FR2280383A1 - Nouveaux 17a,21-diesters de 17a,21-dihydroxy steroides, leur procede de preparation, et leur application - Google Patents

Nouveaux 17a,21-diesters de 17a,21-dihydroxy steroides, leur procede de preparation, et leur application

Info

Publication number
FR2280383A1
FR2280383A1 FR7523787A FR7523787A FR2280383A1 FR 2280383 A1 FR2280383 A1 FR 2280383A1 FR 7523787 A FR7523787 A FR 7523787A FR 7523787 A FR7523787 A FR 7523787A FR 2280383 A1 FR2280383 A1 FR 2280383A1
Authority
FR
France
Prior art keywords
diesters
new
application
preparation process
dihydroxy steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7523787A
Other languages
English (en)
Other versions
FR2280383B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoire Glaxo Wellcome SA
Glaxo Laboratories Ltd
Original Assignee
Laboratoires Glaxo SA
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Glaxo SA, Glaxo Laboratories Ltd filed Critical Laboratoires Glaxo SA
Publication of FR2280383A1 publication Critical patent/FR2280383A1/fr
Application granted granted Critical
Publication of FR2280383B1 publication Critical patent/FR2280383B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7523787A 1974-07-31 1975-07-30 Nouveaux 17a,21-diesters de 17a,21-dihydroxy steroides, leur procede de preparation, et leur application Granted FR2280383A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB33786/74A GB1516095A (en) 1974-07-31 1974-07-31 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series

Publications (2)

Publication Number Publication Date
FR2280383A1 true FR2280383A1 (fr) 1976-02-27
FR2280383B1 FR2280383B1 (fr) 1978-10-06

Family

ID=10357423

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7523787A Granted FR2280383A1 (fr) 1974-07-31 1975-07-30 Nouveaux 17a,21-diesters de 17a,21-dihydroxy steroides, leur procede de preparation, et leur application

Country Status (13)

Country Link
JP (1) JPS51125059A (fr)
BE (1) BE831931A (fr)
CA (1) CA1058610A (fr)
CH (1) CH615442A5 (fr)
DE (1) DE2534051A1 (fr)
DK (1) DK139303B (fr)
ES (1) ES439852A1 (fr)
FR (1) FR2280383A1 (fr)
GB (1) GB1516095A (fr)
IE (1) IE42124B1 (fr)
NL (1) NL7509075A (fr)
SE (1) SE7508654L (fr)
ZA (1) ZA754907B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104746A1 (fr) * 1982-08-30 1984-04-04 The Upjohn Company Esters de 21-hydroxy-corticostéroides et compositions les contenant
FR2600653A1 (fr) * 1986-06-24 1987-12-31 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids
DE4333920A1 (de) 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130320A1 (en) * 1971-03-17 1972-11-03 Sigma Tau Ind Farmaceuti Beta-or dexa-methasone acylamino alkanoic acid esters
FR2205508A1 (fr) * 1972-08-11 1974-05-31 Glaxo Lab Ltd

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130320A1 (en) * 1971-03-17 1972-11-03 Sigma Tau Ind Farmaceuti Beta-or dexa-methasone acylamino alkanoic acid esters
FR2205508A1 (fr) * 1972-08-11 1974-05-31 Glaxo Lab Ltd

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104746A1 (fr) * 1982-08-30 1984-04-04 The Upjohn Company Esters de 21-hydroxy-corticostéroides et compositions les contenant
FR2600653A1 (fr) * 1986-06-24 1987-12-31 Pasteur Strasbourg Universite Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications
WO1988000202A1 (fr) * 1986-06-24 1988-01-14 Universite Louis Pasteur De Strasbourg Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du pregnane
EP0254655A1 (fr) * 1986-06-24 1988-01-27 Université Louis Pasteur de Strasbourg Etablissement public à caractère scientifique et culturel Composés de synthèse associative d'acides aminés soufrés ou non soufrés avec des dérivés du pregnane, leur préparation et leur utilisation

Also Published As

Publication number Publication date
JPS51125059A (en) 1976-11-01
DK346975A (fr) 1976-02-01
AU8353175A (en) 1977-02-03
CH615442A5 (en) 1980-01-31
FR2280383B1 (fr) 1978-10-06
GB1516095A (en) 1978-06-28
IE42124B1 (en) 1980-06-04
SE7508654L (sv) 1976-02-02
NL7509075A (nl) 1976-02-03
DE2534051A1 (de) 1976-02-19
DK139303B (da) 1979-01-29
ES439852A1 (es) 1977-03-01
ZA754907B (en) 1976-07-28
DK139303C (fr) 1979-08-06
BE831931A (fr) 1976-01-30
IE42124L (en) 1976-01-31
CA1058610A (fr) 1979-07-17

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Legal Events

Date Code Title Description
ST Notification of lapse