NO171109C - Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske spiroforbindelser - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske spiroforbindelserInfo
- Publication number
- NO171109C NO171109C NO884406A NO884406A NO171109C NO 171109 C NO171109 C NO 171109C NO 884406 A NO884406 A NO 884406A NO 884406 A NO884406 A NO 884406A NO 171109 C NO171109 C NO 171109C
- Authority
- NO
- Norway
- Prior art keywords
- group
- formula
- atom
- alkyl
- chem
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25210487 | 1987-10-05 | ||
| JP28629787 | 1987-11-12 | ||
| JP8432788 | 1988-04-05 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO884406D0 NO884406D0 (no) | 1988-10-04 |
| NO884406L NO884406L (no) | 1989-04-06 |
| NO171109B NO171109B (no) | 1992-10-19 |
| NO171109C true NO171109C (no) | 1993-01-27 |
Family
ID=27304516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO884406A NO171109C (no) | 1987-10-05 | 1988-10-04 | Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske spiroforbindelser |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US4940795A (da) |
| EP (1) | EP0311313B1 (da) |
| JP (1) | JPH0236183A (da) |
| KR (1) | KR970007947B1 (da) |
| CN (1) | CN1036653C (da) |
| AT (1) | ATE122353T1 (da) |
| AU (1) | AU621559B2 (da) |
| CA (1) | CA1337817C (da) |
| DE (1) | DE3853758T2 (da) |
| DK (1) | DK554288A (da) |
| ES (1) | ES2074441T3 (da) |
| GR (1) | GR3016995T3 (da) |
| HU (1) | HU211687A9 (da) |
| NO (1) | NO171109C (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5412096A (en) * | 1987-10-05 | 1995-05-02 | Yamanouchi Pharmaceutical Co., Ltd. | Hydrochloride salts of heterocyclic spiro compounds |
| ES2074441T3 (es) * | 1987-10-05 | 1995-09-16 | Yamanouchi Pharma Co Ltd | Compuestos espiro heterociclicos y su preparacion. |
| US5594000A (en) * | 1989-06-21 | 1997-01-14 | Astra Ab | Spirofurane derivatives |
| US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
| US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| US5073560A (en) * | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
| IE914238A1 (en) * | 1990-12-19 | 1992-07-01 | Fisons Corp | Novel spirofurane derivatives |
| EP0590150B1 (en) * | 1991-05-15 | 1998-07-08 | Yamanouchi Pharmaceutical Co. Ltd. | (-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro 4,5]decane l-tartrate |
| ES2119174T3 (es) * | 1993-01-28 | 1998-10-01 | Merck & Co Inc | Azaciclos espiro-sustituidos como antagonistas de los receptores de las taquiquininas. |
| DE69318854T2 (de) * | 1993-03-04 | 1998-10-08 | Pfizer | Spiroazacyclischderivate als substanz p antagonisten |
| JP2983141B2 (ja) * | 1993-10-06 | 1999-11-29 | 株式会社三和化学研究所 | 新規化合物及び該化合物を有効成分とする脳機能改善剤 |
| EP0984970B1 (en) | 1997-05-30 | 2003-11-19 | Neurosearch A/S | Spiro-quinuclidine derivatives, their preparation and use |
| US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| CN1368848A (zh) * | 1999-08-13 | 2002-09-11 | 阿温提斯作物科学有限公司 | 用作农药的杂环螺环化合物 |
| US20030060487A1 (en) * | 2000-04-12 | 2003-03-27 | Bamdad R. Shoshana | Treatment of neurodegenerative disease |
| JP2003063964A (ja) * | 2001-08-28 | 2003-03-05 | Senju Pharmaceut Co Ltd | ドライアイまたはドライアイを伴なう疾病の予防治療剤 |
| EP1802258A4 (en) | 2004-09-13 | 2015-09-23 | Chrono Therapeutics Inc | BIOSYNCHRONE TRANSDERMAL MEDICINES |
| US20090082381A1 (en) * | 2005-07-26 | 2009-03-26 | Akiharu Isowaki | Percutaneously Absorbable Ophthalmic Preparation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| AU2006304787A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007104035A1 (en) * | 2006-03-08 | 2007-09-13 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| ITMI20061279A1 (it) * | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| AU2007299920A1 (en) * | 2006-09-19 | 2008-03-27 | Braincells, Inc. | PPAR Mediated Modulation of Neurogenesis |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| AU2007299726A1 (en) * | 2006-09-22 | 2008-03-27 | Braincells, Inc. | Combination comprising an HMG-COA reductase inhibitor and a second neurogenic agent for treating a nervous system disorder and increasing neurogenesis |
| CN101772346B (zh) | 2007-04-02 | 2014-05-07 | 帕金森氏病研究院 | 用于降低治疗副作用的方法和组合物 |
| RU2506266C2 (ru) * | 2009-01-26 | 2014-02-10 | Израэл Инститьют Фо Байолоджикал Рисерч | Бициклические гетероциклические спиросоединения |
| US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| ES2716049T3 (es) | 2012-07-13 | 2019-06-07 | Pain Therapeutics Inc | Un método para inhibir la fosforilación de tau |
| US9433604B2 (en) | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
| JP2018511355A (ja) | 2015-01-28 | 2018-04-26 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 薬剤送達方法及びシステム |
| JP2020503950A (ja) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | 経皮薬剤送達の装置及び方法 |
| AU2019279884A1 (en) | 2018-05-29 | 2020-12-10 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| CN115124545B (zh) * | 2022-08-31 | 2023-01-03 | 南京远淑医药科技有限公司 | 一种促性腺激素释放激素受体拮抗剂中间体的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3305556A (en) * | 1962-11-23 | 1967-02-21 | Pfizer & Co C | Novel hypoglycemic agents |
| NL124853C (da) * | 1963-07-19 | |||
| SU335944A1 (ru) * | 1970-12-15 | 1976-01-25 | Научно-исследовательский институт химии Саратовского государственного университета им.Н.Г.Чернышевского | Способ получени соединений р да 1-окса6-азаспиро(4,4)нонана |
| US3784551A (en) * | 1971-07-08 | 1974-01-08 | Yoshitomi Pharmaceutical | 2-oxo-1,4-dioxa-8-azaspiro (4.5) decanes and related compounds |
| GB1301254A (da) * | 1971-07-08 | 1972-12-29 | ||
| US3839273A (en) * | 1971-11-13 | 1974-10-01 | Sankyo Co | N-substituted piperidine derivatives, process for preparing the same and their use as stabilizers |
| SU434735A1 (ru) * | 1972-03-01 | 1975-12-15 | Научно-исследовательский институт химии Саратовского государственного университета им.Н.Г.Чернышевского | Способ получени 7-метил-(или 2,7диметил)-2-метокси- -пропионитрил1-окса-6-азаспиро-(4,4)-нонана |
| SU465399A1 (ru) * | 1973-07-19 | 1975-03-30 | Научно-исследовательский институт химии при Саратовском государственном университете им.Н.Г.Чернышевского | Способ получени натриевых солей 2-метокси- -карбоксиэтил-1-окса6-азаспиро-(4,4)-нонана |
| IL48452A (en) * | 1975-11-11 | 1979-07-25 | Purdue Frederick Co | Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them |
| US4321379A (en) * | 1981-01-28 | 1982-03-23 | American Cyanamid Company | 4-Aryl-1-oxa-8-azaspiro[4,5]dec-3-en-2-ones |
| SU1002294A1 (ru) * | 1981-08-14 | 1983-03-07 | Ордена Трудового Красного Знамени Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 2,2-Диалкил-3-тиа-8-азаспиро/5,5/ундеканы |
| EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
| US4855290A (en) * | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US4981858A (en) * | 1987-08-13 | 1991-01-01 | State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research | Optical isomers |
| ES2074441T3 (es) * | 1987-10-05 | 1995-09-16 | Yamanouchi Pharma Co Ltd | Compuestos espiro heterociclicos y su preparacion. |
| US5073560A (en) * | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
-
1988
- 1988-09-30 ES ES88309095T patent/ES2074441T3/es not_active Expired - Lifetime
- 1988-09-30 AT AT88309095T patent/ATE122353T1/de not_active IP Right Cessation
- 1988-09-30 DE DE3853758T patent/DE3853758T2/de not_active Expired - Lifetime
- 1988-09-30 EP EP88309095A patent/EP0311313B1/en not_active Expired - Lifetime
- 1988-10-03 CA CA000579193A patent/CA1337817C/en not_active Expired - Fee Related
- 1988-10-04 DK DK554288A patent/DK554288A/da not_active Application Discontinuation
- 1988-10-04 JP JP63251489A patent/JPH0236183A/ja active Granted
- 1988-10-04 NO NO884406A patent/NO171109C/no unknown
- 1988-10-05 US US07/254,375 patent/US4940795A/en not_active Ceased
- 1988-10-05 KR KR1019880012963A patent/KR970007947B1/ko not_active IP Right Cessation
- 1988-10-05 CN CN88109138A patent/CN1036653C/zh not_active Expired - Fee Related
- 1988-10-05 AU AU23449/88A patent/AU621559B2/en not_active Ceased
-
1990
- 1990-01-25 US US07/470,091 patent/US4996210A/en not_active Expired - Fee Related
- 1990-01-25 US US07/470,093 patent/US5041549A/en not_active Expired - Fee Related
-
1992
- 1992-07-07 US US07/909,639 patent/USRE34653E/en not_active Expired - Lifetime
-
1995
- 1995-06-30 HU HU95P/P00638P patent/HU211687A9/hu unknown
- 1995-08-02 GR GR950402111T patent/GR3016995T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK554288A (da) | 1989-05-26 |
| EP0311313A3 (en) | 1990-12-05 |
| NO884406D0 (no) | 1988-10-04 |
| JPH0544948B2 (da) | 1993-07-07 |
| NO171109B (no) | 1992-10-19 |
| ATE122353T1 (de) | 1995-05-15 |
| US5041549A (en) | 1991-08-20 |
| CA1337817C (en) | 1995-12-26 |
| DE3853758D1 (de) | 1995-06-14 |
| AU621559B2 (en) | 1992-03-19 |
| CN1033629A (zh) | 1989-07-05 |
| EP0311313A2 (en) | 1989-04-12 |
| NO884406L (no) | 1989-04-06 |
| EP0311313B1 (en) | 1995-05-10 |
| US4996210A (en) | 1991-02-26 |
| DE3853758T2 (de) | 1995-09-07 |
| US4940795A (en) | 1990-07-10 |
| ES2074441T3 (es) | 1995-09-16 |
| DK554288D0 (da) | 1988-10-04 |
| KR970007947B1 (ko) | 1997-05-19 |
| AU2344988A (en) | 1989-04-06 |
| KR890006649A (ko) | 1989-06-15 |
| JPH0236183A (ja) | 1990-02-06 |
| HU211687A9 (en) | 1995-12-28 |
| USRE34653E (en) | 1994-07-05 |
| CN1036653C (zh) | 1997-12-10 |
| GR3016995T3 (en) | 1995-11-30 |
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