DE3366467D1 - Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them - Google Patents

Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them

Info

Publication number
DE3366467D1
DE3366467D1 DE8383401696T DE3366467T DE3366467D1 DE 3366467 D1 DE3366467 D1 DE 3366467D1 DE 8383401696 T DE8383401696 T DE 8383401696T DE 3366467 T DE3366467 T DE 3366467T DE 3366467 D1 DE3366467 D1 DE 3366467D1
Authority
DE
Germany
Prior art keywords
pyrimidines
imidazo
medicaments
intermediates
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383401696T
Other languages
English (en)
Inventor
Wilfred Roger Tully
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838303612A external-priority patent/GB8303612D0/en
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of DE3366467D1 publication Critical patent/DE3366467D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8383401696T 1982-08-27 1983-08-23 Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them Expired DE3366467D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8224606 1982-08-27
GB838303612A GB8303612D0 (en) 1983-02-09 1983-02-09 Imidazo 1,2-a pyrimidines

Publications (1)

Publication Number Publication Date
DE3366467D1 true DE3366467D1 (en) 1986-10-30

Family

ID=26283682

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383401696T Expired DE3366467D1 (en) 1982-08-27 1983-08-23 Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them

Country Status (19)

Country Link
US (2) US4532243A (de)
EP (1) EP0104104B1 (de)
KR (1) KR890003000B1 (de)
AR (1) AR241020A1 (de)
AU (1) AU559419B2 (de)
CA (1) CA1228589A (de)
DD (1) DD215550A5 (de)
DE (1) DE3366467D1 (de)
DK (1) DK390583A (de)
ES (1) ES525186A0 (de)
FI (1) FI74010C (de)
GB (1) GB2128989B (de)
GR (1) GR79375B (de)
IE (1) IE55900B1 (de)
IL (1) IL69417A (de)
NZ (1) NZ205387A (de)
PH (1) PH20037A (de)
PT (1) PT77258B (de)
SU (1) SU1287752A3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them
GB8334210D0 (en) * 1983-12-22 1984-02-01 Roussel Lab Ltd Imidazo(1 2-c)pyrimidines
GB8432073D0 (en) * 1984-12-19 1985-01-30 Roussel Lab Ltd Chemical compounds
GB8613591D0 (en) * 1986-06-04 1986-07-09 Roussel Lab Ltd Chemical compounds
GB8620060D0 (en) * 1986-08-18 1986-10-01 Roussel Lab Ltd Chemical compounds
US4731446A (en) * 1987-05-01 1988-03-15 The Dow Chemical Company Imidazo[1,2-a]pyrimidine sulfonic acids and acid halides
GB8712466D0 (en) * 1987-05-27 1987-07-01 Roussel Lab Ltd Chemical compounds
GB8719368D0 (en) * 1987-08-15 1987-09-23 Wellcome Found Heterocyclic compounds
US5302586A (en) * 1991-12-19 1994-04-12 G. D. Searle & Co. Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury
RU2003126188A (ru) * 2001-01-26 2005-03-27 Бристол-Маерс Сквибб Компани (Us) Имидазолильные производные как ингибиторы кортикотропин-рилизинг фактора

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594379A (en) * 1968-09-16 1971-07-20 Sandoz Ag 2,3-dihydroimidazo(1,2-c)quinazolines
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
FR2502622A1 (fr) * 1981-03-25 1982-10-01 Synthelabo Derives d'imidazo (1,2-a) pyrimidines, leur preparation et leur application en therapeutique
US4374988A (en) * 1981-11-05 1983-02-22 American Cyanamid Company 4-Heteroarylimidazo-[1,5-A]pyrimidines
IL69417A (en) * 1982-08-27 1987-12-20 Roussel Uclaf 2-acyl imidazo(1,2-a)pyrimidines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL69417A0 (en) 1983-11-30
PH20037A (en) 1986-09-04
IL69417A (en) 1987-12-20
AR241020A1 (es) 1991-04-30
AU559419B2 (en) 1987-03-12
PT77258B (en) 1986-03-21
US4532243A (en) 1985-07-30
GB8322993D0 (en) 1983-09-28
DK390583A (da) 1984-02-28
IE55900B1 (en) 1991-02-14
ES8506314A1 (es) 1985-07-01
SU1287752A3 (ru) 1987-01-30
ES525186A0 (es) 1985-07-01
KR840005812A (ko) 1984-11-19
AR241020A2 (es) 1991-04-30
FI833055A (fi) 1984-02-28
FI74010B (fi) 1987-08-31
PT77258A (en) 1983-09-01
AU1846183A (en) 1984-03-01
GB2128989B (en) 1986-03-19
EP0104104B1 (de) 1986-09-24
US4588720A (en) 1986-05-13
IE832001L (en) 1984-02-27
KR890003000B1 (ko) 1989-08-18
GR79375B (de) 1984-10-22
NZ205387A (en) 1986-06-11
EP0104104A1 (de) 1984-03-28
FI74010C (fi) 1987-12-10
FI833055A0 (fi) 1983-08-26
DD215550A5 (de) 1984-11-14
CA1228589A (en) 1987-10-27
DK390583D0 (da) 1983-08-26
GB2128989A (en) 1984-05-10

Similar Documents

Publication Publication Date Title
DE3166531D1 (en) Imidazo(1,2-a)pyridines, processes for their preparation and pharmaceutical compositions containing them
DE3269604D1 (en) Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
EP0094742A3 (en) Substituted azabicyclo compounds, process for their preparation, pharmaceutical compositions containing them, and their use
IL68133A0 (en) Substituted 1h-pyrazolo(1,5-a)pyrimidines,their preparation and pharmaceutical compositions containing them
IL70522A (en) Derivatives of 5-oxo-5h-1,3,4-thiadiazolo(3,2-a)-pyrimidine-6-carboxamide,their preparation and pharmaceutical compositions containing them
IL68442A0 (en) Imidazo(1,2-a)pyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3366467D1 (en) Imidazo(1,2-a)pyrimidines and their salts, process and intermediates for their preparation, their use as medicaments and compositions containing them
IL69140A0 (en) 2,3,6,7-tetrahydro-5h-thiazolo(3,2-a)pyrimidine derivatives,their preparation and their use as herbicides
EP0018139A3 (en) Pyrido (2,3-d) pyrimidine derivatives, their use, pharmaceutical compositions containing them, processes for preparing the pyrido (2,3-d) pyrimidine derivatives and intermediates useful in the processes
IL70485A (en) Imidazo(1,5-a)pyridine derivatives,their preparation and pharmaceutical compositions containing them
IL65337A0 (en) Imidazo(1,2-a)pyrimidine derivatives,their preparation and pharmaceutical compositions containing them
DE3374404D1 (en) Trans-4-aminobenz(c,d)indol-5-ol derivatives, their salts, their preparation, their use as medicaments and compositions containing them
IL59802A0 (en) Substituted pyrido (1,2-a) pyrimidines,their preparation and pharmaceutical compositions containing them
IL66101A (en) Substituted imidazo(1,5-a)pyridines,their manufacture and pharmaceutical compositions containing them
IL76019A0 (en) Imidazo(1,2-a)quinoline derivatives,their preparation and pharmaceutical compositions containing them
IL66111A0 (en) Imidazo(1,2-a)pyrimidines and salts thereof,their preparation and pharmaceutical compositions containing them
IL67720A (en) Substituted 1,3,4-thiadiazolo(3,2-a)-pyrimidines,their preparation and pharmaceutical compositions containing them
PT71211A (en) Process for the preparation of 3-substituted-tetrahydropyrrolo/1,2-a/pyrimidines and pharmaceutical compositions containing the same and new 3-substituted-tetrahydro-pyrrolo/1,2-a/ pyrimidines
IL56132A (en) 9-amino-4h-pyrido(1,2-a)pyrimidin-4-one compounds,their preparation and pharmaceutical compositions containing them
IL70651A (en) 7-(2-arylethenyl)-5-oxo-5h-thiazolo(3,2-a)pyrimidine-2-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
ZA831611B (en) Substituted 1h-pyrazolo(1,5-a)pyrimidines and process for their preparation
PT76609B (en) Process for the preparation of condensed cycloaliphatic derivatives of substituted pyrido <1,2-a> pyrimidines and of pharmaceutical compositions containing the same
IL70007A (en) 4,6,7,8,9,10-hexahydro-2,3-polymethylene azepino(1,2-a)pyrimidine-4-one derivatives and acid addition salts thereof and pharmaceutical compositions containing them
IL66112A0 (en) 1-substituted imidazo(1,2-a)imidazoles and salts thereof,their preparation and pharmaceutical compositions containing them
DE3062935D1 (en) Pyrido (2,3-d) pyrimidine derivatives, pharmaceutical compositions containing them and processes for preparing the pyrido (2,3-d) pyrimidine derivatives

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee