NO165540C - Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n,n-dimetyl-1-(1-(4-klorfenyl)cyklobutyl)-3-metylbutylamin-hydroklorid-monohydrat. - Google Patents

Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n,n-dimetyl-1-(1-(4-klorfenyl)cyklobutyl)-3-metylbutylamin-hydroklorid-monohydrat.

Info

Publication number
NO165540C
NO165540C NO865093A NO865093A NO165540C NO 165540 C NO165540 C NO 165540C NO 865093 A NO865093 A NO 865093A NO 865093 A NO865093 A NO 865093A NO 165540 C NO165540 C NO 165540C
Authority
NO
Norway
Prior art keywords
cyclobutyl
dimethyl
chlorphenyl
preparing
active compound
Prior art date
Application number
NO865093A
Other languages
English (en)
Norwegian (no)
Other versions
NO865093L (no
NO865093D0 (no
NO165540B (no
Inventor
James Edward Jeffery
Derek Whybrow
Original Assignee
Boots Co Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10589895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO165540(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boots Co Plc filed Critical Boots Co Plc
Publication of NO865093D0 publication Critical patent/NO865093D0/no
Publication of NO865093L publication Critical patent/NO865093L/no
Publication of NO165540B publication Critical patent/NO165540B/no
Publication of NO165540C publication Critical patent/NO165540C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO865093A 1985-12-17 1986-12-16 Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n,n-dimetyl-1-(1-(4-klorfenyl)cyklobutyl)-3-metylbutylamin-hydroklorid-monohydrat. NO165540C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858531071A GB8531071D0 (en) 1985-12-17 1985-12-17 Therapeutic compound

Publications (4)

Publication Number Publication Date
NO865093D0 NO865093D0 (no) 1986-12-16
NO865093L NO865093L (no) 1987-06-18
NO165540B NO165540B (no) 1990-11-19
NO165540C true NO165540C (no) 1991-02-27

Family

ID=10589895

Family Applications (2)

Application Number Title Priority Date Filing Date
NO865093A NO165540C (no) 1985-12-17 1986-12-16 Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n,n-dimetyl-1-(1-(4-klorfenyl)cyklobutyl)-3-metylbutylamin-hydroklorid-monohydrat.
NO2005022C NO2005022I1 (no) 1985-12-17 2005-09-14 N-Dimetyl-1-(1-(4-klorfenyl)cyklobutylÜ-3-metylbutylamin (sibutramin hydroklorid)

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2005022C NO2005022I1 (no) 1985-12-17 2005-09-14 N-Dimetyl-1-(1-(4-klorfenyl)cyklobutylÜ-3-metylbutylamin (sibutramin hydroklorid)

Country Status (34)

Country Link
US (2) US4929629A (el)
EP (1) EP0230742B1 (el)
JP (1) JPS62155240A (el)
KR (1) KR940008913B1 (el)
CN (1) CN1016245B (el)
AT (1) ATE56942T1 (el)
AU (1) AU601167B2 (el)
CA (1) CA1266278A (el)
CS (1) CS259545B2 (el)
DD (1) DD263050A5 (el)
DE (1) DE3674570D1 (el)
DK (1) DK170770B1 (el)
EG (1) EG17770A (el)
ES (1) ES2018163T4 (el)
FI (1) FI90413C (el)
GB (1) GB8531071D0 (el)
GE (1) GEP19970812B (el)
GR (1) GR3001069T3 (el)
HU (1) HU201901B (el)
IE (1) IE59429B1 (el)
IL (1) IL80934A (el)
IN (1) IN163129B (el)
LU (1) LU90865I2 (el)
MX (1) MX4684A (el)
NL (1) NL300065I1 (el)
NO (2) NO165540C (el)
NZ (1) NZ218578A (el)
PH (1) PH22481A (el)
PL (1) PL149519B1 (el)
PT (1) PT83958B (el)
SU (1) SU1443796A3 (el)
UA (1) UA7206A1 (el)
YU (1) YU46033B (el)
ZA (1) ZA869078B (el)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
EP0647134A4 (en) * 1992-06-23 1997-07-30 Sepracor Inc METHODS AND COMPOSITIONS USED TO TREAT DEPRESSION AND OTHER CONDITIONS WITH OPTICALLY PURE SIBUTRAMINE (-).
EP0708639A4 (en) * 1992-06-23 1997-08-20 Sepracor Inc METHOD AND COMPOSITIONS FOR TREATMENT OF DEPRESSION AND OTHER DISEASES USING OPTICALLY PURE SIBUTTRAMINE
US5459164A (en) * 1994-02-03 1995-10-17 Boots Pharmaceuticals, Inc. Medical treatment
DE4443891A1 (de) * 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
GB9619757D0 (en) 1996-09-21 1996-11-06 Knoll Ag Chemical process
GB9619961D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9619962D0 (en) * 1996-09-25 1996-11-13 Knoll Ag Medical treatment
GB9727131D0 (en) 1997-12-24 1998-02-25 Knoll Ag Therapeutic agents
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en) * 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6974838B2 (en) * 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
US6331571B1 (en) * 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6696495B2 (en) 1998-12-02 2004-02-24 Snowden Pharmaceuticals, Llc Treatment of disorders secondary to organic impairments
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
BR0007633A (pt) * 1999-01-20 2002-01-02 Knoll Pharmaceutical Co Processo para ajudar a parar de fumar
BG65170B1 (bg) * 1999-03-17 2007-05-31 Knoll Gmbh Използване на n-заместени производни на 1-[1-(4-хлорофенил)циклобутил]-3-метилбутиламин за производство на лекарство за лечение на разстройства при храненето
MXPA01009461A (es) * 1999-03-19 2004-03-19 Abbott Gmbh & Co Kg Tratamiento de osteoartritis.
US6441046B1 (en) 1999-03-19 2002-08-27 Abbott Gmbh & Co. Kg Control of metabolism
US6376551B1 (en) 1999-03-19 2002-04-23 Knoll Pharmaceutical Company Treatment of chronic fatigue syndrome
WO2000056321A1 (en) 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of hyperactivity disorders
WO2000056315A1 (en) * 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of pain
US6433020B1 (en) 1999-03-19 2002-08-13 Knoll Pharmaceutical Company Treatment of cardiovascular disease
WO2000056319A1 (en) 1999-03-19 2000-09-28 Knoll Pharmaceutical Company Treatment of orthostatic hypotension
PL359467A1 (en) * 1999-03-19 2004-08-23 Knoll Gmbh Method of treating sleep apnoea
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
US6803387B1 (en) 1999-03-19 2004-10-12 Abbott Gmbh & Co. Kg Treatment of neuropathic pain or fibromyalgia
AU3894600A (en) 1999-03-19 2000-10-09 Knoll Pharmaceutical Company Method of treating sexual dysfunction
PL351958A1 (en) * 1999-03-19 2003-07-14 Knoll Gmbh Treatment of some tumours associated with gain in weight
US6403650B1 (en) 1999-03-19 2002-06-11 Knoll Pharmaceutical Company Treatment of pulmonary hypertension
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US6380200B1 (en) 1999-12-07 2002-04-30 Pfizer, Inc. Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
PE20011065A1 (es) 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US6232347B1 (en) 2000-03-17 2001-05-15 Knoll Pharmaceutical Company Treatment of osteoarthritis
WO2002083631A1 (en) * 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
JP3813152B2 (ja) * 2002-03-12 2006-08-23 メルク エンド カムパニー インコーポレーテッド 置換アミド類
KR100536750B1 (ko) * 2002-10-05 2005-12-16 한미약품 주식회사 시부트라민 메탄술폰산염의 결정성 반수화물을 포함하는약학 조성물
CA2501321C (en) * 2002-10-05 2008-07-08 Hanmi Pharm. Co., Ltd. Pharmaceutical composition comprising crystalline sibutramine methanesulfonate hemihydrate
US20040122033A1 (en) * 2002-12-10 2004-06-24 Nargund Ravi P. Combination therapy for the treatment of obesity
GB0310361D0 (en) * 2003-05-06 2003-06-11 Cipla Ltd Pharmaceutical compound
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
AP2007003979A0 (en) * 2004-11-23 2007-06-30 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
EP1846359A4 (en) 2005-01-06 2010-03-31 Cj Cheiljedang Corp INORGANIC ACID SALTS OF SIBUTRAMINE
US8283312B2 (en) * 2005-02-04 2012-10-09 The Research Foundation Of State University Of New York Compositions and methods for modulating body weight and treating obesity-related disorders
KR100781882B1 (ko) * 2005-07-12 2007-12-05 주식회사유한양행 시부트라민을 함유하는 약제학적 조성물
CA2617654A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
EP1938811A4 (en) * 2005-09-22 2008-12-17 Eisai R&D Man Co Ltd MEDICAL COMPOSITION FOR THE TREATMENT OF BULAMINE AND BULAMIC DEPRESSIONS
US8911751B2 (en) * 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EA200801738A1 (ru) * 2006-02-23 2008-12-30 Пфайзер Лимитед Пиперидиноилпирролидиновые агонисты меланокортинового рецептора 4 типа
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
EP2066329B1 (en) 2006-09-15 2017-09-06 Reviva Pharmaceuticals, Inc. Synthesis, methods of using, and compositions of cyclobutylmethylamines
KR20090064478A (ko) 2006-11-13 2009-06-18 화이자 프로덕츠 인크. 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도
AU2007323193A1 (en) * 2006-11-20 2008-05-29 Glenmark Pharmaceuticals S.A. Acetylene derivatives as Stearoyl CoA Desaturase inhibitors
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US20080221057A1 (en) * 2007-02-16 2008-09-11 Wyeth Secreted protein ccdc80 regulates adipocyte differentiation
WO2008124122A1 (en) * 2007-04-09 2008-10-16 Scidose, Llc Combinations of statins and anti-obesity agent and glitazones
AP2009005026A0 (en) * 2007-04-09 2009-12-31 Scidose Llc Combinations of statins and anti-obesity agent
WO2009037542A2 (en) 2007-09-20 2009-03-26 Glenmark Pharmaceuticals, S.A. Spirocyclic compounds as stearoyl coa desaturase inhibitors
JP5530438B2 (ja) * 2008-08-06 2014-06-25 ファイザー・リミテッド Ｍｃ４作動薬としてのジアゼピンおよびジアゾカン化合物
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
US20120053172A1 (en) 2009-02-12 2012-03-01 Cooperatieve Mirzorg U.A. Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
ME02016B (me) 2009-11-02 2015-05-20 Pfizer Derivati dioksabiciklo[3.2.1]oktan-2,3,4-triola
US20120070465A1 (en) 2010-03-29 2012-03-22 Astellas Pharma Inc. Pharmaceutical composition for modified release
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
AU2011275547B2 (en) 2010-07-06 2015-10-29 Astrazeneca Ab Therapeutic agents 976
EP3400944B1 (en) 2010-11-04 2020-07-15 Albireo AB Ibat inhibitors for the treatment of liver diseases
AU2011326872C1 (en) 2010-11-08 2015-02-19 Albireo Ab A pharmaceutical combination comprising an IBAT inhibitor and a bile acid binder
UY34194A (es) 2011-07-15 2013-02-28 Astrazeneca Ab ?(3-(4-(espiroheterocíclico)metil)fenoxi)azetidin-1-il)(5-(fenil)-1,3,4-oxadiazol-2-il)metanona en el tratamiento de la obesidad?
EP2890370B1 (en) 2012-08-31 2019-10-09 The Regents of the University of California Agents useful for treating obesity, diabetes and related disorders
CN110372522B (zh) * 2019-07-30 2020-10-02 南京工业大学 一种从含有戊二胺的固相中汽提回收戊二胺的方法
US12097189B1 (en) 2024-02-09 2024-09-24 Astellas Pharma Inc. Pharmaceutical composition for modified release

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1124485B (de) * 1960-02-12 1962-03-01 Hoechst Ag Verfahren zur Herstellung von analeptisch wirksamen Phenylcycloalkylmethylaminen
SE7600674L (sv) * 1975-02-05 1976-08-06 Rohm & Haas Fungicider
ZA821577B (en) * 1981-04-06 1983-03-30 Boots Co Plc Therapeutic agents
US4443449A (en) * 1981-04-06 1984-04-17 The Boots Company Limited Arylcyclobutylalkylamines and anti-depression composition and methods using same
IE52768B1 (en) * 1981-04-06 1988-02-17 Boots Co Ltd 1-arylcyclobutylalkylamine compounds useful as therapeutic agents
GB2115409B (en) * 1982-02-24 1985-08-07 Zyma Sa Novel crystal modifications of (+)-catechin
DK101683A (da) * 1982-03-12 1983-09-13 Duphar Int Res Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf
ZA836848B (en) * 1982-09-30 1984-05-30 Boots Co Plc Therapeutic agents
IE56001B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylmethylamine compounds
IE56000B1 (en) * 1982-09-30 1991-03-13 Boots Co Plc 1-arylcyclobutylalkylamine compounds
GB8501192D0 (en) * 1985-01-17 1985-02-20 Boots Co Plc Therapeutic agents
GB8704777D0 (en) * 1987-02-28 1987-04-01 Boots Co Plc Medical treatment
JP2675573B2 (ja) * 1988-03-31 1997-11-12 科研製薬株式会社 脳機能改善剤
IE61928B1 (en) * 1988-11-29 1994-11-30 Boots Co Plc Treatment of obesity

Also Published As

Publication number Publication date
NZ218578A (en) 1989-04-26
FI865030A0 (fi) 1986-12-10
ES2018163B3 (es) 1991-04-01
UA7206A1 (uk) 1995-06-30
US4929629A (en) 1990-05-29
AU6644286A (en) 1987-06-18
PH22481A (en) 1988-09-12
CS930586A2 (en) 1988-02-15
EP0230742B1 (en) 1990-09-26
IE59429B1 (en) 1994-02-23
CN1016245B (zh) 1992-04-15
YU205086A (en) 1987-12-31
NO865093L (no) 1987-06-18
GEP19970812B (en) 1997-02-10
GB8531071D0 (en) 1986-01-29
HU201901B (en) 1991-01-28
FI90413C (fi) 1994-02-10
ES2018163T4 (es) 2012-06-14
PL263020A1 (en) 1988-05-12
DK585786D0 (da) 1986-12-05
JPH0144176B2 (el) 1989-09-26
ZA869078B (en) 1987-07-29
EP0230742A1 (en) 1987-08-05
JPS62155240A (ja) 1987-07-10
DD263050A5 (de) 1988-12-21
SU1443796A3 (ru) 1988-12-07
KR940008913B1 (ko) 1994-09-28
US5068440A (en) 1991-11-26
NO865093D0 (no) 1986-12-16
NL300065I1 (nl) 2001-12-01
MX4684A (es) 1993-12-01
DK170770B1 (da) 1996-01-15
YU46033B (sh) 1992-12-21
CA1266278A (en) 1990-02-27
IE863102L (en) 1987-06-17
PT83958B (pt) 1989-05-12
NO2005022I1 (no) 2005-10-03
IN163129B (el) 1988-08-13
HUT45964A (en) 1988-09-28
GR3001069T3 (en) 1992-03-20
PT83958A (en) 1987-01-01
FI90413B (fi) 1993-10-29
DE3674570D1 (de) 1990-10-31
LU90865I2 (fr) 2002-02-18
NO165540B (no) 1990-11-19
ATE56942T1 (de) 1990-10-15
IL80934A (en) 1990-07-26
PL149519B1 (en) 1990-02-28
CN86108547A (zh) 1987-08-19
AU601167B2 (en) 1990-09-06
FI865030L (fi) 1987-06-18
KR870005961A (ko) 1987-07-08
CS259545B2 (en) 1988-10-14
DK585786A (da) 1987-06-18
EG17770A (en) 1991-03-30

Similar Documents

Publication Publication Date Title
NO165540C (no) Analogifremgangsmaate for fremstilling av den terapeutisk aktive forbindelse n,n-dimetyl-1-(1-(4-klorfenyl)cyklobutyl)-3-metylbutylamin-hydroklorid-monohydrat.
KR900701261A (ko) 비만증 치료방법
ATA84882A (de) Therapeutisches abgabesystem zur verabreichung eines wirkstoffes durch die haut
GEP20063773B (en) Steroid Sulphatase Inhibitors
SE8504720L (sv) Ny lekemedelsberedning
DE3464333D1 (en) Use of a salt of the acid n-acetyl (alpha, beta) aspartylglutamic for the manufacture of a drug having an anti-allergic activity for local administration
DE3361609D1 (en) New n-((2-oxo-1-pyrrolidinyl)acetyl)piperazines, the methods of producing such new compounds and their salts as well as pharmaceutical preparations for therapeutic use containing these compounds or salts
IT8448983A0 (it) Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
DK211489A (da) Farmaceutisk praeparat
GR3001862T3 (en) Pharmaceutical preparation for tinea pedis
FR2244481A1 (en) Oral treatment of diabetes - with a complex of glibenclamide and phenformin
DE3751597D1 (de) Verwendung von 15-Deoxyspergualin als Arzneimittel.
WO1987003590A1 (fr) Medicament pour le traitement des maladies du foie
ES2042715T3 (es) Remedio medico veterinario y humano que tiene una actividad antivirial y antitumoral que contiene 2,6-diamino-3-fenil-azo-piridina.
SE8702227D0 (sv) New use

Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: REDUCTIL KAPSEL, HARD 10MG REDUCTIL KAPSEL, HARD 15MG; NAT. REG. NO/DATE: 99/2894,99/2895 20021202; FIRST REG. NO/DATE: LI , IKS54770 19990113

Spc suppl protection certif: 2005022

Filing date: 20050914

MK1K Patent expired