NO155055C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater. - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.

Info

Publication number
NO155055C
NO155055C NO802546A NO802546A NO155055C NO 155055 C NO155055 C NO 155055C NO 802546 A NO802546 A NO 802546A NO 802546 A NO802546 A NO 802546A NO 155055 C NO155055 C NO 155055C
Authority
NO
Norway
Prior art keywords
carbolin
preparation
carboxylic acid
acid derivatives
therapeutic active
Prior art date
Application number
NO802546A
Other languages
English (en)
Norwegian (no)
Other versions
NO155055B (no
NO802546L (no
Inventor
Ulrich Eder
Guentyer Neef
Andreas Huth
Dieter Rahtz
Ralph Schmiechen
Claus Thyco Braestrup
Mogens Cherley Nielsen
Joergen Anders Christensen
Mogens Engelstoft
Henning Schou
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK88980A external-priority patent/DK88980A/da
Priority claimed from DE19803015816 external-priority patent/DE3015816A1/de
Priority claimed from DE19803023567 external-priority patent/DE3023567A1/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO802546L publication Critical patent/NO802546L/no
Publication of NO155055B publication Critical patent/NO155055B/no
Publication of NO155055C publication Critical patent/NO155055C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO802546A 1979-08-29 1980-08-28 Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater. NO155055C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK362279 1979-08-29
DK88980A DK88980A (da) 1980-02-29 1980-02-29 Beta-carbonline-3-carboxylsyrederivater og fremgangsmaader til fremstilling af samme
DE19803015816 DE3015816A1 (de) 1980-04-22 1980-04-22 4-substituierte- (beta) -carbolin-3-carbonsaeurederivate, ihre herstellung und verwendung
DE19803023567 DE3023567A1 (de) 1980-06-20 1980-06-20 Substituierte (beta) -carbolin-3-carbonsaeurederivate

Publications (3)

Publication Number Publication Date
NO802546L NO802546L (no) 1981-03-02
NO155055B NO155055B (no) 1986-10-27
NO155055C true NO155055C (no) 1987-02-04

Family

ID=27432526

Family Applications (1)

Application Number Title Priority Date Filing Date
NO802546A NO155055C (no) 1979-08-29 1980-08-28 Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-carboxylsyrederivater.

Country Status (16)

Country Link
US (2) US4371536A (xx)
EP (1) EP0030254B1 (xx)
CA (1) CA1150246A (xx)
DD (1) DD152935A5 (xx)
DE (1) DE3069559D1 (xx)
ES (1) ES494590A0 (xx)
FI (1) FI68829C (xx)
HU (1) HU186744B (xx)
IE (1) IE50229B1 (xx)
IL (1) IL60906A (xx)
NO (1) NO155055C (xx)
NZ (1) NZ194747A (xx)
PL (1) PL226479A1 (xx)
PT (1) PT71744B (xx)
RO (1) RO80265B (xx)
YU (1) YU215580A (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240513A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung
DE3240514A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK149270C (da) * 1983-05-27 1986-08-25 Schering Ag Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2555988A1 (fr) * 1983-12-06 1985-06-07 Centre Nat Rech Scient Derive de b-carbolines, procede pour leurs preparations et medicament les contenant
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DE3535928A1 (de) * 1985-10-04 1987-04-09 Schering Ag Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3545776A1 (de) * 1985-12-20 1987-06-25 Schering Ag 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3609699A1 (de) * 1986-03-20 1987-09-24 Schering Ag 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
DE3608089A1 (de) * 1986-03-08 1987-09-10 Schering Ag Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
EP0285671B1 (en) * 1986-10-13 2003-09-03 Asahi Kasei Kabushiki Kaisha Pyridine derivatives
DE4029389A1 (de) * 1990-09-13 1992-03-26 Schering Ag Verfahren zur herstellung von (beta)-carbolin-derivaten
US5350750A (en) * 1991-04-27 1994-09-27 Schering Aktiengesellschaft β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents
GB9508195D0 (en) * 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
AU710079B2 (en) * 1996-04-04 1999-09-16 F. Hoffmann-La Roche Ag Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
DK0923581T3 (da) * 1996-08-09 2003-08-04 Boehringer Ingelheim Pharma 4-substituerede beta-carboliner som immunmodulatorer
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
AR036040A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
ES2383001T3 (es) 2001-10-02 2012-06-15 Pharmacia & Upjohn Company Llc Compuestos de heteroarilo condensado sustituidos con azabicíclico para el tratamiento de enfermedades
EP1442037A1 (en) 2001-11-09 2004-08-04 PHARMACIA & UPJOHN COMPANY Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands
US20030176456A1 (en) * 2001-12-21 2003-09-18 June Harry L. Methods for reducing alcohol cravings in chronic alcoholics
AU2003219690A1 (en) 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
CN100503607C (zh) * 2003-06-02 2009-06-24 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物类化合物及其应用
CA2563761C (en) * 2004-04-26 2009-12-29 Pfizer Inc. Inhibitors of the hiv integrase enzyme
EP1756103A2 (en) 2004-04-26 2007-02-28 Pfizer, Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
EA200800758A1 (ru) * 2005-10-07 2008-08-29 Пфайзер Продактс Инк. Ингибиторы фермента интегразы вич
BRPI0718089A2 (pt) 2006-10-28 2013-11-05 Methylgene Inc Composto, uso do composto, composição, e, métodos para inibir histona desacetilase e para tratar uma doença de expansão da poliglutamina
AU2013205135B2 (en) * 2006-10-28 2015-11-05 Forum Pharmaceuticals Inc. Inhibitors of histone deacetylase
US8268854B2 (en) 2008-05-22 2012-09-18 The Uwm Research Foundation, Inc. Aza-beta-carbolines and methods of using same
CN104211699A (zh) * 2013-06-05 2014-12-17 首都医科大学 β-咔啉衍生物,其制备,纳米结构,抗肿瘤活性和应用
CN104628722B (zh) * 2015-01-30 2016-06-22 华南农业大学 一种骆驼蓬碱酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA786351A (en) * 1968-05-28 Leonard Frederick PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLIN-CARBOXYLIC ACID AMIDE DERIVATIVES
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
GB1084256A (xx) * 1963-11-06
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung

Also Published As

Publication number Publication date
EP0030254A1 (en) 1981-06-17
FI802720A (fi) 1981-03-01
IL60906A0 (en) 1980-10-26
PL226479A1 (xx) 1981-10-30
RO80265B (ro) 1983-04-30
NO155055B (no) 1986-10-27
PT71744B (en) 1981-06-08
EP0030254B1 (en) 1984-10-31
IE801806L (en) 1981-02-28
NZ194747A (en) 1988-11-29
FI68829C (fi) 1985-11-11
DE3069559D1 (en) 1984-12-06
IE50229B1 (en) 1986-03-05
US5010077A (en) 1991-04-23
CA1150246A (en) 1983-07-19
RO80265A (ro) 1983-04-29
ES8106305A1 (es) 1981-08-16
NO802546L (no) 1981-03-02
IL60906A (en) 1985-11-29
ES494590A0 (es) 1981-08-16
PT71744A (en) 1980-09-01
HU186744B (en) 1985-09-30
US4371536A (en) 1983-02-01
FI68829B (fi) 1985-07-31
DD152935A5 (de) 1981-12-16
YU215580A (en) 1984-02-29

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