TR200003168T2 - C-7, C-10 DI-CBZ bakkatin III'ten paklitaksel sentezi için yararlı aracılar ve yöntemler - Google Patents
C-7, C-10 DI-CBZ bakkatin III'ten paklitaksel sentezi için yararlı aracılar ve yöntemlerInfo
- Publication number
- TR200003168T2 TR200003168T2 TR2000/03168T TR200003168T TR200003168T2 TR 200003168 T2 TR200003168 T2 TR 200003168T2 TR 2000/03168 T TR2000/03168 T TR 2000/03168T TR 200003168 T TR200003168 T TR 200003168T TR 200003168 T2 TR200003168 T2 TR 200003168T2
- Authority
- TR
- Turkey
- Prior art keywords
- paclitaxel
- baccatin iii
- methods
- cbz baccatin
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Mevcut bulus,C-7,C-10 di-CBZ bakkatin III'ün bir N-karbamat korumali,C-2 korumali 3-fenil izoserin yan zinciri ile esterlenmesinden olusan, paklitaksel veya bir paklitaksel analogu üretme yöntemi ile ilgilidir.Elde edilen bilesen,daha sonra paklitaksel veya bir paklitaksel analogu üretmek için korumasi giderilir ve asile edilir.Mevcut bulus ayrica bir 10-hidroksi paklitaksel analogunun asile edilmesi için alternatif bu yöntemle ilgilidir.Mevcut bulus ilave olarak, paklitaksel veya paklitaksel analogunun üretilmesinde kullanilma amaçli bir C-10 metal alkoksit kimyasal ara bilesenine yöneliktir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/071,261 US6066749A (en) | 1998-05-01 | 1998-05-01 | Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis |
US09/071,258 US6048990A (en) | 1998-05-01 | 1998-05-01 | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200003168T2 true TR200003168T2 (tr) | 2001-06-21 |
Family
ID=26752024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/03168T TR200003168T2 (tr) | 1998-05-01 | 1999-04-29 | C-7, C-10 DI-CBZ bakkatin III'ten paklitaksel sentezi için yararlı aracılar ve yöntemler |
Country Status (17)
Country | Link |
---|---|
US (1) | US6448417B1 (tr) |
EP (1) | EP1082316B1 (tr) |
JP (1) | JP2002513786A (tr) |
KR (1) | KR20010043230A (tr) |
CN (1) | CN100348589C (tr) |
AT (1) | ATE269854T1 (tr) |
AU (1) | AU745731B2 (tr) |
BR (1) | BR9910103A (tr) |
CA (1) | CA2331094A1 (tr) |
DE (1) | DE69918300T2 (tr) |
ES (1) | ES2230849T3 (tr) |
IL (1) | IL139316A0 (tr) |
NO (1) | NO20005340L (tr) |
PT (1) | PT1082316E (tr) |
RU (1) | RU2000130226A (tr) |
TR (1) | TR200003168T2 (tr) |
WO (1) | WO1999057105A1 (tr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001098286A1 (en) | 2000-06-22 | 2001-12-27 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
ES2503265T3 (es) * | 2002-08-04 | 2014-10-06 | Phyton Holdings, Llc | Métodos para convertir amidas de taxano en paclitaxel u otros taxanos |
CA2634453A1 (en) * | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
WO2012117417A1 (en) * | 2011-02-28 | 2012-09-07 | Shilpa Medicare Limited | Process for preparing (2r, 3s) 2-benzyloxy-3-tert-butoxy carbonyl amino-3-phenyl propionic acid |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2629818B1 (fr) | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
FR2629819B1 (fr) | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
US5015744A (en) | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
FR2678930B1 (fr) * | 1991-07-10 | 1995-01-13 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii. |
US5229526A (en) | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
US5948919A (en) | 1993-02-05 | 1999-09-07 | Napro Biotherapeutics, Inc. | Paclitaxel synthesis from precursor compounds and methods of producing the same |
EP1260507A1 (en) | 1993-02-05 | 2002-11-27 | Bryn Mawr College | Synthesis of taxol, analogs and intermediates with variable A-nng side chains |
US5684175A (en) | 1993-02-05 | 1997-11-04 | Napro Biotherapeutics, Inc. | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor |
US5675025A (en) | 1995-06-07 | 1997-10-07 | Napro Biotherapeutics, Inc. | Paclitaxel synthesis from precursor compounds and methods of producing the same |
US5688977A (en) | 1996-02-29 | 1997-11-18 | Napro Biotherapeutics, Inc. | Method for docetaxel synthesis |
US6107497A (en) | 1996-02-29 | 2000-08-22 | Napro Biotherapeutics, Inc. | Intermediate for use in docetaxel synthesis and production method therefor |
US5750736A (en) | 1996-07-11 | 1998-05-12 | Napro Biotherapeutics, Inc. | Method for acylating 10-deacetylbaccatin III selectively at the c-10 position |
US5750737A (en) | 1996-09-25 | 1998-05-12 | Sisti; Nicholas J. | Method for paclitaxel synthesis |
US5914411A (en) | 1998-01-21 | 1999-06-22 | Napro Biotherapeutics, Inc. | Alternate method for acylating 10-deacetylbaccatin III selectively at the C-10 position |
US6048990A (en) | 1998-05-01 | 2000-04-11 | Napro Biotherapeutics, Inc. | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
US6066749A (en) | 1998-05-01 | 2000-05-23 | Napro Biotherapeutics, Inc. | Method for conversion of C-2'-O-protected-10-hydroxy taxol to c-2'-O-protected taxol:useful intermediates in paclitaxel synthesis |
-
1999
- 1999-04-29 IL IL13931699A patent/IL139316A0/xx unknown
- 1999-04-29 CN CNB998057061A patent/CN100348589C/zh not_active Expired - Fee Related
- 1999-04-29 WO PCT/US1999/009321 patent/WO1999057105A1/en active IP Right Grant
- 1999-04-29 CA CA002331094A patent/CA2331094A1/en not_active Abandoned
- 1999-04-29 JP JP2000547075A patent/JP2002513786A/ja active Pending
- 1999-04-29 EP EP99918900A patent/EP1082316B1/en not_active Expired - Lifetime
- 1999-04-29 TR TR2000/03168T patent/TR200003168T2/tr unknown
- 1999-04-29 AT AT99918900T patent/ATE269854T1/de not_active IP Right Cessation
- 1999-04-29 US US09/674,404 patent/US6448417B1/en not_active Expired - Fee Related
- 1999-04-29 RU RU2000130226/04A patent/RU2000130226A/ru not_active Application Discontinuation
- 1999-04-29 KR KR1020007012169A patent/KR20010043230A/ko not_active Application Discontinuation
- 1999-04-29 PT PT99918900T patent/PT1082316E/pt unknown
- 1999-04-29 BR BR9910103-3A patent/BR9910103A/pt not_active IP Right Cessation
- 1999-04-29 AU AU36707/99A patent/AU745731B2/en not_active Ceased
- 1999-04-29 DE DE69918300T patent/DE69918300T2/de not_active Expired - Fee Related
- 1999-04-29 ES ES99918900T patent/ES2230849T3/es not_active Expired - Lifetime
-
2000
- 2000-10-23 NO NO20005340A patent/NO20005340L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999057105A1 (en) | 1999-11-11 |
CN1299355A (zh) | 2001-06-13 |
US6448417B1 (en) | 2002-09-10 |
RU2000130226A (ru) | 2002-11-10 |
PT1082316E (pt) | 2004-11-30 |
KR20010043230A (ko) | 2001-05-25 |
CN100348589C (zh) | 2007-11-14 |
JP2002513786A (ja) | 2002-05-14 |
DE69918300D1 (de) | 2004-07-29 |
ATE269854T1 (de) | 2004-07-15 |
ES2230849T3 (es) | 2005-05-01 |
DE69918300T2 (de) | 2005-06-30 |
AU3670799A (en) | 1999-11-23 |
CA2331094A1 (en) | 1999-11-11 |
NO20005340L (no) | 2000-12-27 |
EP1082316B1 (en) | 2004-06-23 |
NO20005340D0 (no) | 2000-10-23 |
EP1082316A1 (en) | 2001-03-14 |
IL139316A0 (en) | 2001-11-25 |
AU745731B2 (en) | 2002-03-28 |
BR9910103A (pt) | 2000-12-26 |
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