NO144527C - Analogifremg.m. ved fremst. av anti-inflammatorisk virksomme estere av 2-brom-6beta,9alfa-difluor-11beta,16alfa,17alfa,21-tetrahydroksypregna- eller 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroksypregna-1,4-dien-3,20-dioner - Google Patents

Analogifremg.m. ved fremst. av anti-inflammatorisk virksomme estere av 2-brom-6beta,9alfa-difluor-11beta,16alfa,17alfa,21-tetrahydroksypregna- eller 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroksypregna-1,4-dien-3,20-dioner

Info

Publication number
NO144527C
NO144527C NO750633A NO750633A NO144527C NO 144527 C NO144527 C NO 144527C NO 750633 A NO750633 A NO 750633A NO 750633 A NO750633 A NO 750633A NO 144527 C NO144527 C NO 144527C
Authority
NO
Norway
Prior art keywords
9alfa
6beta
11beta
difluor
inflammatorally
Prior art date
Application number
NO750633A
Other languages
English (en)
Norwegian (no)
Other versions
NO144527B (no
NO750633L (de
Inventor
Mario Riva
Luciano Toscano
Original Assignee
Pierrel Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel Spa filed Critical Pierrel Spa
Publication of NO750633L publication Critical patent/NO750633L/no
Publication of NO144527B publication Critical patent/NO144527B/no
Publication of NO144527C publication Critical patent/NO144527C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO750633A 1974-02-27 1975-02-25 Analogifremg.m. ved fremst. av anti-inflammatorisk virksomme estere av 2-brom-6beta,9alfa-difluor-11beta,16alfa,17alfa,21-tetrahydroksypregna- eller 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroksypregna-1,4-dien-3,20-dioner NO144527C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8928/74A GB1499822A (en) 1974-02-27 1974-02-27 2-bromo-6beta-fluoropregna-1,4-diene-3,20-diones
GB2998474 1974-07-05
GB3294574 1974-07-25
GB4998274 1974-11-19

Publications (3)

Publication Number Publication Date
NO750633L NO750633L (de) 1975-08-28
NO144527B NO144527B (no) 1981-06-09
NO144527C true NO144527C (no) 1981-09-23

Family

ID=27447687

Family Applications (1)

Application Number Title Priority Date Filing Date
NO750633A NO144527C (no) 1974-02-27 1975-02-25 Analogifremg.m. ved fremst. av anti-inflammatorisk virksomme estere av 2-brom-6beta,9alfa-difluor-11beta,16alfa,17alfa,21-tetrahydroksypregna- eller 2-brom-6beta,9alfa-difluor-11beta,17alfa,21-trihydroksypregna-1,4-dien-3,20-dioner

Country Status (18)

Country Link
JP (1) JPS5614677B2 (de)
AR (1) AR218601A1 (de)
BE (1) BE826030A (de)
CA (1) CA1064476A (de)
CH (1) CH608243A5 (de)
DE (3) DE2508136C3 (de)
DK (1) DK144068C (de)
ES (3) ES435067A1 (de)
FI (1) FI56188C (de)
FR (1) FR2261776B1 (de)
GB (1) GB1499822A (de)
IE (1) IE42112B1 (de)
LU (1) LU71908A1 (de)
NO (1) NO144527C (de)
NZ (1) NZ176716A (de)
RO (1) RO78881A (de)
SE (1) SE410736B (de)
YU (3) YU108281A (de)

Also Published As

Publication number Publication date
ES455933A1 (es) 1978-05-01
SE410736B (sv) 1979-10-29
IE42112B1 (en) 1980-06-04
DK144068C (da) 1982-05-03
DE2508136C3 (de) 1979-06-21
CH608243A5 (en) 1978-12-29
YU108281A (en) 1982-02-28
DE2533323B2 (de) 1978-11-16
YU108381A (en) 1982-02-28
NZ176716A (en) 1978-07-10
FR2261776A1 (de) 1975-09-19
IE42112L (en) 1975-08-27
DK61575A (de) 1975-10-27
DE2533377B2 (de) 1978-11-16
LU71908A1 (de) 1975-06-24
FR2261776B1 (de) 1978-07-21
RO78881A (ro) 1982-07-06
YU108481A (en) 1982-02-28
DE2533377C3 (de) 1979-08-02
FI750537A (de) 1975-08-28
NO144527B (no) 1981-06-09
ES435067A1 (es) 1977-07-01
JPS5614677B2 (de) 1981-04-06
ES455934A1 (es) 1978-05-01
CA1064476A (en) 1979-10-16
GB1499822A (en) 1978-02-01
FI56188C (fi) 1979-12-10
SE7502146L (de) 1975-08-28
DE2533323C3 (de) 1979-07-12
DE2533377A1 (de) 1976-02-05
AR218601A1 (es) 1980-06-30
FI56188B (fi) 1979-08-31
DE2508136B2 (de) 1978-11-02
DK144068B (da) 1981-11-30
DE2508136A1 (de) 1975-10-30
DE2533323A1 (de) 1976-02-12
NO750633L (de) 1975-08-28
JPS50126652A (de) 1975-10-04
BE826030A (fr) 1975-06-16

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