NO176797C - Fremgangsmåte for utvinning av renset, renaturert, rekobminant interleukin-2 fra transformerte mikroorganismer - Google Patents

Fremgangsmåte for utvinning av renset, renaturert, rekobminant interleukin-2 fra transformerte mikroorganismer

Info

Publication number
NO176797C
NO176797C NO885678A NO885678A NO176797C NO 176797 C NO176797 C NO 176797C NO 885678 A NO885678 A NO 885678A NO 885678 A NO885678 A NO 885678A NO 176797 C NO176797 C NO 176797C
Authority
NO
Norway
Prior art keywords
oxidized
guanidine hydrochloride
transformed microorganisms
purified
recobminant
Prior art date
Application number
NO885678A
Other languages
English (en)
Norwegian (no)
Other versions
NO885678L (no
NO176797B (no
NO885678D0 (no
Inventor
Sidney N Wolfe
Glenn Dorin
John T Davis
Amy Lim
Flint Smith
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of NO885678L publication Critical patent/NO885678L/no
Publication of NO885678D0 publication Critical patent/NO885678D0/no
Publication of NO176797B publication Critical patent/NO176797B/no
Publication of NO176797C publication Critical patent/NO176797C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO885678A 1987-05-11 1988-12-21 Fremgangsmåte for utvinning av renset, renaturert, rekobminant interleukin-2 fra transformerte mikroorganismer NO176797C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4840887A 1987-05-11 1987-05-11
US16714488A 1988-03-25 1988-03-25
PCT/US1988/001043 WO1988008849A1 (en) 1987-05-11 1988-03-31 Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms

Publications (4)

Publication Number Publication Date
NO885678L NO885678L (no) 1988-12-21
NO885678D0 NO885678D0 (no) 1988-12-21
NO176797B NO176797B (no) 1995-02-20
NO176797C true NO176797C (no) 1995-05-31

Family

ID=26726091

Family Applications (1)

Application Number Title Priority Date Filing Date
NO885678A NO176797C (no) 1987-05-11 1988-12-21 Fremgangsmåte for utvinning av renset, renaturert, rekobminant interleukin-2 fra transformerte mikroorganismer

Country Status (9)

Country Link
EP (1) EP0368857B1 (ja)
JP (1) JP2955294B2 (ja)
AT (1) ATE156491T1 (ja)
AU (1) AU622860B2 (ja)
DE (1) DE3855986T2 (ja)
DK (1) DK10189D0 (ja)
IL (1) IL86326A (ja)
NO (1) NO176797C (ja)
WO (1) WO1988008849A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
EP0337243A1 (en) * 1988-04-14 1989-10-18 F. Hoffmann-La Roche Ag Process for purifying recombinant human interleukin-2
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
WO1992012429A1 (fr) * 1991-01-10 1992-07-23 Teijin Limited Analyse a sensibilite elevee de facteur tissulaire et kit utilise a cet effet
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
JPH08502661A (ja) * 1993-08-04 1996-03-26 チバ−ガイギー アクチェンゲゼルシャフト 高分子量デスルファトヒルジン
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
JPH11509551A (ja) * 1995-07-21 1999-08-24 アムジエン・インコーポレーテツド 蛋白質を塩から分離することのできる連続静止相を用いてバッファー交換により蛋白質を巻き戻す方法
WO2003097669A2 (en) * 2002-05-17 2003-11-27 Københavns Universitet Method for purifying denatured proteins having a desired disulfide bond configuration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (ja) * 1982-12-22 1984-10-02 Genentech Inc
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
JPH0640832B2 (ja) * 1985-05-10 1994-06-01 味の素株式会社 インタ−ロイキン２ポリペプチドの回収方法
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2

Also Published As

Publication number Publication date
WO1988008849A1 (en) 1988-11-17
JP2955294B2 (ja) 1999-10-04
NO885678L (no) 1988-12-21
EP0368857A1 (en) 1990-05-23
AU622860B2 (en) 1992-04-30
NO176797B (no) 1995-02-20
DK10189A (da) 1989-01-11
AU1627988A (en) 1988-12-06
IL86326A0 (en) 1988-11-15
DK10189D0 (da) 1989-01-11
IL86326A (en) 1997-02-18
JPH02503384A (ja) 1990-10-18
DE3855986T2 (de) 1998-02-05
NO885678D0 (no) 1988-12-21
EP0368857B1 (en) 1997-08-06
DE3855986D1 (de) 1997-09-11
ATE156491T1 (de) 1997-08-15

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