US5770396A
(en)
*
|
1992-04-16 |
1998-06-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E
|
ATE264388T1
(de)
*
|
1992-09-24 |
2004-04-15 |
Tanox Biosystems Inc |
Umgestaltete monoklonale antikörper gegen ein immunglobulinisotyp
|
US6066718A
(en)
*
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
US5958708A
(en)
*
|
1992-09-25 |
1999-09-28 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
US20020193575A1
(en)
|
1993-09-07 |
2002-12-19 |
Smithkline Beecham P.L.C. |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
US5928904A
(en)
*
|
1993-09-07 |
1999-07-27 |
Smithkline Beecham Corporation |
DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
US5914110A
(en)
*
|
1993-09-07 |
1999-06-22 |
Smithkline Beecham Corporation |
Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
|
GB9324013D0
(en)
*
|
1993-11-22 |
1994-01-12 |
3I Res Expl Ltd |
Polypeptides
|
DE69501817T2
(de)
*
|
1994-01-18 |
1998-09-10 |
Genentech Inc |
Verfahren zur behandlung von parasitären infektionen unter verwendung von ige-antagonisten
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
US20040197326A1
(en)
*
|
1995-07-27 |
2004-10-07 |
Genentech, Inc. |
Method for treatment of allergic asthma
|
DE69718150T3
(de)
*
|
1996-03-01 |
2009-03-05 |
Novartis Ag |
Peptid-immunogene zur schutzimpfung gegen und behandlung von allergien
|
US5958880A
(en)
*
|
1996-12-19 |
1999-09-28 |
Heska Corporation |
Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
US6172213B1
(en)
|
1997-07-02 |
2001-01-09 |
Genentech, Inc. |
Anti-IgE antibodies and method of improving polypeptides
|
US5994511A
(en)
|
1997-07-02 |
1999-11-30 |
Genentech, Inc. |
Anti-IgE antibodies and methods of improving polypeptides
|
US6057127A
(en)
*
|
1998-01-29 |
2000-05-02 |
Heska Corporation |
Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof
|
US6504013B1
(en)
*
|
2000-02-01 |
2003-01-07 |
Idexx Laboratories, Inc. |
Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody
|
US7393529B2
(en)
*
|
1998-04-09 |
2008-07-01 |
Idexx Laboratories, Inc. |
Methods and compositions for inhibiting binding of IgE to a high affinity receptor
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
US6299875B1
(en)
*
|
1998-06-04 |
2001-10-09 |
Panacea Pharmaceuticals, Llc |
Methods to block IGE binding to cell surface receptors of mast cells
|
TWI227241B
(en)
*
|
1998-06-20 |
2005-02-01 |
United Biomedical Inc |
IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
|
IL145025A0
(en)
*
|
1999-02-25 |
2002-06-30 |
Smithkline Beecham Biolog |
Epitopes or mimotopes derived from the c-epsilon-3 or c-epsilon-4 domains of ige, antagonists thereof, and their therapeutic uses
|
US6889145B1
(en)
|
2000-03-15 |
2005-05-03 |
Northwestern University |
Three-dimensional model of a Fc region of an IgE antibody and uses thereof
|
US8703126B2
(en)
|
2000-10-12 |
2014-04-22 |
Genentech, Inc. |
Reduced-viscosity concentrated protein formulations
|
SI1324776T2
(en)
|
2000-10-12 |
2018-06-29 |
Genentech, Inc. |
Concentrated protein formulations with reduced viscosity
|
WO2003066662A2
(en)
|
2002-02-05 |
2003-08-14 |
Genentech, Inc. |
Protein purification
|
WO2003102132A2
(en)
|
2002-04-26 |
2003-12-11 |
Genetech, Inc. |
Non-affinity purification of proteins
|
US7365168B2
(en)
|
2002-10-15 |
2008-04-29 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
US20060034845A1
(en)
|
2002-11-08 |
2006-02-16 |
Karen Silence |
Single domain antibodies directed against tumor necrosis factor alpha and uses therefor
|
US9320792B2
(en)
|
2002-11-08 |
2016-04-26 |
Ablynx N.V. |
Pulmonary administration of immunoglobulin single variable domains and constructs thereof
|
CA2505326A1
(en)
|
2002-11-08 |
2004-05-21 |
Ablynx N.V. |
Camelidae antibodies against immunoglobulin e and use thereof for the treatment of allergic disorders
|
EP1558645B1
(en)
|
2002-11-08 |
2011-07-27 |
Ablynx N.V. |
Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation
|
AU2004229335C1
(en)
|
2003-04-04 |
2010-06-17 |
Genentech, Inc. |
High concentration antibody and protein formulations
|
SI1648940T1
(sl)
|
2003-07-28 |
2016-08-31 |
Genentech, Inc. |
Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A
|
EP1673395A1
(en)
|
2003-10-15 |
2006-06-28 |
PDL BioPharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
TWI391399B
(zh)
|
2005-05-25 |
2013-04-01 |
Hoffmann La Roche |
測定溶離多肽之鹽濃度之方法
|
US8080249B2
(en)
*
|
2005-06-30 |
2011-12-20 |
Risk Glifford G |
Methods to treating chronic obstructive pulmonary disease
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
US8163886B2
(en)
|
2006-12-21 |
2012-04-24 |
Emd Millipore Corporation |
Purification of proteins
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
MX2009007632A
(es)
|
2007-01-22 |
2009-07-24 |
Genentech Inc |
Precipitacion de polielectrolito y purificacion de proteinas.
|
AR065368A1
(es)
|
2007-02-15 |
2009-06-03 |
Astrazeneca Ab |
Anticuerpos para moleculas de ige
|
DE17196350T1
(de)
|
2007-07-09 |
2018-12-27 |
Genentech, Inc. |
Verhindern der disulfid-bindungsreduktion während der rekombinanten herstellung von polypeptiden
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
US20110189704A1
(en)
|
2007-08-23 |
2011-08-04 |
Mitsubishi Chemical Medience Corporation |
Non-specific reaction inhibitor
|
HUE037409T2
(hu)
|
2007-10-30 |
2018-08-28 |
Genentech Inc |
Antitest-tisztítás kationcserés kromatográfiával
|
WO2009151514A1
(en)
|
2008-06-11 |
2009-12-17 |
Millipore Corporation |
Stirred tank bioreactor
|
WO2010019148A1
(en)
|
2008-08-14 |
2010-02-18 |
Genentech, Inc. |
Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
|
CN103599541A
(zh)
|
2008-09-10 |
2014-02-26 |
弗·哈夫曼-拉罗切有限公司 |
用于防止蛋白质氧化降解的组合物和方法
|
JP2012512244A
(ja)
|
2008-12-16 |
2012-05-31 |
イー・エム・デイー・ミリポア・コーポレイシヨン |
タンパク質の精製
|
EP2370561B1
(en)
|
2008-12-16 |
2019-08-07 |
EMD Millipore Corporation |
Stirred tank reactor and method
|
US8435488B2
(en)
|
2009-02-27 |
2013-05-07 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
SG174258A1
(en)
|
2009-03-06 |
2011-10-28 |
Genentech Inc |
Antibody formulation
|
KR20180114966A
(ko)
|
2009-08-11 |
2018-10-19 |
제넨테크, 인크. |
글루타민-비함유 세포 배양 배지에서의 단백질의 생성
|
MX2012002565A
(es)
|
2009-09-01 |
2012-05-29 |
Genentech Inc |
Purificacion de proteina mejorada a traves de una elucion de proteina a modificada.
|
CN106983862A
(zh)
|
2010-03-22 |
2017-07-28 |
弗·哈夫曼-拉罗切有限公司 |
对于稳定含有蛋白质的制剂有用的组合物和方法
|
MX2012012743A
(es)
|
2010-05-03 |
2012-11-23 |
Genentech Inc |
Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina.
|
US8691918B2
(en)
|
2010-05-17 |
2014-04-08 |
Emd Millipore Corporation |
Stimulus responsive polymers for the purification of biomolecules
|
ES2599412T3
(es)
|
2010-05-28 |
2017-02-01 |
F. Hoffmann-La Roche Ag |
Disminución del nivel de lactato y aumento de la producción de polipéptidos regulando por disminución la expresión de la lactato deshidrogenasa y de la piruvato deshidrogenasa quinasa
|
KR101924653B1
(ko)
|
2010-06-24 |
2018-12-03 |
제넨테크, 인크. |
단백질-함유 제제를 안정화시키기 위한 알킬글리코시드 함유 조성물 및 방법
|
WO2012021773A1
(en)
|
2010-08-13 |
2012-02-16 |
Genentech, Inc. |
Antibodies to il-1beta and il-18, for treatment of disease
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
UA112062C2
(uk)
|
2010-10-04 |
2016-07-25 |
Бьорінгер Інгельхайм Інтернаціональ Гмбх |
Cd33-зв'язувальний агент
|
US20130012689A1
(en)
|
2011-07-08 |
2013-01-10 |
Emd Millipore Corporation |
Depth Filters For Disposable Biotechnological Processes
|
WO2013087912A1
(en)
|
2011-12-16 |
2013-06-20 |
Synthon Biopharmaceuticals B.V. |
Compounds and methods for treating inflammatory diseases
|
MX360453B
(es)
|
2011-12-22 |
2018-11-01 |
Genentech Inc |
Cromatografia de membrana de intercambio ionico.
|
AU2013240280A1
(en)
|
2012-03-27 |
2014-10-16 |
Genentech, Inc. |
Improved harvest operations for recombinant proteins
|
MY188825A
(en)
|
2012-05-18 |
2022-01-06 |
Genentech Inc |
High-concentration monoclonal antibody formulations
|
GB2503883A
(en)
*
|
2012-07-09 |
2014-01-15 |
King S College London |
Variant IgE with reduced affinity to CD23
|
US9393327B2
(en)
|
2012-12-19 |
2016-07-19 |
Genentech, Inc. |
Methods and compositions for radiohalogen protein labeling
|
ES2825574T3
(es)
|
2014-07-09 |
2021-05-17 |
Hoffmann La Roche |
Ajuste del pH para mejorar la recuperación por descongelación de bancos de células
|
AU2017242031B2
(en)
|
2016-03-29 |
2023-07-27 |
Geltor, Inc. |
Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
|
GB201610198D0
(en)
|
2016-06-10 |
2016-07-27 |
Ucb Biopharma Sprl |
Anti-ige antibodies
|
KR102579836B1
(ko)
|
2016-12-22 |
2023-09-15 |
제넨테크, 인크. |
동결건조된 폴리펩타이드의 재구성 시간을 감소시키기 위한 방법 및 제제
|
CA3049967A1
(en)
*
|
2017-01-06 |
2018-07-12 |
The Regents Of The University Of California |
Therapeutic anti-ige antibodies and methods and compositions thereof
|
EP3635093A1
(en)
|
2017-06-08 |
2020-04-15 |
Polpharma Biologics S.A. |
Improved methods of cell culture
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
JP7169985B2
(ja)
|
2017-11-07 |
2022-11-11 |
ヒュービットジェノミクス株式会社 |
IgEクラスに特異的な免疫反応の抑制効果を介した乳児期のアレルギー素因獲得を阻止する方法
|
RS65472B1
(sr)
|
2018-07-03 |
2024-05-31 |
Bristol Myers Squibb Co |
Postupak proizvodnje rekombinantnih proteina
|
MA53859A
(fr)
|
2018-10-10 |
2022-01-19 |
Boehringer Ingelheim Int |
Procédé de transfert de gaz de membrane dans une culture de bioréacteur à haute densité
|
CN113660953A
(zh)
|
2019-04-01 |
2021-11-16 |
豪夫迈·罗氏有限公司 |
用于稳定含蛋白质制剂的组合物和方法
|
WO2020210440A1
(en)
|
2019-04-12 |
2020-10-15 |
Geltor, Inc. |
Recombinant elastin and production thereof
|
EP4007808A1
(en)
|
2019-08-01 |
2022-06-08 |
Bristol-Myers Squibb Company |
Methods of improving protein productivity in fed-batch cell cultures
|
US20230250191A1
(en)
|
2020-07-10 |
2023-08-10 |
Shanghai Jemincare Pharmaceutical Co., Ltd. |
Anti-ige engineered antibody and application thereof
|
JP2023542924A
(ja)
|
2020-09-22 |
2023-10-12 |
ブリストル-マイヤーズ スクイブ カンパニー |
治療タンパク質を生産するための方法
|
WO2023015234A1
(en)
|
2021-08-05 |
2023-02-09 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
WO2023049687A1
(en)
|
2021-09-21 |
2023-03-30 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|