NL195051C - Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. - Google Patents
Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. Download PDFInfo
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- A61P35/00—Antineoplastic agents
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/16011—Orthomyxoviridae
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- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Virology (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9071187A | 1987-08-28 | 1987-08-28 | |
| US9071187 | 1987-08-28 | ||
| US11033587A | 1987-10-20 | 1987-10-20 | |
| US11033587 | 1987-10-20 | ||
| US18605488A | 1988-04-25 | 1988-04-25 | |
| US18605488 | 1988-04-25 | ||
| US23439088A | 1988-08-23 | 1988-08-23 | |
| US23439088 | 1988-08-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NL8820679A NL8820679A (nl) | 1989-07-03 |
| NL195051C true NL195051C (nl) | 2003-07-01 |
Family
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8820679A NL195051C (nl) | 1987-08-28 | 1988-08-24 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
| NL300130C NL300130I2 (nl) | 1987-08-28 | 2003-07-09 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
| NL300138C NL300138I2 (nl) | 1987-08-28 | 2003-11-25 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
| NL300139C NL300139I1 (nl) | 1987-08-28 | 2003-11-25 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL300130C NL300130I2 (nl) | 1987-08-28 | 2003-07-09 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
| NL300138C NL300138I2 (nl) | 1987-08-28 | 2003-11-25 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
| NL300139C NL300139I1 (nl) | 1987-08-28 | 2003-11-25 | Recombinant-pokkenvirussen, immunologische samenstellingen die een recombinant-pokkenvirus omvatten en werkwijze voor het tot expressie brengen van het DNA in een recombinant-pokkenvirus. |
Country Status (17)
| Country | Link |
|---|---|
| JP (3) | JP3348156B2 (de) |
| KR (1) | KR970011149B1 (de) |
| AR (1) | AR241939A1 (de) |
| AT (1) | AT408549B (de) |
| AU (2) | AU2427588A (de) |
| BE (1) | BE1002134A5 (de) |
| CH (2) | CH679933A5 (de) |
| DE (4) | DE10399031I1 (de) |
| DK (1) | DK175904B1 (de) |
| FR (1) | FR2621487B1 (de) |
| GB (1) | GB2217718B (de) |
| IL (1) | IL87581A0 (de) |
| IT (1) | IT1229484B (de) |
| LU (2) | LU90951I2 (de) |
| NL (4) | NL195051C (de) |
| NZ (1) | NZ225970A (de) |
| WO (1) | WO1989003429A1 (de) |
Families Citing this family (121)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5505941A (en) * | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US7045313B1 (en) | 1982-11-30 | 2006-05-16 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant vaccinia virus containing a chimeric gene having foreign DNA flanked by vaccinia regulatory DNA |
| DE10399031I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| US5286639A (en) * | 1987-09-16 | 1994-02-15 | Nippon Zeon Co., Ltd. | Recombinant avipoxvirus |
| DE3813093A1 (de) * | 1988-04-19 | 1989-11-09 | Immuno Ag | Rekombinantes plasmid, verfahren zum herstellen eines rekombinanten avipoxvirus, rekombinantes avipoxvirus und dessen verwendung |
| US5631154A (en) * | 1988-06-10 | 1997-05-20 | Therion Biologics, Incorporated | Self assembled, defective, non-self-propagating lentivirus particles |
| AU623913B2 (en) * | 1988-06-24 | 1992-05-28 | British Technology Group Limited | Fowlpox virus non-essential regions |
| US5093258A (en) * | 1988-08-26 | 1992-03-03 | Therion Biologics Corporation | Recombinant fowlpox virus and recombination vector |
| CA2001001A1 (en) * | 1988-10-21 | 1990-04-21 | Matthew M. Binns | Fowlpox virus promoter |
| US6248333B1 (en) | 1990-04-04 | 2001-06-19 | Health Research Inc. | Isolated nucleic acid sequence of equine herpesvirus type 1 glycoprotein D (EHV-1 gD) |
| US5204243A (en) * | 1990-02-14 | 1993-04-20 | Health Research Incorporated | Recombinant poxvirus internal cores |
| US5514375A (en) * | 1990-08-15 | 1996-05-07 | Virogenetics Corporation | Flavivirus recombinant poxvirus vaccine |
| MY109299A (en) * | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
| FR2668064B1 (fr) * | 1990-10-23 | 1994-12-16 | Transgene Sa | Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne. |
| US5756102A (en) * | 1990-11-20 | 1998-05-26 | Virogenetics Corporation | Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants |
| US6309647B1 (en) | 1999-07-15 | 2001-10-30 | Aventis Pasteur | Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants |
| AU672359B2 (en) * | 1991-03-07 | 1996-10-03 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US5503834A (en) * | 1990-11-20 | 1996-04-02 | Virogenetics Corporation | Measles virus recombinant poxvirus vaccine |
| IE71643B1 (en) * | 1990-11-20 | 1997-02-26 | Virogenetics Corp | A recombinant poxviral vaccine for canine distemper |
| US5759841A (en) * | 1990-11-20 | 1998-06-02 | Virogenetics Corporation | Immunological composition of measles virus utilizing recombinant poxvirus |
| US5338679A (en) * | 1991-01-08 | 1994-08-16 | Her Majesty The Queen In Right Of Canada, As Represented By National Research Council Canada And Forestry Canada | Vertebrate poxvoris expression vector under the control of entomopoxvirus spheroidin gene promoter |
| US5756101A (en) * | 1991-07-01 | 1998-05-26 | Pasteur Merieux Serums Et Vaccins | Malaria recombinant poxvirus |
| US5863542A (en) * | 1991-03-07 | 1999-01-26 | Virogenetics Corporation | Recombinant attenuated ALVAC canaryopox virus containing heterologous HIV or SIV inserts |
| US5766598A (en) * | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| WO1992022641A1 (en) * | 1991-06-14 | 1992-12-23 | Virogenetics Corporation | Immunodeficiency virus recombinant poxvirus vaccine |
| US5766597A (en) * | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Malaria recombinant poxviruses |
| AU674491B2 (en) * | 1991-03-20 | 1997-01-02 | Virogenetics Corporation | Recombinant poxvirus malaria vaccine |
| WO1993003145A1 (en) * | 1991-07-26 | 1993-02-18 | Virogenetics Corporation | Infectious bursal disease virus recombinant poxvirus vaccine |
| EP0538496B1 (de) * | 1991-08-26 | 2003-10-29 | Baxter Healthcare S.A. | Ein intaktes FPV-tk-Gen enthaltender rekombinanter Virus der Vogelpocken |
| US5443831A (en) * | 1991-10-29 | 1995-08-22 | University Of Delaware | Gene encoding glycoprotein B of Infectious Laryngotracheitis Virus |
| US6251403B1 (en) | 1992-01-13 | 2001-06-26 | Syntro Corporation | Recombinant swinepox virus |
| US6127163A (en) * | 1992-01-13 | 2000-10-03 | Syntro Corporation | Recombinant swinepox virus |
| US6497882B1 (en) | 1992-01-13 | 2002-12-24 | Syntro Corporation | Recombinant swinepox virus |
| US6033904A (en) * | 1992-01-13 | 2000-03-07 | Syntro Corporation | Recombinant swinepox virus |
| US5869312A (en) * | 1992-01-13 | 1999-02-09 | Syntro Corporation | Recombinant swinepox virus |
| US6328975B1 (en) | 1992-01-13 | 2001-12-11 | Syntro Corporation | Recombinant swinepox virus |
| AU680609B2 (en) * | 1992-01-13 | 1997-08-07 | Virogenetics Corporation | Marek's disease virus recombinant poxvirus vaccine |
| CA2142325A1 (en) * | 1992-09-21 | 1994-03-31 | William T. L. Lee | Recombinant retroviral vector against felv and/or fiv |
| US5925358A (en) * | 1993-02-26 | 1999-07-20 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| AU727278B2 (en) * | 1993-02-26 | 2000-12-07 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof II |
| US6136318A (en) * | 1993-02-26 | 2000-10-24 | Cochran; Mark D. | Recombinant fowlpox viruses and uses thereof |
| WO1994019014A1 (en) * | 1993-02-26 | 1994-09-01 | Syntro Corporation | Recombinant fowlpox virus s-fpv-043 and uses thereof |
| US5496731A (en) * | 1993-03-25 | 1996-03-05 | Xu; Hong-Ji | Broad-spectrum tumor suppressor genes, gene products and methods for tumor suppressor gene therapy |
| US5843742A (en) * | 1994-12-16 | 1998-12-01 | Avigen Incorporated | Adeno-associated derived vector systems for gene delivery and integration into target cells |
| EP0753581A1 (de) | 1995-07-10 | 1997-01-15 | Immuno Ag | Verbesserte rekombinante eukaryotische zytoplasmatische Viren, Methode ihrer Herstellung und ihrer Verwendung als Impfstoffe |
| US5858373A (en) * | 1995-12-01 | 1999-01-12 | Virogenetics Corporation | Recombinant poxvirus-feline infectious peritionitis virus, compositions thereof and methods for making and using them |
| JP4475683B2 (ja) | 1996-07-25 | 2010-06-09 | アメリカ合衆国 | 腫瘍関連抗原に対する免疫のための組換えポックス・ウイルス |
| US6106825A (en) * | 1997-05-07 | 2000-08-22 | University Of Florida | Entomopoxvirus-vertebrate gene delivery vector and method |
| WO1999007869A1 (en) * | 1997-08-05 | 1999-02-18 | University Of Florida | Live recombinant vaccine comprising inefficiently or non-replicating virus |
| US6248582B1 (en) * | 1997-10-08 | 2001-06-19 | Imran Khan | Gene deleted recombinant FeLV proviral DNA for production of vaccines against FeLV |
| JPH11165762A (ja) | 1997-12-01 | 1999-06-22 | Lintec Corp | チップ体搬送用カバーテープおよび封止構造体 |
| US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US6221349B1 (en) | 1998-10-20 | 2001-04-24 | Avigen, Inc. | Adeno-associated vectors for expression of factor VIII by target cells |
| US6200560B1 (en) | 1998-10-20 | 2001-03-13 | Avigen, Inc. | Adeno-associated virus vectors for expression of factor VIII by target cells |
| US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| WO2001000665A2 (en) | 1999-06-28 | 2001-01-04 | Oklahoma Medical Research Foundation | Inhibitors of memapsin 2 and use thereof |
| IL151097A0 (en) | 2000-02-23 | 2003-04-10 | Smithkline Beecham Biolog | Tumour-specific animal proteins |
| AU2001273149A1 (en) | 2000-06-28 | 2002-01-08 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
| WO2002080982A2 (en) | 2001-01-12 | 2002-10-17 | Chiron Corporation | Nucleic acid mucosal immunization |
| BR0207761A (pt) * | 2001-03-08 | 2006-01-31 | Akzo Nobel Nv | Uso de um vìrus leporipox recombinante vivo, vacina, e, vìrus leporipox recombinante vivo |
| JP4499311B2 (ja) * | 2001-04-27 | 2010-07-07 | シャープ株式会社 | 放送受信端末 |
| JP2005504513A (ja) | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| AU2002320314A1 (en) | 2001-07-05 | 2003-01-21 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US20030198621A1 (en) | 2001-07-05 | 2003-10-23 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
| EP1581119B1 (de) | 2001-12-17 | 2013-01-30 | Corixa Corporation | Zusammensetzungen und verfahren zur behandlung und diagnose von entzündlicher darmerkrankung |
| US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| CA2512108C (en) | 2003-01-06 | 2013-04-02 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| US20070073048A1 (en) | 2003-05-15 | 2007-03-29 | Ying Lian | Hiv polynucleotides and polypeptides derived from botswana mj4 |
| US7261882B2 (en) | 2003-06-23 | 2007-08-28 | Reagents Of The University Of Colorado | Methods for treating neuropathic pain by administering IL-10 polypeptides |
| WO2006032475A2 (en) | 2004-09-22 | 2006-03-30 | Glaxosmithkline Biologicals S.A. | Staphylococcal immunogenic compositions |
| JP5215865B2 (ja) | 2005-11-22 | 2013-06-19 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | ノロウイルス抗原およびサポウイルス抗原 |
| WO2007120368A2 (en) | 2006-01-09 | 2007-10-25 | The Regents Of The University Of California | Immunostimulatory combinations for vaccine adjuvants |
| WO2007106536A2 (en) | 2006-03-14 | 2007-09-20 | Oregon Health & Science University | Methods for producing an immune response to tuberculosis |
| JP5596980B2 (ja) | 2007-02-28 | 2014-10-01 | アメリカ合衆国 | ブラキュリポリペプチドおよび使用方法 |
| US20120040367A1 (en) | 2007-10-15 | 2012-02-16 | The University Of Queensland | Construct system and uses therefor |
| US8691502B2 (en) | 2008-10-31 | 2014-04-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| BRPI1005670A8 (pt) | 2009-01-05 | 2017-12-26 | Epitogenesis Inc | composições adjuvantes e processos de uso. |
| WO2010099472A2 (en) | 2009-02-27 | 2010-09-02 | The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services | Spanx-b polypeptides and their use |
| WO2011063263A2 (en) | 2009-11-20 | 2011-05-26 | Oregon Health & Science University | Methods for producing an immune response to tuberculosis |
| US20130052221A1 (en) | 2010-02-26 | 2013-02-28 | The Govt. of the U.S, as represented by The Sec. of The Dept. of Health and Human Services | Dna-protein vaccination protocols |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| WO2012106281A2 (en) | 2011-01-31 | 2012-08-09 | The General Hospital Corporation | Multimodal trail molecules and uses in cellular therapies |
| WO2012151272A2 (en) | 2011-05-02 | 2012-11-08 | Tremrx, Inc. | T-cell vaccination with viral vectors via mechanical epidermal disruption |
| EP2723365A1 (de) | 2011-06-21 | 2014-04-30 | Oncofactor Corporation | Zusammensetzungen und verfahren zur behandlung und diagnose von krebs |
| EP2723378A4 (de) | 2011-06-24 | 2015-01-28 | Epitogenesis Inc | Pharmazeutische zusammensetzungen mit einer kombination aus ausgewählten trägern, vitaminen, tanninen und flavonoiden als antigenspezifischen immunmodulatoren |
| WO2013082106A1 (en) | 2011-12-02 | 2013-06-06 | The General Hospital Corporation | Differentiation into brown adipocytes |
| EP2890720B1 (de) | 2012-08-30 | 2019-07-17 | The General Hospital Corporation | Zusammensetzungen und verfahren zur behandlung von krebs |
| WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
| US20150224181A1 (en) | 2012-09-14 | 2015-08-13 | The United States Of America As Represented By The Secretary Department Of Health And Human Se | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
| US10640771B2 (en) | 2013-04-17 | 2020-05-05 | Genzyme Corporation | Compositions and methods for treating and preventing macular degeneration |
| JP6649250B2 (ja) | 2013-05-21 | 2020-02-19 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 操作されたヘム結合性構成物およびその使用 |
| EP3068783B1 (de) | 2013-11-15 | 2020-09-23 | The Board of Trustees of the Leland Stanford Junior University | Agonisten des hypokretin-rezeptors 2 zur verwendung zur behandlung von herzversagen |
| CN106163573A (zh) | 2014-02-06 | 2016-11-23 | 建新公司 | 用于治疗和预防黄斑变性的组合物及方法 |
| EP3194446B1 (de) | 2014-09-18 | 2022-10-26 | Cedars-Sinai Medical Center | Zusammensetzungen und verfahren zur behandlung von fibrose |
| US20180071380A1 (en) | 2015-03-20 | 2018-03-15 | The Regents Of The University Of Michigan | Immunogenic compositions for use in vaccination against bordetella |
| WO2016168601A1 (en) | 2015-04-17 | 2016-10-20 | Khalid Shah | Agents, systems and methods for treating cancer |
| CN107708718B (zh) | 2015-04-22 | 2022-01-11 | 西达-赛奈医疗中心 | 用于治疗2型糖尿病的肠内递送的苦味寡肽 |
| EP3294755B1 (de) | 2015-05-13 | 2023-08-23 | The United States of America as represented by the Secretary of the Department of Health and Human Services | Methoden und zusammensetzungen beruhend auf konstruktenenthaltend konservierte elemente zur induktion einer immunantwort |
| WO2016196366A1 (en) | 2015-05-29 | 2016-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Extension of replicative lifespan in diseases of premature aging using p53 isoforms |
| WO2017004022A2 (en) | 2015-06-29 | 2017-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Degron fusion constructs and methods for controlling protein production |
| KR102895580B1 (ko) | 2015-12-09 | 2025-12-03 | 진강 메디신 (오스트레일리아) 피티와이 엘티디 | 치료를 위한 면역조절용 조성물 |
| CA3028682A1 (en) | 2016-06-20 | 2017-12-28 | Howard Y. Chang | Circular rnas and their use in immunomodulation |
| WO2018018082A1 (en) | 2016-07-26 | 2018-02-01 | The Australian National University | Immunostimulatory compositions and uses therefor |
| EP3682004A4 (de) | 2017-09-15 | 2021-05-26 | The Board of Trustees of the Leland Stanford Junior University | Multiplex-herstellung und barcodierung von genetisch veränderten zellen |
| US10917454B1 (en) | 2019-08-01 | 2021-02-09 | Rohde & Schwarz Gmbh & Co. Kg | System and method for ATC voice quality assurance |
| EP4419684A1 (de) | 2021-10-21 | 2024-08-28 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Retroelementerzeugte transkriptionsfaktorköder |
| WO2023077147A2 (en) | 2021-11-01 | 2023-05-04 | Pellis Therapeutics, Inc. | T-cell vaccines for patients with reduced humoral immunity |
| WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2023183589A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Rt-dna fidelity and retron genome editing |
| US20250215458A1 (en) | 2022-03-25 | 2025-07-03 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David | Production of reverse transcribed DNA (RT-DNA) using a retron reverse transcriptase from exogenous RNA |
| EP4499839A1 (de) | 2022-03-25 | 2025-02-05 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Verfahren zur beurteilung der manipulierten retron-aktivität und verwendungen davon |
| MA71557A (fr) | 2022-07-18 | 2025-05-30 | Renagade Therapeutics Management Inc. | Composants d'édition génique, systèmes et procédés d'utilisation |
| WO2024044673A1 (en) | 2022-08-24 | 2024-02-29 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Dual cut retron editors for genomic insertions and deletions |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| WO2024233791A1 (en) | 2023-05-11 | 2024-11-14 | Seelos Therapeutics, Inc. | Methods of treating neurodegenerative disorders |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK489481A (da) * | 1980-11-10 | 1982-05-11 | Searle & Co | Plasmidvektor og frmgangsmaade til fremstilling deraf |
| US4603112A (en) * | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| AU570940B2 (en) * | 1982-11-30 | 1988-03-31 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Process for producing poxvirus recombinants for expression offoreign genes |
| FR2563434B1 (fr) * | 1984-04-25 | 1986-07-25 | Transgene Sa | Vaccin contre la rage et procede pour sa preparation |
| WO1986000528A1 (en) * | 1984-07-05 | 1986-01-30 | Genex Corporation | Cloned gene and method for making and using the same |
| DD235669A1 (de) * | 1985-03-26 | 1986-05-14 | Akad Wissenschaften Ddr | Verfahren zur herstellung eines blv-kodierten huellproteins |
| WO1986005806A1 (en) * | 1985-03-29 | 1986-10-09 | National Research Development Corporation | Infectious bronchitis virus spike protein |
| EP0213894A3 (de) * | 1985-08-23 | 1987-10-21 | Advanced Genetics Research Institute | Defektive Viruspartikelimpfstoffe und Verfahren zur Anwendung derselben |
| AU607399B2 (en) * | 1985-09-09 | 1991-03-07 | Cetus Corporation | Infectious recombinant virus vaccine for feline leukemia |
| GR862412B (en) * | 1985-09-25 | 1987-01-23 | Oncogen | Vaccines and immuinoassays for acquired immune deficiency syndrome |
| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| AU8075787A (en) * | 1986-09-22 | 1988-04-07 | Australian National University, The | Recombinant poxviruses |
| WO1988002022A1 (en) * | 1986-09-22 | 1988-03-24 | Commonwealth Scientific And Industrial Research Or | Recombinant poxviruses |
| EP0261940A3 (de) * | 1986-09-23 | 1989-07-05 | Applied Biotechnology, Inc. | Pseudorabies-Impfstoffe und DNS-Vektoren zur Rekombination mit Poxviren |
| DE3853088T2 (de) * | 1987-03-27 | 1995-10-19 | Nippon Zeon Co | Rekombinantes Avipoxvirus. |
| DE10399031I1 (de) * | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
| GB8724885D0 (en) * | 1987-10-23 | 1987-11-25 | Binns M M | Fowlpox virus promotors |
| FR2632863B2 (fr) * | 1987-10-29 | 1990-08-31 | Transgene Sa | Virus du fowlpox recombinant et vaccins derives de ces virus |
| AU623913B2 (en) * | 1988-06-24 | 1992-05-28 | British Technology Group Limited | Fowlpox virus non-essential regions |
| WO1990010693A1 (en) * | 1989-03-08 | 1990-09-20 | Health Research, Inc. | Recombinant poxvirus host selection system |
| JP3895366B2 (ja) * | 1990-09-25 | 2007-03-22 | キャンタブ ファーマシューティカルズ リサーチ リミティド | ウィルス ワクチン |
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1987
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