BE866031A - Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation - Google Patents

Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation

Info

Publication number
BE866031A
BE866031A BE186827A BE186827A BE866031A BE 866031 A BE866031 A BE 866031A BE 186827 A BE186827 A BE 186827A BE 186827 A BE186827 A BE 186827A BE 866031 A BE866031 A BE 866031A
Authority
BE
Belgium
Prior art keywords
antidiarrheics
diarylalkyl
octanes
azabicyclo
useful
Prior art date
Application number
BE186827A
Other languages
English (en)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BE866031A publication Critical patent/BE866031A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BE186827A 1977-04-18 1978-04-17 Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation BE866031A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,189 US4125531A (en) 1977-04-18 1977-04-18 2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number Publication Date
BE866031A true BE866031A (fr) 1978-10-17

Family

ID=25143721

Family Applications (1)

Application Number Title Priority Date Filing Date
BE186827A BE866031A (fr) 1977-04-18 1978-04-17 Nouveaux 2-(2,2-diarylalkyl)-1-azabicyclo (2,2,2)octanes, utiles notamment comme antidiarrheiques, et leur procede de preparation

Country Status (19)

Country Link
US (1) US4125531A (fr)
JP (1) JPS53132596A (fr)
AT (1) AT357553B (fr)
AU (1) AU3516178A (fr)
BE (1) BE866031A (fr)
DE (1) DE2816633A1 (fr)
DK (1) DK166978A (fr)
ES (1) ES468874A1 (fr)
FI (1) FI781161A (fr)
FR (1) FR2387980A1 (fr)
GB (1) GB1569249A (fr)
IE (1) IE46737B1 (fr)
IL (1) IL54519A0 (fr)
NL (1) NL7804145A (fr)
NO (1) NO781333L (fr)
NZ (1) NZ186991A (fr)
PT (1) PT67910B (fr)
SE (1) SE7804307L (fr)
ZA (1) ZA782212B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
US5242930A (en) * 1991-02-11 1993-09-07 Merck Sharp & Dohme Ltd. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
EP1615646B2 (fr) 2003-04-08 2022-07-27 Progenics Pharmaceuticals, Inc. Formulations pharmaceutiques contenant de la methylnaltrexone
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
TWI553009B (zh) 2007-03-29 2016-10-11 普吉尼製藥公司 末梢性類鴉片受體拮抗劑及其用途
PL2565195T3 (pl) 2007-03-29 2015-10-30 Wyeth Llc Obwodowy receptor opioidowy i jego antagoniści oraz ich zastosowania
AU2008233133B2 (en) 2007-03-29 2014-03-27 Progenics Pharmaceuticals, Inc. Crystal forms of (R) -N-methylnaltrexone bromide and uses thereof
KR101581480B1 (ko) 2008-02-06 2015-12-30 프로제닉스 파머슈티컬스, 인코포레이티드 (ｒ),(ｒ)-2,2'-비스-메틸날트렉손의 제조법 및 용도
CA2676881C (fr) 2008-09-30 2017-04-25 Wyeth Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506672A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) * 1976-03-08 1977-03-22 G. D. Searle & Co. 2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

Also Published As

Publication number Publication date
IE780745L (en) 1978-10-18
NL7804145A (nl) 1978-10-20
JPS53132596A (en) 1978-11-18
IL54519A0 (en) 1978-07-31
DE2816633A1 (de) 1978-10-19
IE46737B1 (en) 1983-09-07
PT67910A (en) 1978-05-01
FI781161A (fi) 1978-10-19
DK166978A (da) 1978-10-19
GB1569249A (en) 1980-06-11
PT67910B (en) 1979-11-14
ZA782212B (en) 1979-11-28
FR2387980A1 (fr) 1978-11-17
NO781333L (no) 1978-10-19
US4125531A (en) 1978-11-14
ES468874A1 (es) 1978-12-01
ATA266178A (de) 1979-12-15
SE7804307L (sv) 1978-10-19
NZ186991A (en) 1979-12-11
AU3516178A (en) 1979-10-25
AT357553B (de) 1980-07-25

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