FR2409996B1 - 05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation - Google Patents

05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation

Info

Publication number
FR2409996B1
FR2409996B1 FR787833311A FR7833311A FR2409996B1 FR 2409996 B1 FR2409996 B1 FR 2409996B1 FR 787833311 A FR787833311 A FR 787833311A FR 7833311 A FR7833311 A FR 7833311A FR 2409996 B1 FR2409996 B1 FR 2409996B1
Authority
FR
France
Prior art keywords
prostacycline
ppe
antithrombotic
preparation process
especially useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR787833311A
Other languages
English (en)
Other versions
FR2409996A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2409996A1 publication Critical patent/FR2409996A1/fr
Application granted granted Critical
Publication of FR2409996B1 publication Critical patent/FR2409996B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR787833311A 1977-11-25 1978-11-24 05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation Expired FR2409996B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT30029/77A IT1088036B (it) 1977-11-25 1977-11-25 15-epi-prostaciclina e prostaciclina analoghi

Publications (2)

Publication Number Publication Date
FR2409996A1 FR2409996A1 (fr) 1979-06-22
FR2409996B1 true FR2409996B1 (fr) 1985-07-26

Family

ID=11228900

Family Applications (1)

Application Number Title Priority Date Filing Date
FR787833311A Expired FR2409996B1 (fr) 1977-11-25 1978-11-24 05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation

Country Status (13)

Country Link
US (2) US4285966A (fr)
JP (1) JPS5481259A (fr)
BE (1) BE872266A (fr)
CA (1) CA1198416A (fr)
CH (1) CH643838A5 (fr)
DE (1) DE2850885A1 (fr)
FR (1) FR2409996B1 (fr)
GB (1) GB2008581B (fr)
HU (1) HU181425B (fr)
IT (1) IT1088036B (fr)
NL (1) NL7811572A (fr)
SE (1) SE444437B (fr)
ZA (1) ZA786234B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1098350B (it) * 1977-07-28 1985-09-07 Upjohn Co Derivati prostaglandinici
DE2902809A1 (de) * 1979-01-25 1980-08-07 Hoechst Ag Neue analoga von prostacyclin
DE3029984C2 (de) 1980-08-08 1983-12-15 Grünenthal GmbH, 5190 Stolberg 2-Oxabicyclo [3.3.0] octanderivate und diese enthaltende Arzneimittel
US4401824A (en) * 1982-03-08 1983-08-30 The Upjohn Company Benzopyran compounds, derivatives of prostaglandins
JPS60181041A (ja) * 1984-02-29 1985-09-14 Sankyo Co Ltd カルバサイクリン誘導体
JPS60172941A (ja) * 1984-02-16 1985-09-06 Sankyo Co Ltd カルバサイクリン類
US4616034A (en) * 1985-02-28 1986-10-07 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
US4158667A (en) * 1976-02-04 1979-06-19 The Upjohn Company 6-Keto PGF analogs
GB1583961A (en) 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4123441A (en) * 1976-09-22 1978-10-31 The Upjohn Company Enlarged-hetero-ring prostacyclin analogs
US4124601A (en) * 1976-12-30 1978-11-07 The Upjohn Company Certain 5-halo-6,9α-epoxy-14-bromo(or chloro)-PGF1 compounds
AU524786B2 (en) 1977-03-07 1982-10-07 The Upjohn Company Prostacyclins
ZA782614B (en) 1977-06-06 1979-04-25 Univ Chicago Novel prostacyclin analogs and chemical synthesis

Also Published As

Publication number Publication date
ZA786234B (en) 1979-10-31
HU181425B (en) 1983-07-28
US4285966A (en) 1981-08-25
NL7811572A (nl) 1979-05-29
GB2008581A (en) 1979-06-06
CH643838A5 (de) 1984-06-29
GB2008581B (en) 1982-06-30
SE444437B (sv) 1986-04-14
FR2409996A1 (fr) 1979-06-22
CA1198416A (fr) 1985-12-24
BE872266A (fr) 1979-03-16
IT1088036B (it) 1985-06-04
DE2850885A1 (de) 1979-05-31
US4321205A (en) 1982-03-23
JPS5481259A (en) 1979-06-28
SE7812124L (sv) 1979-05-26

Similar Documents

Publication Publication Date Title
FR2497203B1 (fr) Nouveaux 7-oxa-bicycloheptanes et -bicycloheptenes utiles notamment comme agents cardiovasculaires, et leur procede de preparation
BE869500A (fr) Procede de preparation de l'ethylene
BE865260A (fr) Procede de preparation d'octafluoropropane
BE869294A (fr) Procede de determination de l'amylase
IT7830144A0 (it) Metodo per la preparazione disolfato di calcio fibroso disperdibile e prodotto cosi'ottenuto.
BE869163A (fr) Thioethers basiques et leur procede de preparation
BE866031A (fr) Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation
NL7803143A (nl) Instillatiepreparaat, alsmede werkwijze voor de bereiding daarvan.
LU80476A1 (fr) Nouvelles 4-quinolyl-guanidines,utiles notamment comme anti-inflammatoires,et leur procede de preparation
IL54370A0 (en) Preparation for the treatment of herpes zoster and other herpes infections, as well as method for manufacture thereof
GB2000137B (en) Process for the preparation of 7,8-dihydro-14-hydroxynormorphine
FR2409996B1 (fr) 05-epi-prostacycline et analogues, utiles notamment comme agents antithrombotiques et thrombolytiques et leur procede de preparation
IT1101612B (it) Procedimento per la produzione di 2,6-diamminonebularine
FR2342734A1 (fr) Nouvelles cephalosporines, utiles notamment comme antibacteriens, et leur procede de preparation
BE865805A (fr) 1,2,3-thiadiazol-3-in-5-ylidene-urees, leur procede de preparation et leur utilisation
IT7825106A0 (it) Acetilenprostaglandine eprocedimento per la loro preparazione.
BE872294A (fr) Procede de preparation de 3-iodorifamycine s et de 3-bromorifamycine s
BE856895A (fr) 1-azolyl-butanes halogenes, leur procede de preparation et leur application comme fongicides
IT1102597B (it) Procedimento per la produzione di 2,3-dimetil-pentanale
IT1098842B (it) Processo per la preparazione di 2,3-diidro-7-benzofuranoli e intermedio benzodiossolico per detto processo
LU78874A1 (fr) Procede de preparation de nouvelles sulfonylhydrazones de 1,4-dioxo-et 4-oxoquinoxaline-2-carboxaldehyde
BE866662A (fr) Procede de preparation de 3,5-dihalogenanilines
BE864301A (fr) 1-arylamino-2,4-dinitronaphtalenes, leur procede de preparation et leur application comme pesticides
BE869481A (fr) Procede de preparation de pyridazinones-3, nouvelles pyridazinones-3 et leur utilisation comme herbicides
FR2327244A1 (fr) Pyrazolyltriazoles utiles comme herbicides et leur procede de preparation

Legal Events

Date Code Title Description
CD Change of name or company name
ST Notification of lapse