ES8506314A1 - Procedimiento para preparar nuevas imidazo-(1,2-a)-pirimidinas - Google Patents

Procedimiento para preparar nuevas imidazo-(1,2-a)-pirimidinas

Info

Publication number
ES8506314A1
ES8506314A1 ES525186A ES525186A ES8506314A1 ES 8506314 A1 ES8506314 A1 ES 8506314A1 ES 525186 A ES525186 A ES 525186A ES 525186 A ES525186 A ES 525186A ES 8506314 A1 ES8506314 A1 ES 8506314A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
group
pyrimidines
imidazo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525186A
Other languages
English (en)
Other versions
ES525186A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838303612A external-priority patent/GB8303612D0/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES8506314A1 publication Critical patent/ES8506314A1/es
Publication of ES525186A0 publication Critical patent/ES525186A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR NUEVAS IMIDAZO-1,2-A-PIRIMIDINAS.COMPRENDE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), PARA OBTENER UN COMPUESTO DE FORMULA (IV), Y CICLISAR ESTE COMPUESTO PARA OBTENER NUEVAS IMIDAZO-1,2-A-PIRIMIDINAS DE FORMULA (I) EN DONDE R REPRESENTA UN GRUPO ALQUILO DE CADENA LINEAL DE C 1 A 8, UN GRUPO ALQUENILO DE CADENA LINEAL DE C 2 A 8 Y OTROS; R1 Y R2 PUEDEN SER IGUALES O DIFERENTES Y REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE H, UN GRUPO ALQUILO DE CADENA LINEAL DE C 1 A 8, UN GRUPO ALQUENILO DE CADENA LINEAL DE C 2 A 5, UN GRUPO CICLOALQUILO DE C 3 A 7 Y OTROS; X REPRESENTA UN ATOMO DE OXIGENO O AZUFRE; Y R3 REPRESENTA UN GRUPO ALQUILO DE C 1 A 5. LA REACCION SE EFECTUA A TEMPERATURA AMBIENTE.
ES525186A 1982-08-27 1983-08-26 Procedimiento para preparar nuevas imidazo-(1,2-a)-pirimidinas Granted ES525186A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8224606 1982-08-27
GB838303612A GB8303612D0 (en) 1983-02-09 1983-02-09 Imidazo 1,2-a pyrimidines

Publications (2)

Publication Number Publication Date
ES8506314A1 true ES8506314A1 (es) 1985-07-01
ES525186A0 ES525186A0 (es) 1985-07-01

Family

ID=26283682

Family Applications (1)

Application Number Title Priority Date Filing Date
ES525186A Granted ES525186A0 (es) 1982-08-27 1983-08-26 Procedimiento para preparar nuevas imidazo-(1,2-a)-pirimidinas

Country Status (19)

Country Link
US (2) US4532243A (es)
EP (1) EP0104104B1 (es)
KR (1) KR890003000B1 (es)
AR (1) AR241020A1 (es)
AU (1) AU559419B2 (es)
CA (1) CA1228589A (es)
DD (1) DD215550A5 (es)
DE (1) DE3366467D1 (es)
DK (1) DK390583A (es)
ES (1) ES525186A0 (es)
FI (1) FI74010C (es)
GB (1) GB2128989B (es)
GR (1) GR79375B (es)
IE (1) IE55900B1 (es)
IL (1) IL69417A (es)
NZ (1) NZ205387A (es)
PH (1) PH20037A (es)
PT (1) PT77258B (es)
SU (1) SU1287752A3 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
GB8334210D0 (en) * 1983-12-22 1984-02-01 Roussel Lab Ltd Imidazo(1 2-c)pyrimidines
GB8432073D0 (en) * 1984-12-19 1985-01-30 Roussel Lab Ltd Chemical compounds
GB8613591D0 (en) * 1986-06-04 1986-07-09 Roussel Lab Ltd Chemical compounds
GB8620060D0 (en) * 1986-08-18 1986-10-01 Roussel Lab Ltd Chemical compounds
US4731446A (en) * 1987-05-01 1988-03-15 The Dow Chemical Company Imidazo[1,2-a]pyrimidine sulfonic acids and acid halides
GB8712466D0 (en) * 1987-05-27 1987-07-01 Roussel Lab Ltd Chemical compounds
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
US5302586A (en) * 1991-12-19 1994-04-12 G. D. Searle & Co. Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury
RU2003126188A (ru) * 2001-01-26 2005-03-27 Бристол-Маерс Сквибб Компани (Us) Имидазолильные производные как ингибиторы кортикотропин-рилизинг фактора

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
FR2502622A1 (fr) * 1981-03-25 1982-10-01 Synthelabo Derives d'imidazo (1,2-a) pyrimidines, leur preparation et leur application en therapeutique
US4374988A (en) * 1981-11-05 1983-02-22 American Cyanamid Company 4-Heteroarylimidazo-[1,5-A]pyrimidines
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL69417A0 (en) 1983-11-30
PH20037A (en) 1986-09-04
IL69417A (en) 1987-12-20
AR241020A1 (es) 1991-04-30
DE3366467D1 (en) 1986-10-30
AU559419B2 (en) 1987-03-12
PT77258B (en) 1986-03-21
US4532243A (en) 1985-07-30
GB8322993D0 (en) 1983-09-28
DK390583A (da) 1984-02-28
IE55900B1 (en) 1991-02-14
SU1287752A3 (ru) 1987-01-30
ES525186A0 (es) 1985-07-01
KR840005812A (ko) 1984-11-19
AR241020A2 (es) 1991-04-30
FI833055A (fi) 1984-02-28
FI74010B (fi) 1987-08-31
PT77258A (en) 1983-09-01
AU1846183A (en) 1984-03-01
GB2128989B (en) 1986-03-19
EP0104104B1 (fr) 1986-09-24
US4588720A (en) 1986-05-13
IE832001L (en) 1984-02-27
KR890003000B1 (ko) 1989-08-18
GR79375B (es) 1984-10-22
NZ205387A (en) 1986-06-11
EP0104104A1 (fr) 1984-03-28
FI74010C (fi) 1987-12-10
FI833055A0 (fi) 1983-08-26
DD215550A5 (de) 1984-11-14
CA1228589A (en) 1987-10-27
DK390583D0 (da) 1983-08-26
GB2128989A (en) 1984-05-10

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506