NL193263C - Werkwijze voor het vervaardigen van een bloeddichte kunstader die een geneesmiddel afgeeft. - Google Patents
Werkwijze voor het vervaardigen van een bloeddichte kunstader die een geneesmiddel afgeeft. Download PDFInfo
- Publication number
- NL193263C NL193263C NL8500239A NL8500239A NL193263C NL 193263 C NL193263 C NL 193263C NL 8500239 A NL8500239 A NL 8500239A NL 8500239 A NL8500239 A NL 8500239A NL 193263 C NL193263 C NL 193263C
- Authority
- NL
- Netherlands
- Prior art keywords
- collagen
- gel
- tetracycline
- drug
- water
- Prior art date
Links
- 210000001367 artery Anatomy 0.000 title claims description 19
- 239000003814 drug Substances 0.000 title claims description 18
- 229940079593 drug Drugs 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 229920001436 collagen Polymers 0.000 claims description 77
- 108010035532 Collagen Proteins 0.000 claims description 76
- 102000008186 Collagen Human genes 0.000 claims description 76
- 239000004098 Tetracycline Substances 0.000 claims description 24
- 229960002180 tetracycline Drugs 0.000 claims description 24
- 238000000576 coating method Methods 0.000 claims description 23
- 229930101283 tetracycline Natural products 0.000 claims description 23
- 235000019364 tetracycline Nutrition 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 19
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 17
- 239000000725 suspension Substances 0.000 claims description 14
- 150000003522 tetracyclines Chemical class 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 10
- 239000002002 slurry Substances 0.000 claims description 10
- 210000003462 vein Anatomy 0.000 claims description 10
- 239000004014 plasticizer Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 7
- 239000000512 collagen gel Substances 0.000 claims description 6
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims description 6
- 229910052753 mercury Inorganic materials 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 230000003115 biocidal effect Effects 0.000 claims description 2
- OFVLGDICTFRJMM-WESIUVDSSA-N tetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O OFVLGDICTFRJMM-WESIUVDSSA-N 0.000 claims 10
- 238000002360 preparation method Methods 0.000 claims 7
- 238000002347 injection Methods 0.000 claims 6
- 239000007924 injection Substances 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 4
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 3
- 230000037396 body weight Effects 0.000 claims 3
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims 1
- 239000004100 Oxytetracycline Substances 0.000 claims 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 108010020199 glutaraldehyde-cross-linked collagen Proteins 0.000 claims 1
- 229960002591 hydroxyproline Drugs 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
- 229960000625 oxytetracycline Drugs 0.000 claims 1
- 235000019366 oxytetracycline Nutrition 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 description 19
- 239000005020 polyethylene terephthalate Substances 0.000 description 12
- 229920004934 Dacron® Polymers 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- WKJGTOYAEQDNIA-IOOZKYRYSA-N (6r,7r)-7-[[(2r)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate Chemical compound O.C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CS[C@@H]32)C(O)=O)=O)N)=CC=CC=C1 WKJGTOYAEQDNIA-IOOZKYRYSA-N 0.000 description 6
- 241000283690 Bos taurus Species 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229960005361 cefaclor Drugs 0.000 description 6
- 239000004744 fabric Substances 0.000 description 6
- 241000588724 Escherichia coli Species 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- 229930186147 Cephalosporin Natural products 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 229940124587 cephalosporin Drugs 0.000 description 2
- 150000001780 cephalosporins Chemical class 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 238000009941 weaving Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 238000002768 Kirby-Bauer method Methods 0.000 description 1
- 229920001410 Microfiber Polymers 0.000 description 1
- 102000002151 Microfilament Proteins Human genes 0.000 description 1
- 108010040897 Microfilament Proteins Proteins 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127090 anticoagulant agent Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000003658 microfiber Substances 0.000 description 1
- 210000003632 microfilament Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- UWYHMGVUTGAWSP-JKIFEVAISA-N oxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1 UWYHMGVUTGAWSP-JKIFEVAISA-N 0.000 description 1
- 229960001019 oxacillin Drugs 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2002/065—Y-shaped blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57509184A | 1984-01-30 | 1984-01-30 | |
| US57509184 | 1984-01-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NL8500239A NL8500239A (nl) | 1985-08-16 |
| NL193263B NL193263B (nl) | 1999-01-04 |
| NL193263C true NL193263C (nl) | 1999-05-06 |
Family
ID=24298898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8500239A NL193263C (nl) | 1984-01-30 | 1985-01-29 | Werkwijze voor het vervaardigen van een bloeddichte kunstader die een geneesmiddel afgeeft. |
Country Status (11)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4699141A (en) * | 1986-01-16 | 1987-10-13 | Rhode Island Hospital | Neovascularization |
| DE3608158A1 (de) * | 1986-03-12 | 1987-09-17 | Braun Melsungen Ag | Mit vernetzter gelatine impraegnierte gefaessprothese und verfahren zu ihrer herstellung |
| FI83729C (fi) * | 1987-11-26 | 1991-08-26 | Biocon Oy | Kirurgisk implantat. |
| US6004346A (en) * | 1990-02-28 | 1999-12-21 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| JPH05502179A (ja) * | 1990-02-28 | 1993-04-22 | メドトロニック インコーポレーテッド | 管状器官内薬剤溶出装具 |
| CS277367B6 (en) * | 1990-12-29 | 1993-01-13 | Krajicek Milan | Three-layered vascular prosthesis |
| CA2074924A1 (en) * | 1991-08-05 | 1993-02-06 | Matthew E. Hermes | Method and composition for treating bioabsorbable surgical articles |
| DE4222380A1 (de) * | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
| US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
| DE69535595T2 (de) * | 1994-02-18 | 2008-06-05 | Organogenesis, Inc., Canton | Verfahren zur Herstellung einer Bio-umbaubaren Transplantatprothese aus Kollagen |
| FR2722678B1 (fr) * | 1994-07-25 | 1996-12-27 | Braun Celsa Sa B | Prothese medicale a embranchement utilisable pour le traitement des anevrismes, dispositif comprenant une telle prothese |
| US5665114A (en) * | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
| US20020095218A1 (en) | 1996-03-12 | 2002-07-18 | Carr Robert M. | Tissue repair fabric |
| DE19521642C2 (de) * | 1995-06-14 | 2000-11-09 | Aesculap Ag & Co Kg | Implantat, seine Verwendung in der Chirurgie und Verfahren zu seiner Herstellung |
| US6177609B1 (en) * | 1997-03-10 | 2001-01-23 | Meadox Medicals, Inc. | Self-aggregating protein compositions and use as sealants |
| SE514944C2 (sv) | 1997-12-30 | 2001-05-21 | Lars Sunnanvaeder | Apparatur för terapeutisk behandling av ett blodkärl |
| US6129757A (en) | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
| AU763724B2 (en) | 1998-06-05 | 2003-07-31 | Duke University School Of Medicine | Bioengineered vascular graft support prostheses |
| WO1999062424A2 (en) | 1998-06-05 | 1999-12-09 | Organogenesis Inc. | Bioengineered tubular graft prostheses |
| DE69940507D1 (de) | 1998-06-05 | 2009-04-16 | Organogenesis Inc | Biotechnisch erzeugte gefässprothese für die implantation |
| CA2334364C (en) | 1998-06-05 | 2011-01-04 | Organogenesis Inc. | Bioengineered flat sheet graft prostheses |
| US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
| US6797743B2 (en) | 2000-09-27 | 2004-09-28 | Michigan Biotechnology Institute | Antimicrobial polymer |
| US6939554B2 (en) * | 2002-02-05 | 2005-09-06 | Michigan Biotechnology Institute | Antimicrobial polymer |
| US7204940B2 (en) | 2002-03-20 | 2007-04-17 | Michigan Biotechnology Institute | Conductive polymer-based material |
| US6951902B2 (en) | 2002-08-16 | 2005-10-04 | Michigan Biotechnology Institute | Two dimensional polymer that generates nitric oxide |
| US6923996B2 (en) | 2003-05-06 | 2005-08-02 | Scimed Life Systems, Inc. | Processes for producing polymer coatings for release of therapeutic agent |
| US7329531B2 (en) * | 2003-12-12 | 2008-02-12 | Scimed Life Systems, Inc. | Blood-tight implantable textile material and method of making |
| JP4719133B2 (ja) * | 2006-11-21 | 2011-07-06 | 株式会社東京機械製作所 | 咥折装置 |
| DE102009037134A1 (de) | 2009-07-31 | 2011-02-03 | Aesculap Ag | Tubuläres Implantat zum Ersatz von natürlichen Blutgefäßen |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185332B (de) * | 1961-03-01 | 1965-01-14 | Ethicon Inc | Chirurgische Prothese |
| CH472219A (de) * | 1963-06-15 | 1969-05-15 | Spofa Vereinigte Pharma Werke | Hochporöse Kollagen-Gewebe-Blutgefässprothese und Verfahren zur Herstellung derselben |
| US3272204A (en) * | 1965-09-22 | 1966-09-13 | Ethicon Inc | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands |
| US3479670A (en) * | 1966-10-19 | 1969-11-25 | Ethicon Inc | Tubular prosthetic implant having helical thermoplastic wrapping therearound |
| DE1566358B2 (de) * | 1967-03-09 | 1977-04-21 | Meadox Medicals, Inc., Haiedon, NJ. (V.StA.) | Gefaessprothese fuer chirurgische zwecke |
| DE1766340A1 (de) * | 1967-05-19 | 1971-07-01 | Vyzk Ustav Pletarzsky | Textil-Kollagenprothese |
| FR2029155A5 (en) * | 1969-01-15 | 1970-10-16 | Mo Med I | Prosthetic vessels of high biological - permeability |
| US3688317A (en) * | 1970-08-25 | 1972-09-05 | Sutures Inc | Vascular prosthetic |
| US3928653A (en) * | 1975-02-05 | 1975-12-23 | Tee Pak Inc | Collagen slurry containing partial fatty acid esters of glycerin |
| DE2601289C3 (de) * | 1976-01-15 | 1978-07-13 | B. Braun Melsungen Ag, 3508 Melsungen | Verfahren zum Abdichten von synthetischen Velours-Gefäßprothesen |
| DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
| SU904693A1 (ru) * | 1980-05-12 | 1982-02-15 | Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им. И.М.Сеченова | Протез сосуда |
| US4416028A (en) * | 1981-01-22 | 1983-11-22 | Ingvar Eriksson | Blood vessel prosthesis |
| US4546500A (en) * | 1981-05-08 | 1985-10-15 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
| WO1983003536A1 (en) * | 1982-04-19 | 1983-10-27 | Massachusetts Inst Technology | A multilayer bioreplaceable blood vessel prosthesis |
-
1985
- 1985-01-28 IL IL74180A patent/IL74180A/xx not_active IP Right Cessation
- 1985-01-29 FR FR858501219A patent/FR2558720B1/fr not_active Expired
- 1985-01-29 CA CA000473090A patent/CA1250235A/en not_active Expired
- 1985-01-29 GB GB08502156A patent/GB2153235B/en not_active Expired
- 1985-01-29 NL NL8500239A patent/NL193263C/nl not_active IP Right Cessation
- 1985-01-30 SE SE8500422A patent/SE464009B/sv not_active IP Right Cessation
- 1985-01-30 BE BE0/214420A patent/BE901611A/fr not_active IP Right Cessation
- 1985-01-30 DE DE3503126A patent/DE3503126C2/de not_active Expired - Lifetime
- 1985-01-30 AU AU38196/85A patent/AU575617B2/en not_active Ceased
- 1985-01-30 CH CH411/85A patent/CH670380A5/de not_active IP Right Cessation
- 1985-01-30 JP JP60014591A patent/JPH0636817B2/ja not_active Expired - Lifetime
-
1987
- 1987-04-13 GB GB08708756A patent/GB2187192B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| BE901611A (fr) | 1985-05-17 |
| DE3503126C2 (de) | 1996-05-15 |
| GB2187192A (en) | 1987-09-03 |
| GB2153235A (en) | 1985-08-21 |
| CH670380A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-06-15 |
| IL74180A (en) | 1992-06-21 |
| GB2187192B (en) | 1988-12-14 |
| FR2558720B1 (fr) | 1989-10-20 |
| JPS6192672A (ja) | 1986-05-10 |
| IL74180A0 (en) | 1985-04-30 |
| SE464009B (sv) | 1991-02-25 |
| DE3503126A1 (de) | 1985-08-01 |
| JPH0636817B2 (ja) | 1994-05-18 |
| NL193263B (nl) | 1999-01-04 |
| SE8500422D0 (sv) | 1985-01-30 |
| FR2558720A1 (fr) | 1985-08-02 |
| GB8708756D0 (en) | 1987-05-20 |
| AU575617B2 (en) | 1988-08-04 |
| CA1250235A (en) | 1989-02-21 |
| NL8500239A (nl) | 1985-08-16 |
| GB2153235B (en) | 1988-12-14 |
| AU3819685A (en) | 1985-08-08 |
| GB8502156D0 (en) | 1985-02-27 |
| SE8500422L (sv) | 1985-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL193263C (nl) | Werkwijze voor het vervaardigen van een bloeddichte kunstader die een geneesmiddel afgeeft. | |
| US5197977A (en) | Drug delivery collagen-impregnated synthetic vascular graft | |
| NL193264C (nl) | Werkwijze voor het vervaardigen van een bloeddichte kunstader. | |
| US5538735A (en) | Method of making a drug delivery system using hollow fibers | |
| US5851230A (en) | Vascular graft with a heparin-containing collagen sealant | |
| US4842575A (en) | Method for forming impregnated synthetic vascular grafts | |
| US5108424A (en) | Collagen-impregnated dacron graft | |
| EP0633032B1 (en) | Antibacterial vascular prosthesis and surgical suture | |
| DE60009275T2 (de) | Gefässtransplantat aus expandiertem polytetrafluorethylen mit einer beschichtung | |
| US3272204A (en) | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands | |
| EP0372969A1 (en) | Low molecular weight heparin, heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process | |
| Guidoin et al. | Polyester prostheses as substitutes in the thoracic aorta of dogs. I. Evaluation of commercial prostheses | |
| Aebischer et al. | Tissue reaction to fabrics coated with turbostratic carbon: subcutaneous versus vascular implants | |
| EP0652017A1 (de) | Beschichtung für Biomaterial | |
| US20050220835A1 (en) | Agent eluting bioimplantable devices and polymer systems for their preparation | |
| RU2835436C1 (ru) | Способ изготовления функционально активной полимерной заплаты для артериальной реконструкции, устойчивой к аневризмообразованию | |
| DE3546875C2 (de) | Aufschlämmung von Kollagenfibrillen zum blutdichten Beschichten eines flüssigkeitsdurchlässigen synthetischen Gefäßersatz-Substrats | |
| AU737348B2 (en) | Vascular graft impregnated with a heparin-containing collagen sealant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| V1 | Lapsed because of non-payment of the annual fee |
Effective date: 20030801 |