ATE499948T1 - Nukleinsäure mukosale immunisierung - Google Patents
Nukleinsäure mukosale immunisierungInfo
- Publication number
- ATE499948T1 ATE499948T1 AT02733782T AT02733782T ATE499948T1 AT E499948 T1 ATE499948 T1 AT E499948T1 AT 02733782 T AT02733782 T AT 02733782T AT 02733782 T AT02733782 T AT 02733782T AT E499948 T1 ATE499948 T1 AT E499948T1
- Authority
- AT
- Austria
- Prior art keywords
- mucosal
- nucleic acid
- mucosal immunization
- replication
- acid mucosal
- Prior art date
Links
- 230000003053 immunization Effects 0.000 title abstract 2
- 238000002649 immunization Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 238000001476 gene delivery Methods 0.000 abstract 2
- 241000710929 Alphavirus Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26155401P | 2001-01-12 | 2001-01-12 | |
US33386101P | 2001-11-27 | 2001-11-27 | |
PCT/US2002/001031 WO2002080982A2 (en) | 2001-01-12 | 2002-01-14 | Nucleic acid mucosal immunization |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE499948T1 true ATE499948T1 (de) | 2011-03-15 |
Family
ID=26948685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02733782T ATE499948T1 (de) | 2001-01-12 | 2002-01-14 | Nukleinsäure mukosale immunisierung |
Country Status (8)
Country | Link |
---|---|
US (2) | US20030021766A1 (de) |
EP (2) | EP2198882A3 (de) |
JP (2) | JP2005502591A (de) |
AT (1) | ATE499948T1 (de) |
AU (1) | AU2002305914A1 (de) |
CA (1) | CA2434546C (de) |
DE (1) | DE60239317D1 (de) |
WO (1) | WO2002080982A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2266656A1 (en) * | 1996-09-17 | 1998-03-26 | Chiron Corporation | Compositions and methods for treating intracellular diseases |
US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
JP2004527524A (ja) * | 2001-04-05 | 2004-09-09 | カイロン コーポレイション | 非経口初回抗原刺激後の粘膜追加免疫 |
ATE437222T1 (de) * | 2001-09-06 | 2009-08-15 | Alphavax Inc | Alphavirus replikon-vektorsysteme |
ES2552687T3 (es) * | 2002-12-13 | 2015-12-01 | Alphavax, Inc. | Partículas alfavíricas y métodos de preparación |
DK1585812T3 (en) | 2002-12-13 | 2017-04-10 | Alphavax Inc | MULTI-ANTI-ANTI-ANTI-VIRUS REPLICATE PARTICLES AND PROCEDURES |
TWI406672B (zh) * | 2002-12-26 | 2013-09-01 | Mountain View Pharmaceuticals | 生物效力增進的β干擾素聚合物共軛體 |
WO2004085660A2 (en) * | 2003-03-20 | 2004-10-07 | Alphavax, Inc. | Improved alphavirus replicons and helper constructs |
PT1631264E (pt) * | 2003-06-02 | 2009-11-03 | Novartis Vaccines & Diagnostic | Composições imunogénicas à base de micropartículas biodegradáveis que compreendem um toxóide de difteria e do tétano |
AU2004257214B2 (en) * | 2003-07-11 | 2010-04-22 | Alphavax, Inc. | Alphavirus-based cytomegalovirus vaccines |
GB0409775D0 (en) * | 2004-04-30 | 2004-06-09 | Mabtech Ab | Assay |
GB0409771D0 (en) * | 2004-04-30 | 2004-06-09 | Mabtech Ab | Assay |
DE602005012382D1 (de) | 2004-05-18 | 2009-03-05 | Alphavax Inc | Von tc-83 abgeleitete alphavirus-vektoren, partikel und verfahren |
ES2647491T3 (es) * | 2004-05-21 | 2017-12-21 | Novartis Vaccines And Diagnostics, Inc. | Vectores del alfavirus para las vacunas del virus de la gripe |
EP2357000A1 (de) * | 2005-10-18 | 2011-08-17 | Novartis Vaccines and Diagnostics, Inc. | Mukosale und systemische Immunisierungen mit Alphavirus-Replikonpartikeln |
ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
AU2008266807B2 (en) * | 2007-06-21 | 2012-08-16 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
ES2662030T3 (es) | 2007-10-15 | 2018-04-05 | Admedus Vaccines Pty Limited | Sistema de construcciones y usos para el mismo |
US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
CA2930693A1 (en) | 2013-11-15 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Methods of treating heart failure with agonists of hypocretin receptor 2 |
BR112016013804A2 (pt) * | 2013-12-16 | 2017-10-10 | Us Health | imunoterapia de câncer distribuindo antígenos mhc de classe ii usando um replicon de vlp |
WO2017004022A2 (en) | 2015-06-29 | 2017-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Degron fusion constructs and methods for controlling protein production |
US10596248B2 (en) | 2015-12-09 | 2020-03-24 | Jingang Medicine (Australia) Pty Ltd | Immunomodulating composition for treatment |
CN108893468A (zh) * | 2018-07-18 | 2018-11-27 | 甘肃农业大学 | 盐生草着丝粒反转录转座子序列元件Gag的分离及其应用 |
US11679163B2 (en) | 2019-09-20 | 2023-06-20 | Hdt Bio Corp. | Compositions and methods for delivery of RNA |
GB2605538B (en) | 2020-03-23 | 2024-06-26 | Hdt Bio Corp | Compositions and methods for delivery of RNA |
WO2023070072A1 (en) | 2021-10-21 | 2023-04-27 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Retroelement-generated transcription factor decoys |
WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
WO2023183588A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Methods of assessing engineered retron activity, and uses thereof |
WO2023183627A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Production of reverse transcribed dna (rt-dna) using a retron reverse transcriptase from exogenous rna |
WO2023183589A1 (en) | 2022-03-25 | 2023-09-28 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Rt-dna fidelity and retron genome editing |
WO2024020346A2 (en) | 2022-07-18 | 2024-01-25 | Renagade Therapeutics Management Inc. | Gene editing components, systems, and methods of use |
WO2024044673A1 (en) | 2022-08-24 | 2024-02-29 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Dual cut retron editors for genomic insertions and deletions |
WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
US4663161A (en) | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
US4871488A (en) | 1985-04-22 | 1989-10-03 | Albany Medical College Of Union University | Reconstituting viral glycoproteins into large phospholipid vesicles |
US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US5135855A (en) | 1986-09-03 | 1992-08-04 | The United States Of America As Represented By The Department Of Health And Human Services | Rapid, versatile and simple system for expressing genes in eukaryotic cells |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
DE10399032I1 (de) | 1987-08-28 | 2004-01-29 | Health Research Inc | Rekombinante Viren. |
US5179022A (en) | 1988-02-29 | 1993-01-12 | E. I. Du Pont De Nemours & Co. | Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner |
EP0434713B1 (de) | 1988-09-13 | 1994-10-12 | Chiron Corporation | Mutanten des hiv-1 Hüllproteins mit fehlenden hypervariabelen domänen. |
ES2116269T3 (es) | 1989-03-21 | 1998-07-16 | Vical Inc | Expresion de secuencias exogenas de polinucleotidos en un vertebrado. |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
FR2658432B1 (fr) | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
MY109299A (en) | 1990-08-15 | 1996-12-31 | Virogenetics Corp | Recombinant pox virus encoding flaviviral structural proteins |
US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
US5612201A (en) * | 1991-05-23 | 1997-03-18 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules useful in determining expression of a tumor rejection antigen precursor |
JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
IT1253009B (it) * | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
JP3444885B2 (ja) | 1992-08-21 | 2003-09-08 | フリーイェ・ユニヴェルシテイト・ブリュッセル | L鎖欠落免疫グロブリン |
US5831005A (en) | 1992-09-24 | 1998-11-03 | Chiron Corporation | Synthesis of N-substituted oligomers |
US5591601A (en) | 1993-05-14 | 1997-01-07 | Ohio University Edison Animal Biotechnology Institute | DNA polymerase gene expression system utilizing an RNA polymerase co-delivered with the gene expression vector system |
US5614413A (en) | 1993-07-01 | 1997-03-25 | The Uab Research Foundation | Encapsidated recombinant poliovirus nucleic acid and methods of making and using same |
US5830877A (en) * | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
ES2328424T3 (es) * | 1993-09-15 | 2009-11-12 | Novartis Vaccines And Diagnostics, Inc. | Vectores de alfavirus recombinantes. |
GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
US5676950A (en) | 1994-10-28 | 1997-10-14 | University Of Florida | Enterically administered recombinant poxvirus vaccines |
US5741492A (en) * | 1996-01-23 | 1998-04-21 | St. Jude Children's Research Hospital | Preparation and use of viral vectors for mixed envelope protein vaccines against human immunodeficiency viruses |
EP0907746B1 (de) | 1996-04-05 | 2008-02-20 | Novartis Vaccines and Diagnostics, Inc. | Alphaviren-vektors mit eine reduzierte inhibierung der synthese von zellmakromolekülen |
AU3210997A (en) * | 1996-05-24 | 1997-12-09 | University Of Maryland At Baltimore | Dna vaccines for eliciting a mucosal immune response |
CA2259961A1 (en) * | 1996-07-10 | 1998-01-15 | Intellivax, Inc. | Protein and peptide vaccines for inducing mucosal immunity |
US5972666A (en) * | 1996-07-26 | 1999-10-26 | G. D. Searle & Co. | Assembly-deficient herpesvirus vaccine |
GB9622660D0 (en) | 1996-10-31 | 1997-01-08 | Biocine Spa | Immunogenic detoxified mutant toxin |
US5842723A (en) | 1996-11-25 | 1998-12-01 | Burex Automotive America, Inc. | Flexible connection arrangement for connecting a pipe of an exhaust system to an engine, especially in a motor vehicle |
US6818222B1 (en) * | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
US6261570B1 (en) * | 1997-05-20 | 2001-07-17 | The United States Of America As Represented By The Secretary Of The Army | Live attenuated virus vaccines for western equine encephalitis virus, eastern equine encephalitis virus, and venezuelan equine encephalitis virus IE and IIIA variants |
CA2333931C (en) * | 1998-07-15 | 2013-09-03 | Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
AU5677399A (en) * | 1998-08-20 | 2000-03-14 | Wistar Institute Of Anatomy And Biology, The | Methods of augmenting mucosal immunity through systemic priming and mucosal boosting |
JP4530317B2 (ja) * | 1998-10-21 | 2010-08-25 | 学校法人北里研究所 | 減毒化トキシンを含むワクチン製剤 |
CN1298851C (zh) * | 1998-11-18 | 2007-02-07 | 牛津生物医学(英国)有限公司 | 多肽 |
US6329201B1 (en) | 1998-12-31 | 2001-12-11 | Chiron Corporation | Compositions and methods for packaging of alphavirus vectors |
CA2360347C (en) | 1998-12-31 | 2013-05-07 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
AU2487300A (en) * | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
JP2002537355A (ja) * | 1999-02-26 | 2002-11-05 | カイロン コーポレイション | 抗原の粘膜送達のための生体接着剤およびアジュバントの使用 |
JP4637368B2 (ja) | 1999-04-14 | 2011-02-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | アルファウイルスに基づくベクター系を利用する免疫応答を生成するための組成物および方法 |
DK1187629T3 (da) * | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
GB9923060D0 (en) | 1999-09-29 | 1999-12-01 | Chiron Spa | Vaccine |
US6534064B1 (en) * | 1999-10-13 | 2003-03-18 | Chiron Corporation | Stabilized protein particles for inducing cellular immune responses |
JP5597335B2 (ja) | 1999-11-19 | 2014-10-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 樹状細胞の微粒子ベースのトランスフェクションおよび活性化 |
US6783939B2 (en) * | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
US9931272B2 (en) | 2010-05-21 | 2018-04-03 | Gregory Sadkhin | Method for reducing a person's weight through hunger control |
GB2530110A (en) | 2014-11-03 | 2016-03-16 | Multi Packaging Solutions Uk Ltd | Packaging |
-
2002
- 2002-01-14 AT AT02733782T patent/ATE499948T1/de active
- 2002-01-14 US US10/051,749 patent/US20030021766A1/en not_active Abandoned
- 2002-01-14 EP EP10003888A patent/EP2198882A3/de not_active Withdrawn
- 2002-01-14 WO PCT/US2002/001031 patent/WO2002080982A2/en active Application Filing
- 2002-01-14 DE DE60239317T patent/DE60239317D1/de not_active Expired - Lifetime
- 2002-01-14 EP EP02733782A patent/EP1363663B1/de not_active Expired - Lifetime
- 2002-01-14 CA CA2434546A patent/CA2434546C/en not_active Expired - Fee Related
- 2002-01-14 AU AU2002305914A patent/AU2002305914A1/en not_active Abandoned
- 2002-01-14 JP JP2002579020A patent/JP2005502591A/ja not_active Withdrawn
-
2010
- 2010-03-11 JP JP2010055112A patent/JP2010138201A/ja active Pending
-
2012
- 2012-01-12 US US13/349,326 patent/US20120114693A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20120114693A1 (en) | 2012-05-10 |
AU2002305914A1 (en) | 2002-10-21 |
EP1363663A2 (de) | 2003-11-26 |
WO2002080982A9 (en) | 2003-04-10 |
US20030021766A1 (en) | 2003-01-30 |
CA2434546C (en) | 2012-09-11 |
EP2198882A3 (de) | 2010-10-13 |
WO2002080982A2 (en) | 2002-10-17 |
EP1363663B1 (de) | 2011-03-02 |
JP2010138201A (ja) | 2010-06-24 |
WO2002080982A3 (en) | 2003-09-18 |
EP2198882A2 (de) | 2010-06-23 |
JP2005502591A (ja) | 2005-01-27 |
CA2434546A1 (en) | 2002-10-17 |
DE60239317D1 (de) | 2011-04-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60239317D1 (de) | Nukleinsäure mukosale immunisierung | |
ATE320792T1 (de) | Mikropartikel zur verabreichung von heterologen nukleinsäure | |
NZ540544A (en) | Nucleic acids and proteins from streptococcus groups A & B | |
WO2003002065A3 (en) | Hcv e1e2 vaccine compositions | |
WO2003059381A3 (en) | Immunogenic preparations and vaccines on the basis of mrna | |
NZ506086A (en) | Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins, antigens comprising derivatised thiol residues and of compositions for vaccination | |
AU2002302921A1 (en) | Gonococcal proteins and nucleic acids | |
IS4518A (is) | Nýtt lyfjaform fyrir bóluefni | |
EP0278940A3 (de) | Hepatitis-B-Virus-Oberflächenantigene und sie enthaltende hybride Antigene | |
WO2000029428A3 (en) | 5t4 tumour-associated antigen for use in tumour immunotherapy | |
DK1047784T3 (da) | Neissera meningitidis-antigener | |
AU5810201A (en) | Immunogenic polypeptides encoded by mage minigenes and uses thereof | |
WO2002061113A3 (en) | Nucleic acid derived vaccine that encodes an antigen linked to a polypeptide that promotes antigen presentation | |
DE69841807D1 (de) | Neisseriale antigene | |
WO2001060402A3 (en) | Proteosome influenza vaccine | |
WO1998056919A3 (en) | Methods and reagents for vaccination which generate a cd8 t cell immune response | |
WO2002032450A3 (en) | Vaccines | |
CA2437201A1 (en) | Methods and compositions useful for stimulating an immune response | |
CA2272338A1 (en) | Immunization of infants | |
WO2001032014A3 (en) | Use of salmonella vectors for vaccination against hellicobacter infection | |
WO2002098456A3 (en) | Antigens and vectors for vaccination | |
WO2003031569A3 (en) | Nucleic acid vaccines using tumor antigen encoding nucleic acids with cytokine adjuvant encoding nucleic acid | |
WO2002036160A3 (es) | Método de obtención de estructuras antigénicas que potencian la reactividad cruzada específica | |
ATE374622T1 (de) | Genetische impstoffe mit adjuvans | |
SI1227840T1 (sl) | Genetske vakcine z adjuvansom |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1363663 Country of ref document: EP |