NO163185C - Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. - Google Patents

Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.

Info

Publication number
NO163185C
NO163185C NO851298A NO851298A NO163185C NO 163185 C NO163185 C NO 163185C NO 851298 A NO851298 A NO 851298A NO 851298 A NO851298 A NO 851298A NO 163185 C NO163185 C NO 163185C
Authority
NO
Norway
Prior art keywords
derivative
benzyl
preparation
condensing
addition salt
Prior art date
Application number
NO851298A
Other languages
English (en)
Norwegian (no)
Other versions
NO851298L (no
Inventor
Hiroshi Ohtaka
Toshiro Kanazawa
Keizo Ito
Goro Tsukamoto
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Publication of NO851298L publication Critical patent/NO851298L/no
Publication of NO163185C publication Critical patent/NO163185C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO851298A 1984-03-30 1985-03-29 Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. NO163185C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59064464A JPS60222472A (ja) 1984-03-30 1984-03-30 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物

Publications (2)

Publication Number Publication Date
NO851298L NO851298L (no) 1985-10-01
NO163185C true NO163185C (no) 1990-04-18

Family

ID=13258978

Family Applications (1)

Application Number Title Priority Date Filing Date
NO851298A NO163185C (no) 1984-03-30 1985-03-29 Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.

Country Status (10)

Country Link
US (1) US4663325A (cs)
EP (1) EP0159566B1 (cs)
JP (1) JPS60222472A (cs)
AT (1) ATE31411T1 (cs)
CA (1) CA1248110A (cs)
DE (1) DE3561199D1 (cs)
ES (3) ES8702393A1 (cs)
FI (1) FI79101C (cs)
GR (1) GR850787B (cs)
NO (1) NO163185C (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
US4792553A (en) * 1986-02-04 1988-12-20 Terumo Kabushiki Kaisha Diene derivatives and vasodilators containing the same
FR2614021B1 (fr) * 1987-04-14 1991-03-01 Andre Buzas Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
EP0682664B1 (en) * 1993-12-08 2001-03-14 Alcon Laboratories, Inc. Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents
ES2224597T3 (es) * 1998-01-29 2005-03-01 Akzo Nobel N.V. Agentes que mejoran la circulacion optica papilar.
RU2204556C2 (ru) * 2001-06-18 2003-05-20 Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина
EP1545519B1 (en) 2002-08-19 2011-03-23 Pfizer Inc. Combination therapy for hyperproliferative diseases
US7433519B2 (en) 2003-04-04 2008-10-07 Avid Technology, Inc. Bitstream format for compressed image data
US7403561B2 (en) 2003-04-04 2008-07-22 Avid Technology, Inc. Fixed bit rate, intraframe compression and decompression of video
WO2004093816A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
US20060135506A1 (en) * 2003-04-22 2006-06-22 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
AU2004242777B2 (en) * 2003-05-30 2011-05-12 Ranbaxy Laboratories Limited Substituted pyrrole derivatives and their use as HMG-Co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
WO2006099244A1 (en) * 2005-03-11 2006-09-21 Hong Kong Nitric Oxide Limited Combination therapy for endothelial dysfunction, angina and diabetes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP1951253A2 (en) 2005-10-26 2008-08-06 Cotherix, Inc. Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
CA2627599A1 (en) * 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Process for (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200744583A (en) * 2006-03-14 2007-12-16 Ranbaxy Lab Ltd Statin stabilizing dosage formulations
WO2008010087A2 (en) * 2006-07-14 2008-01-24 Ranbaxy Laboratories Limited Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof
EP2094643B1 (en) 2006-12-01 2012-02-29 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2008105442A1 (ja) 2007-02-28 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド誘導体
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
CN102936233B (zh) * 2012-11-16 2016-01-20 葛长乐 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型
CN105143203A (zh) 2013-04-17 2015-12-09 辉瑞大药厂 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
WO2017069343A1 (ko) * 2015-10-20 2017-04-27 한국표준과학연구원 위치조절이 용이한 전자현미경용 전자총 및 이를 포함하는 전자현미경
CN109666008A (zh) * 2018-12-31 2019-04-23 辰欣药业股份有限公司 一种盐酸洛美利嗪的合成方法
ES3007652T3 (en) 2019-01-18 2025-03-20 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB705979A (en) * 1951-03-22 1954-03-24 Henri Morren 1.4-aralkyl piperazines and process for the preparation thereof
FR1312427A (fr) * 1961-04-12 1962-12-21 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
FR1303080A (fr) * 1961-07-25 1962-09-07 Science Union Et Compagnie Soc Pipérazines disubstituées
NL7306771A (cs) * 1972-06-02 1973-12-04
DE2900810A1 (de) * 1979-01-11 1980-07-24 Cassella Ag Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent

Also Published As

Publication number Publication date
EP0159566A1 (en) 1985-10-30
JPS60222472A (ja) 1985-11-07
GR850787B (cs) 1985-11-25
ES556981A0 (es) 1988-01-01
FI79101C (fi) 1989-11-10
FI851217L (fi) 1985-10-01
US4663325A (en) 1987-05-05
ATE31411T1 (de) 1988-01-15
FI79101B (fi) 1989-07-31
ES556980A0 (es) 1988-01-01
CA1248110A (en) 1989-01-03
FI851217A0 (fi) 1985-03-26
ES8801237A1 (es) 1988-01-01
EP0159566B1 (en) 1987-12-16
JPH0313232B2 (cs) 1991-02-22
ES8801236A1 (es) 1988-01-01
ES8702393A1 (es) 1987-01-01
ES541728A0 (es) 1987-01-01
DE3561199D1 (en) 1988-01-28
NO851298L (no) 1985-10-01

Similar Documents

Publication Publication Date Title
NO163185C (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.
ES475677A1 (es) Procedimiento para la preparacion de nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamido-1,1-dioxidos.
NO792119L (no) Analogifremgangsmaate for fremstilling av 2-(2-alkoksyetyl)-2`hydroksyl-6,7-benzomorfaner og syreaddisjonssalter derav
DE3268225D1 (de) 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
SU645569A3 (ru) Способ получени производных 4-ариламино-6-метилпиримидина
SE7707731L (sv) Sett att framstella nya piperidyl-indolderivat och salter derav
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
ES504206A0 (es) Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5
ES465225A1 (es) Procedimiento para la preparacion de n-cicloalcohilmetil-2- fenilamino-imidazolinas-(2).
ATE83482T1 (de) Piperidin-derivate, deren herstellung und deren verwendung als heilmittel.
SE7902302L (sv) Nya n-fenylalaninderivat, deras framstellning och deras anvendning som lekemedel
DK16188D0 (da) Guanidinoeddikesyre- og ethanamidinoeddikesyre-derivater, deres fremstilling og deres anvendelse som soedemidler
ATE6369T1 (de) Neue imidazolderivate, ihre herstellung und diese derivate enthaltende arzneimittel.
SE7900601L (sv) 1-naftyl-ettiksyraderivat jemte forfarande for deras framstellning
NO164170C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzhydryl-4-cinnamyl-piperazinderivater.
ES452735A1 (es) Un procedimiento para preparar compuestos de aroilfenilnaf- taleno.
ES405651A1 (es) Procedimiento para la preparacion de nuevos acidos 4 - (4 -bifenilil) - 4 - hidroxi - butiricos, sus esteres o lacto- nas.
SE8703494L (sv) Mellanprodukter anvendbara vid framstellning av 2-tiofen-ettiksyraderivat
NO833665L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-hydroksy-2h-1,2-benzotiazin-3-karboksamid-1,1-dioksyd-derivater
ES519530A0 (es) Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas.
IE44951L (en) Pyridoindoles
NO901401L (no) Fremgangsmaate for fremstilling av nye 1-difenylmethylpiperidinderivater.
ES8204435A1 (es) Un procedimiento para la preparacion de 2-(1-piperacinil)-4-(pirimidinaminas)

Legal Events

Date Code Title Description
MK1K Patent expired