NL1022443C2 - Sphingolipiden voor verbetering van de samenstelling van de darmflora. - Google Patents
Sphingolipiden voor verbetering van de samenstelling van de darmflora. Download PDFInfo
- Publication number
- NL1022443C2 NL1022443C2 NL1022443A NL1022443A NL1022443C2 NL 1022443 C2 NL1022443 C2 NL 1022443C2 NL 1022443 A NL1022443 A NL 1022443A NL 1022443 A NL1022443 A NL 1022443A NL 1022443 C2 NL1022443 C2 NL 1022443C2
- Authority
- NL
- Netherlands
- Prior art keywords
- sphingolipids
- sphingolipid
- phytosphingosine
- composition
- sphinganine
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Confectionery (AREA)
- Saccharide Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1022443A NL1022443C2 (nl) | 2003-01-20 | 2003-01-20 | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| JP2006500733A JP2006516278A (ja) | 2003-01-20 | 2004-01-20 | 腸内細菌叢の組成の改善のためのスフィンゴ脂質 |
| US10/542,838 US8703172B2 (en) | 2003-01-20 | 2004-01-20 | Sphingolipids for improvement of the composition of the intestinal flora |
| EP04703547A EP1585509B1 (en) | 2003-01-20 | 2004-01-20 | Sphingolipids for improvement of the composition of the intestinal flora |
| DE602004016727T DE602004016727D1 (de) | 2003-01-20 | 2004-01-20 | Sphingolipiden zur verbesserung der darmflorazusammensetzung |
| AT04703547T ATE409030T1 (de) | 2003-01-20 | 2004-01-20 | Sphingolipiden zur verbesserung der darmflorazusammensetzung |
| PCT/NL2004/000046 WO2004064819A1 (en) | 2003-01-20 | 2004-01-20 | Sphingolipids for improvement of the composition of the intestinal flora |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1022443 | 2003-01-20 | ||
| NL1022443A NL1022443C2 (nl) | 2003-01-20 | 2003-01-20 | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL1022443C2 true NL1022443C2 (nl) | 2004-07-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL1022443A NL1022443C2 (nl) | 2003-01-20 | 2003-01-20 | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8703172B2 (https=) |
| EP (1) | EP1585509B1 (https=) |
| JP (1) | JP2006516278A (https=) |
| AT (1) | ATE409030T1 (https=) |
| DE (1) | DE602004016727D1 (https=) |
| NL (1) | NL1022443C2 (https=) |
| WO (1) | WO2004064819A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20010688A1 (it) * | 2001-11-21 | 2003-05-21 | Univ Roma | Composti immunoregolatori. |
| EP1585508B1 (en) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels |
| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| US20050196461A1 (en) * | 2004-01-14 | 2005-09-08 | Udell Ronald G. | Ceramide formulations suitable for oral administration |
| JP2005281257A (ja) * | 2004-03-30 | 2005-10-13 | Snow Brand Milk Prod Co Ltd | 美肌剤 |
| JP2008521888A (ja) * | 2004-11-30 | 2008-06-26 | ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー | 脂肪症の、又は肝毒性及びその後遺症の治療及び予防におけるスフィンゴ脂質 |
| US8025552B2 (en) * | 2004-12-30 | 2011-09-27 | The United States Of America As Represented By The Secretary Of Agriculture | Artificial diets for honey bees |
| GB0513431D0 (en) * | 2005-06-30 | 2005-08-10 | Kherion Technology Ltd | Prophylactic compositions and uses |
| US20090162482A1 (en) * | 2007-12-21 | 2009-06-25 | S.A.F.E. Research & Development, Llc | Nutritional Compositions for Bees |
| CN101945589A (zh) * | 2007-12-21 | 2011-01-12 | 荷兰纽迪希亚公司 | 用于改善肠道微生物群的非消化性碳水化合物的用途 |
| JP6675752B2 (ja) * | 2016-02-23 | 2020-04-01 | 国立大学法人佐賀大学 | 腸内Ｂｌａｕｔｉａ ｃｏｃｃｏｉｄｅｓ増殖刺激剤 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2820037A1 (fr) * | 2001-01-29 | 2002-08-02 | Dermaconcept Jmc | Composition dermatologique a usage veterinaire comprenant une base sphingoide |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3622666A (en) * | 1968-03-04 | 1971-11-23 | Stanley Drug Products Inc | Methods for treating bacterial infections with phrenosin |
| FR2492259A1 (fr) | 1980-10-21 | 1982-04-23 | Idinvex Sa | Formulation d'heparine |
| JPS61152632A (ja) | 1984-12-26 | 1986-07-11 | Dai Ichi Seiyaku Co Ltd | 抗動脈硬化剤 |
| JPS6344842A (ja) | 1986-08-12 | 1988-02-25 | Kao Corp | 油中水中油型乳化油脂組成物 |
| IT1235162B (it) | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisosfingolipidi |
| US5190876A (en) | 1988-12-27 | 1993-03-02 | Emory University | Method of modifying cellular differentiation and function and compositions therefor |
| JPH05508863A (ja) | 1990-08-13 | 1993-12-09 | デューク・ユニバーシティ | セラミドを使用して細胞分裂を誘導する方法 |
| US5543390A (en) * | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| US5232837A (en) | 1991-08-05 | 1993-08-03 | Emory University | Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination |
| US5374616A (en) | 1991-10-18 | 1994-12-20 | Georgetown University | Compositions containing sphingosylphosphorylcholine and the use thereof as a cellular growth factor |
| JPH05320048A (ja) * | 1992-05-19 | 1993-12-03 | Shiseido Co Ltd | 抗酸化剤 |
| US6190894B1 (en) | 1993-03-19 | 2001-02-20 | The Regents Of The University Of California | Method and compositions for disrupting the epithelial barrier function |
| US5478860A (en) | 1993-06-04 | 1995-12-26 | Inex Pharmaceuticals Corp. | Stable microemulsions for hydrophobic compound delivery |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6773719B2 (en) | 1994-03-04 | 2004-08-10 | Esperion Luv Development, Inc. | Liposomal compositions, and methods of using liposomal compositions to treat dislipidemias |
| US20020182250A1 (en) | 1995-09-06 | 2002-12-05 | Goro Hori | Lipid metabolism improving agent |
| WO1997011706A1 (en) | 1995-09-29 | 1997-04-03 | Georgetown University | Use of sphingosylphosphorylcholine as a wound-healing agent |
| DE19602108A1 (de) * | 1996-01-22 | 1997-07-24 | Beiersdorf Ag | Gegen Bakterien, Parasiten, Protozoen, Mycota und Viren wirksame Substanzen |
| AU2195297A (en) | 1996-02-20 | 1997-09-02 | Sloan-Kettering Institute For Cancer Research | Combinations of pkc inhibitors and therapeutic agents for treating cancers |
| JP4545235B2 (ja) | 1996-03-28 | 2010-09-15 | ディーエスエム アイピー アセッツ ビー．ブイ． | 顆粒状微生物バイオマスの製造法とそのバイオマスからの貴重化合物の単離法 |
| ATE286735T1 (de) | 1997-04-10 | 2005-01-15 | Kirin Brewery | Verwendung von a-glycosylceramiden zur herstellung eines therapeutischen mittelszur behandlung von autoimmunkrankheiten |
| US6800661B1 (en) | 1997-04-15 | 2004-10-05 | Board Of Trustees Of The University Of Illinois | Spisulosine compounds |
| ES2210767T3 (es) | 1997-05-02 | 2004-07-01 | Cosmoferm B.V. | Composiciones antimicrobianas para uso topico. |
| US5989803A (en) | 1997-09-05 | 1999-11-23 | The Trustees Of Columbia University In The City Of New York | Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase |
| WO1999012890A1 (fr) * | 1997-09-11 | 1999-03-18 | Takara Shuzo Co., Ltd. | Derives de sphingosine et composition medicamenteuse |
| EP1053243B1 (en) * | 1998-02-12 | 2011-03-30 | Emory University | Sphingolipid derivatives and their methods of use |
| JP3581010B2 (ja) | 1998-03-18 | 2004-10-27 | 雪印乳業株式会社 | 脂質の消化吸収機能改善剤 |
| WO1999061581A2 (en) | 1998-05-26 | 1999-12-02 | Office Of The Dean Of Research And Graduate Education | Sphingosine kinase, cloning, expression and methods of use |
| CA2362549A1 (en) | 1999-02-24 | 2000-08-31 | John Hopkins University | Compositions and methods for modulating serum cholesterol |
| JP3544493B2 (ja) | 1999-06-10 | 2004-07-21 | 雪印乳業株式会社 | 乳幼児用栄養組成物 |
| KR100341793B1 (ko) | 1999-07-02 | 2002-06-24 | 권 영 근 | 스핑고신 1-포스페이트를 유효성분으로 포함하는 혈관신생 촉진제 |
| WO2001003739A1 (fr) | 1999-07-12 | 2001-01-18 | Ono Pharmaceutical Co., Ltd. | Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate |
| JP2001213858A (ja) | 1999-11-24 | 2001-08-07 | Sagami Chem Res Center | スフィンゴシン誘導体 |
| JP2001158736A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 骨関節疾患の予防及び改善剤 |
| JP2001158735A (ja) | 1999-11-30 | 2001-06-12 | Snow Brand Milk Prod Co Ltd | 歯周病の予防及び改善剤 |
| AU784722B2 (en) | 2000-02-18 | 2006-06-01 | Merck & Co., Inc. | Aryloxyacetic acids for diabetes and lipid disorders |
| WO2001072701A1 (en) | 2000-03-28 | 2001-10-04 | The Liposome Company, Inc. | Ceramide derivatives and method of use |
| JP2002068998A (ja) | 2000-08-29 | 2002-03-08 | Meiji Milk Prod Co Ltd | 経腸栄養および静脈栄養に伴う脂肪肝発生予防組成物 |
| AU2001212597A1 (en) | 2000-10-27 | 2002-05-06 | N.V. Marc Boone | Method for obtaining products enriched in phospho- and sphingolipids |
| US6949247B2 (en) | 2000-12-28 | 2005-09-27 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Stable skin care compositions containing a retinoid and a retinoid booster system |
| JP2002226394A (ja) | 2001-02-01 | 2002-08-14 | Meiji Milk Prod Co Ltd | 脂質代謝改善組成物 |
| DK1406641T3 (da) | 2001-06-18 | 2009-05-04 | Neptune Technologies & Bioress | Krillekstrakter til forebyggelse og/eller behandling af cardiovaskulære sygdomme |
| CA2493888C (en) | 2001-07-27 | 2013-07-16 | Neptune Technologies & Bioressources Inc. | Natural marine source phospholipids comprising flavonoids, polyunsaturated fatty acids and their applications |
| DE60117900D1 (de) | 2001-09-05 | 2006-05-11 | Charmzone Co | Phytosphingosinderivate mit Antitumorwirkung |
| US20030109044A1 (en) | 2001-10-16 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Methods of using 279, a human G protein-coupled protein receptor |
| JP4035759B2 (ja) | 2001-11-06 | 2008-01-23 | 独立行政法人産業技術総合研究所 | アミノアルコールリン酸化合物、製造方法、及びその利用方法 |
| JP2003155231A (ja) * | 2001-11-20 | 2003-05-27 | Kikkoman Corp | 医薬及び抗アレルギー剤 |
| JP2003252765A (ja) | 2002-02-28 | 2003-09-10 | Snow Brand Milk Prod Co Ltd | 腸管運動機能不全性疾患の治療剤 |
| DE10217555A1 (de) | 2002-04-19 | 2004-02-19 | Degussa Bioactives Deutschland Gmbh | Physiologisch verträgliche, Phospholipid-haltige, stabile und harte Matrix |
| AU2003239489A1 (en) | 2002-05-17 | 2003-12-02 | Esperion Therapeutics, Inc. | Method of treating dyslipidemic disorders |
| WO2004016257A1 (en) | 2002-08-14 | 2004-02-26 | Tae-Yoon Kim | A composition comprising phytospingosine derivatives for apoptosis induction |
| EP1585508B1 (en) | 2003-01-20 | 2009-04-01 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Use of sphingolipids for reducing plasma cholesterol and triacylglycerol levels |
| NL1022443C2 (nl) | 2003-01-20 | 2004-07-22 | Tno | Sphingolipiden voor verbetering van de samenstelling van de darmflora. |
| GB0301395D0 (en) | 2003-01-21 | 2003-02-19 | Univ Aston | Inflammatory disorder treatment |
| US20040171522A1 (en) | 2003-02-27 | 2004-09-02 | Yaron Ilan | Regulation of immune responses by manipulation of intermediary metabolite levels |
| US9717754B2 (en) | 2003-02-27 | 2017-08-01 | Enzo Therapeutics, Inc. | Glucocerebroside treatment of disease |
| WO2004096140A2 (en) | 2003-04-25 | 2004-11-11 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
| US8282773B2 (en) | 2007-12-14 | 2012-10-09 | Andritz Inc. | Method and system to enhance fiber development by addition of treatment agent during mechanical pulping |
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2003
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2004
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- 2004-01-20 DE DE602004016727T patent/DE602004016727D1/de not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2820037A1 (fr) * | 2001-01-29 | 2002-08-02 | Dermaconcept Jmc | Composition dermatologique a usage veterinaire comprenant une base sphingoide |
Non-Patent Citations (5)
| Title |
|---|
| BIBEL D J ET AL: "ANTIMICROBIAL ACTIVITY OF SPHINGOSINES", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 98, no. 3, 1992, pages 269 - 273, XP008021438, ISSN: 0022-202X * |
| FANTINI, J., ET AL.: "Synthetic Soluble Analogs of Galactosylceramide (GalCer) Bind to the V3 Domain of HIV-1 gp120 and Inhibit HIV-1-induced Fusion and Entry", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 11, 1997, pages 7245 - 7252, XP002253228 * |
| MERRILL JR A H ET AL: "Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases", JOURNAL OF NUTRITION 1995 UNITED STATES, vol. 125, no. 6 SUPPL., 1995, pages 1677S - 1682S, XP008021437, ISSN: 0022-3166 * |
| RUEDA, R., ET AL.: "Addition of gangliosides to an adapted milk formula modifies levels of fecal Escherichia coli in preterm newborn infants", J. PEDIATR., vol. 133, 1998, pages 90 - 94, XP008000724 * |
| VESPER, H., ET AL.: "Sphingolipids in Food and the Emerging Importance of Sphingolipids to Nutrition", JOURNAL OF NUTRITION, vol. 129, 1999, pages 1239 - 1250, XP008000798 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004016727D1 (de) | 2008-11-06 |
| EP1585509B1 (en) | 2008-09-24 |
| ATE409030T1 (de) | 2008-10-15 |
| US20060134182A1 (en) | 2006-06-22 |
| JP2006516278A (ja) | 2006-06-29 |
| US8703172B2 (en) | 2014-04-22 |
| EP1585509A1 (en) | 2005-10-19 |
| WO2004064819A1 (en) | 2004-08-05 |
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