ATE261985T1 - Verfahren zur herstellung von richtig gefaltetem, biologisch aktivem, rekombinantem protein - Google Patents
Verfahren zur herstellung von richtig gefaltetem, biologisch aktivem, rekombinantem proteinInfo
- Publication number
- ATE261985T1 ATE261985T1 AT96939406T AT96939406T ATE261985T1 AT E261985 T1 ATE261985 T1 AT E261985T1 AT 96939406 T AT96939406 T AT 96939406T AT 96939406 T AT96939406 T AT 96939406T AT E261985 T1 ATE261985 T1 AT E261985T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- recombinant protein
- biologically active
- properly folded
- producing properly
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 210000001236 prokaryotic cell Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9504019A SE9504019D0 (sv) | 1995-11-13 | 1995-11-13 | Method for production of proteins |
| PCT/SE1996/001456 WO1997018233A1 (en) | 1995-11-13 | 1996-11-12 | Method for producing a correctly folded, biological active recombinant protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261985T1 true ATE261985T1 (de) | 2004-04-15 |
Family
ID=20400188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939406T ATE261985T1 (de) | 1995-11-13 | 1996-11-12 | Verfahren zur herstellung von richtig gefaltetem, biologisch aktivem, rekombinantem protein |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6605706B1 (de) |
| EP (1) | EP0952981B1 (de) |
| JP (1) | JP3930051B2 (de) |
| AT (1) | ATE261985T1 (de) |
| AU (1) | AU705192B2 (de) |
| CA (1) | CA2236751C (de) |
| DE (1) | DE69631906T2 (de) |
| NO (1) | NO320175B1 (de) |
| SE (1) | SE9504019D0 (de) |
| WO (1) | WO1997018233A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6653098B1 (en) | 1998-02-23 | 2003-11-25 | G. D. Searle & Co. | Method of producing mouse and human endostatin |
| US6924120B1 (en) | 1998-03-31 | 2005-08-02 | Tonghua Gantech Biotechnology, Ltd. | Chaperone protein containing an intramolecular chaperone-like sequence and its application to insulin production |
| GB9913437D0 (en) * | 1999-06-09 | 1999-08-11 | Medical Res Council | Fusion proteins |
| FR2820424B1 (fr) * | 2001-02-05 | 2004-01-02 | Merieux Oravax | Procede de purification de alpa |
| SG162834A1 (en) | 2006-07-14 | 2010-07-29 | Genentech Inc | Refolding of recombinant proteins |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| JP7570428B2 (ja) * | 2020-11-05 | 2024-10-21 | シミックホールディングス株式会社 | 組み換えインスリン様成長因子ｉの製造方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8505922D0 (sv) * | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
| US5231178A (en) | 1991-01-16 | 1993-07-27 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Method for the purification of intact, correctly-folded insulin-like growth factor-1 |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| SG46612A1 (en) * | 1992-12-02 | 1998-02-20 | Hoechst Ag | Process for obtaining proinsulin in processing correctly linked cystine bridges |
| US5407810A (en) * | 1993-08-20 | 1995-04-18 | Genentech, Inc. | Aqueous multiple-phase isolation of polypeptide |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
-
1995
- 1995-11-13 SE SE9504019A patent/SE9504019D0/xx unknown
-
1996
- 1996-11-12 AU AU76596/96A patent/AU705192B2/en not_active Ceased
- 1996-11-12 US US09/051,941 patent/US6605706B1/en not_active Expired - Fee Related
- 1996-11-12 EP EP96939406A patent/EP0952981B1/de not_active Expired - Lifetime
- 1996-11-12 WO PCT/SE1996/001456 patent/WO1997018233A1/en not_active Ceased
- 1996-11-12 JP JP51878397A patent/JP3930051B2/ja not_active Expired - Fee Related
- 1996-11-12 CA CA002236751A patent/CA2236751C/en not_active Expired - Fee Related
- 1996-11-12 DE DE69631906T patent/DE69631906T2/de not_active Expired - Fee Related
- 1996-11-12 AT AT96939406T patent/ATE261985T1/de not_active IP Right Cessation
-
1998
- 1998-05-12 NO NO19982155A patent/NO320175B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997018233A1 (en) | 1997-05-22 |
| SE9504019D0 (sv) | 1995-11-13 |
| CA2236751A1 (en) | 1997-05-22 |
| DE69631906T2 (de) | 2005-01-20 |
| AU7659696A (en) | 1997-06-05 |
| AU705192B2 (en) | 1999-05-20 |
| NO982155D0 (no) | 1998-05-12 |
| CA2236751C (en) | 2007-01-09 |
| DE69631906D1 (de) | 2004-04-22 |
| JP2000500023A (ja) | 2000-01-11 |
| US6605706B1 (en) | 2003-08-12 |
| JP3930051B2 (ja) | 2007-06-13 |
| HK1023781A1 (en) | 2000-09-22 |
| EP0952981A1 (de) | 1999-11-03 |
| NO320175B1 (no) | 2005-11-07 |
| NO982155L (no) | 1998-05-12 |
| EP0952981B1 (de) | 2004-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |