US5770396A
(en)
*
|
1992-04-16 |
1998-06-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E
|
DE69333484T2
(de)
*
|
1992-09-24 |
2005-03-24 |
Novartis Ag |
Umgestaltete monoklonale Antikörper gegen ein Immunglobulinisotyp
|
US5958708A
(en)
*
|
1992-09-25 |
1999-09-28 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
US6066718A
(en)
*
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
US20020193575A1
(en)
|
1993-09-07 |
2002-12-19 |
Smithkline Beecham P.L.C. |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
US5928904A
(en)
*
|
1993-09-07 |
1999-07-27 |
Smithkline Beecham Corporation |
DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
GB9324013D0
(en)
*
|
1993-11-22 |
1994-01-12 |
3I Res Expl Ltd |
Polypeptides
|
JP3825798B2
(ja)
*
|
1994-01-18 |
2006-09-27 |
ジェネンテク,インコーポレイテッド |
IgEアンタゴニストを用いる寄生虫感染症の治療法
|
US20040197326A1
(en)
*
|
1995-07-27 |
2004-10-07 |
Genentech, Inc. |
Method for treatment of allergic asthma
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
RU2193413C2
(ru)
*
|
1996-03-01 |
2002-11-27 |
Новартис Аг |
Пептидные иммуногены для вакцинации и лечения аллергии
|
US5958880A
(en)
*
|
1996-12-19 |
1999-09-28 |
Heska Corporation |
Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
US6172213B1
(en)
|
1997-07-02 |
2001-01-09 |
Genentech, Inc. |
Anti-IgE antibodies and method of improving polypeptides
|
US5994511A
(en)
|
1997-07-02 |
1999-11-30 |
Genentech, Inc. |
Anti-IgE antibodies and methods of improving polypeptides
|
US6057127A
(en)
|
1998-01-29 |
2000-05-02 |
Heska Corporation |
Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof
|
US7393529B2
(en)
*
|
1998-04-09 |
2008-07-01 |
Idexx Laboratories, Inc. |
Methods and compositions for inhibiting binding of IgE to a high affinity receptor
|
US6504013B1
(en)
*
|
2000-02-01 |
2003-01-07 |
Idexx Laboratories, Inc. |
Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
US6299875B1
(en)
|
1998-06-04 |
2001-10-09 |
Panacea Pharmaceuticals, Llc |
Methods to block IGE binding to cell surface receptors of mast cells
|
TWI227241B
(en)
*
|
1998-06-20 |
2005-02-01 |
United Biomedical Inc |
IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
|
NZ513680A
(en)
*
|
1999-02-25 |
2001-09-28 |
Peptide Therapeutics Ltd |
Epitodes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of IgE, antagonists thereof, and their therapeutic uses
|
US6889145B1
(en)
|
2000-03-15 |
2005-05-03 |
Northwestern University |
Three-dimensional model of a Fc region of an IgE antibody and uses thereof
|
DE60139944D1
(de)
|
2000-10-12 |
2009-10-29 |
Genentech Inc |
Niederviskose konzentrierte proteinformulierungen
|
US8703126B2
(en)
|
2000-10-12 |
2014-04-22 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
AU2003210802B2
(en)
|
2002-02-05 |
2009-09-10 |
Genentech Inc. |
Protein purification
|
KR100788093B1
(ko)
|
2002-04-26 |
2007-12-21 |
제넨테크, 인크. |
단백질의 비친화성 정제
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
JP2006520584A
(ja)
|
2002-11-08 |
2006-09-14 |
アブリンクス エン.ヴェー. |
安定化単一ドメイン抗体
|
AU2003286004A1
(en)
|
2002-11-08 |
2004-06-07 |
Ablynx N.V. |
Single domain antibodies directed against interferon- gamma and uses therefor
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
PT1610820E
(pt)
|
2003-04-04 |
2010-12-16 |
Novartis Ag |
Formulações de elevada concentração de anticorpos e proteínas
|
EP1648940B1
(en)
|
2003-07-28 |
2016-04-27 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
WO2005037867A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
ALTERATION OF Fc-FUSION PROTEIN SERUM HALF-LIVES BY MUTAGENESIS OF POSITIONS 250, 314 AND/OR 428 OF THE HEAVY CHAIN CONSTANT REGION OF IG
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
TWI391399B
(zh)
|
2005-05-25 |
2013-04-01 |
Hoffmann La Roche |
測定溶離多肽之鹽濃度之方法
|
WO2007032804A2
(en)
*
|
2005-06-30 |
2007-03-22 |
Clifford Risk |
Novel uses for anti-ige therapy
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
WO2008079280A1
(en)
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
MX2009007632A
(es)
|
2007-01-22 |
2009-07-24 |
Genentech Inc |
Precipitacion de polielectrolito y purificacion de proteinas.
|
AR065368A1
(es)
|
2007-02-15 |
2009-06-03 |
Astrazeneca Ab |
Anticuerpos para moleculas de ige
|
US20090053786A1
(en)
|
2007-07-09 |
2009-02-26 |
Yung-Hsiang Kao |
Prevention of disulfide bond reduction during recombinant production of polypeptides
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
WO2009025364A1
(ja)
|
2007-08-23 |
2009-02-26 |
Mitsubishi Kagaku Iatron, Inc. |
非特異反応抑制剤
|
SI2215117T2
(en)
|
2007-10-30 |
2018-04-30 |
Genentech, Inc. |
Purification of the antibody by cation exchange chromatography
|
US8999702B2
(en)
|
2008-06-11 |
2015-04-07 |
Emd Millipore Corporation |
Stirred tank bioreactor
|
DK2848625T3
(da)
|
2008-08-14 |
2019-10-07 |
Genentech Inc |
Fremgangsmåder til fjernelse af en kontaminant under anvendelse af ion bytningsmembrankromatografi med forskydning af naturligt forekommende proteiner
|
CN103599541A
(zh)
|
2008-09-10 |
2014-02-26 |
弗·哈夫曼-拉罗切有限公司 |
用于防止蛋白质氧化降解的组合物和方法
|
SG171764A1
(en)
|
2008-12-16 |
2011-07-28 |
Millipore Corp |
Purification of proteins
|
US20100190963A1
(en)
|
2008-12-16 |
2010-07-29 |
Millipore Corporation |
Stirred Tank Reactor And Method
|
EP2400992B1
(en)
|
2009-02-27 |
2015-07-22 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
BRPI1006519A2
(pt)
|
2009-03-06 |
2016-08-09 |
Genentech Inc |
formulação de anticorpos
|
LT2464725T
(lt)
|
2009-08-11 |
2020-06-10 |
F. Hoffmann-La Roche Ag |
Baltymų gamyba ląstelių mitybinėje terpėje, kurioje nėra glutamino
|
WO2011028753A1
(en)
|
2009-09-01 |
2011-03-10 |
Genentech, Inc. |
Enhanced protein purification through a modified protein a elution
|
EP3513810A1
(en)
|
2010-03-22 |
2019-07-24 |
F. Hoffmann-La Roche AG |
Compositions and methods useful for stabilizing protein- containing formulations
|
BR112012027828A2
(pt)
|
2010-05-03 |
2016-08-09 |
Genentech Inc |
composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína
|
BR112012028977B1
(pt)
|
2010-05-17 |
2020-05-05 |
Emd Millipore Corp |
método de purificação de biomolécula por meio de polímeros estímulo-responsivos
|
EP2576580B1
(en)
|
2010-05-28 |
2016-09-14 |
F.Hoffmann-La Roche Ag |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
MX339666B
(es)
|
2010-06-24 |
2016-06-03 |
Genentech Inc * |
Composiciones y metodos para estabilizar formulaciones que contienen proteinas.
|
CN103154032A
(zh)
|
2010-08-13 |
2013-06-12 |
弗·哈夫曼-拉罗切有限公司 |
用于疾病治疗的针对IL-1β和IL-18的抗体
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
UA112062C2
(uk)
|
2010-10-04 |
2016-07-25 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Cd33-зв'язувальний агент
|
ES2809211T3
(es)
|
2011-07-08 |
2021-03-03 |
Emd Millipore Corp |
Filtros de profundidad mejorados para procesos biotecnológicos desechables
|
WO2013087913A1
(en)
|
2011-12-16 |
2013-06-20 |
Synthon Biopharmaceuticals B.V. |
Compounds and methods for treating inflammatory diseases
|
JP6605202B2
(ja)
|
2011-12-22 |
2019-11-13 |
ジェネンテック, インコーポレイテッド |
イオン交換膜クロマトグラフィー
|
MY171729A
(en)
|
2012-03-27 |
2019-10-25 |
Genentech Inc |
Improved harvest operations for recombinant proteins
|
RU2711089C2
(ru)
|
2012-05-18 |
2020-01-15 |
Дженентек, Инк. |
Высококонцентрированные составы моноклональных антител
|
GB2503883A
(en)
*
|
2012-07-09 |
2014-01-15 |
King S College London |
Variant IgE with reduced affinity to CD23
|
CA2898146C
(en)
|
2012-12-19 |
2020-12-01 |
Charles Andrew BOSWELL |
Methods and compositions for radiohalogen protein labeling
|
KR102355306B1
(ko)
|
2014-07-09 |
2022-01-24 |
제넨테크, 인크. |
세포 은행의 해동 회수를 개선하는 ph 조정
|
KR20190012145A
(ko)
|
2016-03-29 |
2019-02-08 |
젤터, 인코포레이티드 |
주변세포질 부피 대 세포질 부피의 비가 0.5:1 내지 10:1인 그람-음성 박테리아에서의 단백질의 발현
|
GB201610198D0
(en)
|
2016-06-10 |
2016-07-27 |
Ucb Biopharma Sprl |
Anti-ige antibodies
|
KR102579836B1
(ko)
|
2016-12-22 |
2023-09-15 |
제넨테크, 인크. |
동결건조된 폴리펩타이드의 재구성 시간을 감소시키기 위한 방법 및 제제
|
US11518818B2
(en)
*
|
2017-01-06 |
2022-12-06 |
The Regents Of The University Of California |
Therapeutic anti-IgE antibodies and methods and compositions thereof
|
WO2018224673A1
(en)
|
2017-06-08 |
2018-12-13 |
Zaklady Farmaceutyczne Polpharma S.A. |
Improved methods of cell culture
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
BR112020006339A2
(pt)
|
2017-11-07 |
2020-11-03 |
Hubit Genomix, Inc. |
método para prevenção primária de distúrbios alérgicos durante a infância através de imunossupressão específica da classe ige
|
PT3818078T
(pt)
|
2018-07-03 |
2024-04-18 |
Bristol Myers Squibb Co |
Métodos de produção de proteínas recombinantes
|
MA53859A
(fr)
|
2018-10-10 |
2022-01-19 |
Boehringer Ingelheim Int |
Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité
|
AU2020254582A1
(en)
|
2019-04-01 |
2021-09-30 |
Genentech, Inc. |
Compositions and methods for stabilizing protein-containing formulations
|
EP3953380A4
(en)
|
2019-04-12 |
2023-01-25 |
Geltor, Inc. |
RECOMBINATION ELASTIN AND ASSOCIATED PRODUCTION
|
CN114514311A
(zh)
|
2019-08-01 |
2022-05-17 |
百时美施贵宝公司 |
改进补料分批细胞培养物中蛋白质产量的方法
|
KR20230042030A
(ko)
|
2020-07-10 |
2023-03-27 |
상하이 제민케어 파마슈티칼 컴퍼니 리미티드 |
항-IgE 조작된 항체 및 이의 적용
|
EP4217383A1
(en)
|
2020-09-22 |
2023-08-02 |
Bristol-Myers Squibb Company |
Methods for producing therapeutic proteins
|
WO2023015234A1
(en)
|
2021-08-05 |
2023-02-09 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
WO2023049687A1
(en)
|
2021-09-21 |
2023-03-30 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|