NO163185C - Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. - Google Patents
Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater.Info
- Publication number
- NO163185C NO163185C NO851298A NO851298A NO163185C NO 163185 C NO163185 C NO 163185C NO 851298 A NO851298 A NO 851298A NO 851298 A NO851298 A NO 851298A NO 163185 C NO163185 C NO 163185C
- Authority
- NO
- Norway
- Prior art keywords
- derivative
- benzyl
- preparation
- condensing
- addition salt
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 4
- KUAJKNGLESWEFE-UHFFFAOYSA-N 1-benzhydryl-4-benzylpiperazine Chemical class C=1C=CC=CC=1CN(CC1)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 KUAJKNGLESWEFE-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- IQXXEPZFOOTTBA-UHFFFAOYSA-N 1-benzylpiperazine Chemical compound C=1C=CC=CC=1CN1CCNCC1 IQXXEPZFOOTTBA-UHFFFAOYSA-N 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- -1 benzyl halide Chemical class 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59064464A JPS60222472A (ja) | 1984-03-30 | 1984-03-30 | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO851298L NO851298L (no) | 1985-10-01 |
| NO163185C true NO163185C (no) | 1990-04-18 |
Family
ID=13258978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO851298A NO163185C (no) | 1984-03-30 | 1985-03-29 | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4663325A (Direct) |
| EP (1) | EP0159566B1 (Direct) |
| JP (1) | JPS60222472A (Direct) |
| AT (1) | ATE31411T1 (Direct) |
| CA (1) | CA1248110A (Direct) |
| DE (1) | DE3561199D1 (Direct) |
| ES (3) | ES8702393A1 (Direct) |
| FI (1) | FI79101C (Direct) |
| GR (1) | GR850787B (Direct) |
| NO (1) | NO163185C (Direct) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61161272A (ja) * | 1985-01-11 | 1986-07-21 | Kanebo Ltd | 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物 |
| US4792553A (en) * | 1986-02-04 | 1988-12-20 | Terumo Kabushiki Kaisha | Diene derivatives and vasodilators containing the same |
| FR2614021B1 (fr) * | 1987-04-14 | 1991-03-01 | Andre Buzas | Derives de la 1-((1,1-diphenyl)-1-alcenyl)-piperazine, procede d'obtention et compositions pharmaceutiques les contenant |
| DE4108527A1 (de) * | 1991-03-15 | 1992-09-17 | Basf Ag | Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung |
| AU646926B2 (en) * | 1991-03-20 | 1994-03-10 | Duphar International Research B.V. | Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity |
| CA2153979C (en) * | 1993-12-08 | 2003-10-21 | Mark Hellberg | Compounds having both potent calcium antagonist and antioxidant activity and use thereof as cytoprotective agents |
| KR100585299B1 (ko) * | 1998-01-29 | 2006-06-01 | 악조 노벨 엔.브이. | 시신경유두 순환 개선제 |
| RU2204556C2 (ru) * | 2001-06-18 | 2003-05-20 | Федеральное государственное унитарное предприятие "Новокузнецкий научно-исследовательский химико-фармацевтический институт" | Способ получения 1-(парахлорбензгидрил)-4-(2-оксиэтил)пиперазина |
| BR0313593A (pt) | 2002-08-19 | 2005-07-12 | Pfizer Prod Inc | Terapia de combinação para doenças hiperproliferativas |
| US7403561B2 (en) | 2003-04-04 | 2008-07-22 | Avid Technology, Inc. | Fixed bit rate, intraframe compression and decompression of video |
| US7433519B2 (en) | 2003-04-04 | 2008-10-07 | Avid Technology, Inc. | Bitstream format for compressed image data |
| US20050159403A1 (en) * | 2003-04-22 | 2005-07-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage |
| WO2004093813A2 (en) * | 2003-04-22 | 2004-11-04 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders |
| OA13174A (en) * | 2003-05-30 | 2006-12-13 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-Co inhibitors. |
| US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
| US20060205727A1 (en) * | 2005-03-11 | 2006-09-14 | Wayne Kaesemeyer | Combination therapy for endothelial dysfunction, angina and diabetes |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| EP2351569B1 (en) | 2005-10-26 | 2012-08-22 | Asahi Kasei Pharma Corporation | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| EP1951253A2 (en) * | 2005-10-26 | 2008-08-06 | Cotherix, Inc. | Fasudil in combination therapies for the treatment of pulmonary arterial hypertension |
| WO2007054896A1 (en) * | 2005-11-08 | 2007-05-18 | Ranbaxy Laboratories Limited | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2008020314A2 (en) * | 2006-03-14 | 2008-02-21 | Ranbaxy Laboratories Limited | Statin stabilizing dosage formulations |
| WO2008010087A2 (en) * | 2006-07-14 | 2008-01-24 | Ranbaxy Laboratories Limited | Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof |
| CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
| WO2008105442A1 (ja) | 2007-02-28 | 2008-09-04 | Asahi Kasei Pharma Corporation | スルホンアミド誘導体 |
| WO2012037665A1 (en) | 2010-09-24 | 2012-03-29 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions |
| CN102936233B (zh) * | 2012-11-16 | 2016-01-20 | 葛长乐 | 一种1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧苯基)哌嗪二盐酸盐晶型 |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| WO2017069343A1 (ko) * | 2015-10-20 | 2017-04-27 | 한국표준과학연구원 | 위치조절이 용이한 전자현미경용 전자총 및 이를 포함하는 전자현미경 |
| CN109666008A (zh) * | 2018-12-31 | 2019-04-23 | 辰欣药业股份有限公司 | 一种盐酸洛美利嗪的合成方法 |
| AU2020209215B2 (en) | 2019-01-18 | 2023-02-02 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB705979A (en) * | 1951-03-22 | 1954-03-24 | Henri Morren | 1.4-aralkyl piperazines and process for the preparation thereof |
| FR1312427A (fr) * | 1961-04-12 | 1962-12-21 | Science Union Et Compagnie Soc | Nouveaux dérivés de la pipérazine et leurs préparations |
| FR1303080A (fr) * | 1961-07-25 | 1962-09-07 | Science Union Et Compagnie Soc | Pipérazines disubstituées |
| NL7306771A (Direct) * | 1972-06-02 | 1973-12-04 | ||
| DE2900810A1 (de) * | 1979-01-11 | 1980-07-24 | Cassella Ag | Substituierte n-benzhydryl-n'-p- hydroxybenzyl-piperazine und verfahren zu ihrer herstellung |
| GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
-
1984
- 1984-03-30 JP JP59064464A patent/JPS60222472A/ja active Granted
-
1985
- 1985-03-25 US US06/715,813 patent/US4663325A/en not_active Expired - Lifetime
- 1985-03-26 FI FI851217A patent/FI79101C/fi not_active IP Right Cessation
- 1985-03-26 CA CA000477468A patent/CA1248110A/en not_active Expired
- 1985-03-27 AT AT85103707T patent/ATE31411T1/de not_active IP Right Cessation
- 1985-03-27 DE DE8585103707T patent/DE3561199D1/de not_active Expired
- 1985-03-27 EP EP85103707A patent/EP0159566B1/en not_active Expired
- 1985-03-28 GR GR850787A patent/GR850787B/el unknown
- 1985-03-29 ES ES541728A patent/ES8702393A1/es not_active Expired
- 1985-03-29 NO NO851298A patent/NO163185C/no not_active IP Right Cessation
-
1986
- 1986-07-29 ES ES556981A patent/ES8801237A1/es not_active Expired
- 1986-07-29 ES ES556980A patent/ES8801236A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO851298L (no) | 1985-10-01 |
| DE3561199D1 (en) | 1988-01-28 |
| JPS60222472A (ja) | 1985-11-07 |
| ATE31411T1 (de) | 1988-01-15 |
| US4663325A (en) | 1987-05-05 |
| FI79101C (fi) | 1989-11-10 |
| JPH0313232B2 (Direct) | 1991-02-22 |
| CA1248110A (en) | 1989-01-03 |
| ES8702393A1 (es) | 1987-01-01 |
| ES541728A0 (es) | 1987-01-01 |
| ES556981A0 (es) | 1988-01-01 |
| ES556980A0 (es) | 1988-01-01 |
| EP0159566A1 (en) | 1985-10-30 |
| FI79101B (fi) | 1989-07-31 |
| GR850787B (Direct) | 1985-11-25 |
| ES8801236A1 (es) | 1988-01-01 |
| EP0159566B1 (en) | 1987-12-16 |
| FI851217L (fi) | 1985-10-01 |
| FI851217A0 (fi) | 1985-03-26 |
| ES8801237A1 (es) | 1988-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO163185C (no) | Analogifremgangsmaate for fremstilling av nye terapeutisk aktive piperazinderivater. | |
| MX5680E (es) | Procedimiento para la preparacion de 2-(2-alcoxietil)-2'-hidroxi-6,7-benzomorfanos | |
| DE3268225D1 (de) | 9-(2-(3-indolyl)ethyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones | |
| SU645569A3 (ru) | Способ получени производных 4-ариламино-6-метилпиримидина | |
| SE7703842L (sv) | Nya piperazin- och piperinderivat | |
| ATE75722T1 (de) | Neue diphenylpropylamin-derivate, ihre herstellung sowie ihre pharmazeutische verwendung. | |
| NO157452C (no) | Analogifremgangsmaate for fremstilling av et terapeutisk aktivt bispidinderivat. | |
| ES504206A0 (es) | Procedimiento para la preparacion de nuevas 5,10-dihidro -11h-dibenzo b,e 1,4 diazepin-11-onas, sustituidas en posi- cion 5 | |
| ES441592A1 (es) | Procedimiento para la preparacion de nuevas piridobenzodia- zepinonas. | |
| ATE83482T1 (de) | Piperidin-derivate, deren herstellung und deren verwendung als heilmittel. | |
| SE7902302L (sv) | Nya n-fenylalaninderivat, deras framstellning och deras anvendning som lekemedel | |
| DK16188D0 (da) | Guanidinoeddikesyre- og ethanamidinoeddikesyre-derivater, deres fremstilling og deres anvendelse som soedemidler | |
| SE7611953L (sv) | Forfarande for framstellning av aroyl-fenyl-naftalenderivat anvendbara sasom antifertilitets- och antitumormedel | |
| DK193181A (da) | Fremgangmaade til fremstilling af imidazolderivater | |
| SE7900601L (sv) | 1-naftyl-ettiksyraderivat jemte forfarande for deras framstellning | |
| NO164170C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzhydryl-4-cinnamyl-piperazinderivater. | |
| NO833665L (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-hydroksy-2h-1,2-benzotiazin-3-karboksamid-1,1-dioksyd-derivater | |
| SE7712447L (sv) | Sett att framstella nya bensofenonderivat | |
| IE44951L (en) | Pyridoindoles | |
| ES8106143A1 (es) | Procedimiento para la preparacion de derivados de cinamoil- piperidinobutirofenona | |
| NO931602L (no) | Nye enantiomerer avledet fra (s)-2-amino-2-(3,4-diklorbenzyl)-1-propanol | |
| NO901401L (no) | Fremgangsmaate for fremstilling av nye 1-difenylmethylpiperidinderivater. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |