ATE269854T1 - Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii - Google Patents

Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii

Info

Publication number
ATE269854T1
ATE269854T1 AT99918900T AT99918900T ATE269854T1 AT E269854 T1 ATE269854 T1 AT E269854T1 AT 99918900 T AT99918900 T AT 99918900T AT 99918900 T AT99918900 T AT 99918900T AT E269854 T1 ATE269854 T1 AT E269854T1
Authority
AT
Austria
Prior art keywords
paclitaxel
added
analog
hydroxy
acylating
Prior art date
Application number
AT99918900T
Other languages
English (en)
Inventor
Nicholas J Sisti
Herbert R Brinkman
James D Mcchesney
Madhavi C Chander
Xian Liang
Jan Zygmunt
Original Assignee
Napro Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/071,261 external-priority patent/US6066749A/en
Priority claimed from US09/071,258 external-priority patent/US6048990A/en
Application filed by Napro Biotherapeutics Inc filed Critical Napro Biotherapeutics Inc
Application granted granted Critical
Publication of ATE269854T1 publication Critical patent/ATE269854T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99918900T 1998-05-01 1999-04-29 Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii ATE269854T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/071,261 US6066749A (en) 1998-05-01 1998-05-01 Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis
US09/071,258 US6048990A (en) 1998-05-01 1998-05-01 Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
PCT/US1999/009321 WO1999057105A1 (en) 1998-05-01 1999-04-29 Methods and useful intermediates for paclitaxel synthesis from c-7, c-10 di-cbz baccatin iii

Publications (1)

Publication Number Publication Date
ATE269854T1 true ATE269854T1 (de) 2004-07-15

Family

ID=26752024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99918900T ATE269854T1 (de) 1998-05-01 1999-04-29 Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii

Country Status (17)

Country Link
US (1) US6448417B1 (de)
EP (1) EP1082316B1 (de)
JP (1) JP2002513786A (de)
KR (1) KR20010043230A (de)
CN (1) CN100348589C (de)
AT (1) ATE269854T1 (de)
AU (1) AU745731B2 (de)
BR (1) BR9910103A (de)
CA (1) CA2331094A1 (de)
DE (1) DE69918300T2 (de)
ES (1) ES2230849T3 (de)
IL (1) IL139316A0 (de)
NO (1) NO20005340L (de)
PT (1) PT1082316E (de)
RU (1) RU2000130226A (de)
TR (1) TR200003168T2 (de)
WO (1) WO1999057105A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001098286A1 (en) 2000-06-22 2001-12-27 Nitromed, Inc. Nitrosated and nitrosylated taxanes, compositions and methods of use
ES2503265T3 (es) * 2002-08-04 2014-10-06 Phyton Holdings, Llc Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
CA2634453A1 (en) * 2005-12-21 2007-06-28 Tapestry Pharmaceuticals, Inc. Novel compounds and methods for forming taxanes and using the same
WO2012117417A1 (en) * 2011-02-28 2012-09-07 Shilpa Medicare Limited Process for preparing (2r, 3s) 2-benzyloxy-3-tert-butoxy carbonyl amino-3-phenyl propionic acid

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
US5229526A (en) 1991-09-23 1993-07-20 Florida State University Metal alkoxides
US5948919A (en) 1993-02-05 1999-09-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
EP1260507A1 (de) 1993-02-05 2002-11-27 Bryn Mawr College Synthese von Taxol, Analogen und Zwischenverbindungen mit veränderlichen A-ring Seiten Ketten
US5684175A (en) 1993-02-05 1997-11-04 Napro Biotherapeutics, Inc. C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor
US5675025A (en) 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5688977A (en) 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
US6107497A (en) 1996-02-29 2000-08-22 Napro Biotherapeutics, Inc. Intermediate for use in docetaxel synthesis and production method therefor
US5750736A (en) 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5750737A (en) 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US5914411A (en) 1998-01-21 1999-06-22 Napro Biotherapeutics, Inc. Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position
US6048990A (en) 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
US6066749A (en) 1998-05-01 2000-05-23 Napro Biotherapeutics, Inc. Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis

Also Published As

Publication number Publication date
WO1999057105A1 (en) 1999-11-11
CN1299355A (zh) 2001-06-13
US6448417B1 (en) 2002-09-10
RU2000130226A (ru) 2002-11-10
PT1082316E (pt) 2004-11-30
KR20010043230A (ko) 2001-05-25
CN100348589C (zh) 2007-11-14
JP2002513786A (ja) 2002-05-14
DE69918300D1 (de) 2004-07-29
ES2230849T3 (es) 2005-05-01
DE69918300T2 (de) 2005-06-30
AU3670799A (en) 1999-11-23
CA2331094A1 (en) 1999-11-11
NO20005340L (no) 2000-12-27
EP1082316B1 (de) 2004-06-23
NO20005340D0 (no) 2000-10-23
TR200003168T2 (tr) 2001-06-21
EP1082316A1 (de) 2001-03-14
IL139316A0 (en) 2001-11-25
AU745731B2 (en) 2002-03-28
BR9910103A (pt) 2000-12-26

Similar Documents

Publication Publication Date Title
US5319112A (en) Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5614645A (en) Methods for making 2-debenzoyl and -2-acyl taxol derivatives
US5470866A (en) Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
HU225973B1 (en) Novel method of esterification of baccatine iii and 10-deacetylbaccatine iii
DK0690856T3 (da) Antitumorforbindelser, farmaceutiske præparater, fremgangsmåder til fremstilling deraf og til behandling
AU2336997A (en) Method for docetaxel synthesis
Georg et al. Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation
DE60009910D1 (de) Verfahren zur herstellung von zsm-5 und zsm-11
AU4502197A (en) Method for paclitaxel synthesis
ATE269854T1 (de) Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii
CN1096453C (zh) 使10－去乙酰基浆果赤霉素iii在c－10位选择性酰化的方法
DE69714761D1 (de) Zwischenprodukt zur verwendung in der docetaxelsynthese und herstellungsverfahren davon
ES2503265T3 (es) Métodos para convertir amidas de taxano en paclitaxel u otros taxanos
ATE308533T1 (de) Zwischenprodukt und verfahren zur teilsynthese von paclitaxel und dessen analogen
CA2889448A1 (en) Process for the preparation of cabazitaxel and its intermediates
US5973170A (en) C-7 metal alkoxides of baccatin III
EP1192126A1 (de) An der c2-hydroxygruppe geschützte, aktivierte n-acyl(2r,3s)-3-phenylisoserinester und verfahren zu ihrer herstellung
IL153043A (en) Intermediate for baccatin iii derivatives and methods for the production thereof

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1082316

Country of ref document: EP

REN Ceased due to non-payment of the annual fee