NO175259C - Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser

Info

Publication number
NO175259C
NO175259C NO894287A NO894287A NO175259C NO 175259 C NO175259 C NO 175259C NO 894287 A NO894287 A NO 894287A NO 894287 A NO894287 A NO 894287A NO 175259 C NO175259 C NO 175259C
Authority
NO
Norway
Prior art keywords
preparation
hydrogen
therapeutically active
analogous process
triazolo
Prior art date
Application number
NO894287A
Other languages
English (en)
Norwegian (no)
Other versions
NO894287D0 (no
NO894287L (no
NO175259B (no
Inventor
Kazuo Okano
Shuhei Miyazawa
Richard Stephen John Clark
Shinya Abe
Tetsuya Kawahara
Naoyuki Shimomura
Osamu Asano
Hiroyuki Yoshimura
Mitsuaki Miyamoto
Yoshinori Sakuma
Kenzo Muramoto
Hiroshi Obaishi
Koukichi Harada
Hajime Tsunoda
Oppfinnere Ytterligere
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO894287D0 publication Critical patent/NO894287D0/no
Publication of NO894287L publication Critical patent/NO894287L/no
Priority to NO923459A priority Critical patent/NO301072B1/no
Publication of NO175259B publication Critical patent/NO175259B/no
Publication of NO175259C publication Critical patent/NO175259C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO894287A 1988-10-31 1989-10-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser NO175259C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO923459A NO301072B1 (no) 1988-10-31 1992-09-04 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP27546088 1988-10-31
JP29706888 1988-11-24
JP31801688 1988-12-16
JP33162288 1988-12-28

Publications (4)

Publication Number Publication Date
NO894287D0 NO894287D0 (no) 1989-10-27
NO894287L NO894287L (no) 1990-05-02
NO175259B NO175259B (no) 1994-06-13
NO175259C true NO175259C (no) 1994-09-21

Family

ID=27479049

Family Applications (1)

Application Number Title Priority Date Filing Date
NO894287A NO175259C (no) 1988-10-31 1989-10-27 Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser

Country Status (15)

Country Link
EP (3) EP0606103B1 (da)
JP (1) JP2756004B2 (da)
KR (1) KR910009332B1 (da)
CN (1) CN1036520C (da)
AT (3) ATE234306T1 (da)
AU (1) AU621413B2 (da)
CA (1) CA2000985C (da)
DE (3) DE68929049T2 (da)
DK (1) DK540689A (da)
FI (1) FI95708C (da)
HU (1) HU217127B (da)
NO (1) NO175259C (da)
NZ (1) NZ231188A (da)
PH (1) PH27461A (da)
PT (1) PT92153B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH30676A (en) * 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
GB8907257D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-paf and anti-ischemic agents
GB8907256D0 (en) * 1989-03-31 1989-05-17 Rech Et D Applic Scient Scras New derivatives of hetrazepine as anti-asthmatic anti-allergic and gastro-intestinal protectors
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten
DE4027470A1 (de) * 1990-08-30 1992-03-05 Boehringer Ingelheim Kg Neue hetrazepinoide amide
DE4107521A1 (de) * 1991-03-08 1992-09-10 Boehringer Ingelheim Kg Neue acylaminosubstituierte hetrazepine
US5686479A (en) * 1991-12-11 1997-11-11 Yoshitomi Pharmaceutical Industries, Ltd. Immunosuppressive drug
TW219935B (da) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
US5530141A (en) * 1992-03-04 1996-06-25 Center For Innovative Technology 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
WO1994001430A1 (en) 1992-07-13 1994-01-20 Cytomed, Inc. 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
JP2523259B2 (ja) * 1993-06-30 1996-08-07 エスオーエンジニアリング株式会社 フォ―ハ―ス内のガラス温度制御方法
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
WO1998058930A1 (fr) * 1997-06-25 1998-12-30 Nikken Chemicals Co., Ltd. Composes de triazolo-1,4-diazepine et composition medicinale les contenant
FR2779652B1 (fr) * 1998-06-15 2001-06-08 Sod Conseils Rech Applic Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique
SG109000A1 (en) 2003-07-16 2005-02-28 Asml Netherlands Bv Lithographic apparatus and device manufacturing method
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (es) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
TWI602820B (zh) 2012-06-06 2017-10-21 星宿藥物公司 溴域抑制劑及其用途
EP2864336B1 (en) 2012-06-06 2016-11-23 Constellation Pharmaceuticals, Inc. Benzo[b]isoxazoloazepine bromodomain inhibitors and uses thereof
US10092574B2 (en) 2012-09-26 2018-10-09 Valorisation-Recherche, Limited Partnership Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof
EP3157928B1 (en) 2014-06-20 2019-02-13 Constellation Pharmaceuticals, Inc. Crystalline forms of 2-((4s)-6-(4-chlorophenyl)-1-methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3435973A1 (de) * 1984-10-01 1986-04-10 Boehringer Ingelheim KG, 6507 Ingelheim Diazepine enthaltende pharmazeutische zusammensetzungen mit paf-antagonistischer wirkung
DE3502392A1 (de) * 1985-01-25 1986-07-31 Boehringer Ingelheim KG, 6507 Ingelheim Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen
ES2037013T3 (es) 1986-01-21 1993-06-16 Boehringer Ingelheim Kg Procedimiento para preparar tieno-1,4-diazepinas.
PH30676A (en) 1986-07-22 1997-09-16 Boehringer Ingelhein Kg Hetrazepine compounds which have useful pharmaceutical utility
DE3724031A1 (de) * 1986-07-22 1988-01-28 Boehringer Ingelheim Kg Neue hetrazepine und verfahren zu ihrer herstellung
EP0268242B1 (en) * 1986-11-17 1992-03-18 Yoshitomi Pharmaceutical Industries, Ltd. Paf-antagonistic thienotriazolodiazepine compounds and pharmaceutical uses thereof
EP0368175A1 (de) * 1988-11-06 1990-05-16 Boehringer Ingelheim Kg 3S,7S-3-(Morpholinocarbonyl)-5-(2-chlorphenyl)-7,10-dimethyl-3,4-dihydro-2H,7H-cyclopenta[4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin.
GB8911030D0 (en) * 1989-05-13 1989-06-28 Scras Hetrazepine derivatives
EP0407955A1 (de) * 1989-07-12 1991-01-16 Boehringer Ingelheim Kg Neue Hetrazepine mit PAF-antagonistischer Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AT394563B (de) * 1990-05-09 1992-05-11 Scras Verfahren zur herstellung von thieno-triazolodiazepinderivaten

Also Published As

Publication number Publication date
ATE213247T1 (de) 2002-02-15
KR900006342A (ko) 1990-05-08
AU4376189A (en) 1990-05-03
CN1036520C (zh) 1997-11-26
NO894287D0 (no) 1989-10-27
AU621413B2 (en) 1992-03-12
FI95708B (fi) 1995-11-30
PT92153B (pt) 1995-06-30
DK540689A (da) 1990-05-01
ATE234306T1 (de) 2003-03-15
EP0606103A1 (en) 1994-07-13
EP0677524B1 (en) 2002-02-13
ATE183187T1 (de) 1999-08-15
DE68929372D1 (de) 2002-03-21
CA2000985C (en) 2000-01-18
DE68929049T2 (de) 2000-01-27
NO894287L (no) 1990-05-02
EP0606103B1 (en) 2003-03-12
EP0677524A1 (en) 1995-10-18
CN1121076A (zh) 1996-04-24
PT92153A (pt) 1990-05-31
KR910009332B1 (ko) 1991-11-11
JP2756004B2 (ja) 1998-05-25
CA2000985A1 (en) 1990-04-30
DE68929455T2 (de) 2004-01-08
DE68929049D1 (de) 1999-09-16
NO175259B (no) 1994-06-13
HU217127B (hu) 1999-11-29
PH27461A (en) 1993-07-09
JPH02256682A (ja) 1990-10-17
HU895609D0 (en) 1990-01-28
EP0367110B1 (en) 1999-08-11
EP0367110A1 (en) 1990-05-09
HUT53106A (en) 1990-09-28
DE68929455D1 (de) 2003-04-17
NZ231188A (en) 1991-06-25
DK540689D0 (da) 1989-10-30
FI95708C (fi) 1996-03-11
DE68929372T2 (de) 2002-10-02
FI894867A0 (fi) 1989-10-13

Similar Documents

Publication Publication Date Title
NO175259C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive triazolo-1,4-diazepinforbindelser
ATE86110T1 (de) Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
HUP0202867A2 (hu) CCR5 antagonistákként alkalmazható piperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények
OA09039A (fr) Acides 3-alcenyl-1-azabicyclo(3.2.0)hep-2-ene-2carboxyliques
DK0626968T3 (da) Thiacykliske piperidinylderivater
NO166126C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
ATE175661T1 (de) Benzamid-derivate als vasopressin-antagonisten
DK0643701T3 (da) Benzimidazolderivater, fremgangsmåde til deres fremstilling og deres anvendelse inden for det terapeutiske og kosmetiske område
ES2055235T3 (es) Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
EP0309424A3 (en) New amidino derivatives
MY111474A (en) Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders.
ATE86117T1 (de) Zusammensetzung gegen leberkrankheiten.
SE9601708D0 (sv) Pyridyl- and pyrimidyl-piperazines in the treatment of substance abuse disorders
IT1213219B (it) Derivati amminoalchilnaftalenici ad attivita' farmacologica.
DE69429447D1 (de) Verwendung von 2-aminopurinderivaten zur behandlung und prophylaxe der menschlichen herpesvirus 7 infektionen
DK0814813T3 (da) Anvendelse af penciclovir til behandling af human herpesvirus-8
KR870006898A (ko) 신장염 치료제
ZA885358B (en) Uricosuric composition

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees