ATE101654T1 - Verfahren zur gewinnung von mikrobiell hergestelltem beta-interferon. - Google Patents
Verfahren zur gewinnung von mikrobiell hergestelltem beta-interferon.Info
- Publication number
- ATE101654T1 ATE101654T1 AT88309076T AT88309076T ATE101654T1 AT E101654 T1 ATE101654 T1 AT E101654T1 AT 88309076 T AT88309076 T AT 88309076T AT 88309076 T AT88309076 T AT 88309076T AT E101654 T1 ATE101654 T1 AT E101654T1
- Authority
- AT
- Austria
- Prior art keywords
- microbially
- obtaining
- beta interferon
- beta
- removal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA000578236A CA1340586C (en) | 1988-09-23 | 1988-09-23 | Process for recovering microbially produced interferon-beta |
IE291388A IE62661B1 (en) | 1988-09-23 | 1988-09-26 | Improved process for recovering microbially produced interferon-beta |
EP88309076A EP0360937B1 (de) | 1988-09-23 | 1988-09-30 | Verfahren zur Gewinnung von mikrobiell hergestelltem Beta-Interferon |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE101654T1 true ATE101654T1 (de) | 1994-03-15 |
Family
ID=33568060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88309076T ATE101654T1 (de) | 1988-09-23 | 1988-09-30 | Verfahren zur gewinnung von mikrobiell hergestelltem beta-interferon. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0360937B1 (de) |
AT (1) | ATE101654T1 (de) |
AU (1) | AU631356B2 (de) |
CA (1) | CA1340586C (de) |
DE (1) | DE3887889T2 (de) |
IE (1) | IE62661B1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01132598A (ja) * | 1987-10-14 | 1989-05-25 | Pitman Moore Inc | 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法 |
ES2119779T3 (es) * | 1990-09-05 | 1998-10-16 | Southern Cross Biotech Pty Ltd | Solubilizacion de proteinas en formas activas. |
ES2107449T3 (es) * | 1990-11-23 | 1997-12-01 | Roussel Uclaf | Procedimiento de preparacion de una proteina elegida entre las citoquinas, que comprende al menos un puente disulfuro intramolecular por oxidacion, a un ph inferior a 5,0 de la proteina recombinante reducida correspondiente. |
AU648214B2 (en) * | 1991-12-31 | 1994-04-14 | Lucky Limited | Recombinant gene coding for human alpha interferon and expression vector thereof, etc. |
US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
DE19547933A1 (de) * | 1995-12-22 | 1997-06-26 | Boehringer Mannheim Gmbh | Multimere Formen von IL-16, Verfahren zu ihrer Herstellung und Verwendung |
JPH11335392A (ja) | 1998-05-26 | 1999-12-07 | Hsp Kenkyusho:Kk | 可溶性タンパク質の回収方法 |
US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
EP1300415B1 (de) * | 2001-10-03 | 2007-01-24 | Boehringer Ingelheim International GmbH | Verfahren zum Rekonstituieren eines biologisch aktiven rekombinanten Proteins |
DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR79124B (de) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
IL74094A0 (en) * | 1984-01-23 | 1985-04-30 | Takeda Chemical Industries Ltd | Highly solubilised protein and production thereof |
US4530787A (en) * | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
US4572798A (en) * | 1984-12-06 | 1986-02-25 | Cetus Corporation | Method for promoting disulfide bond formation in recombinant proteins |
US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
US4904602A (en) * | 1985-11-27 | 1990-02-27 | Repligen Corporation | Thioredoxin shufflease and use thereof |
-
1988
- 1988-09-23 CA CA000578236A patent/CA1340586C/en not_active Expired - Fee Related
- 1988-09-26 AU AU22841/88A patent/AU631356B2/en not_active Ceased
- 1988-09-26 IE IE291388A patent/IE62661B1/en not_active IP Right Cessation
- 1988-09-30 EP EP88309076A patent/EP0360937B1/de not_active Expired - Lifetime
- 1988-09-30 AT AT88309076T patent/ATE101654T1/de not_active IP Right Cessation
- 1988-09-30 DE DE3887889T patent/DE3887889T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE62661B1 (en) | 1995-02-22 |
AU2284188A (en) | 1990-03-29 |
CA1340586C (en) | 1999-06-08 |
AU631356B2 (en) | 1992-11-26 |
EP0360937A1 (de) | 1990-04-04 |
DE3887889D1 (de) | 1994-03-24 |
DE3887889T2 (de) | 1994-08-25 |
EP0360937B1 (de) | 1994-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |