiebragt nye tyroidreseptorligander med. den generelle formel I hvor: n er et tall fra 0 til 4;. R! er halogen, trifluormetyl eller en alkylgruppe. med fra 1 til 6 karbonatomer eller en sykloalkyl. med fra 3 til 7 karbonatomer; Rog Rer like eller. forskjellige, og er hydrogen, halogen, alkyl med fra. 1 til 4 karbonatomer eller sykloalkyl med fra 3 til 5. karbonatomer, og hvor minst en av Rog Rer for-skjellig fra hydrogen; Rer et karboksylsyreamid. (CONR'R") eller et acylsulfonamid (CONHS02R'). derivat, eller et av dets farmasøytisk akseptable. salter, og alle deres stereoisomerer; eller når n er lik. eller større enn 1, så kan Rvære en heteroaroma-tisk gruppe som kan være substituert eller usubsti-tuert, eller et amin (NR'RR'). Rer hydrogen eller. acyl (så som acetyl eller benzoyl) eller en annen. gruppe som lar seg bioomdanne til den frie fenol-strukturen (hvor R= H). I tillegg er det tilveiebragt. en fremgangsmåte for å hindre eller behandle en. sykdom som er forbundet med sviktende metabolisme eller som er avhengig av 'ekspresjonen av et. T-regulert gen, og hvor en forbindelse som beskre-. vet ovenfor, blir administrert i en terapeutisk effek-tiv mengde. Eksempler på slike sykdommer som er assosiert med sviktende metabolisme eller er avhengig av ekspresjonen av et T-regulert gen innbe-fatter overvekt, hyperkolesterolemi, arteriosklerose, hjertearytmi, depresjon, osteoporose, hypotyro-idisme, struma, cancer i skjoldbruskkjertelen såvel som glaukom, kongestiv hjertesvikt og hudlidelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9828442.5A GB9828442D0 (en) | 1998-12-24 | 1998-12-24 | Novel thyroid receptor ligands and method II |
PCT/IB1999/002084 WO2000039077A2 (en) | 1998-12-24 | 1999-12-23 | Thyroid receptor ligands |
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NO20012931D0 NO20012931D0 (no) | 2001-06-13 |
NO20012931L true NO20012931L (no) | 2001-08-21 |
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Application Number | Title | Priority Date | Filing Date |
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NO20012931A NO20012931L (no) | 1998-12-24 | 2001-06-13 | Nye tyroidreseptorligander og fremgangsmate II |
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DE3231541A1 (de) | 1982-08-25 | 1984-03-01 | Henning Berlin Gmbh Chemie- Und Pharmawerk, 1000 Berlin | Arzneimittel, enthaltend 3,3',5-trijodthyronamin und verfahren zu seiner herstellung |
US4741897A (en) * | 1986-07-08 | 1988-05-03 | Baxter Travenol | Thyroxine analogs and reagents for thyroid hormone assays |
ES2108855T3 (es) * | 1992-07-21 | 1998-01-01 | Ciba Geigy Ag | Derivados de acido oxamico como agentes hipocolesteremicos. |
AU6476996A (en) * | 1995-06-07 | 1996-12-30 | Karo Bio Ab | Novel uses for thyroid hormones or thyroid hormone-like comp ounds |
US6335459B1 (en) | 1998-12-23 | 2002-01-01 | Syntex (U.S.A.) Llc | Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators |
US6395784B1 (en) * | 2000-06-07 | 2002-05-28 | Bristol-Myers Squibb Company | Benzamide ligands for the thyroid receptor |
-
1998
- 1998-12-24 GB GBGB9828442.5A patent/GB9828442D0/en not_active Ceased
-
1999
- 1999-12-23 CZ CZ20012204A patent/CZ20012204A3/cs unknown
- 1999-12-23 NZ NZ512422A patent/NZ512422A/xx unknown
- 1999-12-23 IL IL14379999A patent/IL143799A0/xx unknown
- 1999-12-23 JP JP2000590990A patent/JP4405088B2/ja not_active Expired - Fee Related
- 1999-12-23 WO PCT/IB1999/002084 patent/WO2000039077A2/en not_active Application Discontinuation
- 1999-12-23 EP EP99962486A patent/EP1144370A2/en not_active Withdrawn
- 1999-12-23 KR KR1020017007766A patent/KR20010108032A/ko not_active Application Discontinuation
- 1999-12-23 BR BR9916851-0A patent/BR9916851A/pt not_active IP Right Cessation
- 1999-12-23 CN CNB998150576A patent/CN1186332C/zh not_active Expired - Fee Related
- 1999-12-23 ID IDW00200101489A patent/ID29013A/id unknown
- 1999-12-23 AU AU18855/00A patent/AU758202B2/en not_active Ceased
- 1999-12-23 CA CA002356319A patent/CA2356319A1/en not_active Abandoned
- 1999-12-23 HU HU0104666A patent/HUP0104666A3/hu unknown
- 1999-12-23 TR TR2001/01834T patent/TR200101834T2/xx unknown
- 1999-12-23 US US09/868,889 patent/US6989402B1/en not_active Expired - Fee Related
- 1999-12-23 RU RU2001120701/04A patent/RU2001120701A/ru not_active Application Discontinuation
-
2001
- 2001-06-13 NO NO20012931A patent/NO20012931L/no not_active Application Discontinuation
- 2001-06-15 ZA ZA200104932A patent/ZA200104932B/en unknown
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2005
- 2005-07-26 US US11/189,654 patent/US7288571B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU1885500A (en) | 2000-07-31 |
CA2356319A1 (en) | 2000-07-06 |
RU2001120701A (ru) | 2003-12-10 |
BR9916851A (pt) | 2001-10-16 |
GB9828442D0 (en) | 1999-02-17 |
KR20010108032A (ko) | 2001-12-07 |
ZA200104932B (en) | 2003-01-15 |
US7288571B2 (en) | 2007-10-30 |
JP4405088B2 (ja) | 2010-01-27 |
CN1337953A (zh) | 2002-02-27 |
US6989402B1 (en) | 2006-01-24 |
NZ512422A (en) | 2004-02-27 |
EP1144370A2 (en) | 2001-10-17 |
IL143799A0 (en) | 2002-04-21 |
HUP0104666A2 (hu) | 2002-03-28 |
US20050282872A1 (en) | 2005-12-22 |
TR200101834T2 (tr) | 2001-12-21 |
ID29013A (id) | 2001-07-26 |
WO2000039077A2 (en) | 2000-07-06 |
JP2002533432A (ja) | 2002-10-08 |
HUP0104666A3 (en) | 2003-05-28 |
AU758202B2 (en) | 2003-03-20 |
CZ20012204A3 (cs) | 2001-11-14 |
WO2000039077A3 (en) | 2000-09-21 |
CN1186332C (zh) | 2005-01-26 |
NO20012931D0 (no) | 2001-06-13 |
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