NO20005340L - Metode og mellomprodukter for Paclitaxelsynteser fra C-7, C- 10 DI-CBZ Baccatin III - Google Patents

Metode og mellomprodukter for Paclitaxelsynteser fra C-7, C- 10 DI-CBZ Baccatin III

Info

Publication number
NO20005340L
NO20005340L NO20005340A NO20005340A NO20005340L NO 20005340 L NO20005340 L NO 20005340L NO 20005340 A NO20005340 A NO 20005340A NO 20005340 A NO20005340 A NO 20005340A NO 20005340 L NO20005340 L NO 20005340L
Authority
NO
Norway
Prior art keywords
paclitaxel
added
analog
hydroxy
acylating
Prior art date
Application number
NO20005340A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005340D0 (no
Inventor
Nicholas J Sisti
Jan Zygmunt
Herbert R Brinkman
Madhavi C Chander
Xian Liang
James D Mcchesney
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/071,258 external-priority patent/US6048990A/en
Priority claimed from US09/071,261 external-priority patent/US6066749A/en
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Publication of NO20005340D0 publication Critical patent/NO20005340D0/no
Publication of NO20005340L publication Critical patent/NO20005340L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20005340A 1998-05-01 2000-10-23 Metode og mellomprodukter for Paclitaxelsynteser fra C-7, C- 10 DI-CBZ Baccatin III NO20005340L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/071,258 US6048990A (en) 1998-05-01 1998-05-01 Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US09/071,261 US6066749A (en) 1998-05-01 1998-05-01 Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
PCT/US1999/009321 WO1999057105A1 (fr) 1998-05-01 1999-04-29 Procedes et intermediaires utiles pour la synthese de paclitaxel a partir de c-7, c-10 di-cbz baccatine iii

Publications (2)

Publication Number Publication Date
NO20005340D0 NO20005340D0 (no) 2000-10-23
NO20005340L true NO20005340L (no) 2000-12-27

Family

ID=26752024

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005340A NO20005340L (no) 1998-05-01 2000-10-23 Metode og mellomprodukter for Paclitaxelsynteser fra C-7, C- 10 DI-CBZ Baccatin III

Country Status (17)

Country Link
US (1) US6448417B1 (fr)
EP (1) EP1082316B1 (fr)
JP (1) JP2002513786A (fr)
KR (1) KR20010043230A (fr)
CN (1) CN100348589C (fr)
AT (1) ATE269854T1 (fr)
AU (1) AU745731B2 (fr)
BR (1) BR9910103A (fr)
CA (1) CA2331094A1 (fr)
DE (1) DE69918300T2 (fr)
ES (1) ES2230849T3 (fr)
IL (1) IL139316A0 (fr)
NO (1) NO20005340L (fr)
PT (1) PT1082316E (fr)
RU (1) RU2000130226A (fr)
TR (1) TR200003168T2 (fr)
WO (1) WO1999057105A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6656966B2 (en) 2000-06-22 2003-12-02 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
ES2503265T3 (es) * 2002-08-04 2014-10-06 Phyton Holdings, Llc Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
CN101370798A (zh) * 2005-12-21 2009-02-18 挂毯药品公司 用于形成紫杉烷的新化合物和方法及其应用
WO2012117417A1 (fr) * 2011-02-28 2012-09-07 Shilpa Medicare Limited Procédé de préparation d'acide (2r, 3s)-2-benzyloxy-3-tert-butoxy-carbonyl amino-3-phényl propionique

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5684175A (en) 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5948919A (en) 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
WO1994018186A1 (fr) 1993-02-05 1994-08-18 Bryn Mawr College Synthese de taxol, d'analogues et d'intermediaires de taxol presentant des chaines laterales du cycle a variables
US5675025A (en) 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6107497A (en) 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5750737A (en) 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6048990A (en) 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6066749A (en) 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis

Also Published As

Publication number Publication date
ATE269854T1 (de) 2004-07-15
AU745731B2 (en) 2002-03-28
CA2331094A1 (fr) 1999-11-11
EP1082316B1 (fr) 2004-06-23
JP2002513786A (ja) 2002-05-14
TR200003168T2 (tr) 2001-06-21
NO20005340D0 (no) 2000-10-23
CN100348589C (zh) 2007-11-14
AU3670799A (en) 1999-11-23
US6448417B1 (en) 2002-09-10
KR20010043230A (ko) 2001-05-25
EP1082316A1 (fr) 2001-03-14
WO1999057105A1 (fr) 1999-11-11
DE69918300T2 (de) 2005-06-30
DE69918300D1 (de) 2004-07-29
RU2000130226A (ru) 2002-11-10
BR9910103A (pt) 2000-12-26
PT1082316E (pt) 2004-11-30
IL139316A0 (en) 2001-11-25
CN1299355A (zh) 2001-06-13
ES2230849T3 (es) 2005-05-01

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application