NO178065C - Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt - Google Patents
Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomproduktInfo
- Publication number
- NO178065C NO178065C NO912902A NO912902A NO178065C NO 178065 C NO178065 C NO 178065C NO 912902 A NO912902 A NO 912902A NO 912902 A NO912902 A NO 912902A NO 178065 C NO178065 C NO 178065C
- Authority
- NO
- Norway
- Prior art keywords
- formula
- well
- compounds
- analogues
- therapeutically active
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
- 235000019166 vitamin D Nutrition 0.000 title 1
- 239000011710 vitamin D Substances 0.000 title 1
- 150000003710 vitamin D derivatives Chemical class 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898904154A GB8904154D0 (en) | 1989-02-23 | 1989-02-23 | Chemical compounds |
| PCT/DK1990/000036 WO1990009991A1 (en) | 1989-02-23 | 1990-02-13 | Novel vitamin d analogues |
| SG131794A SG131794G (en) | 1989-02-23 | 1994-09-12 | Novel vitamin D analogues |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO912902L NO912902L (no) | 1991-07-25 |
| NO912902D0 NO912902D0 (no) | 1991-07-25 |
| NO178065B NO178065B (no) | 1995-10-09 |
| NO178065C true NO178065C (no) | 1996-01-17 |
Family
ID=26295003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO912902A NO178065C (no) | 1989-02-23 | 1991-07-25 | Analogifremgangsmåte ved fremstilling av terapeutisk aktive nye vitamin D-analoger, samt mellomprodukt |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0460032B1 (lt) |
| JP (1) | JP2807083B2 (lt) |
| KR (1) | KR0163194B1 (lt) |
| AT (1) | ATE104957T1 (lt) |
| AU (1) | AU627001B2 (lt) |
| CA (1) | CA2044280C (lt) |
| DE (1) | DE69008517T2 (lt) |
| DK (1) | DK0460032T3 (lt) |
| ES (1) | ES2055905T3 (lt) |
| FI (1) | FI92929C (lt) |
| GB (1) | GB8904154D0 (lt) |
| HK (1) | HK128894A (lt) |
| HU (1) | HU211025B (lt) |
| IE (1) | IE63123B1 (lt) |
| LT (1) | LT3983B (lt) |
| LV (1) | LV10428B (lt) |
| NO (1) | NO178065C (lt) |
| PT (1) | PT93232B (lt) |
| RO (1) | RO109939B1 (lt) |
| RU (1) | RU2037484C1 (lt) |
| SG (1) | SG131794G (lt) |
| WO (1) | WO1990009991A1 (lt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8904153D0 (en) * | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| DE4011682A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | 24-oxa-derivate in der vitamin d-reihe |
| GB9015774D0 (en) * | 1990-07-18 | 1990-09-05 | Leo Pharm Prod Ltd | Novel treatment |
| US5486509A (en) * | 1991-06-28 | 1996-01-23 | University Of Miami | Method of preventing and treating chemotherapy-induced alopecia |
| AU666563B2 (en) * | 1992-08-07 | 1996-02-15 | Wisconsin Alumni Research Foundation | Preparation of 19-nor-vitamin D compounds |
| GB9220272D0 (en) * | 1992-09-25 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9220439D0 (en) * | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US5449668A (en) * | 1993-06-04 | 1995-09-12 | Duphar International Research B.V. | Vitamin D compounds and method of preparing these compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US6316642B1 (en) | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
| US6306844B1 (en) | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
| US6359152B2 (en) | 1997-07-21 | 2002-03-19 | Wisconsin Alumni Research Foundation | 18-substituted-19-nor-vitamin D compounds |
| US5939406A (en) * | 1997-07-21 | 1999-08-17 | Wisconsin Alumni Research Foundation | 18-substituted-19-nor-vitamin D compounds |
| DE69926843T2 (de) * | 1998-03-04 | 2006-06-22 | Teijin Ltd. | Aktives vitamin-d3 enthaltende lotionen in form von emulsionen |
| US5962707A (en) * | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
| BR122012030847B1 (pt) * | 1999-04-23 | 2021-07-06 | Leo Pharma A/S | Composição farmacêutica não aquosa para uso dermatológico, e, uso da mesma |
| JP4803939B2 (ja) * | 2000-04-19 | 2011-10-26 | 中外製薬株式会社 | ビタミンｄ誘導体 |
| US20030018017A1 (en) * | 2001-01-25 | 2003-01-23 | Deluca Hector F. | Method of treatment of type I diabetes |
| JP4469794B2 (ja) * | 2003-02-25 | 2010-05-26 | 神戸天然物化学株式会社 | ビタミンｄ誘導体を合成するための新規な中間体 |
| JP5005340B2 (ja) | 2003-04-10 | 2012-08-22 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | ２−プロピリデン−１９−ノル−ビタミンｄ化合物 |
| US6894037B2 (en) | 2003-07-03 | 2005-05-17 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses |
| US7713951B2 (en) | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| EP1812011A1 (en) | 2004-11-12 | 2007-08-01 | Bioxell S.p.a. | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| EP2010483A2 (en) | 2006-04-05 | 2009-01-07 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof |
| US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
| JP5563324B2 (ja) * | 2010-02-03 | 2014-07-30 | フォーモサ・ラボラトリーズ・インコーポレーテッド | マキサカルシトール中間体およびその製造方法 |
| WO2012122451A2 (en) | 2011-03-09 | 2012-09-13 | Teva Pharmaceutical Industries Ltd. | Polymorphs of maxacalcitol and process for the preparation of maxacalcitol |
| CN102796134B (zh) * | 2012-08-31 | 2015-07-01 | 甘肃皓天化学科技有限公司 | 一种马沙骨化醇中间体的制备方法 |
| CN103910666A (zh) * | 2014-04-15 | 2014-07-09 | 湖南华腾制药有限公司 | 一种制备马沙骨化醇的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1204752A (en) | 1981-11-02 | 1986-05-20 | Robert H. Hesse | Vitamin d analogues |
| CA1332841C (en) * | 1984-11-27 | 1994-11-01 | Noboru Kubodera | Vitamin d derivatives and process for producing the same |
| JPH07100685B2 (ja) | 1985-08-02 | 1995-11-01 | レオ・ファ−マシュ−ティカル・プロダクツ・リミテッド・エイ／エス（レ−ベンス・ケミスケ・ファブリック・プロデュクチオンスアクチ−セルスカブ） | 新規ビタミンｄ類似体 |
| AU614372B2 (en) | 1988-04-21 | 1991-08-29 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) | Novel vitamin d analogues |
| GB8904153D0 (en) * | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
-
1989
- 1989-02-23 GB GB898904154A patent/GB8904154D0/en active Pending
-
1990
- 1990-02-13 AU AU51983/90A patent/AU627001B2/en not_active Ceased
- 1990-02-13 CA CA002044280A patent/CA2044280C/en not_active Expired - Fee Related
- 1990-02-13 AT AT9090903793T patent/ATE104957T1/de not_active IP Right Cessation
- 1990-02-13 RO RO148060A patent/RO109939B1/ro unknown
- 1990-02-13 DE DE69008517T patent/DE69008517T2/de not_active Expired - Fee Related
- 1990-02-13 EP EP90903793A patent/EP0460032B1/en not_active Expired - Lifetime
- 1990-02-13 WO PCT/DK1990/000036 patent/WO1990009991A1/en not_active Ceased
- 1990-02-13 ES ES90903793T patent/ES2055905T3/es not_active Expired - Lifetime
- 1990-02-13 HU HU902300A patent/HU211025B/hu not_active IP Right Cessation
- 1990-02-13 DK DK90903793.9T patent/DK0460032T3/da active
- 1990-02-13 JP JP2504126A patent/JP2807083B2/ja not_active Expired - Fee Related
- 1990-02-13 KR KR1019910700655A patent/KR0163194B1/ko not_active Expired - Fee Related
- 1990-02-22 PT PT93232A patent/PT93232B/pt not_active IP Right Cessation
-
1991
- 1991-06-19 IE IE42190A patent/IE63123B1/en not_active IP Right Cessation
- 1991-07-25 NO NO912902A patent/NO178065C/no not_active IP Right Cessation
- 1991-08-12 FI FI913812A patent/FI92929C/fi active
- 1991-08-22 RU SU915001741A patent/RU2037484C1/ru not_active IP Right Cessation
-
1993
- 1993-09-28 LV LVP-93-1106A patent/LV10428B/en unknown
- 1993-12-06 LT LTIP1536A patent/LT3983B/lt not_active IP Right Cessation
-
1994
- 1994-09-12 SG SG131794A patent/SG131794G/en unknown
- 1994-11-17 HK HK128894A patent/HK128894A/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN AUGUST 2003 |