DE3887889D1 - Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon. - Google Patents

Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon.

Info

Publication number
DE3887889D1
DE3887889D1 DE88309076T DE3887889T DE3887889D1 DE 3887889 D1 DE3887889 D1 DE 3887889D1 DE 88309076 T DE88309076 T DE 88309076T DE 3887889 T DE3887889 T DE 3887889T DE 3887889 D1 DE3887889 D1 DE 3887889D1
Authority
DE
Germany
Prior art keywords
production
beta
removal
beta interferon
chaotropic environment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88309076T
Other languages
English (en)
Other versions
DE3887889T2 (de
Inventor
Susan Hershenson
Jody Thomson
Ze Ev Skaked Ze Ev Skaked
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Publication of DE3887889D1 publication Critical patent/DE3887889D1/de
Application granted granted Critical
Publication of DE3887889T2 publication Critical patent/DE3887889T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
DE3887889T 1988-09-23 1988-09-30 Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon. Expired - Fee Related DE3887889T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA000578236A CA1340586C (en) 1988-09-23 1988-09-23 Process for recovering microbially produced interferon-beta
IE291388A IE62661B1 (en) 1988-09-23 1988-09-26 Improved process for recovering microbially produced interferon-beta
EP88309076A EP0360937B1 (de) 1988-09-23 1988-09-30 Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon

Publications (2)

Publication Number Publication Date
DE3887889D1 true DE3887889D1 (de) 1994-03-24
DE3887889T2 DE3887889T2 (de) 1994-08-25

Family

ID=33568060

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3887889T Expired - Fee Related DE3887889T2 (de) 1988-09-23 1988-09-30 Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon.

Country Status (6)

Country Link
EP (1) EP0360937B1 (de)
AT (1) ATE101654T1 (de)
AU (1) AU631356B2 (de)
CA (1) CA1340586C (de)
DE (1) DE3887889T2 (de)
IE (1) IE62661B1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01132598A (ja) * 1987-10-14 1989-05-25 Pitman Moore Inc 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法
WO1992004382A1 (en) * 1990-09-05 1992-03-19 Bunge (Australia) Pty. Ltd. Solubilization of proteins in active forms
JP3021040B2 (ja) * 1990-11-23 2000-03-15 ヘキスト・マリオン・ルセル 少なくとも１個の分子内ジスルフィド結合を含有する蛋白質を相当する還元された組替え蛋白質を５．０以下のｐＨで酸化することによって製造する方法
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
DE19547933A1 (de) * 1995-12-22 1997-06-26 Boehringer Mannheim Gmbh Multimere Formen von IL-16, Verfahren zu ihrer Herstellung und Verwendung
JPH11335392A (ja) * 1998-05-26 1999-12-07 Hsp Kenkyusho:Kk 可溶性タンパク質の回収方法
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
EP1300415B1 (de) * 2001-10-03 2007-01-24 Boehringer Ingelheim International GmbH Verfahren zum Rekonstituieren eines biologisch aktiven rekombinanten Proteins
DE102008051574A1 (de) * 2008-10-14 2010-04-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung von Interferon-beta und deren Varianten

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
IL74094A0 (en) * 1984-01-23 1985-04-30 Takeda Chemical Industries Ltd Highly solubilised protein and production thereof
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
US4904602A (en) * 1985-11-27 1990-02-27 Repligen Corporation Thioredoxin shufflease and use thereof

Also Published As

Publication number Publication date
EP0360937A1 (de) 1990-04-04
IE62661B1 (en) 1995-02-22
ATE101654T1 (de) 1994-03-15
DE3887889T2 (de) 1994-08-25
AU631356B2 (en) 1992-11-26
AU2284188A (en) 1990-03-29
EP0360937B1 (de) 1994-02-16
CA1340586C (en) 1999-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON CORP. (N.D.GES.D. STAATES DELAWARE), EMERYV

8339 Ceased/non-payment of the annual fee