NO124618B - - Google Patents
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- Publication number
- NO124618B NO124618B NO4148/68A NO414868A NO124618B NO 124618 B NO124618 B NO 124618B NO 4148/68 A NO4148/68 A NO 4148/68A NO 414868 A NO414868 A NO 414868A NO 124618 B NO124618 B NO 124618B
- Authority
- NO
- Norway
- Prior art keywords
- tetracycline
- sodium
- hexametaphosphate
- complex
- potassium
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 claims description 31
- 229960002180 tetracycline Drugs 0.000 claims description 31
- 229930101283 tetracycline Natural products 0.000 claims description 31
- 235000019364 tetracycline Nutrition 0.000 claims description 31
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 26
- 150000003522 tetracyclines Chemical class 0.000 claims description 21
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 19
- 229910052708 sodium Inorganic materials 0.000 claims description 15
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 14
- 229940005740 hexametaphosphate Drugs 0.000 claims description 14
- 239000011734 sodium Substances 0.000 claims description 14
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 14
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 229910052700 potassium Inorganic materials 0.000 claims description 12
- 239000011591 potassium Substances 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000002378 acidificating effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 239000011260 aqueous acid Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims 1
- 235000011009 potassium phosphates Nutrition 0.000 claims 1
- XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 26
- 229960004989 tetracycline hydrochloride Drugs 0.000 description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- 239000000243 solution Substances 0.000 description 15
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- -1 tetracycline salt Chemical class 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- 241000282472 Canis lupus familiaris Species 0.000 description 8
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 8
- 239000002775 capsule Substances 0.000 description 8
- 229910052698 phosphorus Inorganic materials 0.000 description 8
- 239000011574 phosphorus Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- 239000013078 crystal Substances 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NWXMGUDVXFXRIG-WESIUVDSSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O NWXMGUDVXFXRIG-WESIUVDSSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001460678 Napo <wasp> Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229930195708 Penicillin V Natural products 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000003912 lipotropic agent Substances 0.000 description 1
- 229940040504 lipotropic agent Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940056367 penicillin v Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 125000004436 sodium atom Chemical group 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04Q—SELECTING
- H04Q11/00—Selecting arrangements for multiplex systems
- H04Q11/04—Selecting arrangements for multiplex systems for time-division multiplexing
-
- H—ELECTRICITY
- H03—ELECTRONIC CIRCUITRY
- H03K—PULSE TECHNIQUE
- H03K5/00—Manipulating of pulses not covered by one of the other main groups of this subclass
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04J—MULTIPLEX COMMUNICATION
- H04J3/00—Time-division multiplex systems
- H04J3/02—Details
- H04J3/06—Synchronising arrangements
- H04J3/062—Synchronisation of signals having the same nominal but fluctuating bit rates, e.g. using buffers
- H04J3/0626—Synchronisation of signals having the same nominal but fluctuating bit rates, e.g. using buffers plesiochronous multiplexing systems, e.g. plesiochronous digital hierarchy [PDH], jitter attenuators
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L12/00—Data switching networks
- H04L12/28—Data switching networks characterised by path configuration, e.g. LAN [Local Area Networks] or WAN [Wide Area Networks]
- H04L12/42—Loop networks
- H04L12/422—Synchronisation for ring networks
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L27/00—Modulated-carrier systems
- H04L27/02—Amplitude-modulated carrier systems, e.g. using on-off keying; Single sideband or vestigial sideband modulation
- H04L27/04—Modulator circuits; Transmitter circuits
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L7/00—Arrangements for synchronising receiver with transmitter
- H04L7/04—Speed or phase control by synchronisation signals
-
- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
- H04L7/00—Arrangements for synchronising receiver with transmitter
- H04L7/0016—Arrangements for synchronising receiver with transmitter correction of synchronization errors
- H04L7/0033—Correction by delay
- H04L7/0041—Delay of data signal
Landscapes
- Engineering & Computer Science (AREA)
- Computer Networks & Wireless Communication (AREA)
- Signal Processing (AREA)
- Computer Hardware Design (AREA)
- Physics & Mathematics (AREA)
- Nonlinear Science (AREA)
- Synchronisation In Digital Transmission Systems (AREA)
- Pulse Circuits (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processing Of Solid Wastes (AREA)
- Small-Scale Networks (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB48467/67A GB1187489A (en) | 1967-10-25 | 1967-10-25 | Variable Digital Delay Circuit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO124618B true NO124618B (zh) | 1972-05-08 |
Family
ID=10448712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO4148/68A NO124618B (zh) | 1967-10-25 | 1968-10-19 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3588707A (zh) |
| BE (1) | BE722862A (zh) |
| CH (1) | CH484568A (zh) |
| DE (1) | DE1804626C3 (zh) |
| ES (1) | ES359404A1 (zh) |
| FR (1) | FR1599805A (zh) |
| GB (1) | GB1187489A (zh) |
| NL (1) | NL6815261A (zh) |
| NO (1) | NO124618B (zh) |
| SE (1) | SE337844B (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3732374A (en) * | 1970-12-31 | 1973-05-08 | Ibm | Communication system and method |
| US3671872A (en) * | 1971-03-26 | 1972-06-20 | Telemation | High frequency multiple phase signal generator |
| US3781691A (en) * | 1972-05-01 | 1973-12-25 | Itek Corp | Pulse repetition frequency filter circuit |
| DE2627830C2 (de) * | 1976-06-22 | 1982-10-28 | Robert Bosch Gmbh, 7000 Stuttgart | System zur Verzögerung eines Signals |
| US4197506A (en) * | 1978-06-26 | 1980-04-08 | Electronic Memories & Magnetics Corporation | Programmable delay line oscillator |
| US4443765A (en) * | 1981-09-18 | 1984-04-17 | The United States Of America As Represented By The Secretary Of The Navy | Digital multi-tapped delay line with automatic time-domain programming |
| GB2139852B (en) * | 1983-05-13 | 1986-05-29 | Standard Telephones Cables Ltd | Data network |
| US4608706A (en) * | 1983-07-11 | 1986-08-26 | International Business Machines Corporation | High-speed programmable timing generator |
| DE3481472D1 (de) * | 1984-12-21 | 1990-04-05 | Ibm | Digitale phasenregelschleife. |
| US4675612A (en) * | 1985-06-21 | 1987-06-23 | Advanced Micro Devices, Inc. | Apparatus for synchronization of a first signal with a second signal |
| DE3530949A1 (de) * | 1985-08-29 | 1987-03-12 | Tandberg Data | Schaltungsanordnung zum umsetzen von analogsignalen in binaersignale |
| US5036230A (en) * | 1990-03-01 | 1991-07-30 | Intel Corporation | CMOS clock-phase synthesizer |
| US5245231A (en) * | 1991-12-30 | 1993-09-14 | Dell Usa, L.P. | Integrated delay line |
| US5945861A (en) * | 1995-12-18 | 1999-08-31 | Lg Semicon., Co. Ltd. | Clock signal modeling circuit with negative delay |
| KR0179779B1 (ko) * | 1995-12-18 | 1999-04-01 | 문정환 | 클럭신호 모델링 회로 |
| US6154079A (en) * | 1997-06-12 | 2000-11-28 | Lg Semicon Co., Ltd. | Negative delay circuit operable in wide band frequency |
| US6959031B2 (en) * | 2000-07-06 | 2005-10-25 | Time Domain Corporation | Method and system for fast acquisition of pulsed signals |
| US6778603B1 (en) | 2000-11-08 | 2004-08-17 | Time Domain Corporation | Method and apparatus for generating a pulse train with specifiable spectral response characteristics |
| US6704882B2 (en) | 2001-01-22 | 2004-03-09 | Mayo Foundation For Medical Education And Research | Data bit-to-clock alignment circuit with first bit capture capability |
| DE102005061155A1 (de) * | 2005-12-21 | 2007-06-28 | Bosch Rexroth Ag | Kommunikationsstruktur |
-
1967
- 1967-10-25 GB GB48467/67A patent/GB1187489A/en not_active Expired
-
1968
- 1968-09-30 US US763871A patent/US3588707A/en not_active Expired - Lifetime
- 1968-10-14 SE SE13795/68A patent/SE337844B/xx unknown
- 1968-10-19 NO NO4148/68A patent/NO124618B/no unknown
- 1968-10-21 CH CH1568468A patent/CH484568A/de not_active IP Right Cessation
- 1968-10-22 ES ES359404A patent/ES359404A1/es not_active Expired
- 1968-10-23 DE DE1804626A patent/DE1804626C3/de not_active Expired
- 1968-10-24 FR FR1599805D patent/FR1599805A/fr not_active Expired
- 1968-10-25 BE BE722862D patent/BE722862A/xx unknown
- 1968-10-25 NL NL6815261A patent/NL6815261A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES359404A1 (es) | 1970-06-01 |
| NL6815261A (zh) | 1969-04-29 |
| CH484568A (de) | 1970-01-15 |
| SE337844B (zh) | 1971-08-23 |
| BE722862A (zh) | 1969-04-25 |
| DE1804626B2 (de) | 1974-08-29 |
| GB1187489A (en) | 1970-04-08 |
| US3588707A (en) | 1971-06-28 |
| DE1804626C3 (de) | 1975-04-30 |
| DE1804626A1 (de) | 1969-08-21 |
| FR1599805A (zh) | 1970-07-20 |
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