NO165105C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer.Info
- Publication number
- NO165105C NO165105C NO852063A NO852063A NO165105C NO 165105 C NO165105 C NO 165105C NO 852063 A NO852063 A NO 852063A NO 852063 A NO852063 A NO 852063A NO 165105 C NO165105 C NO 165105C
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- piperazinyl
- cyclopropyl
- dihydro
- oxo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843420798 DE3420798A1 (de) | 1984-06-04 | 1984-06-04 | 7-(3-aryl-l-piperazinyl)- sowie 7-(3-cyclohexyl-l-piperazinyl)-3-chinoloncarbonsaeuren |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO852063L NO852063L (no) | 1985-12-05 |
| NO165105B NO165105B (no) | 1990-09-17 |
| NO165105C true NO165105C (no) | 1990-12-27 |
Family
ID=6237597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO852063A NO165105C (no) | 1984-06-04 | 1985-05-23 | Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-cyklopropyl-6-fluor-1,4-dihydro-4-okso-7-(1-piperazinyl)-3-kinolinkarboksylsyrer. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4599334A (no) |
| EP (1) | EP0169993B1 (no) |
| JP (2) | JPS611683A (no) |
| KR (1) | KR920000759B1 (no) |
| AT (1) | ATE39488T1 (no) |
| AU (1) | AU571333B2 (no) |
| CA (1) | CA1248954A (no) |
| DD (1) | DD240016A5 (no) |
| DE (2) | DE3420798A1 (no) |
| DK (1) | DK162527C (no) |
| ES (3) | ES8607294A1 (no) |
| FI (1) | FI82041C (no) |
| GR (1) | GR851314B (no) |
| HU (1) | HU194866B (no) |
| IE (1) | IE57814B1 (no) |
| IL (1) | IL75370A (no) |
| NO (1) | NO165105C (no) |
| NZ (1) | NZ212271A (no) |
| PH (1) | PH22492A (no) |
| PT (1) | PT80580B (no) |
| ZA (1) | ZA854168B (no) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5468861A (en) * | 1984-06-04 | 1995-11-21 | Bayer Aktiengesellschaft | 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof |
| DE3420743A1 (de) * | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| JPS6259263A (ja) * | 1985-09-10 | 1987-03-14 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
| JPH0637489B2 (ja) * | 1985-09-21 | 1994-05-18 | 杏林製薬株式会社 | キノロンカルボン酸誘導体およびその製造方法 |
| DE3683922D1 (de) * | 1985-09-24 | 1992-03-26 | Hoffmann La Roche | Chinolinderivate. |
| AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
| DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| EP0230053A3 (en) * | 1986-01-17 | 1988-03-30 | American Cyanamid Company | 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids |
| EP0230946A3 (en) * | 1986-01-20 | 1988-09-07 | Kyorin Pharmaceutical Co., Ltd. | Process for the preparation of quinolonecarboxylic acid derivatives |
| DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
| US4689423A (en) * | 1986-04-01 | 1987-08-25 | Warner-Lambert Company | Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates |
| HU196987B (en) * | 1986-10-15 | 1989-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing quinoline-carboxylic acid derivatives |
| DE3639465A1 (de) * | 1986-11-18 | 1988-05-19 | Hoechst Ag | Optisch aktive gyrasehemmer, ihre herstellung und verwendung als antibiotika |
| NZ229605A (en) * | 1988-07-15 | 1990-07-26 | Abbott Lab | Preparation of 1,4-dihydro-6-fluoro-7-(piperazin-1-yl)-4-oxo-3-quinoline (or naphthyridine) carboxylic acid derivatives |
| FR2653663A1 (en) * | 1989-10-30 | 1991-05-03 | Bellon Labor Sa Roger | Novel benzo[1,8]naphthyridine derivatives, their preparation and compositions containing them |
| FR2664595B1 (fr) * | 1990-07-10 | 1992-09-18 | Bellon Labor Sa Roger | Nouveaux derives de benzonaphtyridine-1,8, leur preparation et les compositions qui les contiennent. |
| RO108347B1 (ro) * | 1989-10-30 | 1994-04-28 | Bellon Labor Sa Roger | DERIVATI DE BENZO-(b)-NAFTIRIDIN-1,8 SI PROCEDEU DE PREPARARE A ACESTORA |
| EP0449445A3 (en) * | 1990-03-27 | 1993-08-25 | Pfizer Inc. | Preparation of beta-ketoesters useful in preparing quinolone antibiotics |
| ES2147721T3 (es) | 1990-04-18 | 2000-10-01 | Procter & Gamble Pharma | Quinolonil lactamas antimicrobianas. |
| DE10108750A1 (de) * | 2001-02-23 | 2002-09-05 | Bayer Ag | Verbessertes Verfahren zur Herstellung von Fluorchinoloncarbonsäuren |
| KR100519158B1 (ko) * | 2002-12-21 | 2005-10-06 | 주식회사유한양행 | 퀴놀론 카르복실레이트 유도체의 제조방법 |
| BRPI0709772B8 (pt) * | 2006-03-28 | 2021-05-25 | The Protecter & Gamble Company | sais de malato e polimorfos do ácido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-diidro-8-metóxi-4-oxo-3-quinolinocarboxílico |
| CA2647454A1 (en) * | 2006-03-28 | 2007-10-04 | The Procter & Gamble Company | A coupling process for preparing quinolone intermediates |
| EP3784656B1 (de) | 2018-04-25 | 2023-06-28 | Elanco Animal Health GmbH | Verfahren zur hydrolyse von chinoloncarbonsäureestern |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3033157A1 (de) * | 1980-09-03 | 1982-04-01 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| SE440354B (sv) * | 1981-02-19 | 1985-07-29 | Kyorin Seiyaku Kk | Kinolinkarboxylsyraderivat |
| DE3142856A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid |
| JPS5910580A (ja) * | 1982-07-09 | 1984-01-20 | Hokuriku Seiyaku Co Ltd | ７−フエニル置換ピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体 |
| JPS5929685A (ja) * | 1982-08-11 | 1984-02-16 | Hokuriku Seiyaku Co Ltd | ７−置換フエニルピペラジノ−４−オキソ−１，４−ジヒドロキノリン−３−カルボン酸誘導体 |
| IE55898B1 (en) * | 1982-09-09 | 1991-02-14 | Warner Lambert Co | Antibacterial agents |
| DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3248507A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | Mikrobizide mittel auf chinoloncarbonsaeure basis |
| DE3306772A1 (de) * | 1983-02-25 | 1984-08-30 | Bayer Ag, 5090 Leverkusen | Chinolonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DE3318145A1 (de) * | 1983-05-18 | 1984-11-22 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
-
1984
- 1984-06-04 DE DE19843420798 patent/DE3420798A1/de not_active Withdrawn
-
1985
- 1985-05-17 US US06/735,493 patent/US4599334A/en not_active Expired - Fee Related
- 1985-05-22 DE DE8585106252T patent/DE3567021D1/de not_active Expired
- 1985-05-22 AT AT85106252T patent/ATE39488T1/de active
- 1985-05-22 EP EP85106252A patent/EP0169993B1/de not_active Expired
- 1985-05-23 NO NO852063A patent/NO165105C/no unknown
- 1985-05-27 PH PH32319A patent/PH22492A/en unknown
- 1985-05-29 GR GR851314A patent/GR851314B/el unknown
- 1985-05-31 IL IL75370A patent/IL75370A/xx unknown
- 1985-05-31 JP JP60116836A patent/JPS611683A/ja active Pending
- 1985-05-31 IE IE1364/85A patent/IE57814B1/en not_active IP Right Cessation
- 1985-05-31 CA CA000482912A patent/CA1248954A/en not_active Expired
- 1985-05-31 AU AU43206/85A patent/AU571333B2/en not_active Ceased
- 1985-05-31 NZ NZ212271A patent/NZ212271A/xx unknown
- 1985-05-31 FI FI852205A patent/FI82041C/fi not_active IP Right Cessation
- 1985-06-03 ES ES543839A patent/ES8607294A1/es not_active Expired
- 1985-06-03 KR KR1019850003855A patent/KR920000759B1/ko not_active IP Right Cessation
- 1985-06-03 HU HU852145A patent/HU194866B/hu not_active IP Right Cessation
- 1985-06-03 ZA ZA854168A patent/ZA854168B/xx unknown
- 1985-06-03 DK DK249685A patent/DK162527C/da not_active IP Right Cessation
- 1985-06-03 DD DD85276974A patent/DD240016A5/de not_active IP Right Cessation
- 1985-06-03 PT PT80580A patent/PT80580B/pt not_active IP Right Cessation
-
1986
- 1986-02-28 ES ES552574A patent/ES8800196A1/es not_active Expired
- 1986-02-28 ES ES552573A patent/ES8800195A1/es not_active Expired
-
1993
- 1993-12-15 JP JP5342256A patent/JPH06279411A/ja active Pending
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