RO80265B - Procedeu pentru prepararea unor derivati de acid beta-carbolin-3-carboxilic - Google Patents

Procedeu pentru prepararea unor derivati de acid beta-carbolin-3-carboxilic

Info

Publication number
RO80265B
RO80265B RO102050A RO10205080A RO80265B RO 80265 B RO80265 B RO 80265B RO 102050 A RO102050 A RO 102050A RO 10205080 A RO10205080 A RO 10205080A RO 80265 B RO80265 B RO 80265B
Authority
RO
Romania
Prior art keywords
acid derivatives
carboxylic acid
carbolin
esterification
phenoxy
Prior art date
Application number
RO102050A
Other languages
English (en)
Other versions
RO80265A (ro
Inventor
Ulrich Eder
Gunter Neef
Andreas Huth
Dieter Rahtz
Ralph Smiechen
Claus Thico Braestrup
Mogens Charley Nielsen
Joergen Anders Christensen
Mogens Engelstoff
Henning Schou
Original Assignee
Schering Aktiengesellschaft
A/S Ferrosan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK88980A external-priority patent/DK88980A/da
Priority claimed from DE19803015816 external-priority patent/DE3015816A1/de
Priority claimed from DE19803023567 external-priority patent/DE3023567A1/de
Application filed by Schering Aktiengesellschaft, A/S Ferrosan filed Critical Schering Aktiengesellschaft
Publication of RO80265A publication Critical patent/RO80265A/ro
Publication of RO80265B publication Critical patent/RO80265B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de acid beta -carbolin-3 carboxilic cu formula generala I: (vezi form. in desc.)în care R1 reprezinta hidroxi, alcoxi cu 1....7 atomi de carbon, fenoxi, R2 reprezinta hidrogen, alchilcu 1.....7 atomi de carbon, fenoxi, R2 reprezinta hidroxigen,alxil cu 1....5 atomi de carbon, cicloalchil cu 5,6 atomi de carbon fenil, metoxifenil, R3 reprezinta hidrogen, fluor, nitro, nitro, hidroximetil, metoxi, carbetoxi, compusi care actioneaza asupra sistemului central nervos si pot fi folositi în preparate psihofarmaceutice, prin dehidrogenarea derivatilor de acid corespunzatori cu un agent de dehidrogenare ales dintre sulf elementar, diclordicianobenzochinona, cloranil sau paladiu pe suport de carbune la temperaturi cuprinse între 15 degree C si temperatura de reflux a amestecului de reactie urmata eventual de esterificarea sau reesterificarea compusului cu formula I prin metode cunoscute.
RO102050A 1979-08-29 1980-08-27 Procedeu pentru prepararea unor derivati de acid beta-carbolin-3-carboxilic RO80265B (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK362279 1979-08-29
DK88980A DK88980A (da) 1980-02-29 1980-02-29 Beta-carbonline-3-carboxylsyrederivater og fremgangsmaader til fremstilling af samme
DE19803015816 DE3015816A1 (de) 1980-04-22 1980-04-22 4-substituierte- (beta) -carbolin-3-carbonsaeurederivate, ihre herstellung und verwendung
DE19803023567 DE3023567A1 (de) 1980-06-20 1980-06-20 Substituierte (beta) -carbolin-3-carbonsaeurederivate

Publications (2)

Publication Number Publication Date
RO80265A RO80265A (ro) 1983-04-29
RO80265B true RO80265B (ro) 1983-04-30

Family

ID=27432526

Family Applications (1)

Application Number Title Priority Date Filing Date
RO102050A RO80265B (ro) 1979-08-29 1980-08-27 Procedeu pentru prepararea unor derivati de acid beta-carbolin-3-carboxilic

Country Status (16)

Country Link
US (2) US4371536A (ro)
EP (1) EP0030254B1 (ro)
CA (1) CA1150246A (ro)
DD (1) DD152935A5 (ro)
DE (1) DE3069559D1 (ro)
ES (1) ES494590A0 (ro)
FI (1) FI68829C (ro)
HU (1) HU186744B (ro)
IE (1) IE50229B1 (ro)
IL (1) IL60906A (ro)
NO (1) NO155055C (ro)
NZ (1) NZ194747A (ro)
PL (1) PL226479A1 (ro)
PT (1) PT71744B (ro)
RO (1) RO80265B (ro)
YU (1) YU215580A (ro)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3240513A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Indolderivate, verfahren zu ihrer herstellung und deren verwendung zur weiterverarbeitung
DE3240514A1 (de) * 1982-10-29 1984-05-03 Schering AG, 1000 Berlin und 4709 Bergkamen Ss-carboline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DK149270C (da) * 1983-05-27 1986-08-25 Schering Ag Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DE3322895A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ss-carboline, verfahren zur ihrer herstellung und ihre verwendung als arzneimittel (s)
DE3335323A1 (de) * 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2555988A1 (fr) * 1983-12-06 1985-06-07 Centre Nat Rech Scient Derive de b-carbolines, procede pour leurs preparations et medicament les contenant
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DE3535928A1 (de) * 1985-10-04 1987-04-09 Schering Ag Tetrahydro-(beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3545776A1 (de) * 1985-12-20 1987-06-25 Schering Ag 5-aminoalkyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3609699A1 (de) * 1986-03-20 1987-09-24 Schering Ag 5- oder 6-substituierte-(beta)-carbolin-3-carbonsaeureester
DE3608089A1 (de) * 1986-03-08 1987-09-10 Schering Ag Heteroaryl-oxy-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
WO1988002751A1 (en) * 1986-10-13 1988-04-21 Asahi Kasei Kogyo Kabushiki Kaisha Pyridine derivatives
DE4029389A1 (de) * 1990-09-13 1992-03-26 Schering Ag Verfahren zur herstellung von (beta)-carbolin-derivaten
US5350750A (en) * 1991-04-27 1994-09-27 Schering Aktiengesellschaft β-carboline-3-hydroxyalkylcarboxylic acid ester derivatives, process for their production and their use in pharmaceutical agents
GB9508195D0 (en) * 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
WO1997037658A1 (en) * 1996-04-04 1997-10-16 F.Hoffmann-La Roche Ag Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
JP2000516231A (ja) * 1996-08-09 2000-12-05 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 免疫調節物質としての４―置換β―カルボリン
UA74826C2 (en) 2000-05-17 2006-02-15 Ortho Mcneil Pharm Inc ?-carboline derivatives as phosphodiesterase inhibitors
AR036040A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
DK1432707T3 (da) 2001-10-02 2012-06-11 Pharmacia & Upjohn Co Llc Azabicyklisk-substituerede kondenserede heteroarylforbindelser til behandling af sygdomme
US6951868B2 (en) 2001-11-09 2005-10-04 Pfizer Inc. Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
US20030176456A1 (en) * 2001-12-21 2003-09-18 June Harry L. Methods for reducing alcohol cravings in chronic alcoholics
CA2476681A1 (en) 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
PA8586801A1 (es) * 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
CN100503607C (zh) * 2003-06-02 2009-06-24 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物类化合物及其应用
DE602005002746T2 (de) 2004-04-26 2008-02-07 Pfizer Inc. Inhibitoren des hiv-integrase-enzyms
BRPI0510319A (pt) 2004-04-26 2007-10-16 Pfizer inibidores da enzima integrase de hiv
BRPI0616657A2 (pt) * 2005-10-07 2011-06-28 Pfizer Prod Inc inibidores da enzima hiv integrase
AU2013205135B2 (en) * 2006-10-28 2015-11-05 Forum Pharmaceuticals Inc. Inhibitors of histone deacetylase
CN101573333B (zh) 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
WO2009143445A1 (en) * 2008-05-22 2009-11-26 The Uwm Research Foundation, Inc Aza-beta-carbolines and methods of using same
CN104211699A (zh) * 2013-06-05 2014-12-17 首都医科大学 β-咔啉衍生物,其制备,纳米结构,抗肿瘤活性和应用
CN104628722B (zh) * 2015-01-30 2016-06-22 华南农业大学 一种骆驼蓬碱酰胺类化合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA786351A (en) * 1968-05-28 Leonard Frederick PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLIN-CARBOXYLIC ACID AMIDE DERIVATIVES
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
GB1084257A (ro) * 1963-11-06
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS57123180A (en) * 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3322894A1 (de) * 1983-06-23 1985-01-03 Schering AG, 1000 Berlin und 4709 Bergkamen Neue (beta)-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel (h)
DK240184D0 (da) * 1984-05-15 1984-05-15 Ferrosan As Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
DK240084D0 (da) * 1984-05-15 1984-05-15 Ferrosan As New beta-carboline-3-oxadiazolyl derivatives
DE3504045A1 (de) * 1985-02-04 1986-08-07 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von ss-carbolinen durch dehydrierung

Also Published As

Publication number Publication date
ES8106305A1 (es) 1981-08-16
NO802546L (no) 1981-03-02
PL226479A1 (ro) 1981-10-30
IE801806L (en) 1981-02-28
DD152935A5 (de) 1981-12-16
EP0030254B1 (en) 1984-10-31
US5010077A (en) 1991-04-23
IL60906A0 (en) 1980-10-26
FI68829B (fi) 1985-07-31
IE50229B1 (en) 1986-03-05
ES494590A0 (es) 1981-08-16
NZ194747A (en) 1988-11-29
IL60906A (en) 1985-11-29
US4371536A (en) 1983-02-01
CA1150246A (en) 1983-07-19
DE3069559D1 (en) 1984-12-06
FI68829C (fi) 1985-11-11
NO155055B (no) 1986-10-27
RO80265A (ro) 1983-04-29
YU215580A (en) 1984-02-29
FI802720A (fi) 1981-03-01
EP0030254A1 (en) 1981-06-17
PT71744B (en) 1981-06-08
NO155055C (no) 1987-02-04
PT71744A (en) 1980-09-01
HU186744B (en) 1985-09-30

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