PT67910B - Process for preparing 2-(2,2-diarylalquyl)-1-azabicyclo /2.2.2/-octane and related compounds - Google Patents

Process for preparing 2-(2,2-diarylalquyl)-1-azabicyclo /2.2.2/-octane and related compounds

Info

Publication number
PT67910B
PT67910B PT67910A PT6791078A PT67910B PT 67910 B PT67910 B PT 67910B PT 67910 A PT67910 A PT 67910A PT 6791078 A PT6791078 A PT 6791078A PT 67910 B PT67910 B PT 67910B
Authority
PT
Portugal
Prior art keywords
diarylalquyl
azabicyclo
octane
preparing
related compounds
Prior art date
Application number
PT67910A
Other languages
English (en)
Other versions
PT67910A (en
Inventor
Chung Hwai Yen
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT67910A publication Critical patent/PT67910A/pt
Publication of PT67910B publication Critical patent/PT67910B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
PT67910A 1977-04-18 1978-04-17 Process for preparing 2-(2,2-diarylalquyl)-1-azabicyclo /2.2.2/-octane and related compounds PT67910B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,189 US4125531A (en) 1977-04-18 1977-04-18 2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (2)

Publication Number Publication Date
PT67910A PT67910A (en) 1978-05-01
PT67910B true PT67910B (en) 1979-11-14

Family

ID=25143721

Family Applications (1)

Application Number Title Priority Date Filing Date
PT67910A PT67910B (en) 1977-04-18 1978-04-17 Process for preparing 2-(2,2-diarylalquyl)-1-azabicyclo /2.2.2/-octane and related compounds

Country Status (19)

Country Link
US (1) US4125531A (pt)
JP (1) JPS53132596A (pt)
AT (1) AT357553B (pt)
AU (1) AU3516178A (pt)
BE (1) BE866031A (pt)
DE (1) DE2816633A1 (pt)
DK (1) DK166978A (pt)
ES (1) ES468874A1 (pt)
FI (1) FI781161A (pt)
FR (1) FR2387980A1 (pt)
GB (1) GB1569249A (pt)
IE (1) IE46737B1 (pt)
IL (1) IL54519A0 (pt)
NL (1) NL7804145A (pt)
NO (1) NO781333L (pt)
NZ (1) NZ186991A (pt)
PT (1) PT67910B (pt)
SE (1) SE7804307L (pt)
ZA (1) ZA782212B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
JPH03135978A (ja) * 1989-08-08 1991-06-10 Merck Sharp & Dohme Ltd 置換ピリジン、その製法、処方並びに痴呆症における使用法
EP0499313B1 (en) * 1991-02-11 1997-06-11 MERCK SHARP & DOHME LTD. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
PL2368553T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
MX2009010552A (es) 2007-03-29 2009-12-14 Progenics Pharm Inc Antagonistas de receptor de opioide periferico y usos de los mismos.
BRPI0809579B8 (pt) 2007-03-29 2021-05-25 Progenics Pharm Inc formas cristalinas e seus usos
JP5469593B2 (ja) 2007-03-29 2014-04-16 ワイス・エルエルシー 末梢性オピオイド受容体アンタゴニストおよびその使用
US8471022B2 (en) 2008-02-06 2013-06-25 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2′-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506672A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) * 1976-03-08 1977-03-22 G. D. Searle & Co. 2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

Also Published As

Publication number Publication date
NO781333L (no) 1978-10-19
NL7804145A (nl) 1978-10-20
ZA782212B (en) 1979-11-28
FI781161A (fi) 1978-10-19
SE7804307L (sv) 1978-10-19
DE2816633A1 (de) 1978-10-19
JPS53132596A (en) 1978-11-18
AU3516178A (en) 1979-10-25
IE46737B1 (en) 1983-09-07
PT67910A (en) 1978-05-01
ES468874A1 (es) 1978-12-01
AT357553B (de) 1980-07-25
US4125531A (en) 1978-11-14
FR2387980A1 (fr) 1978-11-17
NZ186991A (en) 1979-12-11
ATA266178A (de) 1979-12-15
BE866031A (fr) 1978-10-17
IE780745L (en) 1978-10-18
GB1569249A (en) 1980-06-11
DK166978A (da) 1978-10-19
IL54519A0 (en) 1978-07-31

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