ATE76435T1 - Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. - Google Patents
Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.Info
- Publication number
- ATE76435T1 ATE76435T1 AT86904011T AT86904011T ATE76435T1 AT E76435 T1 ATE76435 T1 AT E76435T1 AT 86904011 T AT86904011 T AT 86904011T AT 86904011 T AT86904011 T AT 86904011T AT E76435 T1 ATE76435 T1 AT E76435T1
- Authority
- AT
- Austria
- Prior art keywords
- somatotropin
- solubilization
- oxidation
- transformed microorganisms
- microorganisms
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 230000003647 oxidation Effects 0.000 title 1
- 238000007254 oxidation reaction Methods 0.000 title 1
- 230000007928 solubilization Effects 0.000 title 1
- 238000005063 solubilization Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108010006025 bovine growth hormone Proteins 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74901685A | 1985-06-26 | 1985-06-26 | |
PCT/US1986/001289 WO1987000204A2 (en) | 1985-06-26 | 1986-06-13 | Purification of somatotropin from transformed microorganisms |
EP86904011A EP0229110B1 (de) | 1985-06-26 | 1986-06-13 | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE76435T1 true ATE76435T1 (de) | 1992-06-15 |
Family
ID=25011872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT86904011T ATE76435T1 (de) | 1985-06-26 | 1986-06-13 | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. |
Country Status (9)
Country | Link |
---|---|
US (2) | US6916914B1 (de) |
EP (2) | EP0229110B1 (de) |
JP (1) | JPH06104070B2 (de) |
AT (1) | ATE76435T1 (de) |
DE (1) | DE3685424D1 (de) |
ES (1) | ES2032383T3 (de) |
GR (1) | GR3004917T3 (de) |
HK (1) | HK64897A (de) |
WO (1) | WO1987000204A2 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987000204A2 (en) * | 1985-06-26 | 1987-01-15 | The Upjohn Company | Purification of somatotropin from transformed microorganisms |
JPH01132598A (ja) * | 1987-10-14 | 1989-05-25 | Pitman Moore Inc | 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法 |
US4958007A (en) * | 1988-05-17 | 1990-09-18 | Schering-Plough Corp. | Extraction of human interleukin-4- from bacteria |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5023323A (en) * | 1990-09-12 | 1991-06-11 | Monsanto Company | Method of somatotropin naturation |
ZA9711733B (en) * | 1996-12-31 | 1998-07-01 | Monsanto Co | Method for solubilization and naturation of somatotropins |
PE20090100A1 (es) * | 2007-03-30 | 2009-02-26 | Wyeth Corp | Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas |
WO2009136568A1 (ja) | 2008-05-08 | 2009-11-12 | 味の素株式会社 | タンパク質のリフォールディング方法 |
CA2790186C (en) * | 2010-03-31 | 2016-11-01 | Amsilk Gmbh | Separation of insoluble target proteins |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
IL59690A (en) | 1980-03-24 | 1983-11-30 | Yeda Res & Dev | Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it |
IE52755B1 (en) | 1980-08-26 | 1988-02-17 | Univ California | Bovine pre-growth and growth hormone |
EP0085036A1 (de) | 1982-01-18 | 1983-08-03 | Monsanto Company | Verfahren zur Verbesserung der Rindermilchproduktion |
CA1224432A (en) | 1982-08-17 | 1987-07-21 | Gary N. Buell | Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
GR79124B (de) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
BG49718A3 (en) | 1983-07-15 | 1992-01-15 | Bio Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
US5037806A (en) * | 1985-02-22 | 1991-08-06 | Monsanto Company | Biologically active method using somatotropins |
US4652630A (en) * | 1985-02-22 | 1987-03-24 | Monsanto Company | Method of somatotropin naturation |
US4612367A (en) * | 1985-04-08 | 1986-09-16 | Eli Lilly And Company | Process for purifying growth hormone-like materials |
WO1987000204A2 (en) * | 1985-06-26 | 1987-01-15 | The Upjohn Company | Purification of somatotropin from transformed microorganisms |
US5023323A (en) * | 1990-09-12 | 1991-06-11 | Monsanto Company | Method of somatotropin naturation |
US5240834A (en) * | 1991-01-22 | 1993-08-31 | Albert Einstein College Of Medicine Of Yeshiva University | Solubilization of protein after bacterial expression using sarkosyl |
-
1986
- 1986-06-13 WO PCT/US1986/001289 patent/WO1987000204A2/en active IP Right Grant
- 1986-06-13 US US08/256,297 patent/US6916914B1/en not_active Expired - Fee Related
- 1986-06-13 DE DE8686904011T patent/DE3685424D1/de not_active Expired - Fee Related
- 1986-06-13 JP JP61503479A patent/JPH06104070B2/ja not_active Expired - Lifetime
- 1986-06-13 EP EP86904011A patent/EP0229110B1/de not_active Expired - Lifetime
- 1986-06-13 AT AT86904011T patent/ATE76435T1/de not_active IP Right Cessation
- 1986-10-08 ES ES198686307769T patent/ES2032383T3/es not_active Expired - Lifetime
- 1986-10-08 EP EP86307769A patent/EP0263902B1/de not_active Expired - Lifetime
-
1992
- 1992-06-12 GR GR920401278T patent/GR3004917T3/el unknown
-
1995
- 1995-05-23 US US08/447,381 patent/US6586575B1/en not_active Expired - Fee Related
-
1997
- 1997-05-15 HK HK64897A patent/HK64897A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6916914B1 (en) | 2005-07-12 |
JPS62503143A (ja) | 1987-12-17 |
ES2032383T3 (es) | 1993-02-16 |
EP0229110A1 (de) | 1987-07-22 |
WO1987000204A3 (en) | 1987-03-12 |
GR3004917T3 (de) | 1993-04-28 |
DE3685424D1 (de) | 1992-06-25 |
US6586575B1 (en) | 2003-07-01 |
EP0263902B1 (de) | 1992-05-27 |
HK64897A (en) | 1997-05-23 |
JPH06104070B2 (ja) | 1994-12-21 |
WO1987000204A2 (en) | 1987-01-15 |
EP0229110B1 (de) | 1992-05-20 |
EP0263902A1 (de) | 1988-04-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ214854A (en) | Oxidation resistant proteins with modified methione residues | |
DE3686654D1 (de) | Verfahren zur isolierung rekombinanter polypeptide in biologisch aktiver form. | |
DE3586773D1 (de) | Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide. | |
DE3681185D1 (de) | Methode zur aufloesung und naturation von somatotropin. | |
ATE76435T1 (de) | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. | |
GR3005985T3 (de) | ||
ATE71658T1 (de) | Verfahren zur herstellung von humanlysozym. | |
ATE98649T1 (de) | Reinigung von lfa-3. | |
DE3855986D1 (de) | Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen | |
EP0312358A3 (de) | Methode zur Herstellung intramolekularer Disulfidbrücken in rekombinanten Proteinen in Gegenwart eines Denaturierungsmittels | |
DE3887889D1 (de) | Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon. | |
ATE72582T1 (de) | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. | |
ES2009588A6 (es) | Un metodo para la preparacion de un polipeptido. | |
ATE133711T1 (de) | Produktion von cystinreste enthaltenden aktiven proteinen | |
FI945325A (fi) | Menetelmä G-CSF:n eristämiseksi ja puhdistamiseksi |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |