SE7804307L - Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar - Google Patents

Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar

Info

Publication number
SE7804307L
SE7804307L SE7804307A SE7804307A SE7804307L SE 7804307 L SE7804307 L SE 7804307L SE 7804307 A SE7804307 A SE 7804307A SE 7804307 A SE7804307 A SE 7804307A SE 7804307 L SE7804307 L SE 7804307L
Authority
SE
Sweden
Prior art keywords
diarylalkyl
azabicyclo
octane
procedure
preparation
Prior art date
Application number
SE7804307A
Other languages
English (en)
Inventor
C H Yen
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7804307L publication Critical patent/SE7804307L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SE7804307A 1977-04-18 1978-04-17 Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar SE7804307L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,189 US4125531A (en) 1977-04-18 1977-04-18 2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number Publication Date
SE7804307L true SE7804307L (sv) 1978-10-19

Family

ID=25143721

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7804307A SE7804307L (sv) 1977-04-18 1978-04-17 Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar

Country Status (19)

Country Link
US (1) US4125531A (sv)
JP (1) JPS53132596A (sv)
AT (1) AT357553B (sv)
AU (1) AU3516178A (sv)
BE (1) BE866031A (sv)
DE (1) DE2816633A1 (sv)
DK (1) DK166978A (sv)
ES (1) ES468874A1 (sv)
FI (1) FI781161A (sv)
FR (1) FR2387980A1 (sv)
GB (1) GB1569249A (sv)
IE (1) IE46737B1 (sv)
IL (1) IL54519A0 (sv)
NL (1) NL7804145A (sv)
NO (1) NO781333L (sv)
NZ (1) NZ186991A (sv)
PT (1) PT67910B (sv)
SE (1) SE7804307L (sv)
ZA (1) ZA782212B (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
DE69220258T2 (de) * 1991-02-11 1997-12-18 Merck Sharp & Dohme Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
PT1615646E (pt) 2003-04-08 2015-02-12 Progenics Pharm Inc Formulações farmacêuticas com metilnaltrexona
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
MX351611B (es) 2007-03-29 2017-10-20 Wyeth Llc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
ES2570374T3 (es) 2007-03-29 2016-05-18 Progenics Pharm Inc Antagonistas del receptor opioide periférico y usos de los mismos
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
WO2009099411A1 (en) 2008-02-06 2009-08-13 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506672A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) * 1976-03-08 1977-03-22 G. D. Searle & Co. 2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

Also Published As

Publication number Publication date
DE2816633A1 (de) 1978-10-19
FR2387980A1 (fr) 1978-11-17
NZ186991A (en) 1979-12-11
ZA782212B (en) 1979-11-28
IE46737B1 (en) 1983-09-07
JPS53132596A (en) 1978-11-18
NL7804145A (nl) 1978-10-20
PT67910A (en) 1978-05-01
NO781333L (no) 1978-10-19
ES468874A1 (es) 1978-12-01
GB1569249A (en) 1980-06-11
PT67910B (en) 1979-11-14
ATA266178A (de) 1979-12-15
AU3516178A (en) 1979-10-25
DK166978A (da) 1978-10-19
IE780745L (en) 1978-10-18
FI781161A (fi) 1978-10-19
IL54519A0 (en) 1978-07-31
BE866031A (fr) 1978-10-17
US4125531A (en) 1978-11-14
AT357553B (de) 1980-07-25

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