NL930104I2 - Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan. - Google Patents

Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan.

Info

Publication number
NL930104I2
NL930104I2 NL930104C NL930104C NL930104I2 NL 930104 I2 NL930104 I2 NL 930104I2 NL 930104 C NL930104 C NL 930104C NL 930104 C NL930104 C NL 930104C NL 930104 I2 NL930104 I2 NL 930104I2
Authority
NL
Netherlands
Prior art keywords
heparin fragments
preparation
anticoagulant activity
selective
sulphate
Prior art date
Application number
NL930104C
Other languages
English (en)
Dutch (nl)
Other versions
NL930104I1 (nl
Original Assignee
Kabipharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20336970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL930104(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kabipharmacia Ab filed Critical Kabipharmacia Ab
Publication of NL930104I1 publication Critical patent/NL930104I1/nl
Publication of NL930104I2 publication Critical patent/NL930104I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NL930104C 1979-01-08 1993-01-28 Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan. NL930104I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7900164 1979-01-08

Publications (2)

Publication Number Publication Date
NL930104I1 NL930104I1 (nl) 1993-10-01
NL930104I2 true NL930104I2 (nl) 1997-02-03

Family

ID=20336970

Family Applications (1)

Application Number Title Priority Date Filing Date
NL930104C NL930104I2 (nl) 1979-01-08 1993-01-28 Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan.

Country Status (11)

Country Link
US (1) US4303651A (enExample)
EP (1) EP0014184B2 (enExample)
JP (1) JPS6344764B2 (enExample)
AT (1) ATE8998T1 (enExample)
CA (1) CA1136620A (enExample)
DE (1) DE3068924D1 (enExample)
DK (1) DK160764C (enExample)
NL (1) NL930104I2 (enExample)
NO (1) NO150801C (enExample)
SU (1) SU1209033A3 (enExample)
WO (1) WO1980001383A1 (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4438261A (en) 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
JPH0258920B2 (enExample) * 1980-10-09 1990-12-11 Boehringer Mannheim Gmbh
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
FR2535324A1 (fr) * 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
ATE15142T1 (de) 1981-05-21 1985-09-15 Akzo Nv Antithrombotikum auf basis von polysacchariden, verfahren zur dessen herstellung und medizinale zusammensetzungen.
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
CA1265132A (en) * 1982-01-15 1990-01-30 Mahmoud Nassr Process for the organic synthesis of oligosaccharides and derivatives thereof
US4539398A (en) * 1982-01-22 1985-09-03 Riker Laboratories, Inc. Affinity fractionation of heparin on immobilized Concanavalin A
DE3366933D1 (en) 1982-06-10 1986-11-20 Kabivitrum Ab Antithrombin-heparin complex
CA1195322A (en) * 1982-07-19 1985-10-15 Eduardo Amaya Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2538404B1 (enExample) * 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
GB8614189D0 (en) * 1986-06-11 1986-07-16 Leo Pharm Prod Ltd Pharmaceutical composition
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
WO1991015217A1 (en) * 1990-04-06 1991-10-17 Washington University Anticoagulant oligosaccharides
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
MX9201801A (es) * 1991-04-16 1992-10-30 Seikagaku Kogyo Co Ltd Oligosacarido que tiene afinidad para el factor de desarrollo del fibroplasto y procedimiento para producirlo.
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
DE4217916C2 (de) * 1992-05-30 1995-05-18 Job Prof Dr Med Harenberg N-Alkylamin- und N-Arylalkylaminderivate von Heparin, Verfahren zu ihrer Herstellung und ihrer Verwendung
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
DE69623840D1 (de) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Zusammensetzung zur Hemmung der Thromboseentstehung
SI0946185T2 (sl) * 1996-11-27 2010-08-31 Aventis Pharma Inc Farmacevtski sestavek, ki obsega spojino z anti-Xa-aktivnostjo in antagonistično spojino za agregacijo ploščic
US6075013A (en) * 1997-06-06 2000-06-13 Hamilton Civic Hospitals Research Development Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
EP1190364A2 (en) 1999-04-23 2002-03-27 Massachusetts Institute Of Technology System and method for polymer notation
HK1045532A1 (zh) * 1999-06-30 2002-11-29 Hamilton Civic Hospitals Research Development, Inc. 抑制与凝结有关凝结因子的肝素成份
JP2002097143A (ja) * 2000-07-18 2002-04-02 Koyo Chemical Kk 血流改善剤及び血栓予防治療剤または食品
EP1315539A2 (en) * 2000-09-08 2003-06-04 Leo Pharma A/S Antithrombotic compositions
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US6933372B2 (en) 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
WO2004108167A1 (en) * 2003-06-05 2004-12-16 Gencell Sas Plasmid encoding fibroblast growth factor for the treatment of hypercholesterolemia or diabetes associated angiogenic defects
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050096294A1 (en) * 2003-10-31 2005-05-05 Takashi Komai Novel anti-coagulant
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
EP2205642B1 (en) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8569262B2 (en) * 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009141821A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
AU2011268470B2 (en) 2010-06-17 2017-02-02 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
DK2794665T3 (da) 2011-12-19 2018-01-29 Dilafor Ab Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
US10016449B2 (en) 2013-05-28 2018-07-10 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
RU2612813C1 (ru) * 2015-12-07 2017-03-13 Павел Андреевич Канаев Способ получения гепарина
JP2021513593A (ja) 2018-02-14 2021-05-27 バイオロジカル イー リミテッド ダルテパリンナトリウムを調製する改善された方法
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US3066076A (en) * 1958-12-15 1962-11-27 Fo We Forschungs Und Verwertun Soluble heparin product and process for preparing same
FR2100735B1 (enExample) * 1970-06-08 1974-08-30 Mar Pha Etu Expl Marques
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
GB1399824A (en) * 1971-08-16 1975-07-02 Mar Pha Etu Expl Marques Heparin esters
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
EP0014184B1 (en) 1984-08-15
NL930104I1 (nl) 1993-10-01
EP0014184A2 (en) 1980-08-06
DK160764C (da) 1991-09-23
DK160764B (da) 1991-04-15
JPS6344764B2 (enExample) 1988-09-06
JPS56500066A (enExample) 1981-01-22
EP0014184B2 (en) 1989-10-18
NO150801C (no) 1984-12-27
US4303651A (en) 1981-12-01
NO802626L (no) 1980-09-05
NO150801B (no) 1984-09-10
EP0014184A3 (en) 1980-10-01
WO1980001383A1 (en) 1980-07-10
SU1209033A3 (ru) 1986-01-30
DE3068924D1 (en) 1984-09-20
ATE8998T1 (de) 1984-09-15
DK380280A (da) 1980-09-05
CA1136620A (en) 1982-11-30

Similar Documents

Publication Publication Date Title
NL930104I1 (nl) Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan
FR2310354A1 (fr) Glucopyranosido-1,6-mannite, son procede de fabrication et son utilisation en tant que succedane du sucre
IT1167610B (it) Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
DK597983D0 (da) Depolymeriseret og oversulfateret heparin, fremgangsmade til fremstilling deraf og farmaceutisk middel indeholdende naevnte heparin
IT8319164A0 (it) Derivati della 5-metiltiopirimidina, processo diloro preparazione e fungicidi contenenti gli stessi come ingredienti attivi.
BE837242A (fr) Plasma sanguin stable, son procede de preparation et ses applications
OA05466A (fr) Nouveaux éthers de (1-phényl-2-triazolyléthyle), leur procédé de préparation et leur application comme fongicides.
BE841840A (fr) Procede de sulfonation (ou de sulfatation) et melangeur
EP0245813A3 (en) Edta-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them
IL53901A (en) Meta-(ergoline-8 -carboxamido)benzamides (or benzenesulfonamides),their production and pharmaceutical compositions containing them
NO810660L (no) Nye lignosulfonsyrederivater, fremgangsmaate for fremstilling av disse og anvendelse av dem som additiver
DE3170001D1 (en) Method for the production of an antithrombin-heparin complex and pharmaceutical compositions containing the complex
FR2409996B1 (fr) 05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation
BE761116A (fr) Nouvelles (1,2,4)-triazolo-(3,2-c) (1,2,4)-triazinones, leur procede depreparation et leur application comme herbicides
BE844065A (fr) Nouvelles 2-phenylimino-thiazolines substituees, leur procede de preparation et compositions ectoparasiticides les contenant
DE3068719D1 (en) Stable solutions of hydrogenated ergotalcaloids or their salts and heparin or its salts,and process for their preparations
IT1031772B (it) Agente di incubazione per nematodi di barbabietola da zucchero
DK140314B (da) Analogifremgangsmåde til fremstilling af beta-D-1(6-amino-9H-purin-9-yl)-1-deoxy-2,3-di-O-nitroribofuranuronsyreethylamid.
RO86858A (ro) Procedeu pentru prepararea unor derivati de acid -2-feno0i-propionic ai pentitelor
IT1158699B (it) Derivati piranochinolinonici,composizioni farmaceutiche che li contengono e metodo per loro preparazione
JPS5233662A (en) Preparation of n2-naphthalenesulfonyl-alginamides and acid addition sa lts thereof
BE846471A (fr) Procede de preparation de 2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-t-butylaminoethyl) pyridine, et intermediaires appropries
FR2349578A1 (fr) Nouvelles 2-phenylimino-thiazolines, leur procede de preparation et compositions ectoparasiticides les contenant
FR2314198A1 (fr) D-homo 5a-pregnene-9(11)ones-20, et leur procede de preparation
OA04983A (fr) Benzomorphanes, leur procédé de préparation et leur application pharmaceutique.