NO175040B - Fremgangsmåte for fremstilling av et preparat for intravenös administrering av 3 - Google Patents
Fremgangsmåte for fremstilling av et preparat for intravenös administrering av 3 Download PDFInfo
- Publication number
- NO175040B NO175040B NO870560A NO870560A NO175040B NO 175040 B NO175040 B NO 175040B NO 870560 A NO870560 A NO 870560A NO 870560 A NO870560 A NO 870560A NO 175040 B NO175040 B NO 175040B
- Authority
- NO
- Norway
- Prior art keywords
- oil
- pregnanolone
- amount
- preparation
- final composition
- Prior art date
Links
- 238000001990 intravenous administration Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 10
- 238000000034 method Methods 0.000 title claims description 5
- AURFZBICLPNKBZ-YZRLXODZSA-N 3alpha-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-YZRLXODZSA-N 0.000 claims abstract description 28
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229950007402 eltanolone Drugs 0.000 claims abstract description 28
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 238000004519 manufacturing process Methods 0.000 claims description 6
- WLNARFZDISHUGS-MIXBDBMTSA-N cholesteryl hemisuccinate Chemical compound C1C=C2C[C@@H](OC(=O)CCC(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 WLNARFZDISHUGS-MIXBDBMTSA-N 0.000 claims description 5
- 229940099371 diacetylated monoglycerides Drugs 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000003549 soybean oil Substances 0.000 claims description 3
- 239000008215 water for injection Substances 0.000 claims description 3
- 235000019485 Safflower oil Nutrition 0.000 claims description 2
- 235000021324 borage oil Nutrition 0.000 claims description 2
- 239000003240 coconut oil Substances 0.000 claims description 2
- 235000019864 coconut oil Nutrition 0.000 claims description 2
- 235000012343 cottonseed oil Nutrition 0.000 claims description 2
- 239000002385 cottonseed oil Substances 0.000 claims description 2
- 239000008344 egg yolk phospholipid Substances 0.000 claims description 2
- 229940068998 egg yolk phospholipid Drugs 0.000 claims description 2
- -1 glyceride lipid Chemical class 0.000 claims description 2
- 150000004668 long chain fatty acids Chemical class 0.000 claims description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 claims description 2
- 150000003904 phospholipids Chemical class 0.000 claims description 2
- 235000005713 safflower oil Nutrition 0.000 claims description 2
- 239000003813 safflower oil Substances 0.000 claims description 2
- 235000012424 soybean oil Nutrition 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 description 11
- 150000003431 steroids Chemical class 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 230000003444 anaesthetic effect Effects 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 239000003193 general anesthetic agent Substances 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 229940124326 anaesthetic agent Drugs 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- USPYDUPOCUYHQL-NHRYOTLXSA-N (8r,9s,10s,13s,14s,17s)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC21 USPYDUPOCUYHQL-NHRYOTLXSA-N 0.000 description 1
- USPYDUPOCUYHQL-VEVMSBRDSA-N 5beta-dihydrodeoxycorticosterone Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 USPYDUPOCUYHQL-VEVMSBRDSA-N 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
- 241000906446 Theraps Species 0.000 description 1
- QRJOQYLXZPQQMX-FWROMSNXSA-N acetic acid [2-[(3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)COC(=O)C)[C@@]2(C)CC1=O QRJOQYLXZPQQMX-FWROMSNXSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- XWYBFXIUISNTQG-VKMGZQQJSA-N alfadolone Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@H]21 XWYBFXIUISNTQG-VKMGZQQJSA-N 0.000 description 1
- 229950008709 alfadolone Drugs 0.000 description 1
- 229950000888 alfadolone acetate Drugs 0.000 description 1
- 229960003305 alfaxalone Drugs 0.000 description 1
- 229940035674 anesthetics Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- NCGLTZSBTFVVAW-KNXRZYMVSA-N minaxolone Chemical compound C1[C@@H](N(C)C)[C@@H]2[C@@]3(C)C[C@H](OCC)[C@@H](O)C[C@@H]3CC[C@H]2[C@@H]2CC[C@H](C(C)=O)[C@]21C NCGLTZSBTFVVAW-KNXRZYMVSA-N 0.000 description 1
- 229960004798 minaxolone Drugs 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008389 polyethoxylated castor oil Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- BFQDICGJHAONBN-OOFWROCWSA-M sodium;4-[2-[(5r,8r,9s,10s,13s,14s,17s)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate Chemical compound [Na+].C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)COC(=O)CCC([O-])=O)[C@@H]4[C@@H]3CC[C@@H]21 BFQDICGJHAONBN-OOFWROCWSA-M 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000583 toxicological profile Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8600632A SE8600632D0 (sv) | 1986-02-13 | 1986-02-13 | Novel pharmaceutical composition |
Publications (4)
Publication Number | Publication Date |
---|---|
NO870560D0 NO870560D0 (no) | 1987-02-12 |
NO870560L NO870560L (no) | 1987-08-14 |
NO175040B true NO175040B (no) | 1994-05-16 |
NO175040C NO175040C (sv) | 1994-08-24 |
Family
ID=20363448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO870560A NO175040B (no) | 1986-02-13 | 1987-02-12 | Fremgangsmåte for fremstilling av et preparat for intravenös administrering av 3 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5028600A (sv) |
EP (1) | EP0233849B1 (sv) |
JP (1) | JPH0788305B2 (sv) |
AT (1) | ATE64526T1 (sv) |
CA (1) | CA1301651C (sv) |
DE (1) | DE3770830D1 (sv) |
DK (1) | DK175504B1 (sv) |
ES (1) | ES2037742T3 (sv) |
FI (1) | FI88676C (sv) |
GR (1) | GR3002299T3 (sv) |
HK (1) | HK83293A (sv) |
NO (1) | NO175040B (sv) |
SE (1) | SE8600632D0 (sv) |
SG (1) | SG102892G (sv) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9302295D0 (sv) * | 1993-07-02 | 1993-07-02 | Kabi Pharmacia Ab | New pharmaceutical composition |
US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
WO1999007381A1 (en) * | 1997-08-11 | 1999-02-18 | Weider Nutrition International, Inc. | Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors |
US20020155161A1 (en) * | 2000-12-29 | 2002-10-24 | Deckelbaum Richard J. | Use of IV emulsions with different triglyceride composition, particle size and apolipoprotein E for targeted tissue delivery of hydrophobic compounds |
KR101020687B1 (ko) * | 2002-07-02 | 2011-03-11 | 니코메드 게엠베하 | 사이클레소나이드 함유 멸균 수성 현탁액 |
PE20050941A1 (es) * | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
WO2006030450A2 (en) * | 2004-09-13 | 2006-03-23 | Bharat Serums & Vaccines Ltd. | Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy |
CN103491976B (zh) * | 2011-01-14 | 2015-04-01 | 卡思伯特·O·辛普金斯 | 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物 |
WO2013043985A1 (en) * | 2011-09-23 | 2013-03-28 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
CN104736158A (zh) | 2012-01-23 | 2015-06-24 | 萨奇治疗股份有限公司 | 神经活性类固醇制剂和治疗中枢神经系统障碍的方法 |
WO2014028398A2 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
RU2667010C2 (ru) | 2012-08-21 | 2018-09-13 | Сейдж Терапьютикс, Инк. | Способы лечения эпилепсии или эпилептического статуса |
EP4335505A3 (en) | 2012-11-30 | 2024-06-05 | The Regents of The University of California | Anticonvulsant activity of steroids |
JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
JP6838074B2 (ja) | 2016-03-08 | 2021-03-03 | セージ セラピューティクス, インコーポレイテッド | 神経刺激性ステロイド、組成物、およびその使用 |
US20220023314A1 (en) * | 2018-12-10 | 2022-01-27 | Halo Science LLC | Stable formulations of anesthetics and associated dosage forms |
EP4017498A4 (en) * | 2019-08-19 | 2022-11-09 | Arizona Board of Regents on behalf of the University of Arizona | TOPICAL NEUROSTEROID FORMULATIONS |
CN114344309B (zh) * | 2021-12-30 | 2024-02-06 | 南京迈诺威医药科技有限公司 | 一种别孕烷醇酮衍生物自乳化制剂及其制备方法 |
US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1215702B (de) * | 1962-07-03 | 1966-05-05 | Merck Ag E | Verfahren zur Herstellung von 1alpha-Alkylthio-3-keto-androstanen |
CA895860A (en) * | 1969-11-05 | 1972-03-21 | Kruger Gunther | PROCESS FOR THE PREPARATION OF 3.alpha.-HYDROXY-5.beta.-PREGNAN-20-ONE |
US3917830A (en) * | 1970-12-17 | 1975-11-04 | Glaxo Lab Ltd | Steroidal anaesthetic composition for intraveneous injection |
US3900561A (en) * | 1970-12-17 | 1975-08-19 | Glaxo Lab Ltd | Pharmaceutical compositions |
US4168308A (en) * | 1976-03-12 | 1979-09-18 | Apoteksvarucentralen Vitrum Ab | Composition for enhancing the administration of pharmacologically active agents |
JPS609726B2 (ja) * | 1980-05-15 | 1985-03-12 | 株式会社 ミドリ十字 | ステロイド製剤 |
JPS5716818A (en) * | 1981-04-25 | 1982-01-28 | Green Cross Corp:The | Steroid fatty emulsion |
JPS60258110A (ja) * | 1984-06-05 | 1985-12-20 | Daigo Eiyou Kagaku Kk | 静脈注射可能なプロゲステロン乳化注射液 |
-
1986
- 1986-02-13 SE SE8600632A patent/SE8600632D0/sv unknown
-
1987
- 1987-01-29 EP EP87850029A patent/EP0233849B1/en not_active Expired - Lifetime
- 1987-01-29 DE DE8787850029T patent/DE3770830D1/de not_active Expired - Fee Related
- 1987-01-29 ES ES198787850029T patent/ES2037742T3/es not_active Expired - Lifetime
- 1987-01-29 AT AT87850029T patent/ATE64526T1/de not_active IP Right Cessation
- 1987-02-06 DK DK198700621A patent/DK175504B1/da not_active IP Right Cessation
- 1987-02-12 CA CA000529609A patent/CA1301651C/en not_active Expired - Fee Related
- 1987-02-12 FI FI870589A patent/FI88676C/sv not_active IP Right Cessation
- 1987-02-12 JP JP62028395A patent/JPH0788305B2/ja not_active Expired - Fee Related
- 1987-02-12 NO NO870560A patent/NO175040B/no not_active IP Right Cessation
-
1989
- 1989-02-28 US US07/316,576 patent/US5028600A/en not_active Expired - Lifetime
-
1991
- 1991-07-11 GR GR91400996T patent/GR3002299T3/el unknown
-
1992
- 1992-10-07 SG SG1028/92A patent/SG102892G/en unknown
-
1993
- 1993-08-12 HK HK832/93A patent/HK83293A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SE8600632D0 (sv) | 1986-02-13 |
FI88676B (fi) | 1993-03-15 |
JPS62192322A (ja) | 1987-08-22 |
NO870560L (no) | 1987-08-14 |
DK62187A (da) | 1987-08-14 |
DK175504B1 (da) | 2004-11-15 |
EP0233849A1 (en) | 1987-08-26 |
FI870589A0 (fi) | 1987-02-12 |
SG102892G (en) | 1992-12-04 |
EP0233849B1 (en) | 1991-06-19 |
HK83293A (en) | 1993-08-20 |
DE3770830D1 (de) | 1991-07-25 |
FI88676C (sv) | 1993-06-28 |
ES2037742T3 (es) | 1993-07-01 |
NO870560D0 (no) | 1987-02-12 |
NO175040C (sv) | 1994-08-24 |
FI870589A (fi) | 1987-08-14 |
DK62187D0 (da) | 1987-02-06 |
CA1301651C (en) | 1992-05-26 |
GR3002299T3 (en) | 1992-12-30 |
JPH0788305B2 (ja) | 1995-09-27 |
ATE64526T1 (de) | 1991-07-15 |
US5028600A (en) | 1991-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO175040B (no) | Fremgangsmåte for fremstilling av et preparat for intravenös administrering av 3 | |
EP0850046B1 (en) | Microemulsions for use as vehicles for administration of active compounds | |
DE3853191T2 (de) | Arzneimittelträger. | |
US20110275705A1 (en) | Stable injectable oil-in-water docetaxel nanoemulsion | |
EP2252267B1 (de) | Lyophilisierte nanoemulsion | |
NO844144L (no) | Legemiddeltilberedning | |
WO2016124162A1 (zh) | 一种丙泮尼地药物组合物及其制备方法 | |
JP2019510048A (ja) | 週1回又は隔週1回の投与に適したリラグルチドの粘弾性ゲル | |
JPH09512794A (ja) | マラリアの治療用のハロファントリン遊離塩基および組成物 | |
EP0598116B1 (en) | Fat emulsion | |
KR100343272B1 (ko) | 생활성스테로이드를함유한약제학적에멀션 | |
EP0350864B1 (en) | Aqueous solution containing fat-soluble vitamin k | |
CN108653204B (zh) | 一种多烯磷脂酰胆碱注射液药物组合物及其制备方法 | |
WO2024056062A1 (zh) | 一种甾体类激素磷脂组合物及其制备方法 | |
JPH0422886B2 (sv) | ||
JPH0489430A (ja) | 低血圧維持剤 | |
MXPA96004611A (es) | Base libre de halogenofantrina para el tratamiento de malaria y composiciones |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |