NO20003111L - Orto-antranilamidderivater som antikoagulanter - Google Patents
Orto-antranilamidderivater som antikoagulanterInfo
- Publication number
- NO20003111L NO20003111L NO20003111A NO20003111A NO20003111L NO 20003111 L NO20003111 L NO 20003111L NO 20003111 A NO20003111 A NO 20003111A NO 20003111 A NO20003111 A NO 20003111A NO 20003111 L NO20003111 L NO 20003111L
- Authority
- NO
- Norway
- Prior art keywords
- anticoagulants
- ortho
- anthranilamide derivatives
- anthranilamide
- derivatives
- Prior art date
Links
- 239000003146 anticoagulant agent Substances 0.000 title abstract 2
- 229940127219 anticoagulant drug Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241001620634 Roger Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Foreliggende oppfinnelse er. rettet mot forbindelser av formel (III). hvori B, C, D, E, R, Roger beskrevet heri. Disse forbindelser er beskrevet som å være anvendbare som antikoagulanter.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99428497A | 1997-12-19 | 1997-12-19 | |
US09/187,459 US6140351A (en) | 1997-12-19 | 1998-11-05 | Ortho-anthranilamide derivatives as anti-coagulants |
PCT/EP1998/007650 WO1999032477A1 (en) | 1997-12-19 | 1998-11-27 | Ortho-anthranilamide derivatives as anti-coagulants |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20003111D0 NO20003111D0 (no) | 2000-06-16 |
NO20003111L true NO20003111L (no) | 2000-08-18 |
Family
ID=26883056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20003111A NO20003111L (no) | 1997-12-19 | 2000-06-16 | Orto-antranilamidderivater som antikoagulanter |
Country Status (19)
Country | Link |
---|---|
US (2) | US6498185B1 (no) |
EP (1) | EP1040108B1 (no) |
JP (1) | JP3811006B2 (no) |
CN (1) | CN1143855C (no) |
AT (1) | ATE260103T1 (no) |
AU (1) | AU751856B2 (no) |
CA (1) | CA2315070A1 (no) |
DE (1) | DE69821985T2 (no) |
DK (1) | DK1040108T3 (no) |
ES (1) | ES2215337T3 (no) |
HU (1) | HUP0101172A3 (no) |
IL (1) | IL135536A0 (no) |
NO (1) | NO20003111L (no) |
NZ (1) | NZ503809A (no) |
PL (1) | PL341044A1 (no) |
PT (1) | PT1040108E (no) |
RU (1) | RU2226529C2 (no) |
SK (1) | SK9432000A3 (no) |
WO (1) | WO1999032477A1 (no) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2214685C (en) | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
PT929547E (pt) | 1996-09-12 | 2003-03-31 | Schering Ag | Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes |
US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
EP1007037A4 (en) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | ANTITHROMBOTIC AGENTS |
CA2294042A1 (en) | 1997-06-26 | 1999-01-07 | David Kent Herron | Antithrombotic agents |
WO1999000126A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
US6127376A (en) | 1998-12-04 | 2000-10-03 | Berlex Laboratories, Inc. | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
US6689780B1 (en) | 1998-12-23 | 2004-02-10 | Eli Lilly And Company | Heteroroaromatic amides as inhibitor of factor Xa |
ATE326453T1 (de) | 1998-12-23 | 2006-06-15 | Lilly Co Eli | Antithrombotische amide |
ES2226485T3 (es) | 1998-12-23 | 2005-03-16 | Eli Lilly And Company | Amidas aromaticas. |
AU3742100A (en) * | 1999-03-16 | 2000-10-04 | Glaxo Group Limited | Nuclear receptor arylating compounds |
DE60022508T2 (de) | 1999-06-14 | 2006-06-08 | Eli Lilly And Co., Indianapolis | Inhibitoren von serin proteasen |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
US6720317B1 (en) | 1999-09-17 | 2004-04-13 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
AU1770001A (en) * | 1999-11-24 | 2001-06-04 | Cor Therapeutics, Inc. | Beta-amino acid-, aspartic acid- and diaminopropionic-based inhibitors of factorxa |
WO2001064643A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | BENZAMIDES AND RELATED INHIBITORS OF FACTOR Xa |
MY138097A (en) * | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
AU2001280438A1 (en) | 2000-07-27 | 2002-02-13 | Eli Lilly And Company | Substituted heterocyclic amides |
AU2002214626A1 (en) * | 2000-09-29 | 2002-04-08 | Cor Therapeutics, Inc. | Quaternary amines and related inhibitors of factor xa |
EP1322637A2 (en) * | 2000-09-29 | 2003-07-02 | Millennium Pharmaceuticals, Inc. | Quaternary amidino based inhibitors of factor xa |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
KR100863923B1 (ko) | 2000-11-22 | 2008-10-17 | 아스텔라스세이야쿠 가부시키가이샤 | 치환된 벤젠 유도체 또는 이의 염 및 이를 포함하는 의약 조성물 |
US7163938B2 (en) * | 2000-11-28 | 2007-01-16 | Eli Lilly And Company | Substituted carboxamides |
DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
BRPI0212726B8 (pt) | 2001-09-21 | 2021-05-25 | Bristol Myers Squibb Co | compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
EP1456175A1 (en) | 2001-12-07 | 2004-09-15 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
AU2003273179A1 (en) | 2002-05-10 | 2003-12-12 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
US7351858B2 (en) | 2002-06-20 | 2008-04-01 | Astrazeneca Ab | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance |
ES2299702T3 (es) | 2002-06-20 | 2008-06-01 | Astrazeneca Ab | Derivados de acido benzoico orto-sustituidos para el tratamiento de la resistencia a la insulina. |
SE0201937D0 (sv) | 2002-06-20 | 2002-06-20 | Astrazeneca Ab | Therapeutic agents |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
US7696225B2 (en) | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
TWI299664B (en) | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
EP1479680A1 (en) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Azaindole derivatives as Factor Xa inhibitors |
PL2256106T3 (pl) | 2003-07-22 | 2015-08-31 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
TW200524915A (en) | 2003-09-26 | 2005-08-01 | Tanabe Seiyaku Co | Carbamoyl-type benzofuran derivatives |
TW200512181A (en) * | 2003-09-26 | 2005-04-01 | Tanabe Seiyaku Co | Amide-type carboxamide derivatives |
US7199149B2 (en) | 2003-10-01 | 2007-04-03 | Bristol Myers Squibb Company | Monocyclic and bicyclic lactams as factor Xa inhibitors |
US7507748B2 (en) * | 2004-07-22 | 2009-03-24 | Amgen Inc. | Substituted aryl-amine derivatives and methods of use |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
ES2323244T3 (es) * | 2005-05-13 | 2009-07-09 | Qosmos | Analisis del trafico en redes de alta velocidad. |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
US8524907B2 (en) | 2006-11-02 | 2013-09-03 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing pharmaceutical salts of a factor Xa inhibitor |
JP2010120852A (ja) * | 2007-03-09 | 2010-06-03 | Daiichi Sankyo Co Ltd | 新規なジアミド誘導体 |
WO2008135524A2 (en) * | 2007-05-02 | 2008-11-13 | Boehringer Ingelheim International Gmbh | Substituted anthranilamides and analogues, manufacturing and use thereof as medicaments |
JP2010530416A (ja) * | 2007-06-20 | 2010-09-09 | メルク・シャープ・エンド・ドーム・コーポレイション | ベンゾオキサゾールアリールアミドから誘導されたcetp阻害剤 |
US7968544B2 (en) | 2007-06-29 | 2011-06-28 | Gilead Sciences, Inc. | Modulators of toll-like receptor 7 |
TW201639852A (zh) | 2008-12-09 | 2016-11-16 | 吉李德科學股份有限公司 | 用於製備可用作類鐸受體調節劑之化合物的中間體化合物 |
US8962652B2 (en) | 2009-10-22 | 2015-02-24 | Gilead Sciences, Inc. | Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections |
WO2012014109A1 (en) | 2010-07-30 | 2012-02-02 | Ranbaxy Laboratories Limited | Heterocyclic sulfonamides as inhibitors of transfer rna synthetase for use as antibacterial agents |
BR112013011188B1 (pt) | 2010-11-05 | 2022-01-04 | Senomyx, Inc | Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
US10266488B2 (en) | 2013-10-10 | 2019-04-23 | Eastern Virginia Medical School | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase |
MX2017000026A (es) | 2014-07-11 | 2017-05-01 | Gilead Sciences Inc | Moduladores de receptores tipo toll para el tratamiento de virus de inmunodeficiencia humana (vih). |
SI3194401T1 (sl) | 2014-09-16 | 2020-12-31 | Gilead Sciences, Inc. | Trdne oblike modulatorja toličnega receptorja |
RU2745616C1 (ru) | 2015-10-01 | 2021-03-29 | Сеномикс, Инк. | Соединения, используемые в качестве модуляторов trpm8 |
WO2020053654A1 (en) | 2018-09-12 | 2020-03-19 | Novartis Ag | Antiviral pyridopyrazinedione compounds |
KR20220070005A (ko) | 2019-09-26 | 2022-05-27 | 노파르티스 아게 | 항바이러스성 피라졸로피리디논 화합물 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB824908A (en) | 1958-06-03 | 1959-12-09 | May & Baker Ltd | Improvements in or relating to triazine derivatives |
JPS5922697B2 (ja) | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−(メタ−アミジノフエノキシ)−化合物 |
ATE167473T1 (de) * | 1990-08-20 | 1998-07-15 | Eisai Co Ltd | Sulfonamid-derivate |
EP0518818A3 (en) | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
US5451700A (en) | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
JP3194953B2 (ja) | 1992-02-14 | 2001-08-06 | コルバス・インターナショナル、インコーポレイテッド | 血栓症抑制剤 |
DE4213919A1 (de) | 1992-04-28 | 1993-11-04 | Thomae Gmbh Dr K | Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
JPH08504769A (ja) | 1992-12-15 | 1996-05-21 | コルバス・インターナショナル、インコーポレイテッド | 因子Xaの新規インヒビター |
US5332822A (en) | 1992-12-24 | 1994-07-26 | Bristol-Myers Squibb Company | Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors |
DE69419141D1 (de) | 1993-02-12 | 1999-07-22 | Corvas Int Inc | Inhibitoren gegen thrombose |
US5633381A (en) | 1994-07-05 | 1997-05-27 | Berlex Laboratories, Inc. | (Z,Z), (Z,E) and (E,Z) isomers of substituted bis(phenylmethylene)cycloketones |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
CA2214685C (en) * | 1995-03-10 | 2008-05-20 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
US5691364A (en) | 1995-03-10 | 1997-11-25 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
US5612363A (en) | 1995-06-02 | 1997-03-18 | Berlex Laboratories, Inc. | N,N-di(aryl) cyclic urea derivatives as anti-coagulants |
US5721214A (en) | 1995-06-07 | 1998-02-24 | Cor Therapeutics, Inc. | Inhibitors of factor Xa |
US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
US5994375A (en) * | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
US5753635A (en) | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
US5693641A (en) | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
PT929547E (pt) | 1996-09-12 | 2003-03-31 | Schering Ag | Derivados da benzamidina substituidos por derivados de aminoacidos ciclicos e de hidroxiacidos ciclicos e seu uso como anticoagulantes |
US6004985A (en) | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
AU8270298A (en) | 1997-06-26 | 1999-01-19 | Eli Lilly And Company | Antithrombotic agents |
CA2294042A1 (en) * | 1997-06-26 | 1999-01-07 | David Kent Herron | Antithrombotic agents |
EP1007037A4 (en) | 1997-06-26 | 2004-10-06 | Lilly Co Eli | ANTITHROMBOTIC AGENTS |
US6140351A (en) * | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
WO2000039117A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
-
1998
- 1998-11-27 PL PL98341044A patent/PL341044A1/xx not_active Application Discontinuation
- 1998-11-27 EP EP98963519A patent/EP1040108B1/en not_active Expired - Lifetime
- 1998-11-27 AT AT98963519T patent/ATE260103T1/de not_active IP Right Cessation
- 1998-11-27 ES ES98963519T patent/ES2215337T3/es not_active Expired - Lifetime
- 1998-11-27 JP JP2000525414A patent/JP3811006B2/ja not_active Expired - Fee Related
- 1998-11-27 NZ NZ503809A patent/NZ503809A/en unknown
- 1998-11-27 WO PCT/EP1998/007650 patent/WO1999032477A1/en not_active Application Discontinuation
- 1998-11-27 PT PT98963519T patent/PT1040108E/pt unknown
- 1998-11-27 RU RU2000119756/04A patent/RU2226529C2/ru not_active IP Right Cessation
- 1998-11-27 SK SK943-2000A patent/SK9432000A3/sk unknown
- 1998-11-27 DK DK98963519T patent/DK1040108T3/da active
- 1998-11-27 HU HU0101172A patent/HUP0101172A3/hu unknown
- 1998-11-27 IL IL13553698A patent/IL135536A0/xx unknown
- 1998-11-27 DE DE69821985T patent/DE69821985T2/de not_active Expired - Fee Related
- 1998-11-27 CA CA002315070A patent/CA2315070A1/en not_active Abandoned
- 1998-11-27 AU AU18759/99A patent/AU751856B2/en not_active Ceased
- 1998-11-27 CN CNB988124173A patent/CN1143855C/zh not_active Expired - Fee Related
-
2000
- 2000-06-16 NO NO20003111A patent/NO20003111L/no not_active Application Discontinuation
- 2000-08-03 US US09/631,452 patent/US6498185B1/en not_active Expired - Fee Related
- 2000-08-03 US US09/631,450 patent/US6380221B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1143855C (zh) | 2004-03-31 |
PL341044A1 (en) | 2001-03-26 |
US6498185B1 (en) | 2002-12-24 |
AU1875999A (en) | 1999-07-12 |
DK1040108T3 (da) | 2004-05-24 |
WO1999032477B1 (en) | 1999-09-10 |
DE69821985T2 (de) | 2005-05-04 |
NO20003111D0 (no) | 2000-06-16 |
WO1999032477A1 (en) | 1999-07-01 |
NZ503809A (en) | 2002-04-26 |
JP3811006B2 (ja) | 2006-08-16 |
CN1282329A (zh) | 2001-01-31 |
SK9432000A3 (en) | 2001-02-12 |
JP2001526283A (ja) | 2001-12-18 |
DE69821985D1 (de) | 2004-04-01 |
HUP0101172A1 (hu) | 2002-05-29 |
EP1040108B1 (en) | 2004-02-25 |
IL135536A0 (en) | 2001-05-20 |
RU2226529C2 (ru) | 2004-04-10 |
HUP0101172A3 (en) | 2002-12-28 |
EP1040108A1 (en) | 2000-10-04 |
AU751856B2 (en) | 2002-08-29 |
PT1040108E (pt) | 2004-06-30 |
ATE260103T1 (de) | 2004-03-15 |
CA2315070A1 (en) | 1999-07-01 |
ES2215337T3 (es) | 2004-10-01 |
US6380221B1 (en) | 2002-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20003111L (no) | Orto-antranilamidderivater som antikoagulanter | |
NO20012701L (no) | Aryl- og heterosyklylsubstituerte pyrimidinderivater som antikoagulanter | |
ATE162800T1 (de) | Inhibitoren mit zweifacher wirkung | |
ES2172864T3 (es) | 2-metoxibenzofenonas fungicidas. | |
BR9804214A (pt) | Compostos. | |
WO1999002514A3 (en) | Epothilone derivatives | |
NL1002835A1 (nl) | Synergistisch stabilisatormengsel. | |
ZA986801B (en) | Chemical compound. | |
TR200800474T2 (tr) | Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem. | |
DK0594702T3 (da) | Substituerede indoler som midler mod AIDS | |
NO920767L (no) | Pyranylcyanoguanidin-derivater | |
TR199801629A2 (xx) | Fungisidal 2 -metoksibenzofenonlar. | |
DK1385515T3 (da) | Spiropyrazole forbindelser | |
PT923554E (pt) | N-benzilpiperidina e derivados tetrahidropiridina | |
AU8350698A (en) | Metalloproteinase inhibitors | |
NO20021409L (no) | Hastighets-kontrollerte partikler | |
NO930520L (no) | Bifenyl-substituerte kinolinderivater | |
FI955498A (fi) | Nipekotiinihappojohdannaisia hyytymistä estävinä aineina | |
NO20016151L (no) | Fremstilling av substituerte piperidin-4-oner | |
ATE254099T1 (de) | Trimethyldecen-verbindungen | |
NO20002321L (no) | Bifenylderivater som farmasøytiske midler | |
ES2092112T3 (es) | Agentes hipoglicemicos de tiazolidindiona. | |
NO981909L (no) | Fungicide forbindelser (B) | |
FI880868A0 (fi) | Välituotteina käyttökelpoisia tetratsoliyhdisteitä | |
DE60111634D1 (de) | Verfahren zur herstellung von thiazolidinedion-derivaten und zwischenprodukte |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |